MICROPOROUS AND MESOPOROUS MATERIALS
·
2024
·
IF 4.8
Tianyu Bai,Jinquan Tao,Yijing Jia,Wenbin Huang,Rongpeng Yao,Xinan Xue,Yasong Zhou,Qiang Wei
In the research of directly synthesizing H-form ZSM-5, ammonium hydroxide is commonly used as an alkali source instead of NaOH to avoid multiple ion exchange steps. However, the volatile nature and the lack of structure-directing effect of ammonium hydroxide limit its application in practical. In this study, n -butylamine (NBA) was used as the main alkali source to directly prepare HZSM-5 zeolites with SiO 2 /Al 2 O 3 ratios ranging from 40 to 300 under traditional hydrothermal conditions. The influence of the amount of NBA, ethanol, seed, and pre-crystallization on the synthesis products was investigated under the condition of SiO 2 /Al 2 O 3 = 80. Theoretical simulation suggested that n -butylamine cations (NBA + ) play the most potent directing role in the formation of the MFI structure but could lead to difficulties in removal during calcination. The addition of ethanol as the zeolite growth modifier (ZGM) could decrease the usage of NBA and reduce the difficulties in calcination, and the addition of seed provided the conditions for initiating crystallization in the system that could not spontaneously nucleate. HZSM-5 with different SiO 2 /Al 2 O 3 ratios were prepared under the optimal crystallization conditions, and the as-synthesized samples exhibited superior textural and acid properties compared to commercial zeolite. Finally, the 1 L scale-up synthesis and MTP reaction were conducted to demonstrate the practicality of this economically and environmentally-friendly synthesis strategy.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
Molecular Catalysis
·
2023
·
IF 4.6
Xiaozhong Wang,Jiali Hu,Cai Xu,Yingqi Chen,Liyan Dai
Herein, a series of NiCu/Al 2 O 3 catalysts were prepared by impregnation method and subsequent thermal treatment under different reduction temperatures. The catalysts exhibited excellent catalytic activity for the amination of diethylene glycol (DEG), and satisfactory yield of tertiarybutylaminoethoxyethanol (TBEE) could be obtained. XRD, N 2 adsorption-desorption, SEM, TEM, XPS, and H 2 -TPR were employed to characterize the catalysts, the interaction between Ni and Cu on the catalytic activity was studied. It was found that NiCu alloy was formed after catalyst reduction, which strengthened the reduction ability of NiO and increased the number of Ni 0 active center, contributing to the enhanced catalytic activity. Moreover, the effects of reaction parameters on catalytic activity were explored. There was no need for a solvent, only 3 molar equivalents of tert‑butylamine (TBA) and 1 wt.% catalyst was required. After 7 h of reaction at 220 °C, satisfactory conversion (89.6%) and selectivity (84.6%) were obtained over the prepared catalyst. Cycle experiment demonstrated that the prepared catalyst retained excellent stability and reusability after six runs without significant loss of catalytic activity. This work provided an efficient catalyst for the catalytic amination of diethylene glycol with tert‑butylamine to TBEE.
研究领域:
化学工程
·
催化科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2021
·
IF 3.196
Xuejuan Yang,Yanhong Zhu,Xinlei Chen,Xingjun Gao,Shouwen Jin,Bin Liu,Li He,Bin Chen,Daqi Wang
Cocrystallization of the simplest bulky organic amine, tert‑butylamine (L), with a series of organic acids got a whole of 10 anhydrous salts with the compositions: tert‑butylammonium 2-(4-chlorophenoxy)-2-methylpropionate [(HL) + ·(cpmppa − ), cpmppa − =2-(4-chlorophenoxy)-2-methylpropionate] (1) , bis(tert‑butylammonium) dibenzoyl- l -tartarate [(HL + ) 2 ·(dbztat) 2− , (dbztat) 2- = dibenzoyl- l -tartarate] (2) , tert‑butylammonium pyrazinecarboxylate [(HL + )·(pyrca) − , pyrca = pyrazinecarboxylate] (3) , tert‑butylammonium 2-(4-chlorobenzoyl)benzoate [(HL + )·(cbzbz) − , cbzbz = 2-(4-chlorobenzoyl)benzoate] (4) , tert‑butylammonium 3-methylsalicylate [(HL + )·(3-msal) − , 3-msal = 3-methylsalicylate] (5) , tert‑butylammonium 4-methylsalicylate [(HL + )·(4-msal) − , 4-msal = 3-methylsalicylate] (6) , tert‑butylammonium 2‑chloro-4-nitrobenzoate [(HL + )·(cnba) − , cnba = 2‑chloro-4-nitrobenzoate] (7) , tert‑butylammonium 4‑bromo-3,5-dimethoxy benzoate [(HL + )·(bdmbza) − , bdmbza = 4‑bromo-3,5-dimethoxy benzoate] (8) , tert‑butylammonium 3,5-diiodosalicylate [(HL + )·(didsal) − , didsal = 3,5-diiodosalicylate] (9) and tert‑butylammonium 3,5,6-trichlorosalicylate [(HL + )·(tcsal) − , tcsal =3,5,6-trichlorosalicylate] (10) . The salts have been featured by XRD, IR and EA, the melting points were also gauged. Their structural and supramolecular aspects are analyzed in detail; all compounds are ionic with H-transferring to the tert‑butylamine. The result unveils that among the whole investigated crystals the NH 2 units in L are protonated when the acids are deprotonated and the crystal packing is interpreted via the strong charge-assisted N H⋯O H-bond from the NH 3 + and the CO 2 − . Apart from the N H⋯O H-bond, the O H···O H-bonds were also found at 5, 6, 9 and 10. 3, 9 and 10 had the additional N H⋯N, N H···I and N H···Cl H-bonds, respectively. Deep analysis of the crystal packing uncovered that a different set of additional O···O, Cl···Cl, Cl···O, Br···O, I···I, CH 3 ···C, CH 3 ···CH, CH 3 ···CH 3 , CH···O/CH 3 ···O, CH 3 ···Cl and CH 3 ···π contacts contribute to the stabilization and expansion of the total structures. For the synergism of the various nonbonding forces these structures had the homo/hetero supramolecular synthons. Some classical synthons of R 2 2 (8), R 4 2 (8), R 4 3 (10) and R 4 4 (12), commonly contained in solids of organic acids with amine, were present in these hydrogen bonding nets.
研究领域:
化学
·
晶体学
·
超分子化学
✓ 已验证
DOI
高影响因子
Analytical Methods
·
2014
·Vol. 6
·期 12
·4228-4233
·
IF 1.938
Liqiang Liu,Huang Kuang,Chifang Peng,Libing Wang,Chuanlai Xu
Salbutamol (SAL) is a short-acting β2-adrenergic receptor agonist (β-agonist) forbidden in livestock production. To develop a more sensitive and specific detection method for SAL, a new hapten was synthesized, keeping the structure of benzene ring side of SAL while changing the tert-butyl group structure that SAL shares with other β-agonists. Ten mice were immunized with a SAL hapten–keyhole limpet hemocyanin (KLH) conjugate, and cells were selected within a urine sample at the cell fusion stage. The best monoclonal antibody (Mab) had an IC50 value of 0.31 ng mL−1 in PBST buffer and an IC50 value of 0.19 ng mL−1 in a swine urine sample diluted five times (with a lower B0 value), and had no cross-reactivity with clenbuterol and other β-agonists. These results show that the hapten design was successful and that the Mab can potentially be used in highly sensitive immunoassays for specifically monitoring the illegal use of SAL in real samples.
研究领域:
免疫学
·
药物检测
·
动物医学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2017
·Vol. 184
·期 3
·961-968
·
IF 4.58
Dong Tiantian,Tang Qinghui,Zhao Kang,Deng Anping,Li Jianguo
The authors describe a dual signal amplification electrochemiluminescent (ECL) immunoassay for ultrasensitive determination of the β-adrenergic agonist salbutamol (SAL). It is based on the use of gold nanoparticles (AuNPs) and silica-coated quantum dots of the type CdSe@SiO 2 . The CdSe@SiO 2 nanoparticles (NPs) were synthesized by water-in-oil reversed-phase microemulsion. Amino-modified NPs were then prepared and used as an ECL signal probe for detection of SAL in the presence of K 2 S 2 O 8 . The gold NPs with their large specific surface carry the antigen, facilitate electron transfer and improve the electrochemical reaction efficiency of QDs and K 2 S 2 O 8 . The ECL immunosensor was fabricated by coating the AuNPs with antigen, and then SAL competed with SAL antigen for the binding sites of the antibody on the CdSe@SiO 2 NPs. Under optimized conditions, the ECL intensity is linearly related to the logarithm of the SAL concentration in the range from 0.001 to 1000 ng mL −1 , with a lower detection limit of 0.17 pg mL −1 (at an S/N ratio of 3). The assay has good operational stability, is highly sensitive and selective. It is judged to possess a wider scope in that it may be applied to many other small molecule analytes for which adequate antibodies are available.
Schematic of a dual signal amplification electrochemiluminescent immunoassay for ultrasensitive detection of the β-adrenergic agonist salbutamol based on the use of gold nanoparticles and CdSe@SiO 2 .
研究领域:
分析化学
·
生物医学工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
LIQUID CRYSTALS
·
2022
·
IF 2.676
Yuxian Zhang,Zhou Yang,Qiong-Hua Wang
We propose an optical sensor based on the inverse opal (IOP) photonic structure infiltrated by a typical liquid crystalline material doped by the reactive compounds. Benefiting from the unique photonic property of the IOP structure, the composite sensor shows not only a typical textural change but also a responsive photonic band gap (PBG) upon the exposure to butylamine (BA) vapour, due to the reorientation of the liquid crystalline molecules induced by the chemical reaction between the dopant and the BA vapour. This approach simplifies the measurement process by capturing the PBG signal instead of the polarised optical texture, which does not require high cost or complex instruments and might be instructive for detecting other volatiles.
研究领域:
材料科学
·
化学传感
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2025
·
IF 5.6
Yifei Wang,Kangfu Zhou,Chuanjun Ye,Yazhuo Shang,Feifei Wang
Microemulsions are thermodynamically stable and homogeneously dispersed systems formed spontaneously by water, oil, surfactants, and co-surfactants at specific proportions under specific conditions. Microemulsions can not only dissolve certain active ingredients to achieve protection and slow release, but also effectively promote their transdermal absorption, further improving the bioavailability due to the nanoscale of the emulsion droplets. In this study, microemulsions formulated with surfactant polyethylene glycol (PEG) fatty acid glycerides were prepared and the effects of oil property, the amphiphilicity of surfactant, the types of co-surfactants, the main/co-surfactant mixing ratio ( K m ) as well as the temperature, pH, ionic strength of the systems on the phase behavior of the studied system were discussed in the framework of the pseudo-ternary phase diagram. The results indicate that lower polarity oils are more likely to form microemulsions constructed by PEG fatty acid glycerides. The formation of microemulsion depends much on the amphiphilicity of surfactant; PEG fatty acid glycerides with higher hydrophile-lipophile balance (HLB) facilitate the formation of microemulsions. The shorter the chain length of co-surfactant (alcohols), the easier it is for the formation of microemulsion. For alcohols with a certain number of carbon chains, the fewer the hydroxyl groups, the easier it is to form microemulsions. This study identifies an optimal K m of 2:1. Based on the fact that PEG fatty acid glycerides are nonionic surfactants, the prepared microemulsions have a good tolerance to pH fluctuations (pH 4–9) and keep stable within a wide temperature range, which enable the microemulsions to be applied in variable environments. The higher concentration salt inhibits microemulsion formation in some degree though the lower concentration salt has no obvious effect on the formation of microemulsion. Furthermore, the types of microemulsions in the single-phase region were further identified, and the microstructure of microemulsions formulated with PEG fatty acid glycerides was investigated by transmission electron microscopy (TEM). Typical spherical oil-in-water (O/W) microemulsions, uniformly distributed water-in-oil (W/O) microemulsions, and the characteristic network structure of bicontinuous microemulsions were observed. On this basis, the water-soluble nicotinamide was singled out to study the transdermal behavior of substance in oil-in-water microemulsion and in traditional emulsion. The results indicate that the substance in microemulsion have better transdermal property compared with conventional emulsion. The present work provides not only fundamental information for the preparation of microemulsions formulated with PEG fatty acid glycerides but also the reference for its application in practice.
研究领域:
药剂学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Jie Cheng,Xiao-Ou Su,Caiqin Han,Shi Wang,Peilong Wang,Su Zhang,Jianchun Xie
Salbutamol (SAL) is a β 2 -adrenergic receptor, which could produce leaner meat with a higher muscle to fat ratio for livestock, has been prohibited for use in animal farming in many countries because of its harmful effect to the health of consumers. In this study, we present a novel method based on surface-enhanced Raman spectroscopy (SERS) for the sensitive and quantitative detection of trace amount of SAL in animal urine samples by reoxidized graphene oxide/gold nanoparticle hybrids (rGO/AuNPs) substrates and the immunomagnetic bead sample treatment. Compared with the regular graphene/gold nanoparticles (GO/AuNPs) substrates, the rGO/AuNPs substrates by the second oxidization pretreatment exhibited an excellent SERS activity with an enhancement factor of ∼10 8 . Under the optimal detection conditions, the limit of detection of SAL in urine sample is 0.5 ng mL −1 with a linear response of the matrix-matched calibration standard curves range from 1.0–20 ng mL −1 , and the recovery of SAL from spiked urine samples are in the range of 85.2–92.5% with the relative standard deviations (RSD) values <3.18%. The inter- and intra- day detection precisions is less than 6.28%, and the storage time of the substrates is no less than 4 weeks under 4 °C temperature. The results of the proposed SERS detection method agree well with those determined by LC–MS/MS, while the detection time is significantly reduced to 15 min/sample. All these are demonstrated to be a reliable, rapid, simple and ultrasensitive analytical method for detecting SAL in urine samples, and could also be applied for the routine monitoring of the illicit use of SAL in animal farming.
研究领域:
分析化学
·
食品安全
·
生物医学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Hao Ren,Jiaqi Liu,Fenhong Su,Sizhan Ge,Ahu Yuan,Weimin Dai,Jinhui Wu,Yiqiao Hu
Photodynamic therapy (PDT) is hampered by poor water solubility and skin phototoxicity of photosensitizers (PSs). Incorporation of PSs into nanocarrier (Nano-PDT) has been designed to overcome these problems. However, self-quenching of PSs highly condensed in Nano-PDT significantly reduced singlet oxygen (1O2) generation, resulting in unsatisfactory PDT efficacy. Here, we developed a novel tripleffect Nano-PDT, which has a special core–shell nanostructure by synergistic integration of perfluorotributylamine (PFTBA) and human serum albumin (HSA) to improve PDT. It has three mechanisms to relight quenched PSs, thereby generating more 1O2. First, PSs uniformly dispersed in the shell, preventing self-quenching caused by π–π stacking. Second, HSA as nanocarrier extends the triplet-state lifetimes of PSs, increasing the amount of 1O2. Third, PFTBA as core dissolves and protects1 O2 to extend the duration time of action of 1O2. Compared with PS-encapsulated Nano-PDT, the self-quenching of PSs in tripleffect Nano-PDT can be effectively overcome. The fluorescence and 1O2 generation of PS are increased by approximately 100-fold and 15-fold, respectively. After intravenous injection into tumor-bearing mice, the tumor growth is significantly inhibited, while the PS-encapsulated Nano-PDT has almost no effect. The novel tripleffect Nano-PDT may guide improvement of existing clinical PDT and future PDT design.
研究领域:
生物医学工程
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Analytical Methods
·
2016
·Vol. 9
·期 12
·3396-3406
·
IF 2.167
Zhang Xiang,Chu Yanxin,Yang Hong,Zhao Kang,Li Jianguo,Du Haijing,She Pei,Deng Anping
Salbutamol (SAL), a kind of β-agonist which can enhance the lean meat-to-fat ratio, has been inhibited as an additive used in animal feeds for livestock production in many countries due to its harmful effect to the consumers. In this study, an ultrasensitive and specific competitive immunochromatographic test (ICT) integrated with surface-enhanced Raman scattering (SERS) for the detection of SAL was described. The immunoprobe was prepared by immobilizing polyclonal antibody against SAL on the surface of Au@Ag nanoparticles in which the Raman reporter (4-mercaptobenzoic acid, MBA) had been sandwiched. After ICT procedures, the specific SERS signals generated from MBA on the test line of the ICT strip were measured for the quantitative determination of SAL. The assay was completed in 15 min. The IC 50 and the limit of detection (LOD) values of the assay for SAL were 0.028 ng mL −1 and 3.0 pg mL −1 , respectively. There was no cross-reactivity (CR) of the assay with other three β-agonists (clenbuterol, phenylethanolamine A, and ractopamine), showing high specificity of the assay. Spiking experiments indicated that the average recoveries ( n = 3) of SAL from swine feed, meat, and urine samples were in ranges of 98.4–105.2 % with the relative standard deviations (RSDs) of 1.7–7.8 %. The results demonstrated that the proposed ICT was a feasible method for ultrasensitive and specific detection SAL in swine feed, meat and urine samples, and could be extended for the detection of other target analytes.
研究领域:
食品安全
·
分析化学
·
兽医学
✓ 已验证
产品关联
DOI
高影响因子
Analytical Methods
·
2014
·Vol. 6
·期 6
·1928-1935
·
IF 1.938
Yinfeng Li,Zhuo Ye,Peili Luo,Ying Li,Baoxian Ye
A novel voltammetric sensor for salbutamol is fabricated via self-assembly of gold nanoparticles on multi-walled carbon nanotubes and Nafion modified electrode. This sensor could improve the oxidation of salbutamol intensively. The oxidation process of salbutamol is studied and some dynamic parameters are calculated using various electrochemical techniques. Under the optimum conditions, the response peak currents have a linear relationship with the salbutamol concentrations in the range of 9.0 × 10−8 to 7.0 × 10−6 mol L−1 with a detectable limit of 5.0 × 10−8 mol L−1. The proposed method is successfully applied to the determination of salbutamol in commercial pharmaceuticals and human serum samples with good accuracy and satisfactory recovery.
研究领域:
分析化学
·
药物分析
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry C
·
2016
·Vol. 5
·期 2
·427-433
·
IF 5.066
Rongguo Wang,Xiaolong Lu,Lifeng Hao,Weicheng Jiao,Wenbo Liu,Jian Zhang,Feng Yuan,Fan Yang
Orthorhombic molybdenum trioxide (α-MoO3) as one kind of potential inorganic photochromic material shows a slow response, poor reversibility and monotonic coloration. Here, we provide an efficient way to improve and tune the photochromism of MoO3. Novel inorganic–organic hybrid composites were successfully prepared by intercalating n-butylamine into the layer space of α-MoO3 and enhanced photochromic properties such as a fast response, superior reversibility, and good stability were achieved. Meanwhile, the solutions of as-prepared hybrids showed solvent-dependent discoloration due to the hole scavenger effect of ethanol. A reversible transformation between an intermediate state and an enhanced, but stable state was realized by switching irradiation. The improved photochromism caused the solutions of hybrids to show diverse discoloration varying from yellow to green to blue color.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）