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菲尼酮

规格或纯度: 98.5%
有货

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货号 (SKU) 包装规格 是否现货 价格 数量
P113217-5g
5g 现货 Stock Image
P113217-25g
25g 现货 Stock Image
P113217-100g
100g 现货 Stock Image
P113217-500g
500g 现货 Stock Image
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五元杂环化合物 吡唑类

基本描述

别名 菲尼酮A,1-苯基-3-吡唑烷酮
英文别名 Phenidone|92-43-3|1-PHENYL-3-PYRAZOLIDINONE|1-phenylpyrazolidin-3-one|1-Phenyl-3-pyrazolidone|Fenidon|3-Pyrazolidinone, 1-phenyl-|Pyrazolidinone, 1-phenyl-|1-Phenyl-3-oxopyrazolidine|2-Pyrazolin-3-ol, 1-phenyl-|1-P-3-P|1-Phenyl-pyrazolidin-3-one|1-Phenylp
规格或纯度 98.5%
英文名称 Phenidone
运输条件 常规运输
产品介绍

溶于热水,极溶于稀酸和碱,溶于沸苯和醇,实际上不溶于醚和石油醚。


名称和标识符

PubChem SID 488180278
EC号 202-155-1
IUPAC Name 1-phenylpyrazolidin-3-one
INCHI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12)
InChi Key CMCWWLVWPDLCRM-UHFFFAOYSA-N
Canonical SMILES C1CN(NC1=O)C2=CC=CC=C2
Isomeric SMILES C1CN(NC1=O)C2=CC=CC=C2
WGK Germany 2
RTECS UQ8750000
PubChem CID 7090
UN Number 2811
Packing Group III
分子量 162.19
Beilstein号 131856
Reaxy-Rn 131856

化学和物理性质

密度 1.188
敏感性 对光敏感、对空气敏感
熔点 119-123°C

安全和危险性(GHS)

象形图
ghs09

Environmental Hazard

ghs07

Harmful

信号词 Warning
危险声明 H411: Toxic to aquatic life with long lasting effects
H302: Harmful if swallowed
预防措施声明 P273,P501,P264,P270,P391,P330,P301+P317
WGK Germany 2
RTECS UQ8750000
Reaxy-Rn 131856
Class 6.1
Merck Index 7309
个人防护装备 dust mask type N95 (US),Eyeshields,Faceshields,Gloves

质检证书(COA)

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参考文献

1. A Wakatsuki,C Izumiya,Y Okatani,Y Sagara.  (1999-07-08)  Oxidative damage in fetal rat brain induced by ischemia and subsequent reperfusion. Relation to arachidonic acid peroxidation..  Biology of the neonate,  76  ((2)):  (84-91).  [PMID:10393992]
2. H C Kim,W K Jhoo,G Bing,E J Shin,M B Wie,W K Kim,K H Ko.  (2000-08-11)  Phenidone prevents kainate-induced neurotoxicity via antioxidant mechanisms..  Brain research,  874  ((1)):  (15-23).  [PMID:10936219]
3. F Stanke-Labesque,P Devillier,P Bedouch,J L Cracowski,O Chavanon,G Bessard.  (2000-08-18)  Angiotensin II-induced contractions in human internal mammary artery: effects of cyclooxygenase and lipoxygenase inhibition..  Cardiovascular research,  47  ((2)):  (376-383).  [PMID:10946074]
4. P Rebuffat,F Aragona,C Tortorella,L K Malendowicz,G G Nussdorfer.  (2001-02-17)  Signaling pathways involved in the A and B receptor-mediated cortisol secretagogue effect of endothelins in the human adrenal cortex..  International journal of molecular medicine,  ((3)):  (301-305).  [PMID:11179511]
5. C Audouin,N Mestdagh,M A Lassoie,R Houssin,J P Hénichart.  (2001-03-30)  N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase..  Bioorganic & medicinal chemistry letters,  11  ((6)):  (845-848).  [PMID:11277534]
6. J C Bedick,H Tunaz,A R Nor Aliza,S M Putnam,M D Ellis,D W Stanley.  (2001-09-07)  Eicosanoids act in nodulation reactions to bacterial infections in newly emerged adult honey bees, Apis mellifera, but not in older foragers..  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP,  130  ((1)):  (107-117).  [PMID:11544147]
7. John Meshki,Florin Tuluc,Ovidiu Bredetean,Zhongren Ding,Satya P Kunapuli.  (2003-11-14)  Molecular mechanism of nucleotide-induced primary granule release in human neutrophils: role for the P2Y2 receptor..  American journal of physiology. Cell physiology,  286  ((2)):  (C264-C271).  [PMID:14613890]
8. Monika Frey,Dieter Spiteller,Wilhelm Boland,Alfons Gierl.  (2004-04-28)  Transcriptional activation of Igl, the gene for indole formation in Zea mays: a structure-activity study with elicitor-active N-acyl glutamines from insects..  Phytochemistry,  65  ((8)):  (1047-1055).  [PMID:15110684]
9. Martin Heil,Sabine Greiner,Harald Meimberg,Ralf Krüger,Jean-Louis Noyer,Günther Heubl,K Eduard Linsenmair,Wilhelm Boland.  (2004-07-09)  Evolutionary change from induced to constitutive expression of an indirect plant resistance..  Nature,  430  ((6996)):  (205-208).  [PMID:15241414]
10. Claudia Cusan,Giampiero Spalluto,Maurizio Prato,Michael Adams,Antje Bodensieck,Rudolf Bauer,Aurelia Tubaro,Paolo Bernardi,Tatiana Da Ros.  (2005-01-18)  Synthesis and biological evaluation of new phenidone analogues as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors..  Farmaco (Societa chimica italiana : 1989),  60  ((1)):  (7-13).  [PMID:15652362]
11. Changjong Moon,Meejung Ahn,Myung-Bok Wie,Hyung-Min Kim,Chang-Sung Koh,Seong-Chul Hong,Moon-Doo Kim,Naoyuki Tanuma,Yoh Matsumoto,Taekyun Shin.  (2005-02-22)  Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes..  Brain research,  1035  ((2)):  (206-210).  [PMID:15722060]
12. Zhengyi Li,Dong-Young Choi,Eun-Joo Shin,Randy L Hunter,Chun Hui Jin,Myung-Bok Wie,Min Soo Kim,Seok Joo Park,Guoying Bing,Hyoung-Chun Kim.  (2008-09-02)  Phenidone protects the nigral dopaminergic neurons from LPS-induced neurotoxicity..  Neuroscience letters,  445  ((1)):  (1-6).  [PMID:18760329]
13. Torsten Hans Schroeder,Wolfgang Artur Krueger,Hans-Jürgen Dieterich,Boris Nohé.  (2008-03-01)  Activity of the lipoxygenase inhibitor 1-phenyl-3-pyrazolidinone (phenidone) and derivatives on the inhibition of adhesion molecule expression on human umbilical vascular endothelial cells..  Biologics : targets & therapy,  ((1)):  (151-160).  [PMID:19707438]
14. Maaike Bruinsma,Sarah van Broekhoven,Erik H Poelman,Maarten A Posthumus,Martin J Müller,Joop J A van Loon,Marcel Dicke.  (2009-10-07)  Inhibition of lipoxygenase affects induction of both direct and indirect plant defences against herbivorous insects..  Oecologia,  162  ((2)):  (393-404).  [PMID:19806367]
15. Venkatesan Radhika,Christian Kost,Wilhelm Boland,Martin Heil.  (2010-02-23)  The role of jasmonates in floral nectar secretion..  PloS one,  ((2)):  (e9265-e9265).  [PMID:20174464]
16. Ender Büyükgüzel,Hasan Tunaz,David Stanley,Kemal Büyükgüzel.  (2011-02-10)  The influence of chronic eicosanoid biosynthesis inhibition on life history of the greater waxmoth, Galleria mellonella and its ectoparasitoid, Bracon hebetor..  Journal of insect physiology,  57  ((4)):  (501-507).  [PMID:21303676]
17. Jun-Hyung Kim,Myeong Seon Jeong,Dong-Yung Kim,Song Her,Myung-Bok Wie.  (2015-09-15)  Zinc oxide nanoparticles induce lipoxygenase-mediated apoptosis and necrosis in human neuroblastoma SH-SY5Y cells..  Neurochemistry international,  90  ():  (204-214).  [PMID:26364578]
18. Wan Mohd Nuzul Hakimi Salleh,Mohd Fariz Kammil,Farediah Ahmad,Hasnah Mohd Sirat.  (2016-01-12)  Antioxidant and Anti-inflammatory Activities of Essential Oil and Extracts of Piper miniatum..  Natural product communications,  10  ((11)):  (2005-2008).  [PMID:26749849]
19. Dong Duan,Sabine Fischer,Patrick Merz,Jochen Bogs,Michael Riemann,Peter Nick.  (2016-02-05)  An ancestral allele of grapevine transcription factor MYB14 promotes plant defence..  Journal of experimental botany,  67  ((6)):  (1795-1804).  [PMID:26842984]
20. Ender Büyükgüzel,Meltem Erdem,Hasan Tunaz,Ceyhun Küçük,Utku Can Atılgan,David Stanley,Kemal Büyükgüzel.  (2016-11-27)  Inhibition of eicosanoid signaling leads to increased lipid peroxidation in a host/parasitoid system..  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology,  204  ():  (121-128).  [PMID:27887946]
21. Yangyang Luo,Ru Bai,Jing Li,Weidong Yang,Ruixiang Li,Qingyang Wang,Guifang Zhao,Dong Duan.  (2019-03-14)  The transcription factor MYB15 is essential for basal immunity (PTI) in Chinese wild grape..  Planta,  249  ((6)):  (1889-1902).  [PMID:30864013]
22. Mandy Otto,Clarissa Bucher,Wantao Liu,Melanie Müller,Tobias Schmidt,Marina Kardell,Marvin Noel Driessen,Jan Rossaint,Eric R Gross,Nana-Maria Wagner.  (2020-06-26)  12(S)-HETE mediates diabetes-induced endothelial dysfunction by activating intracellular endothelial cell TRPV1..  The Journal of clinical investigation,  130  ((9)):  (4999-5010).  [PMID:32584793]
23. M B Wie,Y J Cho,W K Jhoo,H C Kim.  (1999-10-03)  Phenidone attenuates oxygen/glucose deprivation-induced neurotoxicity by antioxidant and antiapoptotic action in mouse cortical cultures..  Neuroscience letters,  272  ((2)):  (91-94).  [PMID:10507549]
24. H Fujita,F Saito,T Sawada,T Kushiro,H Yagi,K Kanmatsuse.  (1999-10-19)  Lipoxygenase inhibition decreases neointimal formation following vascular injury..  Atherosclerosis,  147  ((1)):  (69-75).  [PMID:10525127]
25. R Kumarathasan,F H Leenen.  (2000-06-30)  Is ATP a substrate for 15-lipoxygenase?.  Biochemistry and cell biology = Biochimie et biologie cellulaire,  78  ((2)):  (87-91).  [PMID:10874469]
26. T Sen,A K Dhara,S Bhattacharjee,S Pal,A K Nag Chaudhuri.  (2002-07-12)  Antioxidant activity of the methanol fraction of Pluchea indica root extract..  Phytotherapy research : PTR,  16  ((4)):  (331-335).  [PMID:12112288]
27. Eun-Seon Kim,Eunyoung Choi,Youngsun Kim,Kyoungwon Cho,Ayoung Lee,Jaehan Shim,Randeep Rakwal,Ganesh Kumar Agrawal,Oksoo Han.  (2003-12-20)  Dual positional specificity and expression of non-traditional lipoxygenase induced by wounding and methyl jasmonate in maize seedlings..  Plant molecular biology,  52  ((6)):  (1203-1213).  [PMID:14682619]
28. Hasan Tunaz.  (2006-10-19)  Eicosanoid biosynthesis inhibitors influence mortality of Pieris brassicae larvae co-injected with fungal conidia..  Archives of insect biochemistry and physiology,  63  ((3)):  (93-100).  [PMID:17048247]
29. Sumner H Burstein,Jeffrey K Adams,Heather B Bradshaw,Cristian Fraioli,Ronald G Rossetti,Rebecca A Salmonsen,John W Shaw,J Michael Walker,Robert E Zipkin,Robert B Zurier.  (2007-03-27)  Potential anti-inflammatory actions of the elmiric (lipoamino) acids..  Bioorganic & medicinal chemistry,  15  ((10)):  (3345-3355).  [PMID:17383881]
30. Ivana Holková,Lýdia Bezáková,František Bilka,Andrea Balažová,Marián Vanko,Vítazoslava Blanáriková.  (2010-09-11)  Involvement of lipoxygenase in elicitor-stimulated sanguinarine accumulation in Papaver somniferum suspension cultures..  Plant physiology and biochemistry : PPB,  48  ((10-11)):  (887-892).  [PMID:20829053]
31. J Peng,J J A van Loon,S Zheng,M Dicke.  (2011-02-12)  Herbivore-induced volatiles of cabbage (Brassica oleracea) prime defence responses in neighbouring intact plants..  Plant biology (Stuttgart, Germany),  13  ((2)):  (276-284).  [PMID:21309974]
32. Joonyup Kim,Sara E Patterson,Brad M Binder.  (2012-12-12)  Reducing jasmonic acid levels causes ein2 mutants to become ethylene responsive..  FEBS letters,  587  ((2)):  (226-230).  [PMID:23219920]
33. Woo-Ju Song,Myung-Seon Jeong,Dong-Min Choi,Kil-Nam Kim,Myung-Bok Wie.  (2019-07-25)  Zinc Oxide Nanoparticles Induce Autophagy and Apoptosis via Oxidative Injury and Pro-Inflammatory Cytokines in Primary Astrocyte Cultures..  Nanomaterials (Basel, Switzerland),  ((7)):  ().  [PMID:31330912]