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蛋白质磷酸化
酪氨酸激酶
PP2,Src和RIP2激酶抑制剂

PP2,Src和RIP2激酶抑制剂

Src和RIP2激酶抑制剂

规格或纯度: ≥98%

CAS编号: 172889-27-9
分子式: C₁₅H₁₆ClN₅
分子量: 301.77
EC号: 878-892-3
MDL号: MFCD1568210
PubChem编号: 4878

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货号 (SKU)	包装规格	是否现货	价格	数量
P125361-1mg	1mg	期货
P125361-5mg	5mg	现货
P125361-25mg	25mg	现货
P125361-100mg	100mg	现货

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FYN proto-oncogene，Src family tyrosine kinase Inhibitor LCK proto-oncogene，Src family tyrosine kinase Inhibitor

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基本描述

英文别名	172889-27-9\|pp2\|PP 2\|1-(tert-butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine\|AG 1879\|1-tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine\|1-tert-butyl-3-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-amine\|4-Amino-5-(4-chloropheny
规格或纯度	≥98%
英文名称	PP2
生化机理	PP 2 is an effective and selective inhibitor of c-Src family kinases. The inhibitor has been shown to inhibit Lck, FynT, phosphorylation of focal adhesion kinase (FAK) and potently inhibits Hck, Lck (p56) and Fyn (p59). Additionally, PP 2 was reported to inhibit tyrosone kinase-dependent TcR-induced T cell proliferation. PP 2 studies indicate that this agent has demonstrated the ability to activate ERK 1, ERK 2 and p38. Research sμggests that PP 2 may be useful to help identify c-Src family member substrates. MCF-7 cell research shows that PP 2 down regulates the expression of both enoyl-CoA hydratase short chain 1 and peroxiredoxin 3 (PRDX3), and induces apoptosis. PP 2 is an inhibitor of casein kinase I δ and RICK.
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	PP2(AGL 1879) 是可逆的ATP竞争性的Src家族抑制剂，对p56lck，p59fynT，Hck和Src的IC50分别为4，5，5和100 nM。An effective and selective inhibitor of Src family kinases PP2, a Src family kinase inhibitor, potently inhibits Lck/Fyn with IC50 of 4 nM/5 nM in cell-free assays, ~100-fold less potent to EGFR, inactive for ZAP-70, JAK2 and PKA. An effective and selective inhibitor of Src family kinases

名称和标识符

EC号	878-892-3
IUPAC Name	1-tert-butyl-3-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-amine
INCHI	InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
InChi Key	PBBRWFOVCUAONR-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C)N1C2=NC=NC(=C2C(=N1)C3=CC=C(C=C3)Cl)N
Isomeric SMILES	CC(C)(C)N1C2=NC=NC(=C2C(=N1)C3=CC=C(C=C3)Cl)N
关联CAS	172889-27-9
PubChem CID	4878
MeSH Entry Terms	4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo(3,4-d)pyrimidine;AG 1879;AG1879;PP2 cpd;Src family kinase inhibitor PP2
分子量	301.77

化学和物理性质

溶解性	DMSO 60 mg/mL Water <1 mg/mL Ethanol 2 mg/mL
密度	1.36
敏感性	对空气敏感，对热敏感
折光率	1.68
沸点	493.54° C at 760 mmHg
熔点	193.32°C

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参考文献

1. Li C & Götz J. (2017) Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation.. EMBO J, 36 (21): (3120-3138). [PMID:28864542]
2. Porcu G et al.. (2015) Clobetasol and Halcinonide Act as Smoothened Agonists to Promote Myelin Gene Expression and RxR? Receptor Activation.. PLoS One, 10 (12): (e0144550). [PMID:26658258]
3. Fukushima T et al.. (2019) Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium.. Cell Rep, 29 (12): (4144-4158.e7). [PMID:31851939]
4. Saxena M et al.. (2017) EGFR and HER2 activate rigidity sensing only on rigid matrices.. Nat Mater, 16 (7): (775-781). [PMID:28459445]
5. Cui X et al.. (2018) Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis.. Biomaterials, 161 (): (164-178). [PMID:29421553]
6. Komuro A et al.. (2018) Identification of a novel fusion gene HMGA2-EGFR in glioblastoma.. Int J Cancer, 142 (8): (1627-1639). [PMID:29193056]
7. Tischer DK & Weiner OD. (2019) Light-based tuning of ligand half-life supports kinetic proofreading model of T cell signaling.. Elife, 8 (): (). [PMID:30947808]
8. Yoo JY et al.. (2020) LPS-Induced Acute Kidney Injury Is Mediated by Nox4-SH3YL1.. Cell Rep, 33 (3): (108245). [PMID:33086058]
9. Holley AK et al.. (2014) Manganese superoxide dismutase-mediated inside-out signaling in HaCaT human keratinocytes and SKH-1 mouse skin.. Antioxid Redox Signal, 20 (15): (2347-60). [PMID:24635018]
10. Chang TY et al.. (2017) Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery.. Elife, 6 (): (). [PMID:29271742]
11. Barcus CE et al.. (2016) Prolactin signaling through focal adhesion complexes is amplified by stiff extracellular matrices in breast cancer cells.. Oncotarget, 7 (30): (48093-48106). [PMID:27344177]
12. Nasyrov E et al.. (2019) The neuronal oxygen-sensing pathway controls postnatal vascularization of the murine brain.. FASEB J, 33 (11): (12812-12824). [PMID:31469589]
13. Chen Z et al.. (2021) Toll-Like Receptor 4 Mediated Oxidized Low-Density Lipoprotein-Induced Foam Cell Formation in Vascular Smooth Muscle Cells via Src and Sirt1/3 Pathway.. Mediators Inflamm, 2021 (): (6639252). [PMID:33927570]
14. Lee EJ et al.. (2015) Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation.. Nat Commun, 6 (): (7168). [PMID:25981743]

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