计算溶液所需的质量、体积或浓度。
活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
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货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
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N130841-5g |
5g |
现货 ![]() |
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N130841-25g |
25g |
现货 ![]() |
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N130841-50g |
50g |
现货 ![]() |
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N130841-250g |
250g |
现货 ![]() |
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N130841-500g |
500g |
现货 ![]() |
|
别名 | 2',5-二氯-4'-硝基水杨酸酰替苯胺 |
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英文别名 | NCGC00015735-07 | SCHEMBL67182 | Spectrum5_001083 | 2',5-Dichloro-4'-nitrosalicylanilide | CHEBI:7553 | BAY-2353 | Niclocide (TN) | Vermitid | CCRIS 3437 | Bayluscid | DTXCID5020362 | NICLOSAMIDE [USAN] | Spectrum3_000667 | Tredemine | Bayer 2353 | N-(2'- |
规格或纯度 | Moligand™, ≥98% |
英文名称 | Niclosamide |
生化机理 | 抗蠕虫药,抗癌药和质子试剂。STAT3抑制剂(IC 50 = 0.25μM)。已显示抑制许多下游信号传导途径,包括mTORC1,Wnt /β-catinin,NF-κB,Notch和ROS。 |
储存温度 | 充氩 |
运输条件 | 常规运输 |
备注 | 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
产品介绍 |
Niclosamide is an inhibitor of the Stat3 signaling pathway. Niclosamide inhibits the activation, nuclear translocation and transactivation of Stat3. Niclosamide displays selectivity for Stat3 over Stat1, Stat5, JAK1, JAK2 and Src kinases. Niclosamide inhibits the transcription of Stat3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest of cancer cells with constitutively active Stat3. Niclosamide is also a FRAP inhibitor via reversible inhibition of mTORC1 signaling and stimulates autophagy in vitro. Niclosamide displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.An inhibitor of the Stat3 signaling pathway and also a FRAP inhibitor. Niclosamide is an inhibitor of the Stat3 signaling pathway. Niclosamide inhibits the activation, nuclear translocation and transactivation of Stat3. Niclosamide displays selectivity for Stat3 over Stat1, Stat5, JAK1, JAK2 and Src kinases. Niclosamide inhibits the transcription of Stat3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest of cancer cells with constitutively active Stat3. Niclosamide is also a FRAP inhibitor via reversible inhibition of mTORC1 signaling and stimulates autophagy in vitro. Niclosamide displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells. |
ALogP | 4 |
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作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
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PubChem SID | 488179836 |
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EC号 | 200-056-8, 215-811-7 |
分子类型 | 小分子 |
IUPAC Name | 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide |
INCHI | InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19) |
InChi Key | RJMUSRYZPJIFPJ-UHFFFAOYSA-N |
Canonical SMILES | C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O |
Isomeric SMILES | C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O |
WGK Germany | 2 |
RTECS | VN8400000 |
关联CAS | 50-65-7,1420-04-8,1420-04-8 (2-aminoethanol (1:1)) |
PubChem CID | 4477 |
NSC Number | 178296 |
UN Number | 3077 |
MeSH Entry Terms | Bayer 2353;Bayer 73;Bayluscide;Clonitralide;Fenasal;Niclocide;Niclosamide;Niclosamide, 2-Aminoethanol (1:1);Phenasal;Radewerm;Tr\u00e9d\u00e9mine;Yomesan |
分子量 | 327.12 |
Beilstein号 | 2820605 |
溶解性 | Soluble in ethanol (25 mM), DMSO (10 mM), chloroform (very slightly), and methanol: acetone (1: 1) (50 mg/ml). Insoluble in water. |
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密度 | 1.161 |
敏感性 | 对空气和湿度敏感 |
熔点 | 225-230°C |
分子量 | 327.120 g/mol |
XLogP3 | 4.000 |
氢键供体数Hydrogen Bond Donor Count | 2 |
氢键受体数Hydrogen Bond Acceptor Count | 4 |
可旋转键计数Rotatable Bond Count | 2 |
精确质量Exact Mass | 325.986 Da |
单同位素质量Monoisotopic Mass | 325.986 Da |
拓扑极表面积Topological Polar Surface Area | 95.200 Ų |
重原子数Heavy Atom Count | 21 |
形式电荷Formal Charge | 0 |
复杂度Complexity | 404.000 |
同位素原子数Isotope Atom Count | 0 |
定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
所有立体化学键的总数The total count of all stereochemical bonds | 0 |
共价键合单元计数Covalently-Bonded Unit Count | 1 |
象形图 | GHS09, GHS07 |
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信号词 | Warning |
危险声明 |
H319: 引起严重眼睛刺激 H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响 |
预防措施声明 |
P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P501: 将内容物/容器处理到。。。 P391: 收集溢出物 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续:寻求医疗帮助。 |
WGK Germany | 2 |
RTECS | VN8400000 |
个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
批号(Lot Number) | 证书类型 | 日期 | 货号 |
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分析证书 | 25-04-03 | N130841 |
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分析证书 | 25-04-03 | N130841 |
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分析证书 | 24-12-31 | N130841 |
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分析证书 | 24-12-31 | N130841 |
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分析证书 | 24-12-31 | N130841 |
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分析证书 | 23-02-20 | N130841 |
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分析证书 | 22-09-05 | N130841 |
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分析证书 | 22-09-05 | N130841 |
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分析证书 | 22-09-05 | N130841 |
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分析证书 | 22-09-05 | N130841 |
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分析证书 | 21-04-09 | N130841 |
1. Hao Wu, Xiping Yuan, Min Xie, Jinwei Gao, Zhenzhen Xiong, Rui Song, Zhonggui Xie, Dongsheng Ou. (2023) The Impact of Niclosamide Exposure on the Activity of Antioxidant Enzymes and the Expression of Glucose and Lipid Metabolism Genes in Black Carp (Mylopharyngodon piceus). Genes, 14 (12): (2196). [PMID:38137017] [10.3390/genes14122196] |
2. Han Jiale, Liu Yunhang, Li Fang, Zhu Gan, Guo Meimei, Zhao Hongyuan. (2023) Nanocomposite of graphitized and carboxylated multi-walled carbon nanotubes and chitosan for the highly sensitive detection of niclosamide. IONICS, 29 (8): (3407-3419). [10.1007/s11581-023-05077-w] |
3. Jing Xiang, Hao Wu, Jinwei Gao, Weimin Jiang, Xing Tian, Zhonggui Xie, Tao Zhang, Jia Feng, Rui Song. (2023) Niclosamide exposure disrupts antioxidant defense, histology, and the liver and gut transcriptome of Chinese soft-shelled turtle (Pelodiscus sinensis). ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 260 (115081). [PMID:37262966] [10.1016/j.ecoenv.2023.115081] |
4. Yunhang Liu, Qian Wang, Gan Zhu, Qiwen Ran, Fang Li, Meimei Guo, Guifang Wang, Hongyuan Zhao. (2023) Novel electrochemical sensing platform based on palygorskite nanorods/Super P Li carbon nanoparticles-graphitized carbon nanotubes nanocomposite for sensitive detection of niclosamide. CERAMICS INTERNATIONAL, 49 (21234). [10.1016/j.ceramint.2023.03.253] |
5. Wei Zhong, Jin Zou, Qi Yu, Yansha Gao, Fengli Qu, Shuwu Liu, Hui Zhou, Limin Lu. (2023) Ultrasensitive indirect electrochemical sensing of thiabendazole in fruit and water by the anodic stripping voltammetry of Cu2+ with hierarchical Ti3C2Tx-TiO2 for signal amplification. FOOD CHEMISTRY, 402 (134379). [PMID:36179525] [10.1016/j.foodchem.2022.134379] |
6. Cuiling Wang, Fang Li, Jinna Li, Liusu Cui, Jiateng Zhong, Hongyuan Zhao, Sridhar Komarneni. (2022) Highly sensitive determination of niclosamide based on chitosan functionalized carbon nanotube/carbon black scaffolds with interconnected long- and short-range conductive network. Journal of Materials Research and Technology-JMR&T, 19 (4525). [10.1016/j.jmrt.2022.07.001] |
7. Fang Li, Runqiang Liu, Volodymyr Dubovyk, Qiwen Ran, Bo Li, Yuqi Chang, Hongliang Wang, Hongyuan Zhao, Sridhar Komarneni. (2022) Three-dimensional hierarchical porous carbon coupled with chitosan based electrochemical sensor for sensitive determination of niclosamide. FOOD CHEMISTRY, 366 (130563). [PMID:34289441] [10.1016/j.foodchem.2021.130563] |
8. Hae-Ni Jung, Da-Hee Park, Kyung-Hee Yoo, Hee-Jung Cho, Jae-Han Shim, Ho-Chul Shin, A.M. Abd El-Aty. (2021) Simultaneous quantification of 12 veterinary drug residues in fishery products using liquid chromatography-tandem mass spectrometry. FOOD CHEMISTRY, 348 (129105). [PMID:33508596] [10.1016/j.foodchem.2021.129105] |
9. Hongyuan Zhao, Yuqi Chang, Runqiang Liu, Bo Li, Fang Li, Fulong Zhang, Mingwang Shi, Lin Zhou, Xiaoguang Li. (2021) Facile synthesis of Vulcan XC-72 nanoparticles-decorated halloysite nanotubes for the highly sensitive electrochemical determination of niclosamide. FOOD CHEMISTRY, 343 (128484). [PMID:33129617] [10.1016/j.foodchem.2020.128484] |
1. Domfeh SA et al.. (2021) Cryptolepine inhibits hepatocellular carcinoma growth through inhibiting interleukin-6/STAT3 signalling.. BMC Complement Med Ther, 21 (161). [PMID:34078370] |
2. Martinez R et al.. (2022) Proteomic Changes in the Monolayer and Spheroid Melanoma Cell Models of Acquired Resistance to BRAF and MEK1/2 Inhibitors.. ACS Omega, 7 (4): (3293-3311). [PMID:35128241] |
3. Hao Wu, Xiping Yuan, Min Xie, Jinwei Gao, Zhenzhen Xiong, Rui Song, Zhonggui Xie, Dongsheng Ou. (2023) The Impact of Niclosamide Exposure on the Activity of Antioxidant Enzymes and the Expression of Glucose and Lipid Metabolism Genes in Black Carp (Mylopharyngodon piceus). Genes, 14 (12): (2196). [PMID:38137017] [10.3390/genes14122196] |
4. Han Jiale, Liu Yunhang, Li Fang, Zhu Gan, Guo Meimei, Zhao Hongyuan. (2023) Nanocomposite of graphitized and carboxylated multi-walled carbon nanotubes and chitosan for the highly sensitive detection of niclosamide. IONICS, 29 (8): (3407-3419). [10.1007/s11581-023-05077-w] |
5. Jing Xiang, Hao Wu, Jinwei Gao, Weimin Jiang, Xing Tian, Zhonggui Xie, Tao Zhang, Jia Feng, Rui Song. (2023) Niclosamide exposure disrupts antioxidant defense, histology, and the liver and gut transcriptome of Chinese soft-shelled turtle (Pelodiscus sinensis). ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 260 (115081). [PMID:37262966] [10.1016/j.ecoenv.2023.115081] |
6. Yunhang Liu, Qian Wang, Gan Zhu, Qiwen Ran, Fang Li, Meimei Guo, Guifang Wang, Hongyuan Zhao. (2023) Novel electrochemical sensing platform based on palygorskite nanorods/Super P Li carbon nanoparticles-graphitized carbon nanotubes nanocomposite for sensitive detection of niclosamide. CERAMICS INTERNATIONAL, 49 (21234). [10.1016/j.ceramint.2023.03.253] |
7. Wei Zhong, Jin Zou, Qi Yu, Yansha Gao, Fengli Qu, Shuwu Liu, Hui Zhou, Limin Lu. (2023) Ultrasensitive indirect electrochemical sensing of thiabendazole in fruit and water by the anodic stripping voltammetry of Cu2+ with hierarchical Ti3C2Tx-TiO2 for signal amplification. FOOD CHEMISTRY, 402 (134379). [PMID:36179525] [10.1016/j.foodchem.2022.134379] |
8. Cuiling Wang, Fang Li, Jinna Li, Liusu Cui, Jiateng Zhong, Hongyuan Zhao, Sridhar Komarneni. (2022) Highly sensitive determination of niclosamide based on chitosan functionalized carbon nanotube/carbon black scaffolds with interconnected long- and short-range conductive network. Journal of Materials Research and Technology-JMR&T, 19 (4525). [10.1016/j.jmrt.2022.07.001] |
9. Fang Li, Runqiang Liu, Volodymyr Dubovyk, Qiwen Ran, Bo Li, Yuqi Chang, Hongliang Wang, Hongyuan Zhao, Sridhar Komarneni. (2022) Three-dimensional hierarchical porous carbon coupled with chitosan based electrochemical sensor for sensitive determination of niclosamide. FOOD CHEMISTRY, 366 (130563). [PMID:34289441] [10.1016/j.foodchem.2021.130563] |
10. Hae-Ni Jung, Da-Hee Park, Kyung-Hee Yoo, Hee-Jung Cho, Jae-Han Shim, Ho-Chul Shin, A.M. Abd El-Aty. (2021) Simultaneous quantification of 12 veterinary drug residues in fishery products using liquid chromatography-tandem mass spectrometry. FOOD CHEMISTRY, 348 (129105). [PMID:33508596] [10.1016/j.foodchem.2021.129105] |
11. Hongyuan Zhao, Yuqi Chang, Runqiang Liu, Bo Li, Fang Li, Fulong Zhang, Mingwang Shi, Lin Zhou, Xiaoguang Li. (2021) Facile synthesis of Vulcan XC-72 nanoparticles-decorated halloysite nanotubes for the highly sensitive electrochemical determination of niclosamide. FOOD CHEMISTRY, 343 (128484). [PMID:33129617] [10.1016/j.foodchem.2020.128484] |