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帕比司他

规格或纯度: ≥98%

CAS编号: 404950-80-7
分子式: C₂₁H₂₃N₃O₂
分子量: 349.44
PubChem编号: 6918837

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货号 (SKU)	包装规格	是否现货	价格	数量
P125167-10mg	10mg	现货
P125167-50mg	50mg	现货
P125167-100mg	100mg	现货
P125167-250mg	250mg	现货

查看相关系列

histone deacetylase 1 Inhibitor histone deacetylase 2 Inhibitor histone deacetylase 3 Inhibitor histone deacetylase 4 Inhibitor histone deacetylase 6 Inhibitor histone deacetylase 7 Inhibitor histone deacetylase 8 Inhibitor histone deacetylase 9 Inhibitor Plasmodium falciparum histone deacetylase 1

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基本描述

别名	帕比司他
英文别名	BCP01816\|Panobinostat(LBH589)\|AM808102\|GTPL7489\|NSC 108217\|AKOS005146046\|N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide\|EX-A169\|NVP-LBH 589\|1-Brom-4-methansulfonylbenzen\|EN300-7395075\|LBH-589B\|NVP-LBH589\|NVP-LBH-589\|(E
规格或纯度	≥98%
英文名称	Panobinostat (LBH589)
生化机理	Panobinostat (LBH589) is a HDAC (histone deactylase) inhibitor of research interest for multiple diseases such as multiple myeloma. The deacetylation of histones is associated with transcriptional silencing. Panobinostat was reported to inhibit several human multiple myeloma cell lines with and IC50 ≥ 20nM. Panobinostat was also reported to induce expression of DNA damage response genes and induce apoptosis in Ph- acute lymphoblastic leukemia cells.
应用	An HDAC inhibitor reported to inhibit human multiple myeloma cell lines.
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	Panobinostat (LBH589)是一种新型的，广谱的HDAC抑制剂，IC50为5 nM。Phase 3。An HDAC inhibitor reported to inhibit human multiple myeloma cell lines. Panobinostat (LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM. Phase 3. An HDAC inhibitor reported to inhibit human multiple myeloma cell lines.

名称和标识符

PubChem SID	488195886
IUPAC Name	(E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide
INCHI	InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+
InChi Key	FPOHNWQLNRZRFC-ZHACJKMWSA-N
Canonical SMILES	CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)C=CC(=O)NO
Isomeric SMILES	CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO
PubChem CID	6918837
分子量	349.44

数据库链接

PubChem CID	6918837
ChEMBL Ligand	CHEMBL483254
Wikipedia	Panobinostat
CAS Registry No.	404950-80-7
RCSB PDB Ligand	LBH
PEP	panobinostat
Reactome Reaction	R-HSA-9679787
Reactome Drug	R-ALL-9679810
DrugCentral Ligand	4682
PubChem SID	488195886

化学和物理性质

溶解性	Soluble in DMSO (70 mg/ml), methanol, water (<1.2 mg/ml), DMF (~50 mg/ml), and ethanol (~3.3 mg/ml).

安全和危险性（GHS）

象形图	Toxic Health Hazard Corrosive Harmful
信号词	Danger
危险声明	H315: Causes skin irritation H301: Toxic if swallowed H331: Toxic if inhaled H373: Causes damage to organs through prolonged or repeated exposure H318: Causes serious eye damage H360: May damage fertility or the unborn child H301+H331: Toxic if swallowed or if inhaled
预防措施声明	P261,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P362+P364,P330,P203,P264+P265,P301+P316,P305+P354+P338,P318,P317,P332+P317,P316,P319

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参考文献

1. Mack GS. (2010) To selectivity and beyond.. Nat Biotechnol, 28 (12): (1259-66). [PMID:21139608]
2. Engel JA, Jones AJ, Avery VM, Sumanadasa SD, Ng SS, Fairlie DP, Skinner-Adams T, Andrews KT. (2015) Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites.. Int J Parasitol Drugs Drug Resist, 5 (3): (117-26). [PMID:26199860]
3. Khan N, Jeffers M, Kumar S, Hackett C, Boldog F, Khramtsov N, Qian X, Mills E, Berghs SC, Carey N et al.. (2008) Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors.. Biochem J, 409 (2): (581-9). [PMID:17868033]

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