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氨基酸
对氨基水杨酸钠二水合物, 二氢叶酸还原酶抑制剂

对氨基水杨酸钠二水合物, 二氢叶酸还原酶抑制剂

规格或纯度: 98%

CAS编号: 6018-19-5
分子式: C₇H₆NNaO₃.2H₂O
分子量: 211.15
MDL号: MFCD00151044
PubChem编号: 16211148

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货号 (SKU)	包装规格	是否现货
S115316-10g	10g	现货
S115316-25g	25g	现货
S115316-50g	50g	现货
S115316-100g	100g	现货
S115316-250g	250g	现货
S115316-1kg	1kg	期货

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化学生物学肽化学

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基本描述

别名	4-氨基-2-羟基苯甲酸钠盐二水合物\|4-氨基水杨酸钠盐二水合物
英文别名	6018-19-5\|Sodium 4-aminosalicylate dihydrate\|Parasal sodium\|sodium 4-amino-2-hydroxybenzoate dihydrate\|Pamisyl sodium\|Sodium aminosalicylate\|AMINOSALICYLATE SODIUM\|TEEBACIN\|Nemasol sodium\|Paramisan sodium\|Sodium P.A.S.\|4-Aminosalicylic acid sodium salt di
规格或纯度	98%
英文名称	Sodium 4-aminosalicylate dihydrate
储存温度	充氩
运输条件	常规运输
产品介绍	无臭，味甜带咸，本品在水中易溶，在乙醇中略溶，在乙醚中不溶。

名称和标识符

IUPAC Name	sodium;4-amino-2-hydroxybenzoate;dihydrate
INCHI	InChI=1S/C7H7NO3.Na.2H2O/c8-4-1-2-5(7(10)11)6(9)3-4;;;/h1-3,9H,8H2,(H,10,11);;2*1H2/q;+1;;/p-1
InChi Key	GMUQJDAYXZXBOT-UHFFFAOYSA-M
Canonical SMILES	C1=CC(=C(C=C1N)O)C(=O)[O-].O.O.[Na+]
Isomeric SMILES	C1=CC(=C(C=C1N)O)C(=O)[O-].O.O.[Na+]
RTECS	VO1700000
关联CAS	133-10-8
PubChem CID	16211148
分子量	211.15
Reaxy-Rn	4166128

化学和物理性质

敏感性	对光线敏感，对空气敏感
熔点	250°C

安全和危险性（GHS）

象形图	Harmful
信号词	Warning
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation
预防措施声明	P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319
RTECS	VO1700000
Reaxy-Rn	4166128

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参考文献

1. Lan Hong,Wendy Jiang,Wei Zheng,Su Zeng. (2010-12-17) HPLC analysis of para-aminosalicylic acid and its metabolite in plasma, cerebrospinal fluid and brain tissues.. Journal of pharmaceutical and biomedical analysis, 54 ((5)): (1101-1109). [PMID:21159459]
2. Lan Hong,Wendy Jiang,Hao Pan,Yueming Jiang,Su Zeng,Wei Zheng. (2011-07-20) Brain regional pharmacokinetics of p-aminosalicylic acid and its N-acetylated metabolite: effectiveness in chelating brain manganese.. Drug metabolism and disposition: the biological fate of chemicals, 39 ((10)): (1904-1909). [PMID:21768272]
3. Chih-Cheng Lai,Che-Kim Tan,Yu-Tsung Huang,Chun-Hsing Liao,Po-Ren Hsueh. (2011-07-30) Fluoroquinolone-resistant tuberculosis at a medical centre in Taiwan, 2005-10.. The Journal of antimicrobial chemotherapy, 66 ((10)): (2437-2438). [PMID:21798881]
4. S M Vesenbeckh,J Becker,C Huhnt,B Karras,T T Bauer,H Mauch,H Rüssmann,N Schönfeld. (2011-08-13) Successful oral desensitization to i.v. para-aminosalicylic acid (PAS) using encapsulated PAS dry substance.. Infection, 40 ((2)): (199-202). [PMID:21833615]
5. Cezary Chojnacki,Ewa Walecka-Kapica,Grazyna Klupinska,Monika Pawłowicz,Antoni Florkowski,Patrycja Wachowska-Kelly,Jan Chojnacki. (2011-09-23) [Evaluation of the influence of tianeptine on the psychosomatic status of patients with ulcerative colitis in remission].. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 31 ((182)): (92-96). [PMID:21936344]
6. S Thee,E W Zöllner,M Willemse,A C Hesseling,K Magdorf,H S Schaaf. (2011-09-29) Abnormal thyroid function tests in children on ethionamide treatment.. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 15 ((9)): (1191-1193). [PMID:21943844]
7. Amanda S Fivian-Hughes,Joanna Houghton,Elaine O Davis. (2011-10-29) Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid.. Microbiology (Reading, England), 158 ((Pt 2)): (308-318). [PMID:22034487]
8. Fuqiang An,Ruikui Du,Xiaohua Wang,Min Wan,Xin Dai,Jianfeng Gao. (2011-12-16) Adsorption of phenolic compounds from aqueous solution using salicylic acid type adsorbent.. Journal of hazardous materials, 201-202 (): (74-81). [PMID:22169143]
9. A P Marreilha Dos Santos,Rui L Lucas,Vanda Andrade,M Luísa Mateus,Dejan Milatovic,Michael Aschner,M Camila Batoreu. (2011-12-20) Protective effects of ebselen (Ebs) and para-aminosalicylic acid (PAS) against manganese (Mn)-induced neurotoxicity.. Toxicology and applied pharmacology, 258 ((3)): (394-402). [PMID:22178737]
10. Wei-Ping Qin,Tian-Jia Liang,Yue-Ming Jiang. (2012-02-18) [A chronic moderate manganism poisoning treated with sodium p-aminosalicylic acid].. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 29 ((8)): (619-620). [PMID:22335167]
11. Gaurav Vadnerkar,Suneela Dhaneshwar. (2012-06-26) Macromolecular prodrug of 4-aminosalicylic acid for targeted delivery to inflamed colon.. Current drug discovery technologies, 10 ((1)): (16-24). [PMID:22725691]
12. Shadeed Gad,Lidia Tajber,Owen I Corrigan,Anne Marie Healy. (2012-08-14) Preparation and characterisation of novel spray-dried nano-structured para-aminosalicylic acid particulates for pulmonary delivery: impact of ammonium carbonate on morphology, chemical composition and solid state.. The Journal of pharmacy and pharmacology, 64 ((9)): (1264-1274). [PMID:22881439]
13. Sumit Chakraborty,Todd Gruber,Clifton E Barry,Helena I Boshoff,Kyu Y Rhee. (2012-11-03) Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis.. Science (New York, N.Y.), 339 ((6115)): (88-91). [PMID:23118010]
14. A C Liwa,H S Schaaf,B Rosenkranz,H I Seifart,A H Diacon,P R Donald. (2012-11-24) Para-aminosalicylic acid plasma concentrations in children in comparison with adults after receiving a granular slow-release preparation.. Journal of tropical pediatrics, 59 ((2)): (90-94). [PMID:23174991]
15. Dinamene Santos,M Camila Batoreu,Michael Aschner,Ana P Marreilha dos Santos. (2013-01-15) Comparison between 5-aminosalicylic acid (5-ASA) and para-aminosalicylic acid (4-PAS) as potential protectors against Mn-induced neurotoxicity.. Biological trace element research, 152 ((1)): (113-116). [PMID:23315311]
16. Diana Couto,Daniela Ribeiro,Marisa Freitas,Ana Gomes,José L F C Lima,Eduarda Fernandes. (2011-01-07) Scavenging of reactive oxygen and nitrogen species by the prodrug sulfasalazine and its metabolites 5-aminosalicylic acid and sulfapyridine.. Redox report : communications in free radical research, 15 ((6)): (259-267). [PMID:21208525]
17. Kim S Sugamori,Debbie Brenneman,Denis M Grant. (2011-02-15) Liver-selective expression of human arylamine N-acetyltransferase NAT2 in transgenic mice.. Drug metabolism and disposition: the biological fate of chemicals, 39 ((5)): (882-890). [PMID:21317369]
18. . (2012-03-01) Drugs for inflammatory bowel disease.. Treatment guidelines from the Medical Letter, 10 ((115)): (19-28). [PMID:22361569]
19. Shuichi Yano,Kanako Kobayashi,Toshikazu Ikeda. (2012-05-19) Multidrug-resistant tuberculosis that required 2 years for diagnosis.. BMJ case reports, 2012 (): (doi:10-doi:10). [PMID:22605803]
20. Joo-Hee Kim,Seung Hun Jang,Dong Hoon Kim,Sunghoon Park,Dong-Gyu Kim,Ki-Suck Jung. (2013-01-29) A case of DRESS syndrome induced by the antituberculosis drugs, prothionamide, and para-aminosalycilic acid.. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 110 ((2)): (118-119). [PMID:23352532]
21. J Furin,G Brigden,E Lessem,M C Becerra. (2013-07-06) Novel pediatric delivery systems for second-line anti-tuberculosis medications: a case study.. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 17 ((9)): (1239-1241). [PMID:23827936]

对氨基水杨酸钠二水合物, 二氢叶酸还原酶抑制剂

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基本描述

名称和标识符

化学和物理性质

安全和危险性（GHS）

质检证书(COA)

质检报告(COA)

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质检报告COA

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参考文献