SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Hongli Ma,Yuying Deng,Shuo Wang,Xiang Li,Kaiyan Wu,Honglei Fan,Hongliang Liu
Bio-butanol stands as a notable alternative fuel, predominantly produced through the acetone-butanol-ethanol (ABE) fermentation of saccharide substrates. However, the low concentration, intricate mixture, and azeotropic characteristics of the fermentation byproducts pose significant challenges, making the traditional separation process of biobutanol energy-intensive and expensive, thus hindering its industrial-scale application. This study introduces an innovative and eco-friendly separation process that integrates a pervaporation-fractional condensation (PV-FC) with a superwetting membrane (SWM). The PV-FC efficiently extracts ABE from the solution and effectively isolates n-butanol from acetone and ethanol, enabling Condenser 1 to yield a product primarily composed of n-butanol and water. Subsequently, in the SWM process, n-butanol and water are separated through salt-enhanced phase separation. Notably, n-butanol rapidly permeates through the membrane due to its nonpolar interactions with the SWM, resulting in an exceptionally high n-butanol content of 99.2 wt%. By integrating PV-FC and SWM, we have successfully achieved an environmentally friendly and efficient n-butanol separation process, offering substantial promise for practical n-butanol production.
研究领域:
生物化学工程
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环境科学
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产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2020
·
IF 2.888
Xingchuan Yang,Huanxin Li,Chunmei Cao,Li Xu,Guoji Liu
Liquid-liquid equilibria (LLE) data for ternary systems of water + 1,6-hexanediol + 1-pentanol/ 3-methyl-1-butanol/ 2-methyl-2-butanol were measured at (293.15, 303.15, 313.15 and 323.15) K under 101.3 kPa. Cloud-point method was applied to determine the solubility curves data. Distribution coefficient and separation factors for 1,6-hexanediol were calculated from the measured tie-line data to evaluate the extraction effect of alcohols on 1,6-hexanediol. The reliability of experimental LLE data were tested by Othmer–Tobias equation and Hand equation, NRTL and UNIQUAC models were applied to correlate the measured data and the calculated results show that both models can fit the experimental data very well.
研究领域:
化学工程
·
热力学
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DOI
高影响因子
ELECTROCHEMISTRY
·
2018
·Vol. 86
·期 4
·153-157
·
IF 1.074
Xiyun YANG,Jianfeng ZHANG,Shenghai YANG,Niuchang OUYANG
To understand the role of water on zirconium passivation in n-butanol solutions containing Bun4NBr, composition and corrosion properties of the passive film were studied using cyclic voltammetry, X-ray photoelectron and electrochemical impedance spectroscopy. Zirconium undergoes spontaneous passivation followed by pitting corrosion as a result of passivity breakdown by the aggressive attack of bromide anions. The passive film consists mainly of ZrO2, ZrO2·2H2O and a small amount of zirconium butoxide. The pitting potential shifts positively and pitting corrosion is seriously inhibited with the addition of a small amount of water. Water improves the pitting corrosion resistance of the passive film by changing the thickness and the relative ratio of OH−/O2−. The result is helpful to electrosynthesize zirconium butoxide with high energy efficiency.
研究领域:
材料科学
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电化学
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产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Jijuan Zhou,Dianlong Ge,Yue Liu,Yajing Chu,Xiangxue Zheng,Yan Lu,Yannan Chu
Cellular volatile organic compound (VOC) detection is crucial for studying lung cancer biomarkers. However, the reported VOC biomarkers from the same cell line seem to be inconsistent across different research groups. It is possibly related to the variation in culture media, and the result obtained by a conventional single medium approach (SMA) depends on what medium is used in the cell experiment. This study proposes a multiple media approach (MMA) to investigate reproducible characteristic VOCs of lung cancer cells. Using solid-phase microextraction–gas chromatography–mass spectrometry (SPME-GC-MS) in combination with untargeted analysis, we conducted two independently repetitive experiments to compare lung cancer cells (A549) and normal lung cells (BEAS-2B) under three culture media conditions (RPMI 1640, DMEM, and Ham’s F12). Both experiments indicated that, compared with 62–96 VOCs obtained by the SMA, only two VOCs (3-methyl-1-butanol and 2-methyl-1-butanol) were reproducibly achieved by the MMA. Moreover, their concentrations were significantly lower in lung cancer cells than in normal cells. Further targeted analysis confirmed the downregulation trend of both VOCs in subcutaneous and primary tumor tissues from the lung cancer model mouse. The present work demonstrated that the MMA cell experiment, just like the multicenter trials for cell lines, can facilitate the discovery of reproducible characteristic VOCs. This provides a cellular experimental basis and scientific evidence for lung cancer biomarker investigation and even breath biopsy technique development.
研究领域:
医学
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分析化学
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肿瘤学
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产品关联
DOI
PubMed
高影响因子
ELECTROCHEMISTRY
·
2016
·Vol. 84
·期 12
·948-952
·
IF 0.791
Xiyun YANG,Ling RAN,Shenghai YANG
Anodic dissolution of zirconium in Bun4NBr-containing n-butanol solutions was investigated using cyclic voltammetry, linear sweep voltammetry and potentiostatic current–time transient and scanning electron microscopy (SEM). Zirconium did not exhibit active dissolution due to passivation in the potential region of 0.2 to 1.2 V vs. SCE. The zirconium dissolution in passive state was under mass transfer control. Pitting corrosion took place as a result of passivity breakdown by Br− anions and the typical steady-state pitting potential was between 1.55–1.60 V vs. SCE in n-butanol solutions containing 0.08 M Bun4NBr. SEM images confirmed the occurrence and the intensification of pits with an increase of potential. Increasing Bun4NBr concentration accelerated the pit nucleation and growth. The reaction order leading to pit nucleation process was 1.0 with respect to bromide anions. The dissolution of zirconium in n-butanol solution produced Zr(OC4H9)4.
研究领域:
电化学
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材料科学
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DOI
高影响因子
Chemical Engineering Journal Advances
·
2025
·
IF 7.1
Jisheng Li,Xu Zhao,Yuheng Fan,Changyu Sun,Yufeng Hu,Laiyong Zhang,Fayan Zhu,Jilong Han
Boric acid, a vital chemical in industries, agriculture, and high-tech fields, is primarily extracted from Salt Lake brines via liquid-liquid extraction. The efficiency differences between alcohols remain unclear. This study investigates boric acid extraction using isobutanol and isooctanol, combining experiments and theoretical calculations to reveal microscopic mechanisms. Experiments show that under low pH, multi-stage extraction significantly impacts efficiency, with isooctanol outperforming isobutanol. Computational results reveal that isooctanol’s hydroxyl oxygen has a more negative electrostatic potential, forming stronger, more stable hydrogen bonds with boric acid. Isooctanol also exhibits shorter interaction distances and higher interaction energy with boric acid compared to isobutanol. The study concludes that isooctanol’s superior performance is due to its ability to form more and longer-lived hydrogen bonds. This work provides new theoretical insights into boric acid extraction and aids in designing efficient extractants.
研究领域:
化学工程
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理论计算
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产品关联
DOI
高影响因子
CRYSTENGCOMM
·
2016
·Vol. 18
·期 21
·3842-3849
·
IF 3.849
Chunping Gao,Qi Shi,Jinxiang Dong
The performance of two hydrophobic zeolitic imidazolate frameworks, MAF-6 and TIF-1 Zn, in adsorptive separation of 1-butanol from acetone–butanol–ethanol model fermentation broth was studied and compared to the data reported for ZIF-8. It was found that, in single-component systems, the adsorption capacities of ZIF-8 and MAF-6 were larger than that of TIF-1 Zn, mainly because of their larger pore volume; however, the time necessary to reach equilibrium was shorter when TIF-1 Zn with a larger pore aperture was used. In breakthrough experiments, it was shown that the adsorptive separation mechanism on ZIF-8 and MAF-6 was based on combined thermodynamics and kinetic effects; on TIF-1 Zn, thermodynamic adsorption took place.
研究领域:
生物工程
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
AICHE JOURNAL
·
2024
·Vol. 70
·期 9
·e18495
·
IF 3.5
Jialin Tan,Hao Huang,Hengde Li,Xiaolan Cai,Guangping Zhou,Boxi Zeng,Jinrui He,Xiang Wang,Shaoqu Xie
The biobutanol-based biofuel fermentation is hindered by the challenge of inadequate fermentation broth concentration and the azeotropic systems of water. The application of eucalyptus oil in diesel fuel makes it a promising extractant for biobutanol extraction and dehydration, thus resulting in product recovery and the development of fuel blend technology. Eucalyptus oil-derived 1,8-cineole was applied to acetone-butanol-ethanol (ABE) and isobutanol systems to enhance the butanol recovery and dehydration. The recovery of n-butanol and isobutanol reached 92% and 95%, respectively, while the water removal in a 2% butanol system exceeded 99%. These results demonstrated that 1,8-cineole exhibited a high selectivity toward butanol, thus providing a robust theoretical foundation for the fermentation-based biofuel recovery and the elimination of azeotropic systems. The introduction of high-density diesel-fuel-like eucalyptus oil into low-energy-density biobutanol will increase the energy density of fermentation-based alcohols, yielding linear and cyclic biofuel blends.
研究领域:
生物化学
·
能源生物学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Energy Chemistry
·
2016
·
IF 2.322
Ran An,Guizhuan Xu,Chun Chang,Jing Bai,Shuqi Fang
Butyl levulinate (BL) is a promising new candidate as diesel fuel and fuel additive. In this study, an efficient process for a one-pot synthesis of BL from biomass-derived carbohydrates in butanol medium with the catalysis of metal sulfates was developed. The catalytic activity of a series of metal sulfates for the synthesis of BL from fructose was investigated. Among various metal sulfates, ferric sulfate Fe 2 (SO 4 ) 3 was found to be the most efficient catalyst, which gave a remarkably high BL yield of 62.8 mol% under the conditions of 463 K, 3 h, a catalyst dosage of 5.0 g/L, and fructose concentration of 25 g/L. Different carbohydrates including glucose, cellulose , inulin and sucrose were also used for one-pot synthesis of BL with the catalysis of Fe 2 (SO 4 ) 3 , showing the yields of 39.6, 30.5, 56.6 and 50.1 mol%, respectively. In addition, the recycling and reuse of Fe 2 (SO 4 ) 3 was studied by characterizing them using powder X-ray diffraction (XRD), scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS). A plausible reaction pathway for the one-pot synthesis of BL from fructose was proposed. This study provides a facile and feasible way for the synthesis of BL from biomass.
研究领域:
生物化学
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能源科学
✓ 已验证
产品关联
DOI
高影响因子
ENERGY & FUELS
·
2019
·
IF 3.021
Zhen-Yi Du,Bin-Bin Zhang,Ting-Sheng Chen,Yuli Betancur,Wen-Ying Li
Isobutanol derived from biomass can serve as a potential renewable candidate for the production of light olefins and aromatics, which are the building blocks to manufacture fuels and chemicals in the petrochemical industry. Dependent upon the product requirements, the product selectivity toward olefins or aromatics can be tuned by adjusting the reaction conditions and the properties of HZSM-5 catalysts. On bare HZSM-5, mild conditions (low temperature, low space time, and low acidity) favored the production of olefins and harsh conditions (high temperature, high space time, and high acidity) were more likely to produce aromatics. Ga was impregnated onto HZSM-5 to enhance the production of aromatics. Unexpectedly, Ga introduction only induced the intertransformation between olefins and aromatics without significantly impacting the selectivity of low-value paraffins. The exchanged Ga sites functioning together with Brønsted acid were identified as active Ga species and strengthened the direct dehydrogenation of C6–C8 olefins. The in situ-generated water from isobutanol dehydration affected the formation of Ga species. This resulted in different promotional effects of Ga on the transformation of isobutanol and isobutene. The reaction pathways were developed on the basis of the catalyst evaluation results, in tandem with an in situ diffuse reflectance infrared Fourier transform spectroscopy study on the intermediates formed during isobutanol transformation. Selectivity of olefins and aromatics from isobutanol transformation can be tuned by adjusting reaction conditions and properties of HZSM-5 catalysts.
研究领域:
催化化学
·
能源化学
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产品关联
DOI
高影响因子
Toxins
·
2019
·Vol. 11
·期 3
·142
·
IF 3.895
Rui Wang,Zhaoyue Dong,Xiaolong Zhang,Jingxin Mao,Fancheng Meng,Xiaozhong Lan,Zhihua Liao,Min Chen
Pterocephalus hookeri(C. B. Clarke) Höeck, recorded in the Chinese Pharmacopoeia (2015 version) as a Tibetan medicine for the treatment of various diseases, especially rheumatoid arthritis, was believed to possess a slight toxicity. However, hardly any research has been carried out about it. The present study aimed to evaluate the toxicity in vivo and in vitro. Toxicity was observed by the evaluation of mice weight loss and histopathological changes in the liver. Then, the comparison research between ethyl acetate extract (EAE) and n-butanol extract (BUE) suggested that liver toxicity was mainly induced by BUE. The mechanical study suggested that BUE-induced liver toxicity was closely associated with necrosis detected by MTT and propidium iodide (PI) staining, via releasing lactate dehydrogenase (LDH), reducing the fluidity, and increasing the permeability of the cell membrane. Western blot analysis confirmed that the necrosis occurred molecularly by the up-regulation of receptor-interacting protein kinase 1 (RIP1) and receptor-interacting protein kinase 3 (RIP3), as well as the activation of the nuclear factor-kappa-gene binding (NF-κB) signaling pathway in vivo and in vitro. This finding indicated that the liver toxicity induced by BUE fromP. hookeriwas mainly caused by necrosis, which provides an important theoretical support for further evaluation of the safety of this folk medicine.Keywords:Pterocephalus hookeri;liver toxicity;n-butanol extract;necrosis;inflammationKey Contribution:(1)Pterocephalus hookericould induce liver toxicity in vivo and in vitro. (2) The liver toxicity was induced by n-butanol extract ofP. hookeri. (3) The liver toxicity was mainly caused by necrosis associated with inflammation. (4) This finding provides an important theoretical support for further evaluation of the safety of this Tibetan medicine.
研究领域:
药理学
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毒理学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2014
·
IF 4.28
Xiuting Hu,Hongyan Li,Benxi Wei,Xueming Xu,Zhengyu Jin,Yaoqi Tian
The aim of this study was to examine 1-buatnol–hydrochloric acid (1-butanol–HCl) hydrolysis process of starch . Normal rice starch was hydrolyzed by 0.36% HCl in anhydrous 1-butanol at 40 °C from 4 h to 7 days. The changes in starch granule, crystalline, and molecular weight during the 1-butanol–HCl hydrolysis were determined using SEM, particle size analyzer, XRD, HPSEC–MALLS–RI, and iodine staining. SEM and particle size analyzer analysis showed that the granule morphology significantly changed and the granule size decreased from 5.47 μm to 5.07 μm after the hydrolysis by 1-butanol–HCl for 7 days. XRD results indicated that amorphous areas of normal rice starch were firstly hydrolyzed followed by the ordered areas during 1-butanol–HCl hydrolysis. The peak (2 θ ) of V-type crystallinity was detected at around 20° in the XRD curves of 1-butanol–HCl-hydrolyzed starches. This peak confirmed the formation of amylose–1-butanol complex. HPSEC–MALLS–RI and iodine staining analysis demonstrated that the weight-average molecular weight of normal rice starch sharply decreased from 2.4 × 10 7 Da to 4.9 × 10 5 Da after 1-butanol–HCl hydrolysis for 4 h, then gradually decreased, and finally stabilized at about 2.6 × 10 4 Da after hydrolysis for 4 days. These results suggest that the attack of 1-butanol–HCl on normal rice starch preferentially occurred in the amylopectin molecules of amorphous areas.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）