| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| I427215-1ml |
1ml |
现货  |
|
| 别名 | 咪喹莫特 | 1-(2-甲基丙基)-1 H -咪唑 4,5- c 喹啉-4-胺 | 1-(2-甲基丙基)-4-氨基-1H-咪唑并[4,5-c]喹啉 | 1-异丁基-1H-咪唑[4.5-C]喹啉-4-胺基 |
|---|---|
| 英文别名 | HMS3715N19 | Imiquimod 100 microg/mL in Acetonitrile | Imiquimod- Bio-X | Aldara (TN) | DTXSID7041047 | HY-B0180 | S 26308 | AB00399298-05 | IMIQUIMOD [ORANGE BOOK] | YH44175 | 1-isobutylimidazo[4,5-c]quinolin-4-amine | HB3109 | IMIQUIMOD [JAN] | 4-Amino- |
| 规格或纯度 | Moligand™, 2mM in DMSO |
| 英文名称 | Imiquimod |
| 生化机理 | Toll样受体7激动剂。激活NF-κB并刺激促炎细胞因子。免疫调节剂，抗病毒和抗肿瘤剂。在体内和体外具有活性。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激动剂 |
| 作用机制 | TLR7 激动剂 |
| 产品介绍 |
Imiquimod (R 837) 是一种免疫反应调节剂，作为 toll-like receptor 7 的激动剂起作用。 Product Description Imiquimod (R 837) is an immune response modifier that acts as a toll-like receptor 7 agonist. Product Application Imiquimod is a caspase 3 activator which acts as an immunomodulator and displays antiviral and anti-tumor activity. It is a patient-applied cream used for the treatment of genital warts and basal cell carcinoma. It is also used to cure actinic keratosis on the face and scalp. It belongs to a group of drugs called immune response modifiers, which work by activating the immune system to fight abnormal skin growth. |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | 1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine |
| INCHI | InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17) |
| InChi Key | DOUYETYNHWVLEO-UHFFFAOYSA-N |
| Canonical SMILES | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N |
| Isomeric SMILES | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N |
| WGK Germany | 3 |
| RTECS | NJ5903450 |
| 分子量 | 240.31 |
| Reaxy-Rn | 7710060 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7710060&ln= |
| 熔点 | 297~299℃ |
|---|---|
| 分子量 | 240.300 g/mol |
| XLogP3 | 2.600 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 2 |
| 精确质量Exact Mass | 240.137 Da |
| 单同位素质量Monoisotopic Mass | 240.137 Da |
| 拓扑极表面积Topological Polar Surface Area | 56.700 Ų |
| 重原子数Heavy Atom Count | 18 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 294.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS06, GHS07 |
|---|---|
| 危险声明 |
H413: 可能对水生生物造成长期的有害影响 |
| 预防措施声明 |
P273: 避免释放到环境中。 P501: 将内容物/容器处理到。。。 |
| WGK Germany | 3 |
| RTECS | NJ5903450 |
| Reaxy-Rn | 7710060 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7710060&ln= |
| Merck Index | 4922 |
| 个人防护装备 | Eyeshields， Faceshields， Gloves， type P2 (EN 143) respirator cartridges |
| concentration | 1.8-2.2（mmol/L） |
|---|---|
| NMR Spectrum 1H | Conforms to Structure |
| 1. Haifeng Ni, Sunxiang Qian, Jie Lu, Jie Feng, Xiao-zhou Mou, Jing Zhang. (2023) Natural Polysaccharide Delivery Platforms with Multiscale Structure Used for Cancer Chemoimmunotherapy. MOLECULAR PHARMACEUTICS, (28): [PMID:37752866] [10.1021/acs.molpharmaceut.3c00633] |
| 2. Lu Dehua, Xu Yanming, Yang Xiaodong, Li Ying, Li Mengqing, Zheng Yuanyuan, Wang Yuenan, Wang Weihu, Wang Shubin, Gao Jing, Liu Yajie. (2023) Neutrophil membrane-derived nanoparticle loading TLR7 agonists augments radiotherapy efficacy and boosts abscopal effect via regulating tumor microenvironment. Cancer Nanotechnology, 14 (1): (1-18). [10.1186/s12645-023-00193-8] |
| 3. Hong Liu, Zhenfu Wen, Haolin Chen, Zeyu Yang, Zhicheng Le, Zhijia Liu, Yongming Chen, Lixin Liu. (2022) Nanoadjuvants Actively targeting lymph node conduits and blocking tumor invasion in lymphatic vessels. JOURNAL OF CONTROLLED RELEASE, 352 (497). [PMID:36341931] [10.1016/j.jconrel.2022.10.053] |
| 4. Meiting Li, Yaqian Zhang, Xiaoge Zhang, Zhuoyin Liu, Junjie Tang, Miao Feng, Baizhu Chen, Dalin Wu, Jie Liu. (2022) Degradable Multifunctional Porphyrin-Based Porous Organic Polymer Nanosonosensitizer for Tumor-Specific Sonodynamic, Chemo- and Immunotherapy. ACS Applied Materials & Interfaces, 14 (43): (48489–48501). [PMID:36281484] [10.1021/acsami.2c14776] |
| 5. Jiexin Li, He Ren, Yaping Sun, Gengqi Liu, Xingyue Yang, Qian Qiu, Yuanmeng Ding, Jonathan F. Lovell, Yumiao Zhang. (2021) Magnetic Metal Micelles for Enhanced Delivery of Self-Immolating CD8+ T-Cell Epitopes for Cancer Immunotherapy. CHEMISTRY OF MATERIALS, 33 (24): (9780–9794). [10.1021/acs.chemmater.1c03681] |
| 6. Lili Cheng, Xiaoge Zhang, Junjie Tang, Qijun Lv, Jie Liu. (2021) Gene-engineered exosomes-thermosensitive liposomes hybrid nanovesicles by the blockade of CD47 signal for combined photothermal therapy and cancer immunotherapy. BIOMATERIALS, 275 (120964). [PMID:34147721] [10.1016/j.biomaterials.2021.120964] |
| 7. Zhang Lirong, Zhang Jingjing, Xu Lixia, Zhuang Zijian, Liu Jingjin, Liu Suwan, Wu Yunchao, Gong Aihua, Zhang Miaomiao, Du Fengyi. (2021) NIR responsive tumor vaccine in situ for photothermal ablation and chemotherapy to trigger robust antitumor immune responses. JOURNAL OF NANOBIOTECHNOLOGY, 19 (1): (1-16). [PMID:34001148] [10.1186/s12951-021-00880-x] |
| 8. Yuting Cao, Yan Zhou, Jinbin Pan, Xinyu Zhong, Jianmin Ding, Xiang Jing, Shao-Kai Sun. (2021) A general strategy towards an injectable microwave-sensitive immune hydrogel for combined percutaneous microwave ablation and immunotherapy. CHEMICAL ENGINEERING JOURNAL, 422 (130111). [10.1016/j.cej.2021.130111] |
| 9. Fan Jiang, Binbin Ding, Shuang Liang, Yajie Zhao, Ziyong Cheng, Bengang Xing, Ping'an Ma, Jun Lin. (2021) Intelligent MoS2–CuO heterostructures with multiplexed imaging and remarkably enhanced antitumor efficacy via synergetic photothermal therapy/ chemodynamic therapy/ immunotherapy. BIOMATERIALS, 268 (120545). [PMID:33253965] [10.1016/j.biomaterials.2020.120545] |
| 10. Zhaocheng Li, Jiyuan Gao, Zexing Xiang, Honglei Zhang, Yibei Wang, Xuefei Zhang. (2020) A pH-responsive polymer linked with immunomodulatory drugs: synthesis, characteristics and in vitro biocompatibility. JOURNAL OF APPLIED TOXICOLOGY, 41 (5): (724-735). [PMID:32776438] [10.1002/jat.4042] |
| 11. Xiangbo Meng, Ke Wang, Lin Lv, Ye Zhao, Chen Sun, Lianjun Ma, Bin Zhang. (2019) Photothermal/Photodynamic Therapy with Immune-Adjuvant Liposomal Complexes for Effective Gastric Cancer Therapy. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 36 (6): (1900015). [10.1002/ppsc.201900015] |
| 12. Shiquan Sun, Yong He, Jiaqi Xu, Shaolong Leng, Yu Liu, Huanhuan Wan, Leping Yan, Yunsheng Xu. (2024) Enhancing cell pyroptosis with biomimetic nanoparticles for melanoma chemo-immunotherapy. JOURNAL OF CONTROLLED RELEASE, 367 (470). [PMID:38290565] [10.1016/j.jconrel.2024.01.057] |
| 13. Guangchao Xie, Bingjie Li, Shuyue Guo, Wenjing Hou, Yao Wang, Jiamei Liu, Jialin Zhu, Luchen Chang, Xiaoqing Wang, Xiaoyi Wang, Jinbin Pan, Xi Wei. (2025) Minimalistic Implant for Percutaneous Magnetic Hyperthermia-Based Combination Therapy of Hepatocellular Carcinoma. ACS Applied Materials & Interfaces, 17 (7): (10369-10379). [PMID:39916295] [10.1021/acsami.4c18486] |
| 14. Siqiong Wu, Yongjun Chen, Ke Wang, Mingquan Huang, Liuxuan Yang, Jing Yang, Qiming Wei, Chao Tao, Chunhong Li, Meiling Zhou. (2025) Multifunctional mesoporous polydopamine nanoplatforms for synergistic photothermal-chemotherapy and enhanced immunotherapy in breast cancer treatment. COLLOIDS AND SURFACES B-BIOINTERFACES, 248 (114483). [PMID:39740488] [10.1016/j.colsurfb.2024.114483] |
| 15. Guangchao Xie, Bingjie Li, Xuejun Zhang, Jiaojiao Yu, Shao-Kai Sun. (2024) One-Minute Preparation of Iron Foam-Drug Implant for Ultralow-Power Magnetic Hyperthermia-Based Combination Therapy of Tumors in Vivo. Advanced Science, 11 (11): (2307823). [PMID:38164827] [10.1002/advs.202307823] |
| 16. Siqi Geng, Baoru Fang, Ke Wang, Fang Wang, Yiqing Zhou, Yike Hou, M. Zubair Iqbal, Yanping Chen, Zhangsen Yu. (2024) Polydopamine Nanoformulations Induced ICD and M1 Phenotype Macrophage Polarization for Enhanced TNBC Synergistic Photothermal Immunotherapy. ACS Applied Materials & Interfaces, 16 (44): (59814-59832). [PMID:39450881] [10.1021/acsami.4c11594] |
| 1. Haifeng Ni, Sunxiang Qian, Jie Lu, Jie Feng, Xiao-zhou Mou, Jing Zhang. (2023) Natural Polysaccharide Delivery Platforms with Multiscale Structure Used for Cancer Chemoimmunotherapy. MOLECULAR PHARMACEUTICS, (28): [PMID:37752866] [10.1021/acs.molpharmaceut.3c00633] |
| 2. Lu Dehua, Xu Yanming, Yang Xiaodong, Li Ying, Li Mengqing, Zheng Yuanyuan, Wang Yuenan, Wang Weihu, Wang Shubin, Gao Jing, Liu Yajie. (2023) Neutrophil membrane-derived nanoparticle loading TLR7 agonists augments radiotherapy efficacy and boosts abscopal effect via regulating tumor microenvironment. Cancer Nanotechnology, 14 (1): (1-18). [10.1186/s12645-023-00193-8] |
| 3. Hong Liu, Zhenfu Wen, Haolin Chen, Zeyu Yang, Zhicheng Le, Zhijia Liu, Yongming Chen, Lixin Liu. (2022) Nanoadjuvants Actively targeting lymph node conduits and blocking tumor invasion in lymphatic vessels. JOURNAL OF CONTROLLED RELEASE, 352 (497). [PMID:36341931] [10.1016/j.jconrel.2022.10.053] |
| 4. Meiting Li, Yaqian Zhang, Xiaoge Zhang, Zhuoyin Liu, Junjie Tang, Miao Feng, Baizhu Chen, Dalin Wu, Jie Liu. (2022) Degradable Multifunctional Porphyrin-Based Porous Organic Polymer Nanosonosensitizer for Tumor-Specific Sonodynamic, Chemo- and Immunotherapy. ACS Applied Materials & Interfaces, 14 (43): (48489–48501). [PMID:36281484] [10.1021/acsami.2c14776] |
| 5. Jiexin Li, He Ren, Yaping Sun, Gengqi Liu, Xingyue Yang, Qian Qiu, Yuanmeng Ding, Jonathan F. Lovell, Yumiao Zhang. (2021) Magnetic Metal Micelles for Enhanced Delivery of Self-Immolating CD8+ T-Cell Epitopes for Cancer Immunotherapy. CHEMISTRY OF MATERIALS, 33 (24): (9780–9794). [10.1021/acs.chemmater.1c03681] |
| 6. Lili Cheng, Xiaoge Zhang, Junjie Tang, Qijun Lv, Jie Liu. (2021) Gene-engineered exosomes-thermosensitive liposomes hybrid nanovesicles by the blockade of CD47 signal for combined photothermal therapy and cancer immunotherapy. BIOMATERIALS, 275 (120964). [PMID:34147721] [10.1016/j.biomaterials.2021.120964] |
| 7. Zhang Lirong, Zhang Jingjing, Xu Lixia, Zhuang Zijian, Liu Jingjin, Liu Suwan, Wu Yunchao, Gong Aihua, Zhang Miaomiao, Du Fengyi. (2021) NIR responsive tumor vaccine in situ for photothermal ablation and chemotherapy to trigger robust antitumor immune responses. JOURNAL OF NANOBIOTECHNOLOGY, 19 (1): (1-16). [PMID:34001148] [10.1186/s12951-021-00880-x] |
| 8. Yuting Cao, Yan Zhou, Jinbin Pan, Xinyu Zhong, Jianmin Ding, Xiang Jing, Shao-Kai Sun. (2021) A general strategy towards an injectable microwave-sensitive immune hydrogel for combined percutaneous microwave ablation and immunotherapy. CHEMICAL ENGINEERING JOURNAL, 422 (130111). [10.1016/j.cej.2021.130111] |
| 9. Fan Jiang, Binbin Ding, Shuang Liang, Yajie Zhao, Ziyong Cheng, Bengang Xing, Ping'an Ma, Jun Lin. (2021) Intelligent MoS2–CuO heterostructures with multiplexed imaging and remarkably enhanced antitumor efficacy via synergetic photothermal therapy/ chemodynamic therapy/ immunotherapy. BIOMATERIALS, 268 (120545). [PMID:33253965] [10.1016/j.biomaterials.2020.120545] |
| 10. Zhaocheng Li, Jiyuan Gao, Zexing Xiang, Honglei Zhang, Yibei Wang, Xuefei Zhang. (2020) A pH-responsive polymer linked with immunomodulatory drugs: synthesis, characteristics and in vitro biocompatibility. JOURNAL OF APPLIED TOXICOLOGY, 41 (5): (724-735). [PMID:32776438] [10.1002/jat.4042] |
| 11. Xiangbo Meng, Ke Wang, Lin Lv, Ye Zhao, Chen Sun, Lianjun Ma, Bin Zhang. (2019) Photothermal/Photodynamic Therapy with Immune-Adjuvant Liposomal Complexes for Effective Gastric Cancer Therapy. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 36 (6): (1900015). [10.1002/ppsc.201900015] |
| 12. Shiquan Sun, Yong He, Jiaqi Xu, Shaolong Leng, Yu Liu, Huanhuan Wan, Leping Yan, Yunsheng Xu. (2024) Enhancing cell pyroptosis with biomimetic nanoparticles for melanoma chemo-immunotherapy. JOURNAL OF CONTROLLED RELEASE, 367 (470). [PMID:38290565] [10.1016/j.jconrel.2024.01.057] |
| 13. Guangchao Xie, Bingjie Li, Shuyue Guo, Wenjing Hou, Yao Wang, Jiamei Liu, Jialin Zhu, Luchen Chang, Xiaoqing Wang, Xiaoyi Wang, Jinbin Pan, Xi Wei. (2025) Minimalistic Implant for Percutaneous Magnetic Hyperthermia-Based Combination Therapy of Hepatocellular Carcinoma. ACS Applied Materials & Interfaces, 17 (7): (10369-10379). [PMID:39916295] [10.1021/acsami.4c18486] |
| 14. Siqiong Wu, Yongjun Chen, Ke Wang, Mingquan Huang, Liuxuan Yang, Jing Yang, Qiming Wei, Chao Tao, Chunhong Li, Meiling Zhou. (2025) Multifunctional mesoporous polydopamine nanoplatforms for synergistic photothermal-chemotherapy and enhanced immunotherapy in breast cancer treatment. COLLOIDS AND SURFACES B-BIOINTERFACES, 248 (114483). [PMID:39740488] [10.1016/j.colsurfb.2024.114483] |
| 15. Guangchao Xie, Bingjie Li, Xuejun Zhang, Jiaojiao Yu, Shao-Kai Sun. (2024) One-Minute Preparation of Iron Foam-Drug Implant for Ultralow-Power Magnetic Hyperthermia-Based Combination Therapy of Tumors in Vivo. Advanced Science, 11 (11): (2307823). [PMID:38164827] [10.1002/advs.202307823] |
| 16. Siqi Geng, Baoru Fang, Ke Wang, Fang Wang, Yiqing Zhou, Yike Hou, M. Zubair Iqbal, Yanping Chen, Zhangsen Yu. (2024) Polydopamine Nanoformulations Induced ICD and M1 Phenotype Macrophage Polarization for Enhanced TNBC Synergistic Photothermal Immunotherapy. ACS Applied Materials & Interfaces, 16 (44): (59814-59832). [PMID:39450881] [10.1021/acsami.4c11594] |
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