基本描述

英文别名	CK Activity Assay Kit, Creatine Phosphokinase Activity Assay Kit
规格或纯度	足以进行100次测试（UV）
英文名称	Creatine Kinase Activity Assay Kit
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	肌酸激酶（CK），又称磷酸肌酸激酶，是催化一个磷酸基团从ATP转移到肌酸，产生磷酸肌酸的酶，磷酸肌酸是肌肉和脑组织的重要能量储备。CK是一种由B（大脑）和M（肌肉）亚基组成的二聚体蛋白。现已发现三种同工酶，即：CK-MM、CK-MB和CK-BB。在心肌梗塞、横纹肌溶解、肌营养不良和肾功能衰竭等各种病理状况下，CK水平升高。应用适用性适用于检测多种样品中的肌酸激酶活性，如血液、血清和血浆等。该试剂盒可用于研究多种化合物对肌酸激酶活性的影响。原理通过偶联酶反应确定肌酸激酶活性，在340 nm处测量反应产生的NADPH，结果与样品中的CK活性成比例。在此反应中，磷酸肌酸和ADP转化为肌酸和ATP。己糖激酶将产生的ATP用于磷酸化葡萄糖，生成葡萄糖-6-磷酸；在葡萄糖-6-磷酸脱氢酶存在的情况下，NADP氧化葡萄糖-6-磷酸，生成NADPH和6-磷酸-D-葡萄糖酸。一个单位的CK指pH 6.0时，每分钟将1.0μmole磷酸盐从磷酸肌酸转移到ADP的酶量。该试剂盒的线性范围为30-1,800 单位/L CK活性。制备说明外形 Creatine Kinase (CK), also known as phosphocreatine kinase, is an enzyme that catalyzes the transfer of one phosphate group from ATP to creatine generating phosphocreatine, an important energy reservoir in muscle and brain tissue. CK is a dimeric protein made up of B (brain) and M (muscle) subunits. Three isoenzymes, CK-MM, CK-MB, and CK-BB, have been observed. CK levels are elevated in various pathological conditions including myocardial infarction, rhabdomyolysis, muscular dystrophy, and renal failure.

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参考文献

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复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

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肌酸激酶活性测定试剂盒

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