JOURNAL OF FOOD ENGINEERING
·
2025
·
IF 5.8
Xuanyi Zhang,Xiaojun Lin,Jingwen Wang,Xiaoyu Luo,Baojun Xu
This study focused on enhancing the stability and bioaccessibility of pterostilbene (PTS) by encapsulating it with hydroxypropyl-β-cyclodextrin (HP-β-CD) using high-pressure homogenization (HPH) and pH-shift methods. The encapsulation process was performed at pressures of 50, 100, and 150 MPa along with three different treatments, achieving a maximum encapsulation efficiency of 94.34% and a loading capacity of 14.82% at 150 MPa. The SEM, XRD, and FTIR analyses confirmed encapsulation by revealing significant morphological changes, crystal structure modifications, and host-guest interactions. PTS-HP-β-CD complexes retained 82.22% of PTS at 4°C (28 days) and 76% under UVB (120 min), compared to 56.03% and 21% for free PTS, respectively. Additionally, these complexes exhibited enhanced DPPH scavenging rates (44.95% at 0.02 mg/mL), nearly twice that of free PTS. In the release studies, the complexes’ release behavior aligned with the Higuchi model. Encapsulated PTS revealed lower digestion rates in in-vitro gastric (32.24% vs. 49.88%) and intestinal phases (63.98% vs. 91.01%). Additionally, there was no observable toxicity for PTS-HP-β-CD to human epidermal keratinocytes, supporting its potential use in cosmetics, food, and pharmaceuticals. These results demonstrated that HPH combined with pH-shift methods effectively improved the stability and bioaccessibility of PTS, offering a promising strategy for its formulation.
研究领域:
食品科学
·
药剂学
·
生物学
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产品关联
DOI
高影响因子
Materials Today Communications
·
2020
·
IF 2.678
Xiaomei Zhang,Li Dou,Chengsong Peng,Liang Shi,Xiaoli Ji
A new method involving a coupling reaction and vacuum distillation (RVD) was introduced to prepare the β -CD cross-linking polymeric adsorbent (PCD RVD ). The preparation conditions, including the molar ratio of cross-linking agent and β -CD, dosage of the solvent, reaction time, and vacuum distillation temperature and time, were investigated in detail. Compared with a product prepared at normal pressure, PCD RVD possessed a lower content of β -CD, a higher content of carboxyl groups, a lower adsorption selectivity, and a higher efficiency as well as adsorption capacity to remove dyes methylene blue (MB), and Rhodamine B (RhB), methyl orange (MO). The PCD RVD was characterised by FT-IR, TG, and SEM, and was employed for the adsorption of MB and RhB from an aqueous solution. Results showed that the adsorption quantity of MB ( Q e,MB ) was higher than that of Q e,RhB , except in the acidic medium. The equilibrium data followed the Langmuir isotherm model, and the calculated Q m,MB and Q m,RhB were 250.0 mg/g and 231.5 mg/g, respectively. The adsorption kinetics fitted the pseudo-second-order model. It was inferred that PCD RVD exhibited a high adsorption capacity for both dyes due to its more homogeneous polymeric network formed during RVD and the higher content of carboxyl groups. The differences between Q e,MB and Q e,RhB were mainly attributed to the size of MB and RhB.
研究领域:
化学工程
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环境科学
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材料科学
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2016
·
IF 1.78
Yinghui Deng,Yanhua Pang,Yafei Guo,Yufeng Ren,Fen Wang,Xiali Liao,Bo Yang
Daidzein is an isoflavone of naturally abundance existing in plants and foods which has attracted much attention for its significant benefits on human health. However, its application was severely limited by its poor solubilities, instability and low bioavailability. To overcome these drawbacks, inclusion complexes of daidzein with two cyclodextrin (CD) derivatives, i.e., 2-hydropropyl-β-cyclodextrin (HP-β-CD) and sulfobutyl ether-β-cyclodextrin (SBE-β-CD) were prepared and characterized both in solution and solid state by 1D and 2D NMR , XRD, SEM and elemental analyses. Fluorescence spectroscopy and the Job plot were used to demonstrate a mainly 1:1 inclusion mode between daidzein and CDs. Their thermal stabilities were evaluated with TG and DSC experiments. Moreover, water solubility of daidzein was significantly improved by inclusion complexation with CDs. These results might suggest valuable approaches to developments of new pharmaceutical formulations of daidzein.
研究领域:
药学
·
化学
·
材料科学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Linyun Mou,Ya Lu,Jiale Ma,Shuwei Shu,Jianlong Li,Ganpeng Li
In response to the rapid quality degradation of peaches due to post-harvest decay, this study developed a composite film for preservation. Two primary pathogens responsible for peach decay, Aspergillus flavus and Talaromyces funiculosus , were identified. Molecular docking attributed to the main binding position of citral and geraniol's interactions with type I polyketide synthase on their antifungal effects, as well as the caffeic acid with its tyrosinase on antioxidant efficacy. β -CD-MOFs were synthesized via vapor diffusion, demonstrating exceptional spatial loading via SEM. CEOs (citral + geraniol) encapsulated in β -CD-MOFs were incorporated into a chitosan/pullulan matrix, yielding a film with 260.27 % fracture tensile strain, significantly ( P < 0.001) outperforming pure chitosan (21.87 %), possessing excellent mechanical properties, and the improvement in the water solubility of the film facilitates the release of active compounds. The utilization of a compositel film on peaches has shown significant efficacy in controlling decay index ( P < 0.05), weight loss ( P < 0.05), firmness ( P < 0.05) and production of malondialdehyde ( P < 0.05). Compared to untreated controls, the treated peaches exhibited an extended shelf life of 2 days, highlighting the superior preservation capabilities of the film. Hence, the film presents a promising solution for fruit preservation.
研究领域:
食品科学
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材料科学
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植物病理学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2015
·
IF 3.65
Hailong Zhang,Xiaoyan Huang,Ya Sun,Guangyou Lu,Ke Wang,Zhigang Wang,Jianfeng Xing,Yang Gao
Effects of hydroxypropyl-β-cyclodextrin grafted polyethylenimine (HP-β-CD-PEI) including HP-β-CD-PEI 600 , HP-β-CD-PEI 1800 , HP-β-CD-PEI 10000 on the pulmonary absorption of insulin, calcitonin, 5(6)-carboxyfluorescein (CF) and fluorescein isothiocyanate dextrans (FDs) with various molecular weights (FD4, FD10 and FD70) were examined by an pulmonary absorption study in rats. Pulmonary absorptions of these poorly absorbable drugs were significantly enhanced by HP-β-CD-PEI 1800 and HP-β-CD-PEI 10000 , and HP-β-CD-PEI 1800 with the concentration of 5% (w/v) provided maximal absorption enhancing effect on pulmonary absorption of these model drugs. The toxicity study demonstrated that HP-β-CD-PEI did not induce any toxic action to rat pulmonary membranes. In addition, zeta potential of insulin solution changed to positive by addition of various HP-β-CD-PEI, meanwhile, the degree of positive charge was linearly correlated with absorption enhancing effect of HP-β-CD-PEI, suggesting that positive charge of HP-β-CD-PEI might be related to their absorption enhancing mechanisms for enhancing pulmonary absorption of insulin in rats. In conclusion, HP-β-CD-PEI is a potential and safe absorption enhancer for improving absorption of hydrophilic macromolecules especially peptide and protein drugs by pulmonary delivery.
研究领域:
药理学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2022
·
IF 6.978
Zixue Li,Wei Zhao,Na Liang,Pengfei Yan,Shaoping Sun
In this study, a tumor-targeting and pH-sensitive inclusion complex based on the host–guest recognition between the chitosan and folic acid grafted HP-β-CD (FA–CS–CD) and stearic acid modified 2-benzimidazolemethanol (BM-SA) was designed and fabricated for the controlled delivery of paclitaxel (PTX). Through the combination of computational simulations and experiments, the interaction between FA–CS–CD, BM-SA, and PTX was investigated, and the optimized preparation method was obtained. For the optimized PTX-loaded FA–CS–CD/BM-SA inclusion complex, the particle size and zeta potential were 146 nm and +15.4 mV, respectively. In vitro drug release study revealed the pH-triggered drug release behavior of the inclusion complex. Both in vitro and in vivo evaluations demonstrated that the PTX-loaded FA–CS–CD/BM-SA inclusion complex exhibited enhanced antitumor efficiency and minimized systemic toxicity. This system might be a promising carrier for PTX.
研究领域:
药剂学
·
分子生物学
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DOI
PubMed
高影响因子
CHIRALITY
·
2024
·Vol. 36
·期 7
·e23697
·
IF 2.8
Chaoheng Jia,Futao Li,Anqi Li,Qiwen Li,Lu Huang
Allyl-β-CD was synthesized and used as the chiral functional monomer to prepare chiral organic polymer monolithic columns in capillary HPLC. First, the enantioselectivity of the prepared allyl-β-CD modified organic polymer monolithic capillary columns was investigated. Then, the influences of enantioseparation conditions of chiral drugs were further explored. Finally, the recognition mechanism was studied by molecular docking with AutoDock. Complete enantioseparations of four chiral drugs as well as partial enantioseparations of eight chiral drugs have been achieved. Results showed that the RSD values for run-to-run, day-to-day, and column-to-column variations ranged from 1.2% to 4.6%, 1.4% to 4.7%, and 2.0% to 6.1%, respectively. The enantioselectivity factor rather than resolution is correlated with the binding free energy difference between enantiomers with allyl-β-CD. Furthermore, the abundant ether bonds, hydroxyl groups, and hydrophobic cavities in cyclodextrin are responsible for the enantioseparation ability of the chiral monolithic capillary columns.
研究领域:
分析化学
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药物化学
·
生物信息学
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产品关联
DOI
PubMed
高影响因子
Journal of Nanomaterials
·
2019
·
IF 2.233
Hui Zhang,Jiangying Zhu,Yanqiang Hu,Aonan Chen,Liang Zhou,Hui Gao,Yamei Liu,Shengquan Liu
A novel cellulose/TiO2/β-CD hydrogel with high photocatalytic antibacterial activity and sustained release of drug was prepared. TiO2 sol with a diameter of about 9 nm in this hydrogel was the photoantibacterial agent. β-CD can significantly enhance photoantibacterial activity and the sustained-release effect of this hydrogel. The structure and property of this hydrogel composite were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Escherichia coli and Staphylococcus aureus were selected as model bacteria to evaluate the antibacterial activity of the composite hydrogel under natural light irradiation and darkness, respectively. The in vitro release experiment used curcumin as a model drug in PBS buffer solution. The influence of β-CD on the antibacterial activity and sustained-release effect of the composite hydrogel was investigated. The results showed that the hydrogel composite presented a good photoantibacterial property, while the antibacterial activity can be neglected under the condition of no light. The complete release of curcumin from the composite was achieved after 120 h. Therefore, the hydrogel system has the characteristics of low cost and high effect, which could be used for an antibacterial sustained-release material.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
COMPOSITES PART B-ENGINEERING
·
2022
·
IF 11.322
Dan Liu,Jiajun Qiu,Ru Xu,Junyu Liu,Jiayin Feng,Liping Ouyang,Shi Qian,Yuqin Qiao,Xuanyong Liu
Bacterial infections in wounds often delay the healing process which threaten human health and life. The development of biocompatible hydrogels with antibacterial activity and self-healing to achieve excellent wound closure effectiveness is highly desirable in clinical applications. Herein, a new class of highly stretchable, biocompatible, and antibacterial hydrogel dressings called BPP hydrogel is designed and prepared by chemically cross-linking β-CD with PEI and then physically cross-linking with PVA. The BPP hydrogel exhibits superior properties including excellent antibacterial properties against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli , good biocompatibility for mouse fibroblasts , mouse embryonic fibroblasts and human umbilical vein endothelial cells, outstanding deformability and self-healing performance to protect the wound completely even in special scenes such as pulling and bending. Besides, after damage, the broken BPP hydrogel could heal together, and the healed BPP hydrogel could be stretched to 150% breaking deformation. Furthermore, in vivo experiments further verify that BPP hydrogel has excellent sterilization and healing effect on infectious wounds. This work proves that BPP hydrogel would be a promising material for wound healing and has good prospect for clinical translation.
研究领域:
材料科学
·
医学
·
生物工程
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DOI
高影响因子
INORGANIC CHEMISTRY
·
2022
·
IF 5.436
Yulin Xie,Man Wang,Qianqian Sun,Dongmei Wang,Shuiping Luo,Chunxia Li
Combined photothermal/photodynamic therapy is a promising strategy to achieve an enhanced anticancer effect. However, hypoxia is one of the representative characteristics of the microenvironment of solid tumors, which not only attenuates the therapeutic effects but also promotes tumor invasion and metastasis. Herein, a PtBi-β-CD-Ce6 nanoplatform for the generation of sustained O2 was constructed for more effective tumor therapy. In detail, the catalase (CAT)-like nanozyme, PtBi, which could decompose H2O2 to produce O2, was modified with β-cyclodextrin (β-CD). O2 would be converted into 1O2 by PtBi-β-CD-Ce6 for enhanced photodynamic therapy (PDT) under 650 nm laser irradiation. In addition, by reason of excellent absorption in the near-infrared-II (NIR-II) region, PtBi-β-CD-Ce6 was used for photoacoustic imaging (PA) and photothermal imaging (PT)-guided photothermal therapy (PTT) in the NIR-II biowindow. Furthermore, PtBi-β-CD-Ce6 could be elected to serve as a contrast agent for X-ray computed tomography (CT) imaging due to the apparent X-ray attenuation capability of the Pt and Bi elements themselves. Therefore, by integrating the advantages of overcoming the hypoxia function and photothermal effect into a single nanoplatform, PtBi-β-CD-Ce6 showed an immense possibility in multimodal imaging-guided combined PDT/PTT.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
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DOI
高影响因子
SURFACE AND INTERFACE ANALYSIS
·
2014
·Vol. 47
·期 2
·270-277
·
IF 1.393
Yongli Shi,Suying Ma,Ruiqiong Tian,Yingge Zhao,Qian Jiao,Xu Ma,Qing Shang
A novel amphiphilic copolymer was synthesized from poly (ethylene glycol) methyl ether methacrylate (PEGMA950), methyl methacrylate (MMA) and acryloyl- β -cyclodextrin (acryloyl- β -CD) using the composites of (NH 4 ) 2 S 2 O 8 /NaHSO 3 as the oxidation–reduction initiators. The successful fabrication of poly(PEGMA-co-MMA-co-acryloyl- β -CD) copolymers was confirmed by Fourier transform infrared spectrometer (FTIR), 1 H-nuclear magnetic resonance ( 1 H NMR) spectra. The amphiphilic copolymer could self-assemble into nanoparticles (NPs), and their morphology and particle size distribution were characterized with transmission electron microscopy (TEM), atomic force microscope (AFM) and dynamic light scattering (DLS) methods. Ibuprofen (IBU) was encapsulated in the novel NPs, and the release profiles of IBU were investigated. FTIR and 1 H NMR spectra illustrated that the poly(PEGMA-co-MMA-co-acryloyl- β -CD) copolymers were synthesized without any residual monomers and initiators. TEM and AFM photographs suggested that the obtained NPs were spherical, and the DLS results indicated that the diameter of blank NPs was 157.3 ± 32.7 nm. The IBU release profile showed that the IBU-loaded NPs had certain pH responsibility. Copyright © 2014 John Wiley & Sons, Ltd.
研究领域:
材料科学
·
药剂学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Jianfang Jiang,Kuaqian Deng,Fanglin Dao,Panyang Li,Jiali Huang
Trichlorfon (TCF) is an important chemical for pest and parasite control, but it poses risks to public and environmental health. Thus, the detection of TCF is of great value. In this study, we report a strategy to prepare an AChE-nanoprobe for detecting TCF. Benefiting from the unique and excellent structure of CHO-β-CD, this AChE-nanoprobe can wrap nano-Fe 3 O 4 and covalently bind AChE. As a proof of concept, we prepared an AChE-nanoprobe with a hydrated particle size of 717 nm and a saturation magnetic strength of 64.11 emu/g Fe. The properties were studied in detail. Its catalytic activity was 90 % of that of free AChE, and it had broadened pH, thermal, organic solvents and storage in addition to good reusability, with a residual catalytic activity of 42 % after the 10th cycle and a cumulative catalytic activity 6.9 times higher than that of the free enzyme. The AChE-nanoprobe exhibited good performance in TCF detection; the linear range of TCF was 40–4000 ng/L, and the limit of detection for TCF was 2.8 ng/L. Furthermore, our results suggest that the AChE-nanoprobe has several attractive features, such as easy preparation, outstanding stability and reusability, providing a novel and promising tool for the analysis of TCF.
研究领域:
环境科学
·
分析化学
·
纳米技术
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）