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8-羟基-DPAT

5-HT1 选择性抑制剂 | 激动剂 | 拮抗剂 | 调节剂

规格或纯度: 97%

CAS编号: 78950-78-4
分子式: C₁₆H₂₅NO
分子量: 247.19
PubChem编号: 1220

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货号 (SKU)	包装规格	是否现货	价格	数量
O414014-5mg	5mg	现货
O414014-10mg	10mg	现货
O414014-25mg	25mg	现货
O414014-50mg	50mg	现货
O414014-100mg	100mg	现货

查看相关系列

5-HT1A receptor Agonist 5-HT1B receptor Agonist 5-HT1D receptor Agonist 5-ht1e receptor Agonist 5-HT1F receptor Agonist 5-HT2A receptor Agonist 5-HT2B receptor Agonist 5-HT2C receptor Agonist 5-HT5A receptor Agonist 5-HT7 receptor Agonist

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基本描述

英文别名	8-OH-Dpat\|78950-78-4\|8-Hydroxy-DPAT\|8-HYDROXY-2-(DI-n-PROPYLAMINO)TETRALIN\|7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol\|DPAT\|1-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro-\|CHEMBL56\|dl-8-Hydroxy-2-(dipropylamino)tetralin\|1-Naphthalenol,7-(dip
规格或纯度	97%
英文名称	8-OH-DPAT
生化机理	8-OH-DPAT (8-Hydroxy-DPAT) is a kind of classic 5-HT1A agonist with the pIC50 of 8.19. It has a selectivity of almost-1000 fold for a subtype of the 5-HT1 binding site; Its biological half-life is 1.5 hous.
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	产品介绍： 8-OH-DPAT 是一种有效的，选择性的 5-HT 激动剂，对 5-HT1A 的 pIC50 值为 8.19，对 5-HT7 的 Ki 值为 466 nM，对 5-HT1B (pIC50, 5.42) 和 5-HT (pIC50 <5) 的作用很弱。 Information 8-OH-DPAT (8-Hydroxy-DPAT) is a kind of classic5-HT1Aagonist with the pIC50 of 8.19. It has a selectivity of almost-1000 fold for a subtype of the 5-HT1 binding site; Its biological half-life is 1.5 hous. Targets 5-HT1A (Cell-free) 8.19(pIC50) In vitro The drug is only weakly effective at 5-HT1B subtype, the pIC50 being 5.42 ± 0.08 (n = 5). Since 8-OH-DPAT has no effect on 5-HT1B binding at concentrations lower than 100 nM. 8-OH-DPAT is able to reduce the accumulation of both autophagic-derived and photoreceptor outer segment-derived lipofuscin, increase antioxidant protection and reduce oxidative damage in cultured human RPE cells. In vivo Intravenous administration of the selective 5-HT1A-receptor agonist 8-OH-DPAT rapidly reverses the hypotensive and bradycardic responses established during severe hemorrhage with relatively little variability. 8-OH-DPAT is relatively lipophilic and readily crosses the blood-brain barrier. Cell Research(from reference) Cell lines：Retinal pigment epithelial (RPE) cells Concentrations：10 μM Incubation Time：24 h

名称和标识符

IUPAC Name	7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
INCHI	InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
InChi Key	ASXGJMSKWNBENU-UHFFFAOYSA-N
Canonical SMILES	CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
Isomeric SMILES	CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
关联CAS	78950-78-4
PubChem CID	1220
MeSH Entry Terms	8-Hydroxy-2-(di-n-propylamino)tetralin;8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide;8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide, (+-)-Isomer;8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide, (R)-Isomer,;8-Hydroxy-2-(di-n-propylamino)tetr
分子量	247.19

化学和物理性质

溶解性	Solubility (25°C) In vitro DMSO: 49 mg/mL (198.07 mM); Ethanol: 49 mg/mL (198.07 mM); Water: Insoluble;

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