基本描述

英文别名	CCRIS 6012 \| RP10174 \| 2,4DICHLORO ANILINE \| 2,4-Dichloro Aniline \| NSC8756 \| NSC-8756 \| SCHEMBL158279 \| 2,4-DICHLOROANILINE \| 2,4-di-chloroaniline \| 2,4-dichloro-aniline \| W-105564 \| A830623 \| CHEBI:46635 \| NCGC00257110-01 \| 2,4-dichlorobenzene aniline \|
规格或纯度	≥99%
英文名称	2,4-Dichloroaniline
应用	有机合成中间体,农药中间体。
储存温度	避光
运输条件	常规运输
产品介绍	见光或露置空气中逐渐变色。溶于醇、醚、有机溶剂和酸类，几乎不溶于水。有毒，最小致死量(猫，经口)173mg/kg。有刺激性。 2,4-二氯苯胺可被戴尔福特菌（Delftia tsuruhatensis ）H1降解。利用GC/MS和高效液相色谱法可检测人尿样中的2,4-二氯苯胺代谢物有机合成中间体,农药中间体。 2,4-Dichloroaniline is degraded by Delftia tsuruhatensis H1. 2,4-Dichloroaniline metabolite is detected in human urine sample by GC/MS and high performance liquid chromatograph

AI解读

关联靶点（人）

AR Tclin Androgen Receptor (11781 活性数据)

点击查看靶蛋白信息： AR

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TSHR Tclin Thyroid stimulating hormone receptor (29986 活性数据)

点击查看靶蛋白信息： TSHR

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RXRA Tclin Retinoid X receptor alpha (3637 活性数据)

点击查看靶蛋白信息： RXRA

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)

点击查看靶蛋白信息： CYP3A4

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 活性数据)

点击查看靶蛋白信息： Nfe2l2

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	488181265
EC号	209-057-8
分子类型	小分子
IUPAC Name	2,4-dichloroaniline
INCHI	InChI=1S/C6H5Cl2N/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2
InChi Key	KQCMTOWTPBNWDB-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=C(C=C1Cl)Cl)N
Isomeric SMILES	C1=CC(=C(C=C1Cl)Cl)N
WGK Germany	3
RTECS	BX2600000
PubChem CID	11123
UN Number	3442
Packing Group	II
分子量	162.02
Beilstein号	386422
Reaxy-Rn	386422

化学和物理性质

溶解性	微溶于水，溶于乙醇、乙醚。
密度	1.567
敏感性	对光敏感
闪点(℉)	239 °F
闪点(℃)	115℃
沸点	245°C
熔点	59-65℃
分子量	162.010 g/mol
XLogP3	2.900
氢键供体数Hydrogen Bond Donor Count	1
氢键受体数Hydrogen Bond Acceptor Count	1
可旋转键计数Rotatable Bond Count	0
精确质量Exact Mass	160.98 Da
单同位素质量Monoisotopic Mass	160.98 Da
拓扑极表面积Topological Polar Surface Area	26.000 Å²
重原子数Heavy Atom Count	9
形式电荷Formal Charge	0
复杂度Complexity	97.100
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

一般危化品	一般危化品
象形图	GHS06, GHS08, GHS09
信号词	Danger
危险声明	H301: 吞咽会中毒 H311: 皮肤接触有毒 H331: 吸入会中毒 H373: 通过长时间或反复暴露对器官造成损害 H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P391: 收集溢出物 P330: 漱口 P361+P364: 立即脱掉所有沾染的衣服，清洗后方可重新使用。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 P316: 立即寻求紧急医疗救助。 P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany	3
RTECS	BX2600000
Reaxy-Rn	386422
Class	6.1
个人防护装备	dust mask type N95 (US),Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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找到7个结果

批号(Lot Number)	证书类型	日期	货号
I2424262	分析证书	24-06-27	D103990
B2308403	分析证书	23-02-18	D103990
H2212182	分析证书	22-06-20	D103990
H2212184	分析证书	22-06-20	D103990
H2212185	分析证书	22-06-20	D103990
B2308406	分析证书	21-09-29	D103990
F23151006	分析证书	21-09-29	D103990

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?

1. Cholnam Ri, Fengxiang Li, Hyokchol Mun, Linan Liu, Jingchun Tang. (2023) Ball-milled Fe0/FeS2 enhanced interaction of Shewanella oneidensis MR-1 with anaerobic microbial community: Impact on 2,4-dichloronitrobenzene reduction and methane yield. CHEMICAL ENGINEERING JOURNAL, 452 (139086). [10.1016/j.cej.2022.139086]
2. Di Zhang, Tom Bond, Yang Pan, Mingli Li, Jiayi Luo, Rong Xiao, Wenhai Chu. (2022) Identification, Occurrence, and Cytotoxicity of Haloanilines: A New Class of Aromatic Nitrogenous Disinfection Byproducts in Chloraminated and Chlorinated Drinking Water. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 56 (7): (4132–4141). [PMID:35302737] [10.1021/acs.est.1c07375]
3. Linlin Chen, Junjie Shao, Hui Chen, Caiqin Wang, Xinyi Gao, Xiangyang Xu, Liang Zhu. (2018) Cathode potential regulation in a coupled bioelectrode-anaerobic sludge system for effective dechlorination of 2,4-dichloronitrobenzene. BIORESOURCE TECHNOLOGY, 254 (180). [PMID:29413921] [10.1016/j.biortech.2018.01.092]
4. Ya-Nan Jiao, Hong Chen, Rui-Xia Gao, Yong-Guan Zhu, Christopher Rensing. (2017) Organic compounds stimulate horizontal transfer of antibiotic resistance genes in mixed wastewater treatment systems. CHEMOSPHERE, 184 (53). [PMID:28578196] [10.1016/j.chemosphere.2017.05.149]
5. Deyang Kong, Qing Xia, Guoqiang Liu, Qingguo Huang, Junhe Lu. (2013) Covalent bonding of chloroanilines to humic constituents: Pathways, kinetics, and stability. ENVIRONMENTAL POLLUTION, 180 (48). [PMID:23727567] [10.1016/j.envpol.2013.05.018]
6. Xiaofei Han,Jia Chen,Zhan Li,Kaijun Quan,Hongdeng Qiu. (2020-09-07) Magnetic solid-phase extraction of triazole fungicides based on magnetic porous carbon prepared by combustion combined with solvothermal method.. Analytica chimica acta, 1129 (85-97). [PMID:32891394]

参考文献

1. T Yoshida,M Hirata,T Tabuchi,K Miyajima,K Andoh. (1992-03-01) [Amounts of urinary metabolites of p-chloroaniline and their half lives in a patient with acute poisoning].. Sangyo igaku. Japanese journal of industrial health, 34 ((2)): (126-130). [PMID:1602626]
2. C J van Leeuwen,G Niebeek,M Rijkeboer. (1987-08-01) Effects of chemical stress on the population dynamics of Daphnia magna: a comparison of two test procedures.. Ecotoxicology and environmental safety, 14 ((1)): (1-11). [PMID:3428203]
3. H M Hwang,D McCullum,L Slaughter. (1998-03-04) Phototransformation of 2,4-dichloroaniline in a surface freshwater environment: effects on microbial assemblages.. Bulletin of environmental contamination and toxicology, 60 ((1)): (81-87). [PMID:9484560]
4. I Johnson,P Delaney. (1998-09-02) Development of a 7-day Daphnia magna growth test using image analysis.. Bulletin of environmental contamination and toxicology, 61 ((3)): (355-362). [PMID:9724359]
5. H Segner,C Chesné,J P Cravedi,B Fauconneau,D Houlihan,F LeGac,M Loir,C Mothersill,P Pärt,Y Valotaire,P Prunet. (2001-06-16) Cellular approaches for diagnostic effects assessment in ecotoxicology: introductory remarks to an EU-funded project.. Aquatic toxicology (Amsterdam, Netherlands), 53 ((3-4)): (153-158). [PMID:11408076]
6. J P Cravedi,G Boudry,M Baradat,D Rao,L Debrauwer. (2001-06-16) Metabolic fate of 2,4-dichloroaniline, prochloraz and nonylphenol diethoxylate in rainbow trout: a comparative in vivo/in vitro approach.. Aquatic toxicology (Amsterdam, Netherlands), 53 ((3-4)): (159-172). [PMID:11408077]
7. B Fauconneau,G Paboeuf. (2001-06-16) Sensitivity of muscle satellite cells to pollutants: an in vitro and in vivo comparative approach.. Aquatic toxicology (Amsterdam, Netherlands), 53 ((3-4)): (247-263). [PMID:11408083]
8. Michael Kilemade,Maria Lyons-Alcantara,Tina Rose,Richard Fitzgerald,Carmel Mothersill. (2002-09-03) Rainbow trout primary epidermal cell proliferation as an indicator of aquatic toxicity: an in vitro/in vivo exposure comparison.. Aquatic toxicology (Amsterdam, Netherlands), 60 ((1-2)): (43-59). [PMID:12204586]
9. Michael Kilemade,Carmel Mothersill. (2003-04-25) Expression of delayed cell death (DCD) in the progeny of fish cells surviving 2,4-dichloroaniline (2,4-DCA) exposure.. Aquatic toxicology (Amsterdam, Netherlands), 63 ((3)): (207-219). [PMID:12711411]
10. C Causserand,P Aimar,J P Cravedi,E Singlande. (2005-05-10) Dichloroaniline retention by nanofiltration membranes.. Water research, 39 ((8)): (1594-1600). [PMID:15878032]
11. Jin-feng Peng,Jing-fu Liu,Gui-bin Jiang,Chao Tai,Min-jia Huang. (2005-05-11) Ionic liquid for high temperature headspace liquid-phase microextraction of chlorinated anilines in environmental water samples.. Journal of chromatography. A, 1072 ((1)): (3-6). [PMID:15881452]
12. Chao Wang,Guang-Hua Lu,Yan-Jie Zhou. (2007-07-13) Biodegradability of chlorinated anilines in waters.. Biomedical and environmental sciences : BES, 20 ((2)): (141-145). [PMID:17624189]
13. Li-li Zhang,Dan He,Jian-meng Chen,Yu Liu. (2010-04-27) Biodegradation of 2-chloroaniline, 3-chloroaniline, and 4-chloroaniline by a novel strain Delftia tsuruhatensis H1.. Journal of hazardous materials, 179 ((1-3)): (875-882). [PMID:20417029]
14. Roman Ashauer,Anita Hintermeister,Eva Potthoff,Beate I Escher. (2011-03-12) Acute toxicity of organic chemicals to Gammarus pulex correlates with sensitivity of Daphnia magna across most modes of action.. Aquatic toxicology (Amsterdam, Netherlands), 103 ((1-2)): (38-45). [PMID:21392493]
15. T Yoshida,M Hirata,T Tabuchi,K Miyajima. (1992-01-01) [Excretion of p-chloroaniline metabolites into urine. Excretion of 2,4-dichloroaniline and p-chloroformanilide].. Sangyo igaku. Japanese journal of industrial health, 34 ((1)): (3-9). [PMID:1635272]
16. T Yoshida,M Hirata,T Tabuchi,K Miyajima. (1991-11-01) [Identification of urinary metabolites in a patient of acute poisoning by p-chloroaniline].. Sangyo igaku. Japanese journal of industrial health, 33 ((6)): (501-508). [PMID:1770617]
17. J Struijs,J E Rogers. (1989-10-01) Reductive dehalogenation of dichloroanilines by anaerobic microorganisms in fresh and dichlorophenol-acclimated pond sediment.. Applied and environmental microbiology, 55 ((10)): (2527-2531). [PMID:2604394]
18. C A van Gestel,W A van Dis,E M van Breemen,P M Sparenburg. (1989-12-01) Development of a standardized reproduction toxicity test with the earthworm species Eisenia fetida andrei using copper, pentachlorophenol and 2,4-dichloroaniline.. Ecotoxicology and environmental safety, 18 ((3)): (305-312). [PMID:2612422]
19. I Leguen,P Prunet. (2001-06-16) In vitro effect of various xenobiotics on trout gill cell volume regulation after hypotonic shock.. Aquatic toxicology (Amsterdam, Netherlands), 53 ((3-4)): (201-214). [PMID:11408080]
20. M Kilemade,C Mothersill. (2001-06-21) Heat shock protein 70 levels in rainbow trout primary epidermal cultures in response to 2,4-dichloroaniline exposure: a novel in vitro aquatic toxicity marker.. Environmental toxicology, 16 ((3)): (253-259). [PMID:11409197]
21. Si-Houy Lao,Caroline Loutre,Melissa Brazier,Julian O D Coleman,David J Cole,Robert Edwards,Frederica L Theodoulou. (2003-07-05) 3,4-Dichloroaniline is detoxified and exported via different pathways in Arabidopsis and soybean.. Phytochemistry, 63 ((6)): (653-661). [PMID:12842137]
22. Sophie Pascal-Lorber,Estelle Rathahao,Jean-Pierre Cravedi,Francois Laurent. (2004-01-07) Uptake and metabolic fate of [14C]-2,4-dichlorophenol and [14C]-2,4-dichloroaniline in wheat (Triticum aestivum) and soybean (Glycine max).. Journal of agricultural and food chemistry, 51 ((16)): (4712-4718). [PMID:14705901]
23. N Sundaraganesan,J Karpagam,S Sebastian,J P Cornard. (2009-03-03) The spectroscopic (FTIR, FT-IR gas phase and FT-Raman), first order hyperpolarizabilities, NMR analysis of 2,4-dichloroaniline by ab initio HF and density functional methods.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 73 ((1)): (11-19). [PMID:19251476]
24. Robin P F Dullaart,Rindert de Vries,Joop D Lefrandt. (2014-08-26) Increased large VLDL and small LDL particles are related to lower bilirubin in Type 2 diabetes mellitus.. Clinical biochemistry, 47 ((16-17)): (170-175). [PMID:25149194]
25. Cholnam Ri, Fengxiang Li, Hyokchol Mun, Linan Liu, Jingchun Tang. (2023) Ball-milled Fe0/FeS2 enhanced interaction of Shewanella oneidensis MR-1 with anaerobic microbial community: Impact on 2,4-dichloronitrobenzene reduction and methane yield. CHEMICAL ENGINEERING JOURNAL, 452 (139086). [10.1016/j.cej.2022.139086]
26. Di Zhang, Tom Bond, Yang Pan, Mingli Li, Jiayi Luo, Rong Xiao, Wenhai Chu. (2022) Identification, Occurrence, and Cytotoxicity of Haloanilines: A New Class of Aromatic Nitrogenous Disinfection Byproducts in Chloraminated and Chlorinated Drinking Water. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 56 (7): (4132–4141). [PMID:35302737] [10.1021/acs.est.1c07375]
27. Linlin Chen, Junjie Shao, Hui Chen, Caiqin Wang, Xinyi Gao, Xiangyang Xu, Liang Zhu. (2018) Cathode potential regulation in a coupled bioelectrode-anaerobic sludge system for effective dechlorination of 2,4-dichloronitrobenzene. BIORESOURCE TECHNOLOGY, 254 (180). [PMID:29413921] [10.1016/j.biortech.2018.01.092]
28. Ya-Nan Jiao, Hong Chen, Rui-Xia Gao, Yong-Guan Zhu, Christopher Rensing. (2017) Organic compounds stimulate horizontal transfer of antibiotic resistance genes in mixed wastewater treatment systems. CHEMOSPHERE, 184 (53). [PMID:28578196] [10.1016/j.chemosphere.2017.05.149]
29. Deyang Kong, Qing Xia, Guoqiang Liu, Qingguo Huang, Junhe Lu. (2013) Covalent bonding of chloroanilines to humic constituents: Pathways, kinetics, and stability. ENVIRONMENTAL POLLUTION, 180 (48). [PMID:23727567] [10.1016/j.envpol.2013.05.018]
30. Xiaofei Han,Jia Chen,Zhan Li,Kaijun Quan,Hongdeng Qiu. (2020-09-07) Magnetic solid-phase extraction of triazole fungicides based on magnetic porous carbon prepared by combustion combined with solvothermal method.. Analytica chimica acta, 1129 (85-97). [PMID:32891394]

溶液计算器

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货号 (SKU)	包装规格	是否现货
D103990-25g	25g	现货
D103990-100g	100g	现货
D103990-500g	500g	现货
D103990-2.5kg	2.5kg	现货

2,4-二氯苯胺

库存信息

库存信息

库存信息

库存信息

基本描述

AI解读

关联靶点（人）

关联靶点（其它种属）

作用机制

名称和识别符

化学和物理性质

安全和危险性（GHS）

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关文档

此产品的引用文献

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器