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MI-463

组蛋白甲基转移酶抑制剂

规格或纯度: 99%

CAS编号: 1628317-18-9
分子式: C₂₄H₂₃F₃N₆S
分子量: 484.54
PubChem编号: 90455046

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货号 (SKU)	包装规格	是否现货	价格	数量
M413841-5mg	5mg	现货
M413841-25mg	25mg	现货
M413841-50mg	50mg	现货
M413841-100mg	100mg	现货

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基本描述

英文别名	1H-Indole-2-carbonitrile,4-methyl-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-
规格或纯度	99%
英文名称	MI-463
生化机理	MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM.
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	Information MI-463 MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM. Targets Menin-MLL interaction (Cell-free assay) 15.3 nM In vitro MI-463 demonstrates profound on-target activity in MLL leukemia cells. MI-463 results in substantial growth inhibition, with half-maximal growth inhibitory concentration (GI50) values of 0.23 μM, measured after 7 days of treatment in MLL leukemia cells. MI-463 is effective in inducing differentiation of MLL leukemia cells. Treatment with sub-micromolar concentrations of MI-463 also leads to markedly reduced expression of Hoxa9 and Meis1, downstream targets of MLL fusion proteins substantially upregulated in MLL leukemias. In vivo MI-463 shows substantial survival benefit in mouse models of MLL leukemia. It has very favorable druglike properties, including metabolic stability and PK profile in mice. MI-463 achieves high levels in peripheral blood following a single intravenous or oral dose, while also showing high oral bioavailability(∼45%). In a mouse xenograft model using MV4;11 human MLL leukemia cells implanted into BALB/c nude mice, MI-463 induces strong inhibition of tumor growth with once-daily intraperitoneal (i.p.) administration. It does not impair normal hematopoiesis in vivo. Cell Research(from reference) Cell lines：leukemia cells Incubation Time：6 or 7 days

产品属性

ALogP	5.372
HBD Count	2
Rotatable Bond	6

名称和标识符

PubChem SID	488202498
IUPAC Name	4-methyl-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-1H-indole-2-carbonitrile
INCHI	InChI=1S/C24H23F3N6S/c1-14-15(2-3-21-19(14)8-17(11-28)31-21)12-33-6-4-16(5-7-33)32-22-20-9-18(10-24(25,26)27)34-23(20)30-13-29-22/h2-3,8-9,13,16,31H,4-7,10,12H2,1H3,(H,29,30,32)
InChi Key	DZACSLYTXLZAAF-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C=CC2=C1C=C(N2)C#N)CN3CCC(CC3)NC4=C5C=C(SC5=NC=N4)CC(F)(F)F
Isomeric SMILES	CC1=C(C=CC2=C1C=C(N2)C#N)CN3CCC(CC3)NC4=C5C=C(SC5=NC=N4)CC(F)(F)F
PubChem CID	90455046
分子量	484.54

数据库链接

PubChem SID	488202498

化学和物理性质

溶解性	Solubility (25°C) In vitro DMSO: 96 mg/mL (198.12 mM); Ethanol: 22 mg/mL (45.4 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility	96
DMSO(mM) Max Solubility	198.1260577
Water(mg / mL) Max Solubility	＜1

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