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芍药苷

规格或纯度: ≥98%(HPLC)
有货

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货号 (SKU) 包装规格 是否现货 价格 数量
P101691-100mg
100mg 现货 Stock Image
P101691-500mg
500mg 现货 Stock Image
P101691-5g
5g 现货 Stock Image
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化学生物学 单糖

基本描述

别名 芍药甙
英文别名 AB01566855_01|((2S,2aR,2a1S,3aR,4R,5aR)-4-Hydroxy-2-methyl-2a-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-1,5-dioxa-2,4-methanocyclobuta[cd]pentalen-2a1-yl)methylbenzoate|Q-100296|SCHEMBL549033|Q7124104|.
规格或纯度 ≥98%(HPLC)
英文名称 Paeoniflorin
应用 来自芍药的根。中药上其解痉止痛的属性。抗心肌缺血、具抗凝抑制血小板聚集作用;解痉作用;镇痛、镇静作用;抗炎、抗溃疡作用;保肝作用;调节免疫力作用和抗高血糖作用;耐缺氧作用等。
储存温度 室温
运输条件 常规运输
产品介绍

来自芍药的根。中药上其解痉止痛的属性。抗心肌缺血、具抗凝抑制血小板聚集作用;解痉作用;镇痛、镇静作用;抗炎、抗溃疡作用;保肝作用;调节免疫力作用和抗高血糖作用;耐缺氧作用等。

名称和标识符

PubChem SID 488189795
EC号 245-476-2
IUPAC Name [(1R,2S,3R,5R,6R,8S)-6-hydroxy-8-methyl-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9,10-dioxatetracyclo[4.3.1.02,5.03,8]decan-2-yl]methyl benzoate
INCHI InChI=1S/C23H28O11/c1-20-9-22(29)13-7-23(20,32-18-16(27)15(26)14(25)12(8-24)31-18)21(13,19(33-20)34-22)10-30-17(28)11-5-3-2-4-6-11/h2-6,12-16,18-19,24-27,29H,7-10H2,1H3/t12-,13-,14-,15+,16-,18+,19-,20+,21+,22-,23+/m1/s1
InChi Key YKRGDOXKVOZESV-WRJNSLSBSA-N
Canonical SMILES CC12CC3(C4CC1(C4(C(O2)O3)COC(=O)C5=CC=CC=C5)OC6C(C(C(C(O6)CO)O)O)O)O
Isomeric SMILES C[C@]12C[C@@]3([C@@H]4C[C@]1([C@@]4([C@H](O2)O3)COC(=O)C5=CC=CC=C5)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)O
WGK Germany 3
PubChem CID 442534
分子量 480.46

化学和物理性质

密度 1.63
敏感性 对热敏感
比旋光度 -14 ° (C=1, MeOH)

安全和危险性(GHS)

象形图
ghs07

Harmful

信号词 Warning
危险声明 H302: Harmful if swallowed
预防措施声明 P501,P264,P270,P330,P301+P317
WGK Germany 3

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参考文献

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12. Huan Xu,Jie Song,Xinghua Gao,Zhao Xu,Xianxiang Xu,Yufeng Xia,Yue Dai.  (2012-10-12)  Paeoniflorin attenuates lipopolysaccharide-induced permeability of endothelial cells: involvements of F-actin expression and phosphorylations of PI3K/Akt and PKC..  Inflammation,  36  ((1)):  (216-225).  [PMID:23053726]
13. Ruo-Bing Guo,Guo-Feng Wang,An-Peng Zhao,Jun Gu,Xiu-Lan Sun,Gang Hu.  (2012-11-21)  Paeoniflorin protects against ischemia-induced brain damages in rats via inhibiting MAPKs/NF-κB-mediated inflammatory responses..  PloS one,  ((11)):  (e49701-e49701).  [PMID:23166749]
14. Jian-Zhe Li,Shu-Yi Yu,Jian-Hua Wu,Qing-Rui Shao,Xiao-Min Dong.  (2012-12-06)  Paeoniflorin protects myocardial cell from doxorubicin-induced apoptosis through inhibition of NADPH oxidase..  Canadian journal of physiology and pharmacology,  90  ((12)):  (1569-1575).  [PMID:23210435]
15. Chun Wang,Jun Yuan,Zhao-Yi Yang,Xin-Xin Nie,Li-Hua Song,Wei Wei.  (2013-01-26)  Pharmacokinetics of paeoniflorin microemulsion after repeated dosing in rats with adjuvant arthritis..  Die Pharmazie,  67  ((12)):  (997-1001).  [PMID:23346762]
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18. Rui Hou,Lan Wang,Mao-Bo Du,Ri-Xin Liang,Shu-Zhi Liu,Yan-Li Wang,Jian-Yong Zhang.  (2013-03-13)  [Pharmacokinetic study on three main ingredients of refined coronary cataplasm]..  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,  37  ((23)):  (3641-3646).  [PMID:23477156]
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20. Bohyoung Lee,Jin Bae Weon,Bo-Ra Yun,Jiwoo Lee,Min Rye Eom,Choong Je Ma.  (2013-06-07)  Simultaneous determination of 11 major components in Palmul-tang by HPLC-DAD and LC-MS-MS..  Journal of chromatographic science,  52  ((6)):  (482-492).  [PMID:23741048]
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33. Hsiang-Ru Lin.  (2013-01-04)  Paeoniflorin acts as a liver X receptor agonist..  Journal of Asian natural products research,  15  ((1)):  (35-45).  [PMID:23281636]
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35. Shung-Te Kao,Shulhn-Der Wang,Chih-Che Lin,Li-Jen Lin.  (2018-09-02)  Jin Gui Shen Qi Wan, a traditional Chinese medicine, alleviated allergic airway hypersensitivity and inflammatory cell infiltration in a chronic asthma mouse model..  Journal of ethnopharmacology,  227  ():  (181-190).  [PMID:30172058]
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