JOURNAL OF CHEMICAL THERMODYNAMICS
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2016
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IF 2.196
Dandan Han,Yumin Liu,Xiaona Li,Teng Zhang,Zhenfang Li,Shichao Du,Mingxia Guo,Shijie Xu,Bo Yu,Baohong Hou,Junbo Gong
The solubility of calcium d -pantothenate in (water + methanol) mixtures and the effect of β -alanine on the solubility of calcium d -pantothenate in a constant mole ratio of methanol and water was measured from 263.15 K to 303.15 K by the HPLC analysis method ( P = 0.1 MPa). The solubility of calcium d -pantothenate increased with increasing temperature in all the mixtures at constant composition. Besides, it also increased with mole fraction of water in (water + methanol) mixtures at a constant temperature. Additionally, the solubility of calcium d -pantothenate was enhanced by β -alanine at a given temperature. The experimental solubility in (water + methanol) mixtures was correlated by the modified Apelblat equation, the ternary NRTL equation and Solubility-Polarity Model. The Apelblat equation, the quaternary NRTL equation and the Cohn equation were adopted to correlate the experimental solubility in the (water + methanol + β -alanine) mixtures. Worthwhile, the quaternary NRTL equation was first applied to correlating the quaternary solid-liquid equilibrium. It turned out that all the selected models give good performance on solubility prediction.
研究领域:
药物化学
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物理化学
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DOI
高影响因子
Catalysts
·
2023
·Vol. 13
·期 2
·267
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IF 3.9
Jia Wu,Bao-Di Ma,Yi Xu
A novel and efficient one-pot three-enzyme cascade method for the synthesis of β-alanine from maleic acid was developed. Two recombinantE. colistrains were constructed. TheE. coli(MaiA-AspA) co-expressing maleiccis-trans isomerase (MaiA) and L-aspartase (AspA) catalyzed the biotransformation of maleic acid to L-aspartate via fumaric acid, andE. coli(ADC) expressing L-aspartate-α-decarboxylase (ADC) catalyzed the bioconversion of L-aspartate to β-alanine. After systematic optimization of reaction conditions for each strain, the whole cells of two strains were combined for one-pot synthesis of β-alanine. It was found that the ratio of the two kinds of cells as well as the cell amount play critical roles in the reaction rate and yield of β-alanine. Adding two kinds of cells in one-pot at the beginning of the reaction was better than adding step by step. Under optimal conditions, the concentration of β-alanine reached 751 mM after a 9 h reaction, corresponding to a 93.9% yield and 178 g/L/d space-time yield. The developed new route showed application potential for green and efficient biosynthesis of β-alanine from a cheap substrate by tandem biocatalysts.Keywords:β-alanine;cascade reaction;biotransformation;one-pot
研究领域:
生物化学
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合成生物学
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DOI
高影响因子
LANGMUIR
·
2025
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IF 3.9
Linting Jiang,Lu Yang,Xue Yi,Shengtao Zhang,Hongru Li,Zhiyong Wang,Fang Gao
Zinc corrosion, hydrogen evolution reaction, uneven deposition, and dendrite growth on the zinc anodes are the key factors restraining the electrochemical performance and cycling stability of the aqueous zinc-ion batteries. In this study, learned from the synial membrane, a tiny amount of natural amino acid β-alanine (β-Ala, 0.089 wt %) was introduced as the additive in ZnSO4 electrolyte for strengthening the kinetics of the zinc anode as well as enhancing the performance of zinc ions batteries. A number of modern surface techniques and surface electrochemical analyses were employed to reveal the fundamental reasons for the strengthened zinc anode by β-Ala in ZnSO4 electrolyte. The results show that β-Ala could be adsorbed on zinc electrode surface through intermolecular chelation, which might regulate the chemical environments of the electrolyte and promote uniform deposition of zinc ions. Hence, the β-Ala adsorption film on zinc electrode could suppress the hydrogen evolution reaction and the formation of zinc dendrites, thereby significantly improving the deposition/stripping process of the zinc anode. In particular, the strong hydrogen bonding could restrain the migration of H2O molecules approaching the zinc anode surface, preventing the invasion of water to the zinc electrode surface. Therefore, the addition of dilute β-Ala in the ZnSO4 electrolyte might remarkably prolong the life span of Zn||Zn symmetric batteries to 5000 h under 1 mA cm–2 and 1 mAh cm–2, and to 450 h under 5 mA cm–2 and 3 mAh cm–2 at 298 K, which is much longer than the zinc–zinc symmetric cells including the bare ZnSO4 electrolyte (only 95 h at 5 mA cm–2 and 3 mAh cm–2, and 200 h at 1 mA cm–2 and 1 mAh cm–2). Furthermore, β-Ala was found to significantly improve the cycling stability of Zn||Cu asymmetric cells and Zn||V2O5 full cells. This study provides an effective method for engineering electrolytes to inspire rechargeable zinc-ion batteries by selecting ideal natural biomolecules as the electrolyte additives.
研究领域:
电化学
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材料科学
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DOI
PubMed
高影响因子
Biomolecules
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2024
·Vol. 14
·期 12
·1553
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IF 4.8
Zifu Ni,Linshang Zhang,Azhen Nie,Huan Wang,Xiaoling Wu
As the only naturally occurring β-amino acid, β-alanine has important application prospects in many fields. Driven by the huge demand, biosynthesis is becoming more and more popular as a potential alternative to the chemical synthesis of β-alanine. Although the direct pathway from L-aspartic acid to β-alanine, catalyzed by L-aspartic acid-α-decarboxylase (PanD), is ideal for β-alanine synthesis, it is hindered by the high cost of the substrate and limited economic viability. In this work, a cell-free dual enzyme cascade system based on methylaspartate lyase (EcMAL) and panD was constructed to safely and efficiently synthesize β-alanine using fumarate as a substrate. Taking the previously engineered EcMAL as the target, CgPanD was finally screened as the best candidate through gene mining, sequence alignment, and enzyme property analysis. Finally, under the optimal conditions of 35 °C, pH 8.0, and EcMAL: CgPanD concentration ratio of 1:5, the yield of β-alanine reached 80% theoretical yield within 120 min. This study provides a potential strategy for the biosynthesis of β-alanine, paving the way for future industrial-scale production.
研究领域:
生物化学
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合成生物学
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DOI
PubMed
高影响因子
KOREAN JOURNAL OF CHEMICAL ENGINEERING
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2024
·Vol. 41
·期 8
·2321-2334
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IF 2.9
Chai Xinhan,Huang Weiqiu,Li Xufei,Wang Xinya,Zhou Yankang,Zhu Bing,Li Yuning,Tian Xinchen
Porous carbon foam (PCF), known for its high surface area and abundant functional groups, is considered to exhibit superior adsorption capacity and wide applicability for gases. Wheat, being a widely cultivated and easily accessible crop globally, contains abundant carbon elements. In this study, wheat powder served as the carbon precursor, and β-alanine, rich in amino and carboxyl groups, was introduced into the hierarchical pore structure of wheat powder. Subsequently, the material underwent secondary hydrothermal treatment with the activation agent potassium hydroxide (KOH), resulting in hydrothermal wheat powder PCF (HWPCF) rich in a three-dimensional interconnected structure with layered pores as the representative feature. This structural treatment increased the specific surface area (2278 m 2 ·g −1 ) and total pore volume (1.17 cm 3 ·g −1 ) of PCF, accelerating the rapid mass transfer of gas molecules and significantly enhancing the utilization of adsorption sites in the modified PCF. HWPCF exhibited outstanding adsorption performance for acetone (608.7 mg g −1 ) and n-hexane (517.6 mg g −1 ). In addition, the modified PCF showed good adsorption capacity for CO 2 (4.99 mmol·g −1 ). This study highlights the effective modification of expired wheat powder with β-alanine, reducing the overall carbon footprint of the production process and achieving the reuse of waste in an environmentally friendly manner.
研究领域:
材料科学
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环境科学
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2023
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IF 8.6
Zelai Li,Maohong Fan,Ge Gao,Wufeng Jiang,Xiaoshan Li,Cong Luo,Liqi Zhang,Fan Wu
Electrochemically mediated amine regeneration (EMAR) for CO 2 capture is a promising substitute for traditional organic amine–based CO 2 capture by replacing the thermal process with electricity. To avoid problems such as oxidative degradation, toxicity, volatilization, and precipitation of organic amine absorbent, potassium β–alanine was suggested as an absorbent using EMAR process for the first time in this study. The CO 2 absorption performance under different copper loading and chemical reactions were studied, and cyclic voltammetry, electrochemical impedance spectroscopy, chronocoulometry and the Taffel extrapolation method were used to study the electrochemical characterization. Compared to the benchmark monoethanolamine (MEA) system, a smaller potential difference between oxidation and reduction peak was acquired in the potassium β–alanine system, of which the energy consumption was only 44.1% of the MEA system at the current of 100 A/m 2 . The cathode Faraday efficiency in the potassium β–alanine system was 101.9% higher than that in the MEA system at the current density of 25 A/m 2 . Furthermore, the result of scanning electron microscope of the electrode surface after desorption showed that potassium β–alanine absorbent improved the inhomogeneity of the electrode surface and was in favor of uniform current distribution. Overall, potassium β–alanine can be used as a more environmentally friendly absorbent in the EMAR system and has great potential to further reduce the actual energy consumption and improve the Faraday efficiency and cycling performance.
研究领域:
环境科学
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化学工程
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DOI
高影响因子
Polymers
·
2023
·Vol. 15
·期 24
·4643
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IF 5
Lina Wang,Yue Kang,Weilu Zhang,Jiahao Yang,Haiming Li,Meihong Niu,Yanzhu Guo,Zhiwei Wang
In this work, novel lignin-based nanoparticles (LβNPs) with high acidic tolerance were successfully prepared via electrostatic interaction between β-alanine and lignin nanoparticles. The effects of the mass ratio of lignin nanoparticles to β-alanine and pH value on the morphology and particle sizes of LβNPs were investigated with the aim of obtaining the ideal nanoparticles. The optimized LβNPs were spherical in shape with an average particle size of 41.1 ± 14.5 nm and exhibited outstanding structure stability under high acidic conditions (pH < 4). Subsequently, Pickering emulsions stabilized by LβNPs were prepared using olive oil as the oil phase. Additionally, the effects of pH value, droplet size, morphology, and storage stability on Pickering emulsions were also analyzed. The emulsions displayed excellent stability, and were stable against strongly acidic conditions (pH < 4) after 30 days of storage. The study presented a promising approach to preparing lignin-based nanoparticles with high acidic tolerance (an ideal type of stabilizer to prepare emulsions), and exhibited extremely high potential application values in the fields of drug delivery, food additives, and oily wastewater treatment.Keywords:lignin nanoparticles;β-alanine;Pickering emulsions;acidic tolerance
研究领域:
材料科学
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化学工程
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食品科学
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Yu Yang,Xianbing Song,Manman Wang,Xiaolian Li,Ziqiang Wang,Peng Wang
β-Alanine is an important non-essential amino acid and used in the manufacture of a wide range of drugs, in particular it plays a key role in the biosynthesis of carnosine and pantothenic acid. L-aspartate-α-decarboxylase (PanD) is the key enzyme in the enzymatic preparation of β-alanine. In this study, BsPanD* was modified by protein structure prediction and directed evolution, and a mutant BsPanD* PQ4 with good catalytic properties was obtained, which showed a 40 % increase in activity and remained stable in the pH 6.0–9.0 range. The strain E.coli pRSF Duet-1 - smaiA - ecaspA (pMA) was constructed for efficient co-expression of maleate cis - trans isomerase and L-aspartase, with an apparent activity of 253.4 U/g. The multi-enzyme cascade catalytic process for the preparation of β-alanine with maleate as the substrate was developed. The results showed that when the concentration of ammonium maleate was 1 mol/L, the substrate conversion rate was greater than 99.9 %, and the β-alanine concentration was 87.5 g/L with a yield of 98.3 %. This study not only solved the problem of low activity and poor stability of PanD, but also realized the preparation of β-alanine from maleate, a cheap chemical raw material, and laid the foundation for its industrial application.
研究领域:
生物化学
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酶工程
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合成生物学
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DOI
高影响因子
ACS Applied Materials & Interfaces
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2021
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IF 9.229
Yidong Ming,Yongqi Zhu,Yuan Chen,Bowen Jin,Chenhui Duan,Zihui Liang,Li Zhao,Shimin Wang,Binghai Dong,Haijin Li,Congcong Wu
SnO2 films as a promising electron transport layer (ETL) have been widely used in planar-type perovskite solar cells to achieve an impressive improvement in the conversion efficiency. However, compared with a mesoporous ETL, the interfacial charge carrier transfer of the SnO2 ETL is severely limited due to the issues of oxygen vacancy defects and crystal lattice mismatch between SnO2 and the perovskite, which generally leads to the growth of randomly stacked and porous perovskite layers and subsequently impacts the charge transport and transfer properties. In this work, we developed a facile approach by inducing a bifunctional molecule, β-alanine, into the SnO2 ETL, which can serve as a bridge to modulate the interfacial charge transfer and the perovskite crystallization kinetics. Benefited by the interfacial β-alanine, we grew a highly orientational perovskite layer that exhibited superior charge transport properties. Meanwhile, the β-alanine caused an intimate connection between the perovskite and SnO2 to enhance the interfacial charge transfer. As a result, the power conversion efficiency (PCE) of the β-alanine-modified device achieved a much-improved value of 19.67% and showed high reproducibility. This work provides a way for developing a high-performance ETL toward the scalable fabrication of highly efficient PSCs.
研究领域:
材料科学
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能源科学
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DOI
高影响因子
ACS Applied Materials & Interfaces
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2022
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IF 10.383
Xiaotai Zhang,Man Zhao,Hui Yu,Jian Wang,Wei Sun,Qiang Li,Xingzhong Cao,Peng Zhang
Membrane fouling is one of the persistent headaches for water desalination because of the significant detriment to membrane performance and operating cost control. It is a great challenge to overcome such crisis in a facile and robust manner. This work was dedicated to customizing an antifouling thin-film composite (TFC) reverse osmosis (RO) membrane with a polydopamine (PDA)/β-alanine (βAla)/Cu2+ ternary homogeneous metal–organic hybrid coating. The metal ions were evenly distributed in a continuous organic network via polydentate coordination. The incorporation of βAla enabled a substantial promotion of the Cu2+ loading capacity on the membrane surface. The involved one-step codeposition protocol made the surface engineering practically accessible. The deposition time was optimized to afford an uncompromising permselectivity of the membrane. This novel trinity was a smart blend of anti-adhesive and bactericidal factors, and each component in the all-in-one layer performed its own function. The hydrophilic PDA/βAla phase induced weak deposition propensity of organic foulant and bacteria onto the modified membrane, as elucidated by water flux variation, foulants adhesion profile, and interfacial interaction energy. Meanwhile, the Cu2+-loaded surface strongly inactivated the attached bacteria to further alleviate biofouling. Excellent sustainability and stability implied the reliable performance of such trinity-coated membrane in practical service. Given the simplicity and robustness, this work opened a promising avenue for in situ fouling control of TFC RO membranes during water desalination.
研究领域:
材料科学
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环境工程
·
水处理技术
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DOI
PubMed
高影响因子
Molecular Catalysis
·
2023
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IF 4.6
Bi-Han Guan,Wu-Tong Yin,Bo-Han Cao,Chen Zhao,Jiang Pan,Jian-He Xu
L-Carnosine (L-Car) is a biologically active dipeptide with antioxidant and anti-aging effects, formed by condensation of β-alanine (β-Ala) with L-histidine (L-His), which is used widely in the pharmaceutical and cosmetic industries. Here we report a dipeptide hydrolase originating from Bacillus megaterium , designated as Bm PepD, whose synthetic activity reached 6.5 times that of Sm PepD, which is the highest active dipeptidase reported so far for L-Car biosynthesis in vitro . By site-directed saturation mutagenesis, we obtained a significantly improved variant (T171N) of Bm PepD. It showed a specific activity of 22.9 U mg −1 protein , reaching 1.4 times that of wild-type Bm PepD or 9.1 times that of Sm PepD, which is the highest ever reported among this enzyme class. After optimizing the reaction conditions of variant Bm PepD T171N , we performed the synthetic reaction of L-Car simply from the two free amino acids (0.2 M L-His and 6.5 M β-Ala), achieving a titer of 31.3 mM L-Car with a specific productivity of 283 g Car · g catalyst −1 . This work provides a highly active and substrate (β-alanine)-tolerant dipeptide hydrolase for the facile synthesis of dipeptide L-Car via reversed hydrolysis.
研究领域:
生物化学
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酶工程
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合成生物学
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DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
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2019
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IF 5.589
Yujie Dong,Xinxin Cui,Xu Lu,Xinchi Jian,Qinglong Xu,Chaoqun Tan
Magnetic nanocomposite β-alaninediacetic acid-modified Fe 3 O 4 (β-ADA@Fe 3 O 4 ) was prepared, characterized and evaluated to activate peroxymonosulfate (PMS) for improved degradation of sulfadiazine (SD). The results reveal that β-ADA@Fe 3 O 4 express more efficient catalytic activity in PMS inducement compared with Fe 3 O 4 , and the observed pseudo first rate constant ( k obs ) of SD degradation is enhanced from 1.05 × 10 −2 to 7.02 × 10 −2 min −1 when Fe 3 O 4 is replaced by β-ADA@Fe 3 O 4 . The highest removal rate 54.0% occurs when [PMS] 0 and m(β-ADA@Fe 3 O 4 ) 0 was 0.3 mM and 0.8 g/L at neutral pH. High intensity of hydroxyl radicals ( OH) and relatively low intensity of sulfate radicals (SO 4 − ) are distinguished in system by scavenging experiments and electron paramagnetic resonance (EPR) tests. Results point that β-ADA would significantly promote the circulation of Fe 2+ -Fe 3+ on the surface of β-ADA@Fe 3 O 4 , producing more radicals ( OH, SO 4 − ). The findings herein imply that β-ADA@Fe 3 O 4 is an efficient and green catalyst in activation of peroxymonosulfate under neutral environment.
研究领域:
环境科学
·
催化材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）