Nano Energy
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2025
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IF 17.1
Xiuzi Che,Huiqing Fan,Jiahao Cao,Yongbo Fan,Yuxin Jia,Yidi Duan,Qinghua Guo,Yafei Feng,Weijia Wang
Piezoelectric biomaterials can convert mechanical energy into electricity, which make them attractive for implant applications, such as sensing, energy harvesting, and medical devices. The β-glycine has excellent piezoelectric performance, but their practical use is hindered by instable crystal phase and water solubility. Here, we present a simple method for preparing poly L-lactide (PLLA) composite fibers encapsulating β-glycine nano crystals via coaxial electrospinning. The formation of β-glycine crystals is the synergistic outcome of the ionization of glycine solution under the electric field and the confinement of external PLLA solution, which enhances the piezoelectric performance of the film. The V oc , I sc , and power density of composite film reach 14 V, 0.94 μA, and 0.92 mW/cm 2 , respectively. In addition, PLLA shell stabilizes β-glycine, leading to a stable piezoelectric performance for device applications. The composite film can be ultrasonically driven to generate electric signals, and therefore functions well in promoting cell proliferation and bone tissue repairing in vivo . Moreover, the film can be naturally degraded after long-term implantation. This study provides a strategy to deal with the instability of β-glycine-based biodegradable piezoelectric films, and promotes the implant applications.
研究领域:
生物材料
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组织工程
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纳米技术
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Regenerative Biomaterials
·
2024
·
IF 5.6
Lin Qiaoxia,Zhang Yonggang,Chen Luhua,Zhang Haoyue,An Chuanfeng,Li Chengze,Wang Qifan,Song Jinhui,He Wei,Wang Huanan
Development of piezoelectric biomaterials with high piezoelectric performance, while possessing excellent flexibility, biocompatibility, and biodegradability still remains a great challenge. Herein, a flexible, biocompatible and biodegradable piezoelectric β-glycine-alginate-glycerol (Gly-Alg-Glycerol) film with excellent in vitro and in vivo sensing performance was developed. Remarkably, a single, monolithic β-glycine spherulite, instead of more commonly observed multiple spherulites, was formed in alginate matrix, thereby resulting in outstanding piezoelectric property, including high piezoelectric constant (7.2 pC/N) and high piezoelectric sensitivity (1.97 mV/kPa). The Gly-Alg-Glycerol film exhibited superior flexibility, enabling complex shape-shifting, e.g. origami pigeon, 40% tensile strain, and repeated bending and folding deformation without fracture. In vitro, the flexible Gly-Alg-Glycerol film sensor could detect subtle pulse signal, sound wave, and recognize shear stress applied from different directions. In addition, we have demonstrated that the Gly-Alg-Glycerol film sensor sealed by polylactic acid and beeswax could serve as an in vivo sensor to monitor physiological pressure signals such as heartbeat, respiration, and muscle movement. Finally, the Gly-Alg-Glycerol film possessed good biocompatibility, supporting the attachment and proliferation of rat mesenchymal stromal cells, and biodegradability, thereby showing great potential as biodegradable piezoelectric biomaterials for biomedical sensing applications.
研究领域:
材料科学
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生物医学工程
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生物材料
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传感器
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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