JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2018
·
IF 3.235
Yimeng Zhang,Guangrui Liu,Jinhu Wu
Fatty acids in vegetable oils and animal fats are a potential feedstock for the production of synthetic waxes, and this kind of waxes can be a substitute for petroleum waxes in the future because the feedstock is renewable. This paper described an optimization study on the production of n-triacontane (NTA) from palmitic acid via Kolbe electrolysis using a biphasic solvent system (H 2 O/MeOH as aqueous phase, petroleum ether as organic phase). Response surface methodology (RSM) and Taguchi methodology (TM) were employed to research the production of NTA affected by amounts of KOH, reaction temperature, cell voltage and reaction time. On the basis of analysis of variance and range analysis of the two methods above, the maximum NTA yield was achieved at amounts of KOH of 1.3 equiv., reaction temperature of 57 °C, cell voltage of 20.0 V and reaction time of 20 h for RSM; while the amounts of KOH of 1.3 equiv., reaction temperature of 55 °C, cell voltage of 20.0 V and reaction time of 20 h for TM. Under these optimal conditions, the experimental yields of NTA were 69.5% and 64.7% for RSM and TM, respectively. The final product met the relevant standards of the needle penetration, lead, water soluble acids and alkalis, odor and polycyclic aromatic hydrocarbons by referring to Chinese waxes product standards. The results showed strong potential market applications of Kolbe electrolysis waxes.
研究领域:
化学工程
·
有机化学
·
可再生能源
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
DRUG DELIVERY
·
2018
·
IF 3.095
Yimeng Zhou,Ning Li,Zhixia Qiu,Xiaoyu Lu,Min Fang,Xijing Chen,Lili Ren,Guangji Wang,Pingkai Ouyang
Triacontanol (TA, C30H62O), abundantly present in plant cuticle waxes and bee waxes, has been found to display promising anti-neoplastic potentials. As a long chain fatty alcohol, TA possesses limited aqueous solubility, which hinders its medicinal application. To overcome its solubility barrier, a polymer prodrug was synthesized through attaching TA to poly ethylene glycol (PEG), using succinic acid as a linker with bifunctional amide and ester bonds. Anti-neoplastic effects of PEG-TA were assessed in LoVo and MCF7 cells, anti-proliferative and apoptosis-inducing activities were subsequently confirmed in mouse xenograft model. Encouragingly, PEG-TA possessed selective anti-cancer ability. It did not exhibit significant cytotoxicity on normal cells. Mechanistic examination revealed inhibition of NF-κB nuclear translocation, suppression on matrix degradation enzyme and down-regulation of angiogenic signaling might contribute to its anti-malignant effects. Pharmacokinetics clearly indicated PEGylated TA (named as mPEG2K-SA-TA) substantially enhanced TA delivery with increased plasma exposure (19,791 vs. 336.25 ng·mL−1·h−1, p < .001), mean residence time (8.46 vs. 2.95 h, p < .001) and elimination half-life (7.78 vs. 2.57 h, p < .001) compared to those of original TA. Moreover, mPEG2K-SA-TA appeared to be safe in preliminary toxicological assessment. PEGylated TA also emerged as a functional carrier to deliver hydrophobic chemotherapeutic agents, since it readily self-assembled to micelles in aqueous solution with a low critical micelle concentration (CMC, 19.1 µg·mL−1). Conclusively, PEG-TA conjugate displayed superior anti-neoplastic activities and low toxicity, as well as facilitated the delivery of other hydrophobic agents, which appeared to be an innovative strategy for cancer therapy.
研究领域:
药理学
·
肿瘤学
·
药物递送系统
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2025
·
IF 8.4
Ruizhe Chen,Leilei Cheng,Wenbo Zhang,Jing Gu,Haoran Yuan,Yong Chen
The catalytic pyrolysis of polyethylene for aromatic production is a promising method for waste plastic disposal and resource recovery. This study investigated the nature of metal species and the distribution of acidic sites in low-density polyethylene (LDPE) scission-aromatization reactions using metal-loaded zeolite catalysts. Under the influence of the 1.0Zn/MOR40 catalyst, LDPE achieved a maximum aromatic selectivity of 45.71 % at 500 °C, based on the total product composition. The results indicated that catalysts with a lower Brønsted acid site to Lewis acid site ratio (BAS/LAS) and a higher concentration of [ZnOH] + species favored the reaction, promoting the generation of olefin intermediates and aromatics while suppressing polycyclic aromatic hydrocarbons (PAHs) formation. However, there was an optimal range for the BAS/LAS ratio and [ZnOH] + species concentration. Reaction results involving squalene and triacontane demonstrated that excessive dehydrogenation of reactants and insufficient BAS could hinder the progression of aromatization reactions, resulting in an increased proportion of PAHs. This study provides a comprehensive understanding of the balance between the synergistic and antagonistic effects of metal-acid sites on the aromatization process.
研究领域:
化学工程
·
催化
·
高分子科学
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PLANT PHYSIOLOGY AND BIOCHEMISTRY
·
2024
·
IF 6.1
Bingyao Jiang,Jia Yang,Xingyu Zhong,Shuo Yan,Meizhen Yin,Jie Shen,Bin Lei,Zhaohu Li,Yuyi Zhou,Liusheng Duan
Plant Growth Regulators (PGRs) are functional compounds known for enhancing plant growth and development. However, their environmental impact is a concern due to poor water solubility and the need for substantial organic solvents. Recently, nano-delivery systems have emerged as a solution, offering a broad range of applications for small molecule compounds. This study introduces a nano-delivery system for Triacontanol (TA), utilizing a star polymer (SPc), aimed at promoting maize growth and improving physiological indicators. The system forms nearly spherical nanoparticles through TA's hydroxyl group and SPc's tertiary amine group. The TA/SPc nano-complex notably outperforms separate TA or SPc treatments in maize, increasing biomass, chlorophyll content, and nutrient absorption. It elevates chlorophyll content by 16.4%, 10.0%, and 6.2% over water, TA, and SPc treatments, respectively, and boosts potassium and nitrate ion uptake by up to 2 and 1.6 times compared to TA alone, leading to enhanced plant height and leaf growth. qRT-PCR analysis further demonstrated that the nano-complex enhanced cellular uptake through the endocytosis pathway by up-regulating endocytosis-related gene expression. The employment of TEM to observe vesicle formation during the internalization of maize leaves furnishes corroborative evidence for the participation of the endocytosis pathway in this process. This research confirms that SPc is an effective carrier for TA, significantly enhancing biological activity and reducing TA dosage requirements.
研究领域:
农业科学
·
纳米技术
·
植物生理学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
Drug Delivery and Translational Research
·
2019
·Vol. 10
·期 1
·122-135
·
IF 3.111
Lu Xiaoyu,Fang Min,Yang Yue,Dai Yu,Xu Jiaqiu,Zhao Di,Lu Yang,Chen Xijing,Lu Shan,Li Ning
PEGylated triacontanol (mPEG 2k -b-TRIA) was developed as a dual-functional polymer with remarkable biocompatibility. The polymer could self-assemble to micelles with critical micelle concentration (CMC) 17.62 μg mL −1 . Docetaxel-loaded mPEG 2k -b-TRIA micelles (DTX PMs) were fabricated to evaluate the feasibility of mPEG 2k -b-TRIA as drug delivery system. DTX PMs achieved desirable particle size of 93.7 nm, drug loading of 6.66%, and drug encapsulation efficiency of 89.87%. The drug release was based on first-order kinetics model, thus enabling prolonged release. Meanwhile, pharmacokinetic study also revealed that DTX PMs could improve the exposure level of DTX and prolong its systemic circulation time. Furthermore, DTX PMs demonstrated significantly enhanced cytotoxicity and cellular uptake in vitro compared with DTX solution. The in vivo tumor inhibition study carried out on MCF-7 bearing BALB/c mice model also validated that DTX PMs exhibited stronger anti-tumor activity but low toxicity. Notably, mPEG 2k -b-TRIA made some contribution to inhibit the growth of breast cancer cells in vitro and in vivo, indicating the potential as anti-tumor complementary agents. All the results suggested that mPEG 2k -b-TRIA polymer as a vehicle in the formulation of anti-cancer drugs may provide an effective way to improve their therapeutic efficacy. Consequently, the mPEG 2k -b-TRIA polymers would be another promising carrier for hydrophobic anti-cancer drugs delivery.
研究领域:
药学
·
肿瘤学
·
药物递送系统
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Tingting Wang,Jiawei Jing,Pengfei Huang,Xinyu Guo,Chuan Li,Yuanyuan Qu
Remediation of soil contaminated with long–chain hydrocarbons and affected by salinization poses a considerable challenge. The isolation of a bacterial strain, identified as Pseudomonas aeruginosa DL, from petroleum–contaminated saline–alkali soil has been reported in this study. The strain demonstrated a high capacity to degrade long–chain alkanes and exhibited adaptability to saline–alkali conditions. Gene annotation and analysis of degradation products revealed that the strain DL employed a step–by–step chain–breaking mechanism to degrade long–chain alkanes. Following 160 days of bioaugmented remediation of contaminated soil using the strain DL, 81.36 % degradation of long–chain alkanes, initially present at a concentration of 30,000 mg/kg, was achieved. The activities of soil enzymes, including dehydrogenase, lipase, catalase, and urease, were significantly increased ( p < 0.05). Community structure analysis revealed that Pseudomonas aeruginosa DL successfully colonized the contaminated soil, achieving a relative abundance of 69 %. In addition, alkane–degrading bacterial genera, such as Salinimicrobium , Isoptericola , Gordonia , Achromobacter and Ochrobactrum , emerged as new dominant genera. Microbial cooccurrence networks confirmed that bioaugmentation with the strain DL could streamline interpopulation interactions within the community and enhance associative networks, thereby guiding community evolution toward improved alkane degradation. This study offers valuable strain resources and data support for the bioremediation of saline–alkali soils contaminated with long–chain alkanes.
研究领域:
环境科学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Horticulturae
·
2026
·Vol. 12
·期 7
·851
·
IF 3.4
Zhuoshuai Jin,Xinyu Qi,Meng Liu,Jiasi Han,Lixue Gong,Jiaojiao Li,Qianyu Ji,Liang Zhao,Xuena Yu,Ye Guo,Yingqiang Wen
Cuticular wax metabolites on leaf surfaces function as chemical interfaces that modulate the pre-penetration development of phytopathogenic fungi. However, the specific monomeric constituents in grapevine leaf wax that regulate conidial germination and host recognition by grapevine powdery mildew caused byErysiphe necatorremain elusive. Here, we compared leaf cuticular wax characteristics between four susceptibleVitis viniferacultivars and three resistant Chinese wildVitisaccessions. Scanning electron microscopy coupled with gravimetric analysis revealed that susceptibleV. viniferacultivars exhibited lower wax loads and lamellar crystals, whereas resistant Chinese wildVitisaccessions displayed higher wax accumulation with granular or blocky crystals. Gas chromatography–mass spectrometry profiling further demonstrated divergent compositional patterns: primary alcohols predominated among susceptibleV. viniferacultivars, while aldehydes and alkanes were enriched in resistant Chinese wildVitisaccessions. Paradoxically, in vitro conidial germination assays showed that wax extracts from all grapevines significantly promotedEn.NAFU1 conidial germination, indicating that resistance in Chinese wildVitisaccessions is independent of direct wax-mediated inhibition of spore germination. Bioassays of representative monomers revealed that n-triacontane suppressed germination at high concentrations, whereas n-dotriacontanol and stearic acid stimulated it. Collectively, these findings demonstrate that specific cuticular wax monomers exert distinct biological effects onEn.NAFU1 conidial germination. Given the ubiquitous presence and concentration-dependent stimulatory activity of stearic acid, we hypothesize that this monomer serves as a conserved chemical cue enabling initial host recognition byEn.NAFU1, whereas the differential susceptibility among grapevine genotypes is governed by downstream physical and induced defense mechanisms rather than by variation in stearic acid levels.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）