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利哌酮

非典型抗精神病药。5-HT 2A / D 2拮抗剂。

规格或纯度: ≥98%

CAS编号: 106266-06-2
分子式: C₂₃H₂₇FN₄O₂
分子量: 410.48
MDL号: MFCD00274576
PubChem编号: 5073

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货号 (SKU)	包装规格	是否现货	价格	数量
R127644-500mg	500mg	现货
R127644-1g	1g	现货
R127644-5g	5g	现货
R127644-25g	25g	现货
R127644-100g	100g	现货

查看相关系列

5-HT1A receptor Antagonist 5-HT1B receptor Antagonist 5-HT1D receptor Antagonist 5-ht1e receptor Antagonist 5-HT1F receptor Antagonist 5-HT2A receptor Antagonist 5-HT2C receptor Antagonist 5-HT6 receptor Antagonist 5-HT7 receptor Antagonist D2 receptor Antagonist D3 receptor Antagonist H1 receptor Antagonist α1A-adrenoceptor Antagonist α1B-adrenoceptor Antagonist α1D-adrenoceptor Antagonist

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基本描述

别名	利培酮\|瑞司哌酮
英文别名	risperidone\|106266-06-2\|Risperdal\|Risperidal\|Rispolept\|Risperin\|Rispolin\|Sequinan\|Risperdal Consta\|Risperidal M-Tab\|Risperidona\|Risperidonum\|Apexidone\|Risperdal M-Tab\|Spiron\|Risperidonum [Latin]\|R 64 766\|Belivon\|C23H27FN4O2\|Perseris\|Psychodal\|Zophrenal\|UN
规格或纯度	≥98%
英文名称	Risperidone
生化机理	Risperidone is an antipsychotic; serotonin-dopamine antagonist.Atypical antipsychotic agent. Potent 5-HT 2A antagonist (K i = 0.4 nM). Also displays high affinity at D 2 receptors (K i = 3.13 nM).
应用	Risperidone has been used: · to study its effects on bone formation and differentiation · to investigate the relationship between risperidone (RIS) dosages and RIS plasma levels in autism spectrum disorder (ASD) pediatric patients · to reverse induced schizophrenia-like behavior in mice
储存温度	2-8°C储存
运输条件	冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	Risperidone is a benzisoxazole derivative. It functions as an antagonist for dopamine D2, histamine H1 and α1 and α2 adrenergic receptors. Risperidone is used to treat schizophrenia, bipolar disorder and autism Risperidone has been used: • to study its effects on bone formation and differentiation • to investigate the relationship between risperidone (RIS) dosages and RIS plasma levels in autism spectrum disorder (ASD) pediatric patients • to reverse induced schizophrenia-like behavior in mice Risperidone is a benzisoxazole derivative. It functions as an antagonist for dopamine D2, histamine H1 and α1 and α2 adrenergic receptors. Risperidone is used to treat schizophrenia, bipolar disorder and autism Risperidone has been used: • to study its effects on bone formation and differentiation • to investigate the relationship between risperidone (RIS) dosages and RIS plasma levels in autism spectrum disorder (ASD) pediatric patients • to reverse induced schizophrenia-like behavior in mice

产品属性

ALogP	2.7

名称和标识符

IUPAC Name	3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
INCHI	InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
InChi Key	RAPZEAPATHNIPO-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
Isomeric SMILES	CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
WGK Germany	3
RTECS	UV1164800
PubChem CID	5073
UN Number	2811
Packing Group	III
分子量	410.48
Reaxy-Rn	4891881

数据库链接

PubChem CID	5073
DrugBank Ligand	DB00734
CAS Registry No.	106266-06-2
ChEBI	CHEBI:8871
Wikipedia	Risperidone
BindingDB Ligand	50001885
ChEMBL Ligand	CHEMBL85
PEP	risperidone
RCSB PDB Ligand	8NU
DrugCentral Ligand	2389
GPCRdb Ligand	risperidone

化学和物理性质

溶解性	Soluble in DMSO (10 mM), ethanol (10 mM), chloroform, and methanol. Insoluble in water.
熔点	172 °C

安全和危险性（GHS）

象形图	Toxic Health Hazard Environmental Hazard
信号词	Danger
危险声明	H301: Toxic if swallowed H331: Toxic if inhaled H351: Suspected of causing cancer H411: Toxic to aquatic life with long lasting effects
预防措施声明	P261,P273,P280,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P391,P330,P203,P301+P316,P318,P316
WGK Germany	3
RTECS	UV1164800
Reaxy-Rn	4891881
Class	6.1
Merck Index	8233
个人防护装备	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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参考文献

1. Blessing WW et al.. (2017) Clozapine, chlorpromazine and risperidone dose-dependently reduce emotional hyperthermia, a biological marker of salience.. Psychopharmacology (Berl), 234 (21): (3259-3269). [PMID:28812124]
2. Fijal K et al.. (2014) Co-administration of 5-HT6 receptor antagonists with clozapine, risperidone, and a 5-HT2A receptor antagonist: effects on prepulse inhibition in rats.. Psychopharmacology (Berl), 231 (): (269-81). [PMID:23954911]
3. Malekizadeh Y et al.. (2020) Whole transcriptome in silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side effects.. Alzheimers Dement (N Y), 6 (): (e12078). [PMID:32864416]

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