| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| D409248-1ml |
1ml |
现货  |
|
| 英文别名 | WY 45233 Succinate | Phenol, 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]- |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Desvenlafaxine |
| 生化机理 | 地文拉法辛（WY 45233 Succinate）是一种血清素（5-HT）和去甲肾上腺素（NE）再摄取抑制剂，其Ki值分别为 40.2 nM 和 558.4 nM。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 去甲肾上腺素转运体抑制剂 |
| 产品介绍 |
邻去甲基文拉法辛是文拉法辛的主要活性代谢产物。 Information Desvenlafaxine Desvenlafaxine (WY 45233 Succinate) is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with K i of 40.2 nM and 558.4 nM, respectively. Desvenlafaxine is a serotonin-norepinephrine reuptake inhibitor and is the active metabolite of the antidepressant venlafaxine. Similar to venlafaxine, desvenlafaxine inhibits the neuronal uptake of serotonin and norepinephrine. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter. Desvenlafaxine inhibits [3H]5-HT or [3H]NE uptake for the hSERT or hNET with IC50 of 47.3 and 531.3 nM, respectively. Desvenlafaxine has the potential to inhibit CYP2D6, which could result in increased concentrations of drugs metabolized through this pathway. Induction of CYP3A4 is also possible with desvenlafaxine, which could impact the metabolism of drugs metabolized via this enzyme. In vivo Desvenlafaxine rapidly penetrates the male rat brain and hypothalamus. Desvenlafaxine significantly increases extracellular NE levels compared with baseline in the male rat hypothalamus but had no effect on DA levels using microdialysis. Desvenlafaxine exhibits a linear and dose-proportional pharmacokinetic single-dose profile in a dose range from 100 to 600 mg/day. The absolute bioavailability of the oral formulation is 80.5%. cell lines： Concentrations： Incubation Time： Powder Purity:≥99% |
| ALogP | 2.796 |
|---|---|
| HBD Count | 1 |
| Rotatable Bond | 4 |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | CN(C)CC(C1=CC=C(O)C=C1)C2(O)CCCCC2 |
| 分子量 | 263.38 |
| Reaxy-Rn | 4234613 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4234613&ln= |
| DMSO(mg / mL) Max Solubility | 37 |
|---|---|
| DMSO(mM) Max Solubility | 140.48 |
| Water(mg / mL) Max Solubility | <1 |
| Reaxy-Rn | 4234613 |
|---|---|
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4234613&ln= |
| Concentration(Compounding value) | 9-11（mmol/L） |
|---|---|
| Record the entire process by video | Conform |
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