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YU238259

DNA-PK 抑制剂

规格或纯度: 99%

CAS编号: 1943733-16-1
分子式: C₂₂H₂₂ClN₃O₄S
分子量: 459.95
PubChem编号: 121473004

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货号 (SKU)	包装规格	是否现货	价格	数量
Y413992-5mg	5mg	期货
Y413992-10mg	10mg	现货
Y413992-25mg	25mg	期货
Y413992-50mg	50mg	现货
Y413992-100mg	100mg	现货

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基本描述

英文别名	Benzamide,N-[2-(5-chloro-2-pyridinyl)ethyl]-4-[[[(4-methoxyphenyl)sulfonyl]amino]methyl]-
规格或纯度	99%
英文名称	YU238259
生化机理	YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.
储存温度	避光,-20°C储存
运输条件	超低温冰袋运输
产品介绍	Information YU238259 YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR) , but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays. Targets HDR In vitro YU238259 exhibits potent synthetic lethality in the setting of DNA damage response and DNA repair defects. Treatment with YU238259 is not only synergistic with ionizing radiation (IR), etoposide, and PARP inhibition, but this synergism is heightened by BRCA2-deficiency. Synthetic lethality of YU238259 in HDR-deficient cells results from accumulation of unresolved DSBs following additional inhibition of residual HDR pathway activity. Inhibition of HDR activity by YU238259 has little to no effect on the NHEJ pathway. YU238259 sensitizes tumor cells to radiation therapy and DSB-inducing chemotherapy . In vivo Growth of BRCA2-deficient human tumor xenografts in nude mice is significantly delayed by YU238259 treatment even in the absence of concomitant DNA-damaging therapy. Cell Research(from reference) Cell lines：U2OS cells Concentrations：25 μM Incubation Time：1 h

产品属性

ALogP	3.076
HBD Count	2
Rotatable Bond	9

名称和标识符

IUPAC Name	N-[2-(5-chloropyridin-2-yl)ethyl]-4-[[(4-methoxyphenyl)sulfonylamino]methyl]benzamide
INCHI	InChI=1S/C22H22ClN3O4S/c1-30-20-8-10-21(11-9-20)31(28,29)26-14-16-2-4-17(5-3-16)22(27)24-13-12-19-7-6-18(23)15-25-19/h2-11,15,26H,12-14H2,1H3,(H,24,27)
InChi Key	BIHURSOREGLQBB-UHFFFAOYSA-N
Canonical SMILES	COC1=CC=C(C=C1)S(=O)(=O)NCC2=CC=C(C=C2)C(=O)NCCC3=NC=C(C=C3)Cl
PubChem CID	121473004
分子量	459.95

化学和物理性质

溶解性	Solubility (25°C) In vitro DMSO: 91 mg/mL (197.84 mM); Water: Insoluble; Ethanol: Insoluble;
敏感性	对光敏感
DMSO(mg / mL) Max Solubility	91
DMSO(mM) Max Solubility	197.8475921
Water(mg / mL) Max Solubility	＜1

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