JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2025
·
IF 4.6
Yi He,Runzi Zhang,Shunbi Xie,Xiang He,Xiaoyu Yang,Yao Liu,Mengjun Wang
Food safety has become a significant global concern, with particular attention on pesticide residues in agricultural products. Glyphosate, as a pesticide, poses a serious threat to human health and the environment when present as residue in agricultural products. In this study, we utilized MOF as a framework to prepare concave-structured bimetallic prussian blue nanozyme@silver (Co-Fe PBA@Ag). This nanozyme with sunken surface and synergistic effect of Ag nanoparticles exhibited high catalytic activity than common nanozyme and could catalyze TMB to generate oxTMB under the action of hydrogen peroxide, resulting in a color change from colorless to blue in the solution. However, when the target glyphosate was present, it could inhibit the activity of OH · and consequently blocked the color change reaction, causing the solution to turn from blue to colorless. Based on this principle, we established a triple-mode detection system: colorimetry, smartphone app analysis, and SERS for detecting glyphosate residues in agricultural products such as honey, potatoes, and tea leaves. This triple-mode sensor integrated point-of-care detection capability via colorimetry, sensitive monitoring through smartphone app and accurate detection using Raman technology. It showed potential for the implementation of practical on-site monitoring of pesticide residues in agricultural products.
研究领域:
食品安全
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纳米生物学
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环境科学
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产品关联
DOI
高影响因子
Food Chemistry-X
·
2024
·
IF 6.5
Jinxin Chen,Cheng Zhang,Lunzhao Yi,Fengmin Duan,Ying Gu,Kun Ge,Xuejing Fan
The improvement of detection accuracy without loss of rapidity and sensitivity by optical sensors in complex food analysis is still full of challenges owing to the matrix interference. Herein, a novel and simple self-calibration colorimetric/fluorescence/surface-enhanced Raman spectroscopy (SERS) tri-modal optical sensor based on aminated Rhodamine 6G (R6G-NH 2 ) was developed for highly rapid, sensitive, and accurate detection of Hg 2+ in food samples. The high recognition specificity of R6G-NH 2 for Hg 2+ can be achieved through the metal chelation interaction between Hg 2+ and -NH 2 , -COOH groups in R6G-NH 2 with formation of R6G-NH 2 -Hg 2+ -R6G-NH 2 complex. The DFT and FDTD simulations were adopted to confirm the theoretical feasibility in Hg 2+ detection by tri-modal optical. Under the optimum conditions, the analytical method based on self-calibration tri-modal optical sensor for Hg 2+ detection was established with promising properties (rapidity, linearity, linear range, LOD, and LOQ), providing a strategy in rapid, selective, sensitive, and accurate detection for food safety.
研究领域:
分析化学
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食品科学
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环境科学
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产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS A-GENERAL
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2019
·
IF 4.63
Tingting Xu,Shulan Wang,Li Li,Xuan Liu
Semiconductor photocatalysis is considered as an effective sustainable technology to relieve the emerging global energy shortage issues, while how to design the efficient photocatalyst with enhanced light absorption, charge carrier separation and surface reaction is still a primary barrier for its applications. Herein, SrTiO 3 /TiO 2 /C (STC) heterostructure with tri-modal (micro-, meso-, macro-) pores integrated was synthesized via freeze casting combined with silica colloid as the hard template. Carbon was used as the photosensitizer for extending light absorption, electric field from SrTiO 3 /TiO 2 for enhancing charge carrier separation, and hierarchical pore structures for promoting surface reaction. Silica in different particle sizes was used to tune the pore structure of composites. The as-prepared STC sample reached the photocatalytic hydrogen production rate from water splitting as high as 2.52 mmol h −1 g −1 under UV irradiation, which is 1.5 times of benchmark catalyst P25. Its reactivity for methylene blue (MB) degradation is superior to the corresponding individual compositions and about 4.7 times of SrTiO 3 under UV light irradiation. The current work provides a feasible method to fabricate the hierarchical porous multi-component semiconductor based heterostructures with excellent photochemical performances, which develops our understanding for the design and fabrication of hierarchical porous catalysts.
研究领域:
材料科学
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环境科学
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产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Fei Wang,Xiaoyan Li,Zhining Liu,Xin Zhao,Changxu Zhao,Guangzheng Hou,Qiqi Liu,Xin Liu
Human respiratory adenovirus (ADV) is a highly infectious respiratory virus with potential for pandemics. There are currently no specific drugs to treat ADV worldwide, so early rapid detection of ADV infection is essential. In this study, we developed an innovative magnetic-optical triple-mode lateral flow immunoassay (LFIA) using magnetic quantum dots as immunomarkers. This novel approach addresses the need for rapid and accurate ADV detection, allowing for multimodal quantitative/semiquantitative analysis of magnetic, fluorescent, and visible signals within a mere 15 min. The lower limit of detection (LOD) for magnetic, fluorescent, and visual signals was determined to be 5.6 × 103, 1.2 × 103, and 1.95 × 104 copies/mL, respectively. The detection range for ADV using this approach was 1.2 × 103–5 × 107 copies/mL. Additionally, semiquantitative analysis, which is user-friendly and does not necessitate specialized equipment, was successfully implemented. Notably, seven respiratory viruses showed no cross-reactivity with the generated LFIA test strips. The intrabatch repeatability exhibited a coefficient of variation (CV) of less than 5%, while the interbatch repeatability had a CV of less than 15%. Furthermore, recovery values ranged from 95% to 106.8% for samples analyzed concurrently with dual signals at the same spiking concentration. The assay developed in this study boasts a wide detection range and exceptional sensitivity and specificity. This technique is exceptionally well-suited for on-site rapid detection, with the potential for personal self-testing and early ADV infection diagnosis. Its versatility extends to a broad array of application scenarios.
研究领域:
医学诊断
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病毒学
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免疫学
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产品关联
DOI
PubMed
高影响因子
Biomaterials Advances
·
2025
·
IF 6
Ding-Yi Zhang,Meng-Xi Wang,Chuang Cai,Wei-Wei Cheng,Yin-Jia Cheng,Wen-Long Liu,Rong Huang,Ai-Qing Zhang,Si-Yong Qin
Diabetic wound healing is extremely difficult, originating from the aspects of bacterial infection, continuous inflammation, hypoxia and excessive reactive oxygen species (ROS), etc. Consequently, multifunctional nanoplatforms capable of highly eliminating bacteria, scavenging ROS and promoting angiogenesis possess a promising prospect. This work reports our fabrication of lipopeptide/Ti 3 C 2 T x MXene nanohybrid to cure bacteria-infected diabetic wounds. Ti 3 C 2 T x nanosheet has been employed to disrupt the bacterial membrane through both the physical puncture mediated by direct contact and mild-temperature photothermal therapy (PTT) due to its excellent photothermal conversion efficiency. Moreover, it exhibits the capacities of ROS scavenging and pro-angiogenesis during the diabetic wound healing process. Positively charged lipopeptide integration on 2D Ti 3 C 2 T x MXene improves the contact of Ti 3 C 2 T x nanosheet with negative bacterial membrane for membrane-anchoring. More importantly, drug-free lipopeptide shows antibacterial capacity, which compensates the decline in therapeutic efficacy of mild-temperature PTT because of its inferior heat intensity. The cooperation between 2D Ti 3 C 2 T x MXene and therapeutic lipopeptide allows for the effective cure on bacteria-infected diabetic wound.
研究领域:
生物医学工程
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材料科学
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微生物学
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产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2019
·
IF 10.273
Zhao Wang,Tao Jia,Qianqian Sun,Ye Kuang,Bin Liu,Mengshu Xu,Hui Zhu,Fei He,Shili Gai,Piaoping Yang
The current conventional photo-therapeutic agents often show low therapy efficacy because of their single treatment model, the limited penetration depth of excitation light and hypoxia in the tumor microenvironment (TME). Herein, a new type of phthalocyanine manganese (MnPcE 4 ) photosensitizer with strong NIR absorption was designed and fabricated for the first time, and was used to modify pure Bi nanomaterials to obtain an intelligent multifunctional Bi/MnPcE 4 nanocomposites . The Mn 2+ in the Bi/MnPcE 4 nanocomposite could catalyze H 2 O 2 to generate O 2 , thus helping to overcome TME hypoxia and enhancing the photodynamic therapy (PDT) efficacy. Further, the nanocomposites showed excellent T 1 -weighted MRI performance. Our novel use of a pure metal Bi core, offers lower toxicity, higher CT imaging performance , and a photothermal therapy (PTT) effect triggered by 808 nm near infrared (NIR) laser. Moreover, in vivo fluorescence imaging ( in vivo FL) vividly showed that the nanocomposite rapidly accumulates in tumor sites due to the enhanced permeability and retention (EPR) effect and metabolized in the organs. The presence of Bi enables the use of these nanocomposites as a CT contrast agent, and the Mn content enables them to be used in MRI. This triple imaging ability implies that our nanocomposites have a high potential for use in imaging directed tumor therapy.
研究领域:
生物医学工程
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纳米医学
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肿瘤治疗学
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DOI
高影响因子
TALANTA
·
2020
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IF 5.339
Rui Gao,Dan Li,Siqing Zheng,Haixin Gu,Wei Deng
Accurate and selective in-field detection of metal ions in complex media has gained wide interests due to the complexed matrices and weak affinity towards sensing surface. Herein, we develop a first trimodal method for sensing of Zn 2+ in complex matrices by stimuli-responsive N-[6-piperazinyl-2-pyridinyl]-N-(2-pyridinylmethyl)-2-Pyridinemethanamine dithiocarbamates (DPY) modified gold nanorods (GNRs-DPY). The presence of Zn 2+ triggers the aggregation of GNRs-DPY, leading to increment of color and fluorescence intensity of the sensing system, which could be visually discerned with bare eye. Moreover, the intensive electromagnetic enhancement among “hot spots” of GNRs, generated during self-aggregation of the GNRs-DPY caused by Zn 2+ , lowers the detection limit of SERS assay to 6 × 10 −3 pM. It is noteworthy that GNRs-DPY based sensing platform not only enables distinguishing Zn 2+ from Cd 2+ , with simplicity and rapidity, but also demonstrates as trimodal nanoprobe for sensitive and selective quantitative determination of Zn 2+ in different matrices. Therefore, the GNRs-DPY provides a new strategy for accurate and credible on-spot determination of Zn 2+ in complicated specimens, as well as offering multiple applications in point-of-care monitoring.
研究领域:
分析化学
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纳米生物技术
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环境监测
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分子诊断
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金属离子传感
✓ 已验证
DOI
高影响因子
Biomaterials Science
·
2020
·Vol. 8
·期 21
·5874-5887
·
IF 6.183
Zhihao Zhou,Wei Zhang,Lei Zhang,Yang Cao,Zhigang Xu,Yuejun Kang,Peng Xue
Two-dimensional Bi2Te3 nanosheets (NSs) have recently been validated as a new type of photothermal agent to provide an alternative option for tumor ablation via light-induced hyperthermia. However, the surface of Bi2Te3 NSs lacks active radicals for the conjugation of functional molecules, which undoubtedly impedes their versatile utilization in medical areas. Here, the surface activation of Bi2Te3 NSs was accomplished via the in situ growth of an SiO2 nanoshell assisted by tetraethyl orthosilicate (TEOS). Upon the co-condensation of (3-aminopropyl)triethoxysilane (ATPES), terminal amino groups (–NH2) were generated on the surface of the Bi2Te3@SiO2 NSs, which were further covalently coupled with the photosensitizer chlorin e6 (Ce6) through a standard amide reaction. The resultant Bi2Te3@SiO2/Ce6 (BSC) NSs displayed admirable photothermal properties, a high Ce6 loading capacity, and good biocompatibility. Upon dual-wavelength laser irradiation, an excellent tumor suppression effect arising from thermal ablation and reactive oxygen species (ROS)-induced apoptosis was verified both in cell experiments and in animal studies. In addition, synchronous fluorescence/photoacoustic/infrared (FL/PA/IR) tri-modal imaging could provide useful information for both tumor diagnosis and prognosis. Overall, this facile strategy for the activation of Bi2Te3 is regarded to be universal for the development of more versatile Bi2Te3-based nanoplatforms, which should favor the rapid diagnosis and effective treatment of fatal diseases.
研究领域:
纳米医学
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癌症治疗
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材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2016
·
IF 3.15
Chao Chen,Samiran Bhattacharjee
A trimodal nanoporous silica (TS) having unique trimodal pore structure viz., internal mesopores, textural mesopores and interconnected macropores, has been functionalized with amine using two different methods covalent grafting and wet impregnation. Both were studied as nanocomposite sorbents for CO 2 capture. The effects of the amine loading, immobilization processes and the type of support were investigated. Commercially available silica gel (SG) with a purely mesoporous structure was studied as the support for the amine in order to compare differences in pore structure and amine loading with differences in CO 2 adsorption capacity and kinetics. Amine-grafted TS exhibited much faster CO 2 adsorption kinetics at 35 °C than amine-grafted SG. At the same amine loading, amine-impregnated TS showed higher CO 2 adsorption capacity and faster CO 2 adsorption kinetics than amine-impregnated SG. The CO 2 adsorption capacity of amine-impregnated TS increased as the amine loading increased until 70%, with the highest value of 172 mg/g, while the amine-impregnated SG reached the highest CO 2 adsorption capacity of only 78 mg/g at 40% amine loading. More importantly, amine-impregnated as-prepared TS exhibited even higher CO 2 capture capacity than amine-impregnated TS when the amine loading was below 60%. Results suggest that amine-modified trimodal nanoporous silica sorbents meet the challenges of current CO 2 capture technology.
研究领域:
材料科学
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环境工程
·
化学工程
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产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 17
·14283-14289
·
IF 3.289
Peng Zhang,Yangyang He,Jianhua Liu,Jing Feng,Zhiqiang Sun,Pengpeng Lei,Qinghai Yuan,Hongjie Zhang
Lanthanide-doped nanocrystals have been researched extensively and used for bioimaging because of their optical properties, magnetic properties and X-ray absorption. Core–shell-structured lanthanide-doped nanocrystals have been developed and characterized by TEM and XRD analysis. The nanocrystals are composed of BaYbF5:0.5% Tm as the core and BaGdF5:20% Yb, 0.5% Tm as the shell. Apart from characterization of the nanocrystals, evaluation of both their cytotoxicity via MTT assays and their long-term toxicity via histological analysis showed that their cytotoxicity was low, indicating the possibility of further in vivo imaging. This work combined the functions of trimodal imaging into one nanoplatform and then UCL, CT, and MR imaging with core–shell-structured nanocrystals were investigated both in vitro and in vivo. Taking into consideration its structural characteristics and trimodal imaging abilities, it is expected that the developed multifunctional nanoplatform may be potentially useful for diagnosing diseases at an early stage.
研究领域:
生物医学工程
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材料科学
·
影像医学
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产品关联
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 75
·61436-61439
·
IF 3.84
Nan Li,Yong Shen,Li Qi,Zhibo Li,Juan Qiao,Yi Chen
A versatile method for preparing a reverse phase/weak anion exchange/hydrophilic interaction trimodal polymer monolith was proposed by the one-step copolymerization of amino acid-based monomer and N,N′-methylenebisacrylamide. The retention mechanisms of the resultant monolith were evaluated using different series of small molecules. Furthermore, the separation of protein mixtures could be easily achieved under isocratic elution. The proposed polymer monolith, which has the merits of easy preparation, low mass transfer resistance and good biocompatibility, is a promising separation medium for small and large molecules.
研究领域:
分析化学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yiyao Liu,Yuqing Li,Mingzhe Chen,Fei Pang,Lili Yang,Dengteng Ge
Dynamic optical materials show significant potential for advanced information encryption and anti-counterfeiting, yet multimodal non-contact decryption systems remain challenging. Herein, a feasible strategy is proposed for spatiotemporal encryption through non-contact modulation of structural color (SC), photochromic color (PC), and fluorescent color (FC). This secure film is achieved via compartmentalized microdroplet encapsulation and curing (CMEC) technique based on crosslinked polydimethylsiloxane. The microdroplet integrates three components: (i) superparamagnetic Fe 3 O 4 @SiO 2 nanoparticles (SPIONs) for magnetically responsive SC modulation, (ii) methyl-functionalized spiropyran (MSP) for reversible PC switching and (iii) nitrogen-doped carbon dots (NCDs) that enable time-evolving FC transitions via fluorescence resonance energy transfer with MSP. Initial static information concealment is achieved via optimization of SPIONs parameters. Spatial encryption synergizes SC (red to purple) with PC (red), while temporal security stems from adjustable FC (from blue through pink to red). The CMEC strategy allows facile preparation of multimodal films with versatile compositions. We arrange pixel arrays in single, dual, and triple modes. This yields a Morse-code-based spatiotemporal encryption system that affords over 7.9 × 10 28 rewritable programming possibilities. This methodology establishes a generalizable platform for multimodal high-security encryption systems toward practical applications.
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）