Tungsten
·
2025
·
IF 11.2
Wang Xue,Zhang Li,Han Yu,Li Feng-Bo,Li Shao-Bin
Accurate non-invasive glucose monitoring is crucial for health diagnostics. However, the development of high-performance non-enzymatic electrochemical sensors for this application remains a significant challenge. To address this issue, a novel material, FeOOH encapsulated within zeolitic imidazolate framework-67 (ZIF-67)-derived copper-cobalt-layered double hydroxide (FeOOH@CuCo-LDH), was developed through a vapor-assisted deprotonation process for FeOOH encapsulation, followed by a hydrothermal reaction to synthesize the hollow composite. The synergistic interactions between the multi-metallic composition and the hollow structure significantly enhance glucose oxidation-reduction reactions. This enables the sensor to achieve a wide linear detection range (0.5–722 μmol·L −1 and 722–4222 μmol·L −1 ), high sensitivity (4.05 and 1.43 μA·L·μmol −1 ·cm −2 ), and a low limit of detection (0.83 μmol·L −1 ). The sensor demonstrated excellent performance in practical applications, accurately detecting glucose in saliva under physiological conditions. This study highlights the potential of FeOOH@CuCo-LDH as an excellent electrode material for non-enzymatic electrochemical glucose sensing, offering promising applications in diabetes prevention and diagnosis. Graphical abstract
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Zhihao Liu,Qihao Li,Fu Zhao,Dapeng Zhang,Xinyue Li,Daozheng Fang,Haimeng Li,Qixiang Shang,Fengyan Chen,Zhiyuan Zhen,Yong Zhu,Chang-An Geng,Jianbo Xiao,Jihang Chen
Procyanidin C1 (PCC1) is a biologically relevant oligomeric small molecule and a trimeric epicatechin with the potential to modulate gut microbiota. However, how it reshapes microbiota-linked phosphatidylcholine homeostasis in the context of insulin resistance remains insufficiently defined, limiting the establishment of mechanism-informed design principles for microbiota-directed metabolic modulation. Here, PCC1 improved systemic glucose and insulin sensitivity, promoted hepatic glycogen accumulation, reduced hepatic steatosis, attenuated skeletal muscle fibrosis, and decreased lipid deposition in adipose tissues. Notably, 16S rRNA sequencing revealed that PCC1 treatment enriched Lactobacillus johnsonii and depleted Leptogranulimonas caecicola , which were positively associated with elevated GPCho (16:0/20:5) and circulating eicosapentaenoic acid (EPA) identified by untargeted metabolomics, indicative of enhanced α-linolenic acid metabolism and a gut microbiota-driven contribution to EPA biosynthesis. Meanwhile, lipidomics revealed that PCC1 reduced diacylglycerols, triacylglycerols, ceramides, and lysophosphatidylcholines, while restoring EPA-containing phosphatidylcholines. Transcriptomics further demonstrated that PCC1 induced tissue-specific metabolic reprogramming, activating PPAR signaling in liver, enhancing oxidative phosphorylation in brown adipose tissue (BAT), and stimulating AMPK signaling in skeletal muscle. Importantly, PCC1 reversed HFD-induced phospholipase A2 dysregulation, upregulating Pla2g2d in skeletal muscle and downregulating Pla2g7 in liver and BAT, two genes implicated in EPA release and phospholipid remodeling. Together, integrated multi-omics analyses identify PCC1 as an oligomeric small-molecule modulator associated with improved insulin sensitivity across multiple tissues and implicate an EPA-linked phosphatidylcholine signaling axis that connects microbiota remodeling with host metabolic responses.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2026
·
IF 3.1
Zilong Lv,Chao Yu,Xiuming Liu,Zhilan Jin,Ruiheng He,Jichun Jiang,Shicheng Zhao
Isotactic polypropylene (iPP) suffers from slow crystallization rate, inadequate rigidity, and poor optical properties. Adding nucleating agents offers a promising solution; therefore, developing new nucleating agents is significant. In this study, four novel allyl sorbitol nucleating agents 1,3:2,4-bis-O-(benzylidene)-1-allyl-sorbitol (NA-B), 1,3:2,4-bis-O-(4-methylbenzylidene)-1-allyl-sorbitol (NA-BMe), 1,3:2,4-bis-O-(3,4-dimethyldibenzylidene)-1-allyl-sorbitol (NA-B2Me), and 1,3:2,4-bis-O-(4-chlorobenzylidene)-1-allyl-sorbitol (NA-BCl) were synthesized and characterized. Differential scanning calorimetry (DSC), polarized optical microscopy (POM), and X-ray diffraction (XRD) analyses of nucleated iPP showed that all four compounds were efficient α-nucleating agents, significantly reduced spherulite size, and accelerated crystallization. Mechanical tests exhibited that all nucleating agents enhanced the rigidity of iPP. Specifically, NA-B2Me improved the tensile strength by 16.8%, while NA-BMe enhanced the flexural modulus by 26.9%. These agents also effectively reduced haze, with NA-B2Me reducing by 65.4%. Isothermal crystallization kinetics analysis revealed a decrease in the Avrami exponent for nucleated iPP, supporting the transition toward heterogeneous nucleation induced by the nucleating agents. Molecular dynamics simulations revealed binding energies ranging from 50 to 55 kcal/mol between the nucleating agents and iPP, indicating adsorption interactions that facilitate epitaxial crystallization of iPP. This study presents four effective allyl sorbitol nucleating agents, providing molecular-level guidance for the design of nucleating agents at enhancing rigidity and reducing haze in iPP.
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FOOD CHEMISTRY
·
2026
·
IF 9.8
Zhihao Liu,Fu Zhao,Qihao Li,Qixiang Shang,Daozheng Fang,Xinyue Li,Haimeng Li,Quanrun He,Dapeng Zhang,Juanjuan Cheng,Yong Zhu,Zhongxia Li,Ana Sanches Silva,Jihang Chen
Ellagic acid (EA) is a dietary polyphenol with limited systemic bioavailability, resulting in substantial intestinal exposure. However, the biochemical mechanisms by which EA modulates gut microbiota and metabolism remain unclear. Here, EA improved glucose tolerance and enhanced insulin sensitivity, with histology confirming reduced lipid accumulation and restored tissue architecture in liver, skeletal muscle, brown adipose tissue, and mesenteric fat. Consistently, metagenomic analysis showed that EA enriched Akkermansia muciniphila , Muribaculum intestinale , and Duncaniella dubosii , while reducing Lachnoclostridium phocaeense . These microbial shifts were accompanied by elevated levels of tryptophan-derived metabolites—indole-3-propionic acid, indole, and indole-3-acrylic acid—known to enhance insulin sensitivity. Lipidomic revealed EA decreased triacylglycerols and ceramides, along with restored phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine levels. Transcriptomic revealed EA suppressed hepatic lipogenesis, inhibited MAPK signaling in skeletal muscle, activated thermogenic and oxidative phosphorylation in adipose tissues. Our findings highlight EA as a food-derived polyphenol that alleviates insulin resistance through a gut microbiota–indole metabolite–multi-tissue axis.
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Nano Energy
·
2026
·
IF 16.7
Rui Li,Xupeng Qin,Yang Liu,Shen Cheng,Haixin Sun,Qizheng An,Youcai Che,Jingqiu Shang,Xin Chen,Shuowen Bo,Junfeng Yang,Qinghua Liu
P-modulated Fe single atoms are designed to steer interfacial PCET pathways. • Remote P-doping reconfigures interfacial water networks for optimal proton supply. • In situ spectra and simulations reveal accelerated *COOH formation kinetics. • The FeNPC catalyst achieves a remarkable CO Faradaic efficiency of 98.68%. In electrocatalytic CO₂ reduction reaction (CO₂RR), the rate-determining formation of the key *COOH intermediate requires a facile and moderate proton supply, yet excessive water activation generates abundant adsorbed hydrogen (*H) that triggers the competing hydrogen evolution reaction (HER) and diminishes CO selectivity. Here, we develop a phosphorus-doped Fe single-atom catalyst (FeNPC) to steer interfacial proton-coupled electron transfer (PCET) pathways. P incorporation reconstructs the interfacial hydrogen-bonding network, selectively enriching weakly hydrogen-bonded and free water molecules to ensure an optimal proton supply for *COOH generation while suppressing excessive *H accumulation. In-situ ATR-SEIRAS characterization confirms enhanced *COOH signals, and MD/DFT calculations reveal that P-doping lowers activation barriers for water dissociation and *COOH formation. Consequently, FeNPC achieves a CO Faradaic efficiency of 98.68% at −0.4 V vs. RHE with reliable stability. This work demonstrates that nonmetallic doping optimizes PCET kinetics by reshaping the interfacial water microenvironment, establishing a new paradigm for designing highly-selective CO₂RR electrocatalysts. Download: Download high-res image (273KB) Download: Download full-size image
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Small
·
2026
·
IF 11.8
Hui Lin,Mengfan Pei,Shuo Zhuo,Yunpeng Qu,Dongming Liu,Xusheng Zhang,Wenkai Song,Xigao Jian,Fangyuan Hu
Sodium-ion capacitors (SICs) have garnered significant attention as a new type of electrochemical energy storage device. However, their development is severely limited by the kinetics discrepancy between sluggish Na + storage anodes and rapid capacitive cathodes. To overcome this limitation, a novel slope‑dominant carbon material designated SC─O was utilized to demonstrate the feasibility of a capacity‑kinetics linear matching strategy for achieving enhanced performance in SICs. The SC─O anode maintains high-capacity retention at high rates, enabling linear capacity–kinetics matching between the anode and cathode in SICs and thus achieving optimal performance. When integrated with an activated carbon (AC) cathode, the fabricated SIC demonstrates remarkable energy density (81.3 Wh kg −1 at 9891.2 W kg −1 ) and an ultralong lifespan (92.05% capacity retention after 12 000 cycles). This work provides important guidance for the future design of practical, high-power, long-cycle sodium-ion capacitors based on high-rate/high-capacity battery-type anodes.
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Journal of Energy Chemistry
·
2026
·
IF 15.6
Jingyu Sun,Li Zhang,Fengbo Li,Zhen Cao,Meiyu Liu,Fajun Yang,Shaobin Li
The vanadium disulfide (VS 2 ) possesses great potential as an excellent zinc-ion energy storage material due to low diffusion barrier and reversible redox activity. However, its high-rate zinc-ion storage capability is limited by nanosheet restacking, structural fragility, and vanadium dissolution. Herein, a synergistic strategy integrating oxygen-induced coordination reinforcement with C–N structural and conductive network reinforcement is proposed to realize thermodynamic-kinetic stabilization of VS 2 cathodes. The incorporation of oxygen converts unstable V–S bonds into a stronger, more ordered V–O coordination, reconstructing the ligand field and stabilizing the vanadium valence state, which effectively inhibits dissolution. Concurrently, the polydopamine (PDA)-derived C–N provides stable anchoring sites to immobilize vanadium species, while CNT frameworks build efficient electron/ion transport pathways and buffer volume strain. The DFT calculations and synchrotron analyses verify the ligand-field reconstruction and vanadium stabilization mechanism. Consequently, the VS 2 /V 2 O 3 -NC/MWCNTs-C (denoted as VSO-NC/MWCNTs-C) delivers a high capacity of 358.89 mA h g −1 at 0.5 A g −1 , excellent rate capability of 242.22 mA h g −1 at 10 A g −1 , along with a high energy/power density of 388.64 Wh kg −1 /1000 W kg −1 , maintaining excellent stability over 6000 cycles at 10 A g −1 . This work offers an atomic-level coordination engineering strategy for advanced V-based cathodes for zinc-ion energy storage. The VSO-NC/MWCNTs-C cathode exhibits stable structural integrity, accelerated Zn 2+ transport, and significantly suppressed vanadium dissolution, delivering high capacity, fast kinetics, and long-life cycling for next-generation zinc-ion energy storage. Download: Download high-res image (301KB) Download: Download full-size image
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ACS Applied Polymer Materials
·
2026
·
IF 5.2
Liu Qin,Ding Yunshan,Wei Ping,Sun Hui
Viruses typically possess spike-like surface structures
that play
pivotal roles in their biological functions, including host cell invasion
and signal transduction. Despite the structural advantages of virus-like
architectures, the controlled fabrication of artificial virus-like
nanoparticles (VNPs) remains a significant challenge. Herein, a series
of amphiphilic glycopolymers are designed and synthesized to self-assemble
into VNPs with controlled tentacles on their surfaces. As the initial
concentration increases, the morphology of the assemblies gradually
evolves from spherical nanoparticles to virus-like nanostructures
with an increased number and length of the tentacles. The existence
of glucose moieties is crucial for driving this morphological transformation
owing to their strong hydrogen-bonding interactions and ultrahydrophilicity.
Monitoring the formation process of the VNPs, we found that spherical
nanoparticles were formed at the early stage of self-assembly. With
an increasing water content, the nanoparticles gradually deform and
develop surface wrinkles, followed by the emergence and elongation
of tentacles upon further water addition, leading to the formation
of VNPs, which exhibit morphology-promoted and glucose transporter
1-mediated endocytosis. These findings highlight the significance
of glycosyl groups in promoting the formation of VNPs and provide
fresh insights into the controlled preparation of artificial biomimetic
nanomaterials with precise structures and tailored functionalities.
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ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Fuhui Luo,Fenfen Zeng,Zhongqiao Zhao,Xu Ren,Yong He,Xia Yang,Fengxiang Zhang,Hanqing Pang,Wei Shi
The development of efficient and green extraction methods to meet the needs of the food and pharmaceutical industries for natural products has received widespread attention. In this work, a novel two-step extraction process for acid-electrolyzed oxidizing water (AOEW) pretreatment with deep eutectic solvents (DESs) (EWDES) was designed. Screening of 25 ultrasound-assisted DESs and EWDESs revealed that the extraction rate of EWDES (chlorine chloride-acetic acid) (ChCl-AA) was significantly higher than that of UADES (ChCl-AA) and traditional solvents. Back-propagation-genetic algorithm proved superior to response surface methodology in robustness and predictive intelligence. The mechanism analysis demonstrated that the addition of AOEW significantly enhanced the destruction of the cell wall structure, facilitating the entry of DESs into cells and promoting the formation of hydrogen bonds with components, which aid in the delivery of active ingredients. Notably, the addition of AOEW further promotes the formation of hydrogen bonds between DESs and the active ingredients. The EWDES system demonstrates multifunctional capabilities in enhancing the natural product extraction efficiency through synergistic mechanisms. Furthermore, the green evaluation tools validated the environmental sustainability of EWDES.
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Materials
·
2023
·Vol. 16
·期 3
·1261
·
IF 3.4
Qian Wang,Yuzhe Wang,Guiyong Xiao,Xinde Zhu
In this work, the facile fabrication of Co3O4particles/reduced graphene oxide (Co3O4/rGO) composites on Indium tin oxide (ITO) slide was achieved by an electrophoretic deposition and annealing process. The deposition time and ratio of the precursors were optimized. Structural characterization and chemical composition investigation indicated successful loading of Co3O4particles on graphene sheets. When applied as a non-enzymatic H2O2sensor, Co3O4/rGO showed significant electrocatalytic activity, with a wide linear range (0.1–19.5 mM) and high sensitivity (0.2247 mA mM−1cm−2). The good anti-interference ability, reproducibility, and long-term stability of the constructed sensor were also presented. The application of Co3O4/rGO in real sample analysis was evaluated in human urine sample with satisfactory results, indicating the feasibility of the sensor in physiological and medical applications.
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JOURNAL OF NANOPARTICLE RESEARCH
·
2022
·Vol. 24
·期 1
·1-18
·
IF 2.533
Ning Tianxiang,Luo Yinyi,Liu Piao,Lu Anxian
In this study, a novel method called membrane separation–centrifugation technology is used to purify the AgNPs. The TGA results showed that the AgNPs washed in this method only contained a minimal amount of organic residues (< 5 wt.%). Moreover, the XRD results indicate that the cleaned AgNPs are pure single-crystal cubic phase Ag without other impurities. Furthermore, according to the results of SEM and TEM, the AgNPs cleaned by this technology are nanoscale with an average particle size of only 50 nm and dispersed evenly without agglomeration. The colloid made from AgNPs purified by this method reveals a good Zeta potential of about -34.7 mV, which indicates the excellent stability of AgNPs. After the ink made by these AgNPs is dried at 150℃ for 10 min, a really low electrical resistivity only about 10.7 × 10 –6 Ω·cm is obtained. These results confirm that the membrane separation–centrifugation technology can significantly improve the performances of the AgNPs ink, which can be used in printed electronics.
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ENERGY
·
2022
·
IF 8.857
Yi Wei,Licong Lu,Xudong Zhang,Jianbing Ji
Cellulose was used as feedstock to investigate the effect of electrolysis on the molten salt pyrolysis process . The mechanism of cellulose transformation in the electrochemically assisted molten carbonate pyrolysis (EMCP) system was evaluated by comparison with the molten carbonate pyrolysis (MCP) system. The gas product yield from the EMCP system reached 70.5 wt%, at the expense of the liquid product and tar. The maximum H 2 yields up to 8.31 mol/kg of cellulose at low temperatures without the catalyst in the EMCP system. Cellulose decomposition was catalyzed by the molten salt to produce a large number of volatiles, where the aldehyde groups in the volatiles were electrochemically oxidized to carboxyl groups. Subsequently, the carboxyl compounds combined with alkali metal cations to release hydrogen radicals and then underwent secondary cracking, along with the volatiles having low chemical bond energies. The EMCP system follows the Shrink Cylinder model, which is dominated by the two-dimensional reaction on the surface of the graphite electrode , where the electrolysis process is the determining step.
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