Current Research in Food Science
·
2024
·
IF 6.2
Qiaoyan Wu,Yang Yang,Yue Xu,Bing Wang,Xiaofei Liu,Yan Wang,Guang Zhang,Xin Bian,Chunmin Ma,Na Zhang
Rice is a food with a high starch content, comprising over 75% of its composition. However, prolonged and excessive consumption of this cereal may lead to elevated blood glucose levels, which can increase the risk of obesity, type 2 diabetes, and cardiovascular disease. Butyric acid (BA), the primary energy source for colonic epithelial cells, exhibits the highest utilization rate among short-chain fatty acids, underscoring its importance for human health. In this study, rice starch butyrate (RSB) samples were synthesized using the aqueous phase process, with broken rice starch (RS) and butyric anhydride serving as the substrate. RSB samples with different degrees of substitution (DS) were produced by modulating the addition amount of butyric anhydride. The crystal structures, morphology of starch granules, pasting properties, thermal stability, and in vitro digestibilities of the RSB were investigated and compared with those of native rice starch. Fourier transform infrared (FTIR) spectroscopy confirmed the successful incorporation of butyryl into the starch molecules. With the increase in DS, the roughness of the RSB material's surface gradually increased, leading to the deterioration of the smooth structure on certain surfaces, which resulted in the appearance of cracks and collapses. Additionally, the crystallinity diminished from 24.77% to 7.41% with increasing DS. Concurrently, in vitro digestive characterisation revealed that the percentage of resistant starch increased from 24.33% to 47.72%. Thus, this study can provide a theoretical basis for the development of novel products of amyl butyrate.
研究领域:
食品科学
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营养学
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生物化学
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DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Fuyue Dong,Wei Gao,Pengfei Liu,Xuemin Kang,Bin Yu,Bo Cui
In this study, microcrystalline butyrylated pea starch (MBPS) with higher contents of resistant starch (RS) was synthesized via esterification with butyric anhydride (BA) using microcrystalline pea starch (MPS) as the raw material. With the addition of BA, the new characteristic peaks appeared at 1739 cm −1 and 0.85 ppm obtained from FTIR and 1 H NMR, respectively, and increased with the higher degree of BA substitution. Moreover, an irregular shape of MBPS, such as condensed particles and more cracks or fragments, had been observed by SEM. Further, the relative crystallinity of MPS increased then native pea starch and decreased with the reaction of esterification. MBPS had higher decomposition onset temperature (T o ) and temperature of maximum decomposition (T max ) with increasing DS values. Simultaneously, an increasing trend RS content from 63.04 % to 94.11 % and a decreasing trends in rapidly digestible starch (RDS) and slowly digestible starch (SDS) contents of MBPS were recorded with increasing DS values. MBPS samples showed higher production capacity of butyric acid ranging from 553.82 μmol/L to 892.64 μmol/L during the fermentation process . Compared with MPS, the functional properties of MBPS were significantly improved.
研究领域:
食品科学
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化学
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营养学
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DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·Vol. 141
·期 33
·e55847
·
IF 2.7
Chao Zhang,Erlei Yu,Heyun Wang,Dong Huang,Guojun Ding,Zhonghua Zhao,Zhong Wei
In response to the health and environmental concerns associated with the plasticizer dioctyl phthalate (DOP), this research explores the utilization of methyl oleate (MO) derived from plant oil, 1,2,4-Benzeneticarboxylic anhydride (TMA) and isobutyric anhydride (IA) as a precursor for synthesizing a hyperbranched polyester named IA-MO-TMA. This polyester serves as an alternative plasticizer for Polyvinyl chloride (PVC). The chemical structure of IA-MO-TMA was thoroughly characterized using Fourier Transform Infrared Spectrometer (FTIR) and nuclear magnetic resonance hydrogen spectra, and its molecular weight was assessed. The PVC film, plasticized with IA-MO-TMA, underwent comprehensive testing using techniques such as differential scanning calorimetry, scanning electron microscopy, and thermogravimetric analysis. Notably, the glass transition temperature ( T g ) of the plasticized PVC film exhibited a significant reduction from 75°C to −6.7°C. The plasticized film demonstrated an elongation at break of 318.1%, a tensile strength of 19.2 MPa, and a plasticizing efficiency of 109.9%. Moreover, the use of IA-MO-TMA as a plasticizer increased the initial decomposition temperature of PVC film from 235.6 to 264.1°C. Additionally, the extraction rate of IA-MO-TMA in petroleum ether was found to be 35.6% lower than that of DOP.
研究领域:
材料科学
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高分子化学
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环境科学
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产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Ting Liu,Guorong Chen,Chunxiang Zhao,Jiajia Fu,Agui Xie,Beilei Cai,Luyong Zhang,Huixia Lv
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by barrier dysfunction, immune dysregulation, and oxidative stress. Effective therapy requires strategies that improve local drug retention while addressing both inflammation and barrier repair. In this study, hyaluronic acid–butyrate (HAB) conjugates with different molecular weights were synthesized and evaluated as dual-functional therapeutics for AD. IVPT using normal and AD-like skin demonstrated that HAB, particularly 5 k-HAB, achieved superior penetration and markedly enhanced skin retention (6.47-fold) compared with free butyrate. These improvements were attributed to inflammation-responsive mechanisms: CD44 overexpression in diseased skin, which promotes HA-mediated targeting, and elevated CES2 activity, which triggers local butyrate release. In a DNFB-induced mouse model, 5 k-HAB significantly accelerated lesion resolution, reduced trans-epidermal water loss and erythema, restored hydration, and normalized epidermal structure. Mechanistic studies revealed that 5 k-HAB synergistically promotes keratinocyte proliferation, mitigates oxidative stress, upregulates key barrier proteins, and suppresses inflammatory cytokines more effectively than HA, free butyrate, or higher-MW conjugates. These results highlight the critical importance of using disease-relevant skin models for evaluating dermal drug delivery and show that enhancing local retention is more impactful than penetration alone. Collectively, 5 k-HAB demonstrates a rational, multifunctional approach for targeted transdermal therapy of AD and other inflammatory skin disorders.
研究领域:
皮肤病学
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药物递送
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生物材料
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炎症性皮肤病
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纳米医学
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产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2025
·
IF 5.4
Yu Sun,Li Cui,Wanqiu Peng,Rong Chen,Xueneng Guan,Jiangyun Liu
Parkinson’s disease (PD) is difficult to treat clinically and lacks an effective treatment. The aim of this study was to synthesize and characterize butyrate-modified hyaluronic acid (HA-But), validate its therapeutic efficacy, and elucidate its mechanisms of action in PD. Behavioral tests, including the open field test, Y-maze, and elevated plus maze test, demonstrated that HA-But significantly alleviated motor dysfunction in PD mice. ELISA results indicated a marked reduction in pro-inflammatory cytokine levels following the HA-But treatment. In addition, immunohistochemistry, immunofluorescence, and Western blot analyses revealed that HA-But improved dopaminergic neuron survival and reduced α-synuclein aggregation. Furthermore, HA-But activated PINK1/Parkin-mediated mitophagy, modulated gut microbiota composition, and increased short-chain fatty acid (SCFA) levels, especially butyric acid. Combining HA-But with gastrodin further improved the PD symptoms in mice. These findings suggested the potential of HA-But as a novel approach for PD treatment.
研究领域:
神经科学
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药学
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分子生物学
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肠脑轴
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神经退行性疾病
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产品关联
DOI
PubMed
高影响因子
Acta Pharmaceutica Sinica B
·
2025
·
IF 14.6
Nan Wang,Lingling Wu,Yaya Su,Chi Zhang,Xu Chen,Hailong Yuan
Atopic dermatitis (AD) is a prevalent cutaneous condition with chronic inflammation and immune dysregulation, posing a public health concern owing to its long-lasting and recurrent nature. Butyrate, a short-chain fatty acid produced by gut microbiota, exhibits significant anti-inflammatory effects in AD. Yet, its delivery via butyrylated starch for prolonged release in the colon has not been adequately investigated. In this study, butyrylated Smilax glabra starch (BSGS) was synthesized and its therapeutic potential against AD via modulation of the gut–skin axis was examined. BSGS exhibited a C-type crystalline structure and highly resistance to gastrointestinal digestion. In vitro anaerobic fermentation showed that BSGS effectively promoted the generation of short-chain fatty acids, especially butyrate, and positively influenced the gut microbial composition. In AD mice, BSGS administration considerably mitigated cutaneous inflammation, lowered serum proinflammatory cytokines, restored intestinal barrier integrity, and modulated gut microbiota by increasing Bacteroides and norank_f__Prevotellaceae while decreasing Alistipes and norank_o__RF39 . This therapeutic effect was associated with butyrate release and NF- κ B pathway suppression, as evidenced by the reduced phosphorylation of p65 and I κ B α . These findings establish that BSGS, a novel colon-targeted butyrate donor, holds promising potential in AD treatment by modulating the immune system via the gut–skin axis.
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产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2012
·
IF 3.628
Yihao Luan,Jinming Zhang,Maosheng Zhan,Jin Wu,Jun Zhang,Jiasong He
Using 4-dimethylaminopyridine (DMAP) as the catalyst, highly efficient propionylation and butyralation of cellulose were successfully carried out in an ionic liquid 1-allyl-3-methylimidazolium chloride (AmimCl) under mild conditions. Cellulose propionate (CP) and cellulose butyrate (CB) with a degree of substitution (DS) in the range from 0.89 to 2.89 were synthesized within only 30 min at 30 °C. The DS values of the products could be well controlled just by molar ratio of acid anhydride/anhydroglucose unit (AGU). More interestingly, the conversions of acid anhydrides in both propionylation and butyralation were as high as above 90%, even 96%. Therefore, this work provides a facile and highly efficient way for the synthesis of cellulose esters CP and CB.
研究领域:
化学工程
·
材料科学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Ran Meng,Pin Chen,Ran Feng,Han Tao,Bao Zhang,Dong-Lin Su
In present study, bilayer emulsions with different interfacial structures stabilized by casein/butyrylated dextrin nanoparticles (CDNP), chitosan (CS) and chitosan nanoparticles (CSNP) were prepared to overcome the limitations of conventional emulsions. The effects of chitosan morphology and incorporation sequences on the bilayer emulsions were examined. Bilayer emulsions prepared with CDNP as the inner layer and CS/CSNP as the outer layer were observed to have smaller droplet sizes (1.39 ± 86.74 um and 1.45 ± 7.87 um). Bilayer emulsions prepared with CDNP as the inner layer and CS as the outer layer exhibited the lowest creaming index (2.38 %) after 14 days of storage, indicating excellent stability. Furthermore, bilayer emulsion prepared with CDNP as the inner layer and CS as the outer layer also exhibited a uniform water distribution, excellent protein oxidative stability, and uniformly distributed droplets by the measurement of Low-field NMR, intrinsic tryptophan fluorescence and laser confocal laser scanning microscopy. These results indicated that the study provided a theoretical basis for the development and design of bilayer emulsions with different interfacial structures. This study also provides a new material for the preparation of delivery systems that protect biologically active compounds. Bilayer emulsions are promising for applications in traditional and manufactured food products.
研究领域:
食品科学
·
材料科学
·
生物化学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Xinyu Wang,Guangyu Rong,Junjie Yan,Donghui Pan,Lizhen Wang,Yuping Xu,Min Yang,Yiyun Cheng
Fluorinated polymers have attracted increasing attention in gene delivery and cytosolic protein delivery in recent years. In vivo tracking of fluorinated polymers will be of great importance to evaluate their biodistribution, clearance, and safety. However, tracking of polymeric carriers without changing their chemical structures remains a huge challenge. Herein, we reported a series of fluorinated poly-l-(lysine) (F-PLL) with high gene transfection efficiency and excellent biodegradation. Radionuclide 18F was radiolabeled on F-PLL by halogen replacement without chemical modification. The radiolabeling of F-PLL offers positron emission tomography (PET) imaging for in vivo tracking of the polymers. The biodistribution of F-PLL and the DNA complexes revealed by micro-PET imaging illustrated the rapid clearance of fluorinated polymers from liver and intestine after intravenous administration. The results demonstrated that the polymer F-PLL will not be accumulated in the liver and spleen when administrated as a gene carrier. This work presents a new strategy for in vivo tracking fluorinated polymers via PET imaging.
研究领域:
药学
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生物医学工程
·
核医学
·
基因治疗
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产品关联
DOI
PubMed
高影响因子
MEDICINAL CHEMISTRY RESEARCH
·
2021
·Vol. 30
·期 6
·1240-1248
·
IF 1.965
Shi Bo-Ya,Wang Ze-Hao,Zhang Ning,Xie Yin-Rong,Sun Xiu-Li,Yang Hao-Nan,Wu Yi-Long,Zi Cheng-Ting,Wang Xuan-Jun,Sheng Jun
Novel glucosylated (-)-epigallocatechin-3-gallate derivatives 10 – 13 having the EGCG analogs conjugated to the d -glucosyl azide were synthesized by carrying out the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, and were evaluated for their cytotoxicities against a panel of five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480) using MTT assays. Compounds 10 and 11 showed the highest levels of cytotoxicity against the HL-60 cells with IC 50 values of 4.57 and 3.78 μM, respectively, and showed moderate selectivity toward cancer cell lines. Compound 11 was also shown to induce apoptosis in HL-60 cells. Most notably, inclusion of the perbutyrylated glucose residue in an EGCG derivative was concluded to lead to increased anticancer activity.
研究领域:
药物化学
·
肿瘤学
·
有机合成
✓ 已验证
产品关联
DOI
高影响因子
RENEWABLE ENERGY
·
2020
·
IF 6.274
Zhong Dai,Peng-Gang Ren,Wenwei He,Xin Hou,Fang Ren,Qian Zhang,Yan-Ling Jin
A facile esterification and electrospinning method is utilized to convert the waste lignin into nitrogen-oxygen co-doped esterified lignin/polyacrylonitrile based carbon nanofibers (E-CNFs). The analysis of FTIR and H 1 -NMR shows that the esterification reaction occurs between the hydroxyl group and the anhydride group and the ester bond is established in precursor. The lignin after esterification has lower glass transition temperature (Tg), and hence the obtained E-CNFs exhibit inter-fiber bonding structure, higher heteroatom content , and better wettability, rendering an efficient electron transport network and contributing pseudo capacitance . Such unique structure and morphology endow E-CNFs electrode with ultra-high specific capacitance of 320 F g −1 at 1 A g −1 and 200.4 F g −1 at 20 A g −1 with 6 M KOH aqueous as electrolyte, revealing outstanding rate capability. Moreover, the assembled E-CNFs//E-CNFs symmetric supercapacitors using 1 M Na 2 SO 4 aqueous as electrolyte deliver a high coulombic efficiency of 112.5% at the current density 1 A g −1 , a remarkable energy density of 17.92 Wh kg −1 at the power density of 800 W kg −1 , and excellent cycling stability (∼5.5% loss after 5000 cycles). This inter-fiber bonding structure control strategy provides a perspective and avenue for the further development of high-performance electrode material for supercapacitors applications.
研究领域:
材料科学
·
能源存储
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产品关联
DOI
高影响因子
Polymers
·
2019
·Vol. 11
·期 12
·1968
·
IF 3.164
Wei Chen,Xin-Tong Meng,Hui-Hui Wang,Xue-Qin Zhang,Yi Wei,Zeng-Yong Li,Di Li,Ai-Ping Zhang,Chuan-Fu Liu
Recently, the nanofiber materials derived from natural polymers instead of petroleum-based polymers by electrospinning have aroused a great deal of interests. The lignocellulosic biomass could not be electrospun into nanofiber directly due to its poor solubility. Here, sugarcane bagasse (SCB) was subjected to the homogeneous esterification with different anhydrides, and the corresponding esterified products (SCB-A) were obtained. It was found that the bead-free and uniform nanofibers were obtained via electrospinning even when the mass fraction of acetylated SCB was 70%. According to the thermogravimetric analyses, the addition of SCB-A could improve the thermal stability of the electrospun composite nanofibers. More importantly, in contrast to the pure polyacrylonitrile (PAN) based carbon nanofiber, the SCB-A based carbon nanofibers had higher electrical conductivity and the surface N element content. In addition, the superfine carbon nanofiber mats with minimum average diameter of 117.0 ± 13.7 nm derived from SCB-A were obtained, which results in a larger Brunauer–Emmett–Teller (BET) surface area than pure PAN based carbon nanofiber. These results demonstrated that the combination of the homogeneous esterification and electrospinning could be a feasible and potential way to produce the bio-based carbon nanofibers directly from lignocellulosic without component separation.Keywords:electrospinning;homogeneous esterification;acid anhydrides;carbon nanofiber;lignocellulosic biomass
研究领域:
材料科学
·
生物工程
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）