COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Chenhui Yan,Bowen Zhang,Xing Ai,Chunping Xie,Tao Wang,Jinglin Huang,Guo Chen,Xiaoshan He,Yansong Liu,Zhibing He
Radioiodine anions (I and IO 3 ) pose a serious threat to the environment and human health due to their high radioactivity and solubility. Therefore, it is important to develop efficient and economical adsorbent materials for radioiodine anions. In this work, combined with the excellent properties of chitosan (CS) and (3-acrylamidopropyl) trimethylammonium chloride (AMPTAC), a novel interpenetrating network hydrogel CS@AMPTAC was synthesized to improve the adsorption efficiency of CS hydrogel for I and IO 3 . Due to the electrostatic interaction and anion exchange ability of the quaternary ammonium group (−N + (CH 3 ) 3 Cl⁻), the introduction of AMPTAC constructs a more complex and effective adsorption sites for CS@AMPTAC. Combined with the protonated amino group (−NH 3 + ) in CS, the CS@AMPTAC showed better adsorption efficiency and anti-interference performance than CS. The CS@AMPTAC hydrogel shows excellent adsorption performance over a wide pH range (pH 2–11), which overcomes the sensitivity of traditional adsorbents to pH. Meanwhile, the maximum adsorption capacities of CS@AMPTAC for I and IO 3 are 359.9 mg/g and 312.64 mg/g, respectively, which exhibits remarkable enhancements of 246.26 mg/g and 267.34 mg/g compared to CS. In addition, based on the synergistic adsorption mechanism and the hydrophilicity of CS@AMPTAC, the hydrogel can reach adsorption equilibrium within 30 min. The synergic strategy shows great potential for application in the treatment of radioiodine anions.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Zhihong Han,Mingyi Tan,Daming Chen,Wenzheng Zhang,Zhipeng Lin,Jiahui Zhou,Yuhao Fang,Shengze Zhang,Qihong Wei,Xinghong Zhang,Wenbo Han
High power consumption and operating frequencies of advanced electronic devices result in significant heat generation and a complex electromagnetic environment. This creates an urgent need for materials that cover large areas, have high thermal conductivity, and offer strong electromagnetic compatibility. In this work, large-area graphite films with high thermal conductivity and excellent electromagnetic shielding properties were fabricated using glucose as a carbon source. The introduction of carboxymethyl cellulose (CMC) ensures the integrity of the film, the unidirectional shrinkage, and the template of pyrolyzed polyimide resulting in an oriented graphite structure. The graphite films exhibit in-plane thermal conductivity as high as 567 W/(m∙K), showing significant advantages in lightweight design and heat dissipation over conventional metal-based thermal management materials. The interlayer reflection structure existing in the multilayer graphite film exhibits excellent electromagnetic shielding performance, achieving an EMI shielding effectiveness of 40.79 dB in the Ku band and a shielding efficiency up to 59,399 dB·cm 2 ·g −1 with a thickness of 3 μm, significantly surpassing most reported synthetic materials. Moreover, the excellent mechanical properties further broaden the application potential of these graphite films. This research provides a renewable carbon source, pressure-free orientation and effective solution to meet the urgent demand of modern advanced electronic devices for materials with large-area, high thermal conductivity, and high electromagnetic shielding capacities.
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Yantao Song,Minghui Yang,Tianhao Liu,Ce Sun,Min Jin,Haiyan Tan,Dingyuan Zheng,Yanhua Zhang
Cellulose framework derived from wood has been widely used as reinforcement for high performance hydrogel sensors fabrication. However, due to the native brittleness of wood, the cellulose framework-reinforced hydrogels present mechanical rigidity, limiting their applications as wearable electronics. Herein, we report a time-dependent alkaline treatment strategy to modulate the supramolecular structure of cellulose frameworks. The effect of NaOH treatment duration was systematically investigated to identify an optimal cellulose framework (designated ADW4) that synergistically combines flexibility and mechanical strength. The optimized ADW4 exhibited a highly crystalline structure with superior mechanical properties, demonstrating a 17.1 % increase in tensile strength and a 140.1 % improvement in toughness over natural wood. Employing the obtained optimal cellulose framework as the reinforcement yielded a conductive hydrogel (PADW4-Li), which demonstrated dramatically improved mechanical strength (a 35,700 % increase compared to pure polyacrylamide (PAM)) and excellent ionic conductivity (3 mS cm −1 ). The PADW4-Li hydrogel exhibits high utility, proving capable of not only monitoring physiological signals but also sensitively detecting minute deformations. The regulation of the supramolecular structure of the cellulose framework mediated by this alkali treatment endows it with both flexibility and mechanical strength, providing a new path for its use as the reinforcing phase of composite materials.
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Small
·
2026
·
IF 11.8
Zhaofei Ma,Zhikun Wang,Jingyue Wang,Zhencai Xing,Weihe Wang,Guorui Zhang,Bo Yu,Xiaowei Pei,Yanfei Ma,Chenxi Qin,Songqing Hu,Feng Zhou
Hydrogel lubrication modification of hard polymer surfaces shows broad application prospects in soft robotics, tissue engineering, and biomedical devices. However, orders-of-magnitude differences in modulus can easily lead to stress concentrations at the interface between soft and hard materials, increasing material failure, especially in the field of artificial joint replacement, which involves high-load service. Herein, we propose a robust hydrogel lubricating modification strategy for high-modulus polymer surfaces via gradient-structured stress-transfer dissipation and interfacial polymer chain interpenetrating anchoring. The material modulus of the entire lubrication system increases sequentially from the outside in—the modulus of the hydrogel portion increases by more than two orders of magnitude, from hundreds of kilopascals to megapascals, and then to 10 megapascals, at which point the hydrogel modulus matches the high-modulus polymer (polydimethylsiloxane). The surface of the high-modulus polymer and the hydrogel are anchored together through the interpenetration of polymer chains (anchoring force of 250 N·m −1 ). What's more, this nonhomogeneous surface structure construction achieves high load-bearing and ultra-low friction simultaneously, which are inherently in conflict, with one raised at the expense of the other. This unique approach provides the high-modulus polymer surface with robust lubricating capacity with a low coefficient of friction (COF: ∼0.03) and maintains stable lubricity under ultimate-load and long-term shear conditions (contact stress: ∼12 MPa, friction 5000 cycles). This strategy provides a reference for surface modification of medical interventional devices.
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Coatings
·
2026
·Vol. 16
·期 3
·297
·
IF 3.4
Lingling Cui,Guang Ji,Tongchun Qin,Zhiwei Li,Yan Sheng,Haiqin Ding,Guodong Jia
Traditional artificial joints mainly face the challenges of severe wear and aseptic loosening, which limits their application as joint bearing interfaces under high-stress loading conditions. To improve this problem, inspired by the gradient modulus structure of natural cartilage/subchondral bone and the inherent negative charge characteristics of the surface, a negatively charged hydrogel layer was adhered to a porous Ti6Al4V surface through a combination of ultraviolet irradiation and freeze–thaw cycles. The cross-sectional SEM image exhibited that the hydrogel layer was closely bonded to the hard substrate. After physical doping with SBMA, the lubrication performance of the composite bearing interface was significantly improved, primarily attributable to the biphasic lubrication of the hydrogel layer and the hydration lubrication mechanism of SBMA.
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CARBOHYDRATE POLYMERS
·
2026
·
IF 12.5
Dadong Sun,Zhihua Xu,Li Guo,Bin Yu,Lu Lu,Bo Cui,Xuemin Kang,Zhijun Zhang,Fanfu Meng,Chenghai Li,Guowei Cai
Flexible wearable sensors have developed rapidly due to the urgent demands for human motion monitoring. Eutectogel-based soft materials have exhibited great potential for wearable sensing applications. However, it is still a challenge to develop multifunctional eutectogels with excellent mechanical properties, adhesion, self-healing, fatigue resistance and degradability. In this work, a multifunctional starch-based eutectogel was developed by a one-pot and in-situ photo-polymerization method. The eutectogel had excellent stretchability (2710%), high strength (5.43 MPa), toughness (94.38 MJ/m 3 ), Young's modulus (10.23 MPa), adhesion, fatigue resistance (1000 cycles), degradability and a certain degree of self-healing ability. These properties were closely correlated to the synergistic effect among the amylopectin, polyacrylic acid and choline chloride via hydrogen-bond and electrostatic interactions. The mechanical properties of eutectogel can be adjusted by changing the starch content. A wearable sensor based on the eutectogel was realized accurate and stable monitoring of human joint motions. This study addressed the limitations of the dehydration and single function of the traditional hydrogels, and provides a novel way for the development of the multifunctional bio-based gels for next-generation flexible wearable devices.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 13.2
HuaQing Zhang,Chunling Liu,Xieraili Maimaitiyiming
To enhance the energy density of aqueous zinc-ion hybrid capacitors (ZIHCs), broadening the electrochemical window of hydrogel electrolytes is crucial. However, persistent side reactions initiated by water molecules and the uncontrolled dendritic growth on the zinc anode surface severely limit the improvement of ZIHC operating voltage. To address this challenge, this study proposes a chain–chain synergistic regulation strategy and designs a unique semi-interpenetrating network zwitterionic hydrogel electrolyte (PGCTSE) based on PSBMA and gelatin. This electrolyte effectively regulates Zn 2+ migration behavior and suppresses free water activity, thereby significantly increasing the operating voltage of flexible ZIHCs. Experimental results show that the PGCTSE electrolyte expands the electrochemical stability window (ESW) of flexible ZIHCs to 2.2 V, achieves a Zn 2+ transference number as high as 0.76, and supports highly reversible deposition/stripping on the zinc anode. The flexible ZIHC employing this electrolyte delivers an energy density of 180.8 Wh kg −1 at a power density of 1100 W kg −1 . This study provides a new design concept and experimental foundation for developing gelatin-based hydrogel electrolytes for high-performance ZIHCs.
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INTERNATIONAL IMMUNOPHARMACOLOGY
·
2026
·
IF 4.7
Lu Han,Die Zhang,Weidong Xiao,Chunyan Zeng,Youxiang Chen
Background Pancreatic ductal adenocarcinoma (PDAC) undergoes profound metabolic reprogramming. This study aims to elucidate how PIK3CG deficiency drives glutamine (Gln) metabolic reprogramming in PDAC. Methods We first identified PIK3CG as a key differentially expressed gene in PDAC and confirmed that its expression level correlates with patient survival. We established both in vitro and in vivo PIK3CG -knockdown ( PIK3CG -KD) models. Using these models, we assessed its regulatory effects on the Gln metabolic pathway, mitochondrial reactive oxygen species (mtROS) accumulation, mitochondrial membrane potential, and tumor cell pyroptosis. Moreover, we delineated the specific molecular mechanism linking PIK3CG to downstream signaling. This mechanism crucially involves GLS2 , a key enzyme in glutamine metabolism. Results PIK3CG deficiency suppresses the mechanistic target of rapamycin complex 1 (mTORC1) pathway, leading to enhanced phosphorylation of S6K2. This disrupts the interaction between nuclear S6K2 (Glu163) and P53 (Arg273), ultimately inhibiting GLS2 transcription. Consequently, a series of metabolic disturbances ensue: glutamate (Glu) accumulates substantially, Gln catabolism is blocked, and its influx into the TCA cycle is restricted, resulting in reduced α-ketoglutarate (α-KG) levels. The deficiency in α-KG triggers a significant accumulation of mtROS. Notably, despite elevated ROS levels, pyroptosis is suppressed and accompanied by exacerbated inflammation. Conversely, GLS2 overexpression rescues all the aforementioned phenotypes induced by PIK3CG -KD—including tumor growth, elevated mtROS, suppression of pyroptosis, and inflammatory response—while restoring Gln metabolic homeostasis. Conclusion Our study reveals a novel mechanism by which PIK3CG -KD regulates Gln metabolism and mitochondrial function via the S6K2/P53/GLS2 axis, providing a rationale for metabolic intervention and precision therapy in PIK3CG -deficient PDAC.
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NATURE
·
2026
·Vol. 649
·期 8096
·366-374
·
IF 48.5
Lan Yuqun,Li Shuang,Guo Haitao,Liu Qinyuan,Wang Tairan,Zhou Lianqiao,Fang Jiahuiyu,Zhao Yang,Zhou Zanxin,Wang Qi,Li Jing,Zhu Yiping,Su Rongfang,Wen Xinyi,Xu Xinkai,Wu Yuhong,Wang Zixuan,Liu Bo,Li Jiaqi,Li Hui,Gao Hanfei,Wu Yuchen,Gu Qi,Feng Xi-Qiao,Yu Xinge,Su Yewang
Monitoring internal physiological signals is essential for effective medical care 1 , yet most current technologies rely on external measurements or imaging systems that cannot capture enough deep-tissue dynamics 2 , 3 , 4 , 5 , 6 . Implantable devices offer a solution, but conventional designs often require batteries or magnets 7 , 8 , 9 , 10 , 11 , which carry risks during removal, and existing biodegradable sensors based on passive inductor–capacitor circuits are limited by short readout distances and unstable communication issues 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 . Here we describe a soft, biodegradable, wireless sensing device that can monitor pressure, temperature and strain over long distances (up to 16 cm), maintaining accuracy across varying positions and angles. This is achieved through a ‘pole-moving sweeping’ readout system combined with a folded structure that integrates mechanical flexibility with electromagnetic function. In vivo tests in the abdominal cavity of horses reliably captured deep-tissue pressure and temperature, and ex vivo measurements demonstrated accurate strain monitoring without strict positional control. The long-distance and wide-angle readout of soft biodegradable implants holds translational promise for accessing deep-tissue physiological signals.
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Applied Materials Today
·
2026
·
IF 7
Zhuo Liu,Tengyue Wang,Yuxin Fu,Xiongkun Lin,Henghua Jian,Xiaofang Liang,Lixin Wu,Ai-Zheng Chen,Shi-Bin Wang,Yuewei Li
DLP 3D printing and solvent engineering are combined to fabricate multifunctional PCHs. • SAT crystallization endows PCHs with soft-hard switching and latent heat storage. • Initial NaAc content and immersion pH enable tunable mechanical and thermal performance. • The PCHs exhibit tensile modulus up to 152.29 MPa and adhesion strength on wood up to 540 kPa. • The PCHs enable on-demand adhesion, protection, thermal regulation, and information encryption. Phase change hydrogels (PCHs) have attracted considerable attention for thermal energy storage and personal thermal management because of their high latent heat capacity. However, their practical use remains limited by insufficient structural customizability, interfacial adhesion, mechanical robustness, and durability under complex conditions. Here, we report a multifunctional soft-hard switchable PCH system fabricated through a two-step strategy that decouples hydrogel network construction from the incorporation of sodium acetate trihydrate (SAT) as the phase change component. In this process, 3D-printed hydrogel matrices are immersed in a supersaturated sodium acetate (NaAc) solution to form crystalline SAT layers, yielding a mechanically adaptive architecture with a stiff outer shell and a soft hydrogel interior. By regulating the initial NaAc content in the precursor resin and the pH of the immersion solution, the ionic interactions and crystallization behavior can be modulated, enabling tunable mechanical properties, adhesion, energy absorption, and latent-heat storage. The resulting PCHs exhibit tensile modulus ranging from 0.56 to 152.29 MPa, shear adhesion strengths of up to 540 kPa, and latent heat release of 110.04 J·g⁻¹ . The reversible soft-hard switching enables controllable adhesion, impact and puncture protection, rapid and repeatable heat release, and thermochromic information encryption through exothermic crystallization. This work establishes a two-step generalizable strategy for programmable PCHs and offers an effective route toward multifunctional hydrogels with robust performance under complex environmental conditions. Download: Download high-res image (260KB) Download: Download full-size image
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BIOMACROMOLECULES
·
2026
·Vol. 27
·期 8
·5505-5518
·
IF 5.9
Li Siyu,He Jinying,Zhi Lunhao,Chen Qin,Tian Tian,Zhao Weifeng,Zhao Changsheng
Chronic refractory wounds present a significant clinical
challenge
due to the vicious cycle of excessive exudate and bacterial infections.
Herein, we develop a smart hydrogel dressing via a dual-template strategy
that creates a low-tortuosity structure with gradient microchannels.
Compared with the random porous hydrogel, the optimized structure
accelerates the absorption rate of viscous liquid by ∼17 times.
Crucially, the hydrogel incorporates a thermal feedback loop: the
increase in wound temperature caused by infection stimulates the hydrogel
to rapidly release antibacterial agents, thereby resolving the infection
and effectively cooling the wound; after inflammation suppression,
the residual exudate and antibacterial agents are actively reabsorbed
to achieve on-demand treatment. In an infectious burn model, this
dressing outperforms commercial dressing 3 M Tegaderm by downregulating
inflammatory cytokines, enhancing collagen regeneration, and accelerating
angiogenesis. This study provides a novel and universal design strategy
for the next generation of functional dressings for refractory wounds.
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iScience
·
2026
·Vol. 29
·期 9
·117200
·
IF 4.5
Xudong Li,Chengzhe Yang,Xin Li,Lanxin Li,Youbin Li,Tengyue Liu,Qiang Gao,Lanfeng Huang
Summary Large bone defects remain a clinical challenge due to limited regenerative capacity. In this study, carboxymethyl chitosan (CMCS) hydrogels incorporating gradient nano-hydroxyapatite (nHA) were developed to enhance bone repair. The composite hydrogels exhibited improved mechanical properties, controlled degradation, and good biocompatibility. In vitro , nHA-containing hydrogels promoted bone marrow mesenchymal stem cell (BMSC) proliferation and osteogenic differentiation, as shown by increased alkaline phosphatase (ALP) activity, mineralization, and upregulation of runt-related transcription factor 2 (RUNX2), osteocalcin (OCN), and bone morphogenetic protein-2 (BMP-2). In vivo , implantation in a rat distal femoral condyle defect model showed enhanced new bone formation and improved trabecular structure, particularly in the 1% nHA group. These results suggest that gradient nHA-loaded CMCS hydrogels can effectively enhance osteogenesis and support bone regeneration.
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