EUROPEAN POLYMER JOURNAL
·
2019
·
IF 3.621
Li Song,Bao Zhang,Ge Gao,Chunsheng Xiao,Gao Li
Herein, Pluronic F127 (PEO 99 -PPO 65 -PEO 99 ) end functionalized with α-lipoic acid (LA) (F127-LA) was synthesized and used for preparation of “single-component, multi-responsive” hydrogels through the photo cross-linking of LA components. The F127-LA hydrogels not only possessed thermo- and reduction- double responsiveness, but also demonstrated self-healing properties under UV irradiation due to the existence of dynamic disulfide bonds. The rheological and mechanical properties of the hydrogels can be adjusted by their concentration. The F127-LA hydrogels presented a swelling ratio decrease from 25 °C to 37 °C due to a lower critical solution temperature (LCST)-type thermo-responsive volume phase transition. The bovine serum albumin (BSA) was loaded into F127-LA hydrogels, and their drug release behavior can be regulated by surrounding temperature and reducing agent concentration. The volume shrinkage of the hydrogels promoted the sustained release of BSA above volume phase transition temperature. Cytocompatibility assay of L929 mouse fibroblasts showed that cellular metabolic activity were merely affected by F127-LA, even at concentrations up to 1000 mg L −1 . This study thus provided a very promising route for the preparation of multifunctional hydrogels.
研究领域:
材料科学
·
生物医学工程
·
药物递送
✓ 已验证
产品关联
DOI
高影响因子
Antioxidants
·
2022
·Vol. 11
·期 8
·1530
·
IF 7.675
Qingxiu Liu,Wenxiang Li,Shimeng Huang,Lihong Zhao,Jianyun Zhang,Cheng Ji,Qiugang Ma
The development of single enantiomers with high efficiency and low toxic activity has become a hot spot for the development and application of drugs and active additives. The aim of the present study was to investigate the effectiveness of the application of α-lipoic acid with a different optical rotation to alleviate the inflammation response and oxidative stress induced by oxidized fish oil in laying hens. Sixty-four 124-week-old Peking Red laying hens were randomly allocated to four groups with eight replicates of two birds each. The normal group was fed basal diets supplemented with 1% fresh fish oil (FO), and the oxidative stress model group was constructed with diets supplemented with 1% oxidized fish oil (OFO). The two treatment groups were the S-form of the α-lipoic acid model with 1% oxidized fish oil (OFO + S-LA) and the R-form of the α-lipoic acid model with 1% oxidized fish oil (OFO + R-LA) added at 100 mg/kg, respectively. Herein, these results were evaluated by the breeding performance, immunoglobulin, immune response, estrogen secretion, antioxidant factors of the serum and oviduct, and pathological observation of the uterus part of the oviduct. From the results, diets supplemented with oxidized fish oil can be relatively successful in constructing a model of inflammation and oxidative stress. The OFO group significantly increased the levels of the serum inflammatory factor (TNF-α, IL-1β, IL-6, and IFN-γ) and the oxidative factor MDA and decreased the activity of the antioxidant enzyme (T-AOC, T-SOD, GSH-Px, GSH, and CAT) in the oviduct. The addition of both S-LA and R-LA significantly reduced the levels of serum inflammatory factors (TNF-α, IL-1β, IL-6, and IFN-γ), increased the activity of antioxidant indexes (T-AOC, T-SOD, GSH-Px, GSH, and CAT), and decreased the MDA contents in the serum and oviduct. Meanwhile, the supplementation of S-LA and R-LA also mitigated the negative effects of the OFO on the immunoglobulins (IgA and IgM) and serum hormone levels (P and E2). In addition, it was worth noting that the R-LA was significantly more effective than the S-LA in some inflammatory (IL-1β) and antioxidant indices (T-SOD, GSH, and CAT). Above all, both S-LA and R-LA can alleviate the inflammation and oxidative damage caused by oxidative stress in aged laying hens, and R-LA is more effective than S-LA. Thus, these findings will provide basic data for the potential development of α-lipoic acid as a chiral dietary additive for laying hens.Keywords:S-form of α-lipoic acid;R-form of α-lipoic acid;oxidized fish oil;antioxidant;laying hen
研究领域:
动物科学
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营养学
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免疫学
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生物化学
✓ 已验证
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2020
·
IF 4.469
Cong Huang,Nan Zhang,Qiang Wang,Ping Wang,Yuanyuan Yu,Man Zhou
Extensive research and practice on anti-crease of cotton fabric has been made in the past few decades because of its easy creasing properties. However, it has not achieved a good balance between anti-crease performance, strength loss, hydrophilicity and formaldehyde release until now. In this study, for the first time, α-lipoic acid (ALA) which contains bifunctional groups, carboxyl group and disulfide bond, has been successfully used as an innovative cross-linking agent in the anti-crease functionalization to prepare high crease resistant and hydrophilic cotton fabric without strength loss and formaldehyde release. The mechanism between ALA and cellulose through esterification, disulfide breaking and reconstruction, and anti-crease mechanism based on topological disulfide bridges among cellulosic molecules were illustrated in terms of the characterization analyses of cross-linked ALA and poly(α-lipoic acid). This study provides a completely different idea for the preparation of anti-crease cotton fabric with high strength and hydrophilic without negative environmental impact.
研究领域:
纺织科学
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材料化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Xiang Ke,Shuxian Tang,Zhiyun Dong,Kai Ren,Peng Yu,Xinyuan Xu,Jiaojiao Yang,Jun Luo,Jianshu Li
Development of supramolecular adhesion systems from small molecules is a promising strategy to construct adhesives integrating synthetic simplification and sophisticated properties. Here, we report a facile and green one-pot strategy for fabricating a solvent-free and dynamic supramolecular adhesive via co-heating three readily available feedstocks, a natural small biological molecule (α-lipoic acid), a natural plant polyphenol (tannic acid), and ferric chloride. The adhesive is injectable and self-healing, which can work instantly and repeatedly on various materials (e.g., polytetrafluoroethylene (PTFE)) in diverse conditions (dry, underwater, pH < 7, various ionic environments, and even in vacuum) at room temperature, showing promising applicability in complex environments. The self-strengthening of the supramolecular network with time further improves the adhesion strength of the adhesive for the glass (from about 22 kPa to exceeded 300 kPa after 28 d). More importantly, the adhesive exhibits great potentials to be applied in biomedical fields with wet environments. This ready-to-use and high-performance supramolecular adhesive, constructed by natural small molecules via an extremely facile preparation method, represents a promising universal strategy for both dry and wet adhesion.
研究领域:
材料科学
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生物学
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医学
✓ 已验证
产品关联
DOI
高影响因子
FIBERS AND POLYMERS
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2022
·Vol. 23
·期 8
·2225-2233
·
IF 2.347
Wu Leilei,Bao Xueming,Ren Yiwen,Wang Ping,Zhou Man,Yu Yuanyuan,Wang Qiang
Generally, Bombyx mori silk dyeing is performed using acid dyes. However, the color fastness is always unsatisfactory due to the weak binding forces under neutral conditions. In the present work, graft polymerization of α-lipoic acid (ALA) onto silk fibers was carried out using a two-step method. Briefly, ALA was grafted onto the silk fibers, followed by a reduction-oxidation process to form poly(α-lipoic acid) (PALA) on the fiber surfaces, aiming at improving the electronegativity of fiber surface and realizing cationic dyeing. The results implied that the combined treatments promoted the intermolecular crosslinking between fibroin chains, endowing the silk fiber with low zeta potential simultaneously. A thin sedimentary layer on the fiber surfaces was observed for the PALA-deposited silk fibers, companying with a significant increase in the content of sulfur and O/N ratio, which verified the successful graft polymerization. The modified silk fabric exhibited improved dyeability, and the dyeing depth and color fastness was noticeably higher compared to that of the untreated after cationic dyeing. Meanwhile, the newly-built intermolecular disulfide crosslinks imparted a detectable anti-wrinkle effect to the silk fabric. This study provides a facile strategy for modification of silk fabric with improved dyeing behaviors and physical properties.
研究领域:
材料科学
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纺织工程
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
Aquaculture Reports
·
2025
·
IF 3.7
Hengyang Song,Xiangxiang Suo,Wanting Huang,Yubin Liu,Xiaojuan Huang,Wenshan Cai,Hao Liu,Beiping Tan,Xiaohui Dong
High-fat diets (HD) are extensively used in aquaculture due to saving feed cost, reducing protein level, and improve better fish growth and health conditions. However, the harmful impacts of HD, especially on health, limit application of HD in aquaculture. Due to the harmful effect of HD on hepatic health can be alternatively used α-lipoic acid and tea polyphenols, which exhibit great beneficial effect. This study investigated the effects of α-lipoic acid, tea polyphenols, and their combination on growth performance, antioxidant capacity, and inflammation-related indices in hybrid groupers ( ♀ Epinephelus fuscoguttatus × ♂ E. lanceolatus ) fed a high-fat diet. A basic diet (CK group) with 50 % protein and 17 % lipid content was prepared. α-lipoic acid (LA) and tea polyphenols (TP) were used as additives, and 1000 mg/kg additive was added to the basic diet respectively, and the addition method was LA (LA group), TP (TP group), LA:TP = 1:1 (LA:TP group), LA:TP = 1:2 (LA:2TP group), LA:TP = 2:1 (2LA:TP group). Six experimental diets were fed to hybrid grouper (8.68 ± 0.22 g) for 8 weeks. These results showed that the addition of LA:TP = 1:2 (LA:2TP group) to the diet significantly increased final body weight (FBW), weight gain rate (WGR), specific growth rate (SGR) ( P < 0.05). Compared with CK, LA, TP, LA:TP and 2LA:TP groups, the serum triglyceride (TG) content in the LA:2TP group was obviously decreased ( P < 0.05), and the ratio of high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) was enhanced. In addition, the complements C3 and C4 contents in liver of the LA:2TP group were obviously increased, and the total cholesterol (TC) level was significantly decreased ( P < 0.05). Meanwhile, compared with the CK group, the serum contents of malondialdehyde (MDA) in each group were markedly reduced ( P < 0.05). The results of genes related to inflammation and antioxidation showed that compared with CK, LA, TP and LA:TP groups, the antioxidant genes ( sod , cat ) and anti-inflammatory cytokine genes ( tgf-β , il-10 ) in liver and head kidney of LA:2TP group were obviously up-regulated ( P < 0.05), while those in LA, TP and LA:TP groups were obviously greater than those in CK group ( P < 0.05), and the expression level in 2LA:TP group was the lowest ( P < 0.05). Correspondingly, the pro-inflammatory cytokine genes ( il-6 , tnf-α ) in the 2LA:TP group were significantly up-regulated and greater than those in other groups ( P < 0.05), and the expression level in the LA:2TP group was the lowest ( P < 0.05). In conclusion, adding LA:TP = 1:2 can effectively enhance growth performance, improve antioxidant capacity and reduce the harmful effects of HD diet in hybrid grouper.
研究领域:
水产养殖学
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营养学
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分子生物学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL UROLOGY AND NEPHROLOGY
·
2020
·Vol. 52
·期 7
·1227-1234
·
IF 1.843
Wang Zhenghao,Bai Yunjin,Wang Jiahao,Wang Jia
Objective To investigate the effect of α-lipoic acid (α-LA) in the prevention and treatment of ethylene glycol-induced calcium oxalate deposition in a rat model and preliminary exploration of the mechanism. Methods Sixty male Wistar rats were divided randomly and equally into six groups including two α-LA prevention groups, two α-LA therapeutic groups, one controlled group and one intervention group. Besides controlled group, other group received 1% glycol solution and 2 ml 2% ammonium chloride for 4 weeks as a stone inducer. The prevention groups received 0.1 and 0.2 mg/kg body weight/day/rat α-LA as food supplement during inducing stone and therapeutic groups received 0.1 and 0.2 mg/kg body weight/day/rat α-LA for 4 weeks after 4 weeks stone inducing. Results The volume of urine, the pH and magnesium levels in the preventive and therapeutic groups were higher in a dose-independent manner ( p < 0.05), and urinary calcium was lower ( p < 0.05). Antioxidant stress enzyme activity (glutathione, superoxide dismutase, catalase) in serum and kidney homogenates in the preventive and therapeutic groups underwent significant regeneration ( p < 0.05) and malondialdehyde levels and the production of free radical moieties decreased. Pathological observation demonstrated that there was deformation due to renal tubular expansion in the control group, greater visible inflammatory cell infiltration into the interstitial spaces and partial destruction of the glomerular structures. α-lipoic acid improved the lesions to varying degrees. The extent of crystal deposition was lower in the preventive and therapeutic groups compared with the control group ( p < 0.05). Conclusion The present study indicated that α-LA provides both preventive and therapeutic effects against the deposition of calcium oxalate crystals in rats.
研究领域:
医学
·
药理学
·
泌尿学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EMBO REPORTS
·
2020
·
IF 7.497
Gang Du,Yicheng Qiao,Zhangpeng Zhuo,Jiaqi Zhou,Xiaorong Li,Zhiming Liu,Yang Li,Haiyang Chen
The age-associated decline of adult stem cell function is closely related to the decline in tissue function and age-related diseases. However, the underlying mechanisms that ultimately lead to the observed functional decline of stem cells still remain largely unexplored. This study investigated Drosophila midguts and found a continuous downregulation of lipoic acid synthase, which encodes the key enzyme for the endogenous synthesis of alpha-lipoic acid (ALA), upon aging. Importantly, orally administration of ALA significantly reversed the age-associated hyperproliferation of intestinal stem cells (ISCs) and the observed decline of intestinal function, thus extending the lifespan of Drosophila. This study reports that ALA reverses age-associated ISC dysfunction by promoting the activation of the endocytosis–autophagy network, which decreases in aged ISCs. Moreover, this study suggests that ALA may be used as a safe and effective anti-aging compound for the treatment of ISC-dysfunction-related diseases and for the promotion of healthy aging in humans.
研究领域:
细胞生物学
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衰老研究
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干细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2022
·Vol. 102
·期 15
·7115-7125
·
IF 4.125
Wen-Sen He,Yuying Sun,Zhishuo Li,Haonan Yang,Junjie Li,Qingzhi Wang,Chen Tan,Bin Zou
BACKGROUND α-Lipoic acid has excellent antioxidant activity, but its poor lipid solubility greatly limits its practical application. This study was undertaken (i) to develop a novel and efficient enzymatic synthesis of lipophilic lipoic acid esters using Candida sp. 99-125 lipase as a catalyst; and (ii) to systematically evaluate their antioxidant potential against bulk oil, oil-in-water emulsion (O/W) and cooked ground meat. RESULTS Lipophilic lipoic acid esters were successfully and efficiently synthesized using phytosterols as acyl receptor in the presence of Candida sp . 99-125 lipase. The product was identified as phytosterol lipoate by mass spectrometry, Fourier transform infrared spectroscopy and nuclear magnetic resonance. The maximum conversion of phytosterol lipoate surpassed 90% within 12 h and its final yield exceeded 81%. Interestingly, the oil solubility of lipoic acid was increased at least 25-fold and other physicochemical properties were significantly improved. Most importantly, phytosterol lipoate exhibited higher antioxidant activity than lipoic acid in bulk oil, O/W emulsions and cooked ground meat. CONCLUSION The antioxidant capacity of lipoic acid can be significantly enhanced by esterification with phytosterols. Therefore, phytosterol lipoate could be further developed as a new antioxidant for use in oil- and fat-based foods. © 2022 Society of Chemical Industry.
研究领域:
食品科学
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生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2020
·
IF 7.182
Feng Shen,Haoquan Zhong,Wenjiao Ge,Junli Ren,Xiaohui Wang
Natural active compounds with antioxidant properties and other potential health benefits, like quercetin (Qu), have aroused wide concern for developing bio-functional products. However, their applications are hindered by their intrinsic poor water solubility and chemical instability. In this paper, a natural antioxidant alpha lipoic acid (ALA) was grafted onto chitosan (CS) to synthesize a novel graft polymer (CS-graft-ALA). In particular, this graft-polymer could self-assemble into spherical nanomicelles in water, with a low critical micelle concentration (CMC) of 0.0076 mg/mL. As a robust and active nanocarrier, the CS-graft-ALA micelles showed high efficiency in encapsulating Qu and dispersing Qu in water. As found, the antioxidant activity of Qu was effectively enhanced when entrapped within CS-graft-ALA micelles. Moreover, CS-graft-ALA micelles could significantly improve the photo-stability and temperature-stability of Qu. The Qu/CS-graft-ALA micelles with excellent water dispersability, stability and improved antioxidant activity hold a great potential for wide applications.
研究领域:
食品科学
·
生物材料
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Artificial Cells Nanomedicine and Biotechnology
·
2023
·
IF 5.8
Yanhai Xi,Wenming Pan,Yanyan Liu,Ji Liu,Guohua Xu,Yanguo Su,Daquan Chen,Xiaojian Ye
Osteoporosis is a common disease among the ageing society. Oxidative stress caused by excessive accumulation of reactive oxygen species (ROS) is the aetiology of osteoporosis. α-Lipoic acid (ALA) is an antioxidant in the body, which can eliminate excess ROS in the body and inhibits levels of oxidative stress in cells. Herein, we designed PEGylated hollow gold nanoparticles (HGNPs) loaded with ALA (mPEG@HGNPs-ALA) to remove ROS in the treatment of osteoporosis. First, mPEG@HGNPs with a particle size of ∼63 nm has been successfully synthesized. By comparing the drug loading of mPEG@HGNPs, it was concluded that the optimal mass ratio of mPEG@HGNPs (calculated by the amount of gold) to ALA was ∼1:2. ABTS antioxidant assay showed that free radical removal ability. In vitro results revealed that the preparation had good biocompatibility. At the gold concentration of 1–150 μg/mL, the cell viability of mPEG@HGNPs was more than 100%, which indicated that it could promote the proliferation of osteoblasts. What’s more, mPEG@HGNPs-ALA could effectively remove the ROS caused by H2O2 injury and improve the cell viability. According to these results, it can be considered that mPEG@HGNPs-ALA has the potential to treat osteoporosis.
研究领域:
纳米医学
·
药剂学
·
骨科
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2020
·
IF 7.183
Xiaotai Zhang,Hai Huang,Xiaoming Li,Jian Wang,Yangyang Wei,Huifeng Zhang
Active chlorine-vulnerability is the Achilles' heel for polyamide thin film composite (PA-TFC) reverse osmosis (RO) membranes during water desalination and/or purification. Chlorination disrupts the delicate PA skin layer on porous support, resulting in significantly deteriorative membrane permselectivity and rising maintenance cost. Inspired by the superior antioxidative capacity of biologically endogenous α-lipoic acid (LA), this work was dedicated to tailoring a chlorine-resistant RO membrane with LA sacrificial unit on the surface. It was evidenced that the characteristic dithiolane within LA preferentially reacted with active chlorine in feedwater, and the intimal PA selective layer was thus safeguarded from chlorine-triggered oxidation . The modifier was pre-assembled with LA and polyethylenimine (PEI) as the mediator, subsequently tethered onto membrane surface via one-step chemical coupling without any catalysts. A pretty balance between membrane permselectivity and grafted modifier amount was achieved via regulating the modifier concentration. The modified membrane exhibited significantly ameliorative chlorine-resistance relative to the pristine one, with normalized salt rejection still remained (99.3 ± 0.6)% and only (17 ± 5)% final flux loss after a rigorous static chlorine exposure of 8000 ppm·h under acidic condition (confidence level, P = 95%). The electronic energy differences of chlorination-involved chemical procedures were determined by density functional theory (DFT) calculation, and an energy-favored three-stage tandem oxidation mechanism of LA moiety was proposed. Accordingly, up to 5 equiv. of active chlorine can be captured by a single sacrificial unit. Such intrinsically high chlorine-consumption efficacy of LA-based sacrificial layer would retard the chlorination saturation that commonly invalidates sacrificial layers. This bioinspired work shed light on a novel, facile, and effective anti-chlorine strategy for PA-TFC RO membrane to maintain the stability of service performance.
研究领域:
材料科学
·
环境工程
·
化学工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）