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莫匹罗星, 异亮氨酰-tRNA 合成酶抑制剂

莫匹罗星, 异亮氨酰-tRNA 合成酶抑制剂

窄谱抗生素

规格或纯度: 95%

CAS编号: 12650-69-0
分子式: C₂₆H₄₄O₉
分子量: 500.62
EC号: 231-791-2
MDL号: MFCD01711620
PubChem编号: 446596

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货号 (SKU)	包装规格	是否现货	价格	数量
M102403-50mg	50mg	现货
M102403-100mg	100mg	现货
M102403-250mg	250mg	现货
M102403-1g	1g	现货
M102403-5g	5g	现货
M102403-25g	25g	现货

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基本描述

别名	莫匹罗星\|假单胞菌酸
英文别名	Mupirocin\|12650-69-0\|Pseudomonic acid\|Bactroban\|Mupirocine\|Centany\|Pseudomonic acid A\|Bactoderm\|Mupirocina\|Mupirocinum\|Turixin\|BRL 4910A\|BRL-4910A\|trans-Pseudomonic acid\|9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxir
规格或纯度	95%
英文名称	Mupirocin
生化机理	窄谱抗生素剂。与异亮氨酰t-RNA合成酶结合并抑制蛋白质合成。在体内显示出对革兰氏阳性细菌的剂量依赖性抑菌和杀菌作用。
储存温度	-20°C储存,充氩
运输条件	超低温冰袋运输
备注	25mg/100mg卖完停产，不再备货如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	Pseudomonic Acid, also known as mupirocin, is an antibiotic isolated from Pseudomonas fluorescens which strongly inhibits protein and RNA synthesis. Inhibition of protein synthesis was reversed by isoleucine and Pseudomonic Acid was shown to inhibit IleRS (isoleucyl-tRNA synthetase) in vitro. Pseudomonic Acid also demonstrates weak inhibitory action on FARSL (phenylalanyl-tRNA synthetase). Efficacy against staphylococci and streptococci including multiply resistant Staphylcoccus aureus and Staphylococcus epidermidis is reported with Pseudomonic Acid.An antibiotic inhibitor of isoleucyl-tRNA synthetase Product Describtion: Pseudomonic Acid, also known as mupirocin, is an antibiotic isolated from Pseudomonas fluorescens which strongly inhibits protein and RNA synthesis. Inhibition of protein synthesis was reversed by isoleucine and Pseudomonic Acid was shown to inhibit IleRS (isoleucyl-tRNA synthetase) in vitro. Pseudomonic Acid also demonstrates weak inhibitory action on FARSL (phenylalanyl-tRNA synthetase). Efficacy against staphylococci and streptococci including multiply resistant Staphylcoccus aureus and Staphylococcus epidermidis is reported with Pseudomonic Acid. An antibiotic inhibitor of isoleucyl-tRNA synthetase Product Application： Mupirocin is involved in inhibition of protein synthesis was reversed by isoleucine and Pseudomonic Acid was shown to inhibit IleRS (isoleucyl-tRNA synthetase) in vitro. It also demonstrates weak inhibitory action on FARSL (phenylalanyl-tRNA synthetase). Efficacy against staphylococci and streptococci including multiply resistant Staphylcoccus aureus and Staphylococcus epidermidis is reported with Pseudomonic Acid.

产品属性

ALogP	3

名称和标识符

EC号	231-791-2
IUPAC Name	9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid
INCHI	InChI=1S/C26H44O9/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29)/b16-13+/t17-,18-,19-,20-,21-,24+,25-,26-/m0/s1
InChi Key	MINDHVHHQZYEEK-HBBNESRFSA-N
Canonical SMILES	CC(C1C(O1)CC2COC(C(C2O)O)CC(=CC(=O)OCCCCCCCCC(=O)O)C)C(C)O
Isomeric SMILES	C[C@H]([C@H]1[C@@H](O1)C[C@H]2CO[C@H]([C@@H]([C@@H]2O)O)C/C(=C/C(=O)OCCCCCCCCC(=O)O)/C)[C@H](C)O
WGK Germany	2
RTECS	RA6907000
PubChem CID	446596
分子量	500.62

数据库链接

PubChem CID	446596
CAS Registry No.	12650-69-0
ChEMBL Ligand	CHEMBL719
BindingDB Ligand	50290686
DrugBank Ligand	DB00410
DrugCentral Ligand	1857

化学和物理性质

溶解性	Soluble in ethanol, methanol, DMF, DMSO (≥ 10 mg/ml), and water (limited).
密度	1.183
敏感性	对空气敏感，吸湿
比旋光度	-19° (C=1,MeOH)
沸点	672℃
熔点	78 °C

安全和危险性（GHS）

象形图	Harmful
信号词	Warning
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation H302: Harmful if swallowed H317: May cause an allergic skin reaction
预防措施声明	P261,P305+P351+P338,P280,P302+P352,P321,P501,P264,P270,P272,P333+P313,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317
WGK Germany	2
RTECS	RA6907000
Merck Index	6302
个人防护装备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

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参考文献

1. Hurdle JG, Yendapally R, Sun D, Lee RE. (2009) Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections.. Antimicrob Agents Chemother, 53 (9): (4028-31). [PMID:19581456]
2. Istvan ES, Dharia NV, Bopp SE, Gluzman I, Winzeler EA, Goldberg DE. (2011) Validation of isoleucine utilization targets in Plasmodium falciparum.. Proc Natl Acad Sci U S A, 108 (4): (1627-32). [PMID:21205898]

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