计算溶液所需的质量、体积或浓度。
Recombinant Human RAGE Protein (rp150830) - Protein Bioactivity
Recombinant human HMGB1 at 2.0 μg/mL can bind Recombinant Human RAGE Protein (rp150830) with a linear range of 15.0 -50.0 ng/mL. The EC₅₀ for this effect is 70.0 ng/mL.
ActiBioPure™,Fc标签,His标签,无动物源,无叠氮钠,无载体,生物活性 级 提供 ≥90%(SDS-PAGE) 纯度,适用于对基线干扰要求严格的色谱和分析工作流程。
-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Purity
>90% SDS-PAGE.
Function
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.
Recombinant Human RAGE Protein (rp150830) - Protein Bioactivity
Recombinant human HMGB1 at 2.0 μg/mL can bind Recombinant Human RAGE Protein (rp150830) with a linear range of 15.0 -50.0 ng/mL. The EC₅₀ for this effect is 70.0 ng/mL.
Recombinant Human RAGE Protein (rp150830) - SDS-PAGE
3 μg/lane of Recombinant Human RAGE was resolved with SDS-PAGE under reducing (R) conditions and visualized by Coomassie® Blue staining, showing the band at 77.1 & 38.1 kDa under reducing conditions.
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | rp150830 | |
| 分析证书 | rp150830 | |
| 分析证书 | rp150830 | |
| 分析证书 | rp150830 | |
| 分析证书 | rp150830 | |
| 分析证书 | rp150830 |
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