IEEE Sensors Letters
·
2024
·Vol. 9
·期 1
·1-4
·
IF 2.2
Jiawei Zhai,Bin Luo,Tianyang Liu,Xiaodong Wang,Chunjiang Zhao
Ion-selective electrodes (ISEs) play an important role in the field of electrochemical sensors and have a significant impact on future ion detection. At present, to address the sensor consistency issue in the commercialization process of ISE, we emphasize that automated manufacturing has the potential to achieve calibration-free sensors. First, the design of automated manufacturing requires expert experience to help understand the ISE mechanism and its structure. Then, we introduce two automated manufacturing processes for sensors to help understand the design and manufacturing process. Finally, we propose a device for semiautomated manufacturing of ISE and verify that automated manufacturing of ISE has better consistency and potential reproducibility than manual manufacturing of ISE. The results show that for the transduction layer (conductive graphite adhesive) coated automatically in the same batch, the impedance difference is 4.8 KΩ, while that of the manual batch is 36.6 KΩ. In the performance of cyclic voltammetry, the gap of peak current is reduced from 21.5 to 4.8
μ
A.
研究领域:
传感器技术
·
电化学工程
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高影响因子
Scientific Reports
·
2019
·Vol. 9
·期 1
·1-13
·
IF 4.011
Zhu Mengxiang,Wang Yingying,Ferracci Gaia,Zheng Jing,Cho Nam-Joon,Lee Bae Hoon
Gelatin methacryloyl (GelMA) is a versatile material for a wide range of bioapplications. There is an intense interest in developing effective chemical strategies to prepare GelMA with a high degree of batch-to-batch consistency and controllability in terms of methacryloyl functionalization and physiochemical properties. Herein, we systematically investigated the batch-to-batch reproducibility and controllability of producing GelMA (target highly and lowly substituted versions) via a one-pot strategy. To assess the GelMA product, several parameters were evaluated, including the degree of methacryloylation, secondary structure, and enzymatic degradation, along with the mechanical properties and cell viability of GelMA hydrogels. The results showed that two types of target GelMA with five batches exhibited a high degree of controllability and reproducibility in compositional, structural, and functional properties owing to the highly controllable one-pot strategy.
研究领域:
生物材料学
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组织工程学
·
再生医学
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PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2021
·
IF 2.694
Bingjie Huo,Xiaomin Qiu,Hongru Zhang,Yaning Zhang,Jingwei Yang,Zhaoyou Zhu,Yinglong Wang,Jun Gao
Isoamyl butyrate is a common food additive. Water will be generated by esterification reaction in the process of its formation. Cyclohexane, n-hexane, and n-heptane are often selected as entrainers to remove water and promote the reaction. In this work, the vapor–liquid equilibrium data of the binary systems of isoamyl alcohol + isoamyl butyrate, cyclohexane + isoamyl butyrate, n-hexane + isoamyl butyrate, and n-heptane + isoamyl butyrate were determined by using a modified Rose vapor recirculating-type equilibrium still at 101.3 kPa. Fredenslund test and Van Ness point test methods are used to verify the thermodynamic consistency of the experimental vapor–liquid equilibrium data. In addition, three classical activity coefficient models, Wilson, NRTL, and UNIQUAC, were used to fit the isobaric vapor–liquid equilibrium data of four binary systems. The binary interaction parameters were obtained by regression of experimental data.
研究领域:
化学工程
·
物理化学
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高影响因子
INFRARED PHYSICS & TECHNOLOGY
·
2024
·
IF 3.1
Ye Jin,Junjie Pan,Kejun Cheng
A comprehensive strategy based on high performance liquid chromatography (HPLC) and near infrared (NIR) spectroscopy was developed to assess the quality consistency of Compound Yuxingcao Mixture (CYM) from different manufacturers. Simultaneous determination of 10 marker components (neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, caffeic acid, acteoside, forsythoside A, quercitrin, baicalin, wogonoside and wogonin) in CYM and 7 marker components (neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, hyperoside, isoquercitrin, quercitrin and quercetin) in Houttuyniae Herba was carried out. Similarity analysis using chromatographic fingerprints and principal component analysis (PCA) were also performed to assess the quality consistency of CYM from different manufacturers. NIR spectroscopy combined with partial least squares (PLS), feed-forward back-propagation network (BP-ANN), and particle swarm optimization based least square support vector machine (PSO-LS-SVM) algorithms were employed for rapid determination of higher-concentration marker components (baicalin, wogonoside and chlorogenic acid) and rapid identification of product manufacturers. The comparative results showed that the PSO-LS-SVM models exhibited more satisfactory fitting results and predictive abilities. This study demonstrated that the combination of multi-component simultaneous determination and fingerprint analysis can help to gain an in-depth and comprehensive understanding of the quality of CYM; NIR technique combined with chemometric methods is useful for the rapid determination, identity and consistency evaluation of CYM.
研究领域:
中药学
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分析化学
·
药品质控
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高影响因子
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2021
·
IF 3.935
Yan-Ting Fan,Ping Zhong,Jin-Di Xu,Shan-Shan Zhou,Ming Kong,Gui-Rong Zhou,Qian Mao,Song-Lin Li
Chang-Kang-Fang formula (CKF), a multi-herbs traditional Chinese medicine (TCM) prescription for treating irritable bowel syndrome (IBS), has been clinically applied in the traditional form of mixed-herb decoction (MHD), or in the modern form of combined single-herb decoction (cSHD, so called dispensing granule decoction) in the near decades, but the chemical consistency between the MHD and cSHD is still unknown. Herein, a new strategy by integrating multiple-chromatographic approaches to characterize both polysaccharides and small molecules was developed to compare the chemical consistency between MHD and cSHD. Sixteen small molecules were simultaneously qualified and quantified by UPLC-QTOF-MS/MS, the molecular weight distribution of polysaccharides was characterized by HPGPC-ELSD, while the monosaccharide composition and total saccharides content were determined by HPLC-PDA and UV-VIS, respectively. It was found that the molecular weight range and monosaccharide composition of polysaccharides, as well as the composition of small molecules, were identical between MHD and cSHD. However, the contents of berberine, epiberberine, coptisine, palmatine, albiflorin and paeoniflorin in MHD were significantly lower than those in cSHD, whereas the content of polysaccharides in MHD was higher than that in cSHD, indicating that there is a significant difference in the quality between MHD and cSHD, in particular for the relative contents of major small molecules and polysaccharides. Whether or not these quality variations affect the efficacy and safety of CKF deserves further investigation.
研究领域:
中药学
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色谱分析
·
药物化学
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PubMed
高影响因子
Laser & Photonics Reviews
·
2024
·
IF 9.8
Guo-Juan Wang,Qiang-Qiang Zhu,Shan-Jun Nie,Yue Zhai,Shuang-Qiang Fang,Juan Kang,Le Wang
Laser-driven white light exhibits exceptional brightness and directionality, making it particularly well-suited for spotlight applications. Yet, attaining high-quality white light remains challenging due to the sluggish heat dispersion and inconsistent light uniformity of color converters. In this study, an innovative phosphor-in-glass (PiG) film architecture is introduced, aiming to achieve superior quality laser-driven light, where the traditional Y 3 (Ga,Al) 5 O 12 :Ce 3+ (YAGG:Ce 3+ ) PiG film is topped with a Al 2 O 3 -in-glass (AiG) film. The heightened thermal conductivity of the AiG film facilitates quicker dissipation of heat, consequently elevating the luminescence saturation threshold from 14 to 16 W mm −2 and luminous flux from 1243.8 to 1475.9 lm. The increased light scattering attributed to the AiG film also effectively disperses both laser and emitted light, significantly enhancing the angular consistency of color rendering index (Ra). This improvement is evident as the coefficient of variation (C v ) decreases dramatically from 16.69% to 0.25%. Moreover, by integrating CaAlSiN 3 :Eu 2+ (CASN:Eu 2+ ) into the PiG film and fine-tuning the YAGG:Ce 3+ and CASN:Eu 2+ ratio, a high-quality laser-driven white light achieving an impressive color rendering index (Ra) of 88.7 and offering an adjustable correlated color temperature (CCT) has been developed. This innovation holds tremendous potential as a versatile spotlight solution for both indoor and outdoor settings.
研究领域:
光学工程
·
材料科学
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DOI
高影响因子
TALANTA
·
2021
·
IF 6.057
Xinyue Li,Yaqi Yao,Meiling Chen,Haoran Ding,Chenrui Liang,Ling Lv,Huan Zhao,Guanru Zhou,Zhanglong Luo,Yubo Li,Han Zhang
In the clinical application of Traditional Chinese Medicine (TCM) substitutes, the consistency evaluation of TCM substitutes from different sources is recognized as the main bottleneck. As the most widely used analytical method in TCM consistency evaluation, fingerprint similarity evaluation suffers from insufficient method sensitivity and poor conformity with the actual characteristics of TCM, which is difficult to adapt to the analytical needs of complex substance systems of TCM. This work aims to develop an effective and more accurate method for consistency evaluation using omics strategy and machine learning algorithms. The natural calculus bovis (NCB) were graded into three groups according to the similarity to in vitro cultured bovis (IVCB), and chemical markers between samples of each grade were screened out. Support vector machine (SVM) models with different kernels were then constructed by using the chemical markers as feature variables. The results showed that the classification accuracy of the SVM classifier of NCB and the consistency evaluation SVM model classifier was 95.74% and 100.0%, respectively. The approach demonstrated in the study presented a good analytical performance with higher sensitivity, accuracy for consistency evaluation of TCM.
研究领域:
药理学
·
生物信息学
·
中药
·
机器学习
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PubMed
高影响因子
RSC Advances
·
2020
·Vol. 10
·期 17
·10338-10351
·
IF 3.119
Libing Chen,Fang Zhao,Wenzhu Li,Zeqi Chen,Jianyang Pan,Difeifei Xiong,Bailing Li,Qingjie Zhang,Haibin Qu
This paper evaluates a multiple and global analytical indicator of batch consistency in traditional Chinese medicine injections (TCMIs) via a chemometrics tool, which is more comprehensive to appraise quality consistency of different batches of injections than the traditional method of fingerprint similarity. A commonly used TCMI, Salviae miltiorrhizae and ligustrazine hydrochloride injection (SLI), was employed as a model. With the aid of a chemometrics tool (principal component analysis, PCA), evaluation of multiple and global analytical indicators of batch consistency, which included saccharides, phenolic acids and inorganic salts (18 indicators in total), was carried out to appraise the quality consistency of 13 batches of injection provided by the Guizhou Baite Pharmaceutical Co., Ltd. (Guizhou, China). Compared with the traditional HPLC-UV fingerprint similarity evaluation, the method proposed in the paper can more comprehensively and correctly reflect the quality consistency of different batches of injections. In this paper, the multi-index evaluation result showed poor batch consistency, which was more consistent with the determination results, while the fingerprint similarity evaluation results still showed good batch consistency. The HPLC-UV fingerprint reflects only substances with UV absorption, but it is not able to reflect substances without UV absorption or weak UV absorption, which leads to inappropriate conclusions. Therefore, quality consistency of injections can be effectively appraised by evaluation of multiple and global analytical indicators, instead of HPLC-UV fingerprint only. For visualizing the batch consistency of the multiple and global analytical indicators, a heat map was used to represent the fluctuation. Furthermore, critical indicator identification was also applied to select several indicators that should be paid more attention during the process of quality control of injection. And the analysis result showed that Na+, fructose (Fru), glucose (Glc), manninotriose (Man), danshensu (DSS) and salvianolic acid B (SAB) are the indicators that should be given more attention when controlling the quality of injections, also called critical quality control indicators. The proposed method provides a reference for the quality control of TCMIs and has broad application potential.
研究领域:
中药学
·
分析化学
·
制药工程
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DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2018
·
IF 2.196
Chunli Li,Siqi Gong,Hao Li
Vapor–liquid equilibrium (VLE) data for the binary system of acetone (1) + hexamethyl disiloxane (HMDSO, 2) and the ternary system of acetone (1) + HMDSO (2) + ethyl acetate (EAC, 3) were obtained at 101.3 kPa. The acetone (1) + HMDSO (2) mixture had azeotropic temperature of 329.00 K, x1,az = 0.9661. The binary VLE values and ternary VLE values were confirmed to be thermodynamically consistent using the Herington method and the McDermott–Ellis method, respectively. The binary VLE data were correlated using the nonrandom two-liquid (NRTL), universal quasichemical activity coefficient (UNIQUAC), and Wilson models, and the NRTL model has the best correlation with the experimental data. Furthermore, the acetone (1) + HMDSO (2) + EAC (3) ternary VLE data were predicted with the NRTL model using the binary interaction parameter obtained by association of the contained binary system, and the calculated data were in good agreement with the ternary experimental data. To further describe the ternary system, the residue curves were provided by Aspen Plus using the NRTL model.
研究领域:
化学工程
·
热力学
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DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2020
·
IF 7.632
Yongfeng Bu,Hongyu Liang,Renxing Shi,Haitao Liu,Yanzhi Zhang,Tao Sun,Cheng Lian,Xiangqian Shen,Huaming Li
The maximum power and consistency assessment are key technologies for the practical application of energy storage device packs such as carbon supercapacitors (SCs) connected in series. Herein, we first report a simple practical strategy to efficiently evaluate SCs’ maximum power and consistency by using the dependence of direct-current equivalent series resistance (ESRdc) on current density from small to large and demonstrate its general applicability to SCs using neutral, acidic, and alkaline aqueous electrolytes. With this strategy implemented by a computer program, a group of highly consistent SCs with safe power can be obtained, especially for high-rate consistency associated with ionic resistance under high-power operation. The ESRdc evolution is attributed to the dynamic migration resistance of ions migrating from micro- to meso-/macropores, which contains the real ion migration/storage characteristic information. This study provides real practical application possibilities for solving the problems of SC consistency assessment and rated power setting in batch.
研究领域:
电化学
·
能量存储
·
材料科学
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DOI
高影响因子
FLUID PHASE EQUILIBRIA
·
2025
·
IF 2.7
Litao Chen,Jiansheng Luo,Pengcheng Jing,Wang Ma,Hongtao Liu,Changhong Yu
Equilibrium data, one of the essential fundamental data of gas hydrate, is always needed in its prevention and utilization. In this work, a total of 111 sets of hydrate equilibrium data for CO 2 -containing natural gas in alcohol/salt solutions were measured in a stirred autoclave or rocking cell by using the isochoric pressure searching method. Some equilibrium data failed in the thermodynamic consistency test. It is speculated, after the hydrate formation and dissociation in the insufficiently stirred autoclave, the last hydrate crystal could be in equilibrium with concentrated or diluted solutions which are different from the initial solution. Fake equilibrium data could be reported. The gas hydrate equilibrium data in some solutions were remeasured in a rocking cell apparatus. All the rocking cell measured equilibrium data passed the thermodynamic consistency test. It seems stirred autoclave are likely to report fake gas hydrate equilibrium data, while rocking cell may be more reliable.
研究领域:
化学工程
·
能源科学
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DOI
高影响因子
CURRENT MICROBIOLOGY
·
2025
·Vol. 83
·期 2
·112
·
IF 2.6
Gao Peng,Lu Xie-Feng,Yao Ling,Xu Yuan-Jia,Zhang Shu-Yi,Liu Guo-Hong,Zhou Shun-Gui
Two novel aerobic, rod-shaped, motile bacterial strains, designated as strains sgz302251 T and sgz5001026 T , were both isolated from paddy soils. 16S rRNA gene sequences analysis revealed that strain sgz302251 T exhibited 98.3% similarity with its closest reference strain Paenibacillus vietnamensis N4 T , while strain sgz5001026 T had the highest similarity of 97.5% to Ectobacillus polymachus KACC 18242 T . The average nucleotide identity (ANI) and digital DNA-DNA hybridization (dDDH) values between strains sgz302251 T , sgz5001026 T and their closest reference strains were 86.0% and 21.2%, 84.9% and 22.9%, respectively. The genomic DNA G + C contents of sgz302251 T and sgz5001026 T were 63.4% and 68.8%, respectively. Strain sgz302251 T grew at 20–37 °C (optimum 30 °C), pH 5.0–9.0 (optimum 6.5–7.5) and tolerated 0–1.0% NaCl (optimum 0.5%, w/v), while strain sgz5001026 T grew at 4–45 °C (optimum 37 °C), pH 5.0–9.0 (optimum 6.0) and 0–0.5% NaCl (optimum 0%). The quinone in both strains was MK-7 and major polar lipids were diphosphatidylglycerol (DPG), phosphatidylethanolamine (PE) and phosphatidylglycerol (PG). The main fatty acids (> 5%) of strain sgz302251 T were anteiso-C 15:0 , anteiso-C 17:0 , and C 16:0 , whereas strain sgz5001026 T included anteiso-C 15:0 , iso-C 15:0 , iso-C 16:0 and iso-C 14:0 . Based on the above evidence, the proposed names of the two novel species are Paenibacillus praedii sp. nov. (type strain sgz302251 T = MCCC 1K09633 T = KCTC 43808 T ), Ectobacillus soli sp. nov. (type strain sgz5001026 T = MCCC 1K09373 T = KCTC 25903 T ), respectively.
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高影响因子
危险品化学品经营许可证（带存储）