Food Chemistry-X
·
2026
·
IF 9.2
Wenjie Yu,Qiuning Wang,Qifang Sun,Qiming Zhu,Tao Liu,Shengxiang Yi,Gaowei Zhang,Jie Zhu,Jingze Cao,Jinwang Li,Yan Li,Xiaoqing Fan,Xiali Guo,Yanling Song,Liping Luo
Fat content shapes rice eating and nutritional quality, yet its climate response remains unclear. In this study, we combined six years of multisite field observations across nine provinces in southern China with an interpretable random forest model to identify drivers of rice fat. The model showed that the minimum nighttime temperature during grain filling (TMIN) was identified as the primary factor. Fat content increased with TMIN, whereas the unsaturated fatty acid index (IUFA) exhibited three distinct accumulation patterns and generally declined at higher TMIN. This pattern indicates a physiological tradeoff potentially linked to changes in energy metabolism and membrane stability of rice. Patterns were independently validated in 2024 field trials at 11 sites. Furthermore, projections indicate higher fat under warming but declining IUFA, especially in early- and mid-season rice. These results support climate-resilient cultivation, sustainability, and quality management of rice.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Jingtao Zhou,Muxue Qin,Jiasi Li,Junyu Zhu,Yazhong Chen,De Zhang,Bernard Ntezimana,Zhi Yu,Yuqiong Chen,Dejiang Ni
Phenylalanine degradation dominates aroma formation via transaminase pathway. • Fatty acid autoxidation surpasses enzymatic pathways in aldehyde production. • Glycoside hydrolysis activates terpenoid release during early fermentation. • Ribosomal proteins sustain enzyme synthesis despite cellular disruption. • Protein phosphatases modulate enzyme activities through modifications. This study used multi-omics technologies to analyze aroma formation during Congou black tea fermentation. Volatile compounds were analyzed by headspace solid phase microextraction coupled with gas chromatography mass spectrometry using two columns of different polarity. Fermentation increased total volatile normalized peak area fivefold, with alcohols, aldehydes, and acids increasing over sevenfold. 29 differential metabolites were screened, including amino acid derived phenylacetaldehyde, phenylethanol, and 2-methylbutanal; fatty acid derived ( E,E )-2,4-heptadienal, hexanal, and 1-hexanol; and isoprenoid derived linalool, geraniol, and beta ionone. Transcriptomic, proteomic, and enzyme analyses revealed that biosynthesis contributed to early accumulation of amino acid and isoprenoid derived aromas, whereas ortho quinone mediated Strecker degradation and free radical induced fatty acid auto oxidation dominated generation of amino and fatty acid derived aromas during middle and late fermentation. In conclusion, aroma formation during fermentation results from biosynthesis and non-enzymatic oxidation, with the latter possibly dominating amino and fatty acid derived aromas. Download: Download high-res image (314KB) Download: Download full-size image
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Waste Disposal & Sustainable Energy
·
2025
·
IF 4.5
Guo Jing,Liu Peizu,Cui Kai,Feng Dongsheng,Yi Junming,Li Huidong
The development of sustainable adsorbents that integrate low-cost separation and high contaminant removal efficiency remains a critical challenge in wastewater treatment. This study engineered a sludge-based magnetic floatable particle adsorbent (SMFA-800-0.5) through synergistic co-pyrolysis of municipal sludge, red mud, and hollow glass microspheres (HGM) for the removal of basic fuchsin (BF) from dye wastewater. The results indicated that the dual-function separation approach utilizing Fe 3 O 4 in situ formation from red mud (magnetization of 8.24 A·m −1 ) enables excellent recovery efficiency, eliminating the need for external Fe precursors, while the integration of HGM provides a self-floating capability with 76% surface retention over 3 h. The sludge-derived carbon matrix, enhanced by HGM’s structural support, provides hierarchical pores with a Bruner–Emmett–Teller (BET) surface area of 57.98 m 2 ·g −1 . The addition of bentonite clay effectively addresses powder dispersion issues in flow systems. This material demonstrates superior adsorption performance, achieving a capacity of 106.72 mg·g −1 for BF via pseudo-first-order kinetics. The enhanced adsorption performance is driven by multi-mechanism synergies, including electrostatic attraction and pore filling. This work pioneers a “zero-external-input, dual-recovery” paradigm for sustainable dye removal. Graphical abstract
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Nanomedicine-Nanotechnology Biology and Medicine
·
2023
·
IF 5.4
Chunjing Guo,Min Cao,Ningning Diao,Wenxin Wang,Hongxu Geng,Yanguo Su,Tianying Sun,Xinyue Lu,Ming Kong,Daquan Chen
Diabetic nephropathy (DN) is an important complication of diabetes and is the main cause of end-stage renal disease. The pathogenesis of DN is complex, including glucose and lipid metabolism disorder , inflammation, and so on. Novel hybrid micelles loaded Puerarin (Pue) based on Angelica sinensis polysaccharides (ASP) and Astragalus polysaccharide (APS) were fabricated with pH-responsive ASP-hydrazone-ibuprofen (BF) materials (ASP-HZ-BF, SHB) and sialic acid (SA) modified APS-hydrazone-ibuprofen materials (SA/APS-HZ-BF, SPHB) by thin-film dispersion method. The SA in hybrid micelles can specifically bind to the E -selectin receptor which is highly expressed in inflammatory vascular endothelial cells . The loaded Pue could be accurately delivered to the inflammatory site of the kidney in response to the low pH microenvironment . Overall, this study provides a promising strategy for developing hybrid micelles based on natural polysaccharides for the treatment of diabetic nephropathy by inhibiting renal inflammatory reactions, and antioxidant stress.
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JOURNAL OF APPLIED TOXICOLOGY
·
2023
·
IF 3.3
Miao Yang,Kanmin Mao,Xin Cao,Hongjuan Liu,Xinzheng Wang,Weifeng Mao,Liping Hao
The metabolism of polycyclic aromatic hydrocarbons (PAHs) and the elimination kinetics of their mono-hydroxylated metabolites (OH-PAHs) following single exposure to different combinations of four PAHs (PAH4) were studied. Male Sprague–Dawley rats were orally exposed to a single dose of benzo[a]pyrene (B[a]P) or PAH2 (B[a]P + chrysene), PAH3 (B[a]P + chrysene + benz[a]anthracene), and PAH4 (B[a]P + chrysene + B[a]A + benzo[b]fluoranthene) with each combination adjusted to the same dose of individual compound. OH-PAHs including 3-hydroxybenzo[a]pyrene, 3-hydroxychrysene, 3-hydroxybenz[a]anthracene, and 1-hydroxypyrene (1-OHP) were detected in serum and urine samples collected at six intervals over a 72-h period post-dosing. The hepatic mRNA levels of cytochrome P450 (CYPs) were determined to ascertain the expression induction of PAHs metabolic enzymes. Results showed OH-PAHs (except 1-OHP) peaked within 8 h in serum and were excreted from urine within 24–48 h. The serum and urinary concentration of 3-hydroxybenzo[a]pyrene was significantly increased after PAH4 exposure compared with other PAHs combinations. Inversely, urinary concentration of 3-hydroxychrysene was decreased after PAH4 exposure, and the kinetics of 3-hydroxybenz[a]anthracene or 1-OHP were not different depending on the PAHs combinations. Also, CYPs were markedly induced by PAHs. Notably, the induction levels of CYP1A1 and CYP1B1 were significantly higher after PAH4 exposure compared with B[a]P exposure. The results indicated the metabolism of B[a]P was accelerated after PAH4 exposure which might be partly due to the induction of CYPs. These results confirmed PAHs are rapidly metabolized and suggested potential interactions of PAHs may happen among PAH4 mixture.
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CHEMOSPHERE
·
2023
·
IF 8.8
Miao Yang,Yuxuan Lu,Weifeng Mao,Liping Hao
PAH4 (sum of benzo[a]pyrene, chrysene, benz[a]anthracene and benzo[b]fluoranthene) has been proposed as better marker than benzo[a]pyrene to assess total PAHs exposure in foodstuffs. However, the toxicological behaviors of PAH4 combined exposure remain unclear. This study aimed to investigate PAH4 toxicity effects with non-targeted metabolomics approach and evaluate the external and internal dose-response relationships based on benchmark dose (BMD) analysis. Male Sprague-Dawley rats were treated by gavage with vehicle (corn oil) or four doses of PAH4 (10, 50, 250, 1000 μg/kg·bw) for consecutive 30 days. After the final dose, the liver, blood and urine samples of rats were subsequently collected for testing. The concentrations of urinary mono-hydroxylated PAHs metabolites (OH-PAHs) including 3-hydroxybenzo[a]pyrene (3-OHB[a]P), 3-hydroxychrysene (3-OHCHR) and 3-hydroxybenz[a]anthracene (3-OHB[a]A) were determined to reflect internal PAH4 exposure. Our results showed PAH4 exposure increased relative liver weight and serum aspartate aminotransferase (AST) activity and caused hepatocyte swelling and degeneration, implying hepatotoxicity induced by PAH4. Serum metabolomics suggested PAH4 exposure perturbed lipid metabolism through upregulating the expression of glycerolipids metabolites, which was evidenced by markedly increased serum triglyceride (TG) level and hepatic TG content. Additionally, urinary OH-PAHs concentrations presented strong positive correlations with the external dose, indicating they were able to reflect PAH4 exposure. Furthermore, PAH4 exposure led to a dose-response increase of hepatic TG content, based on which the 95% lower confidence value of BMDs for external and internal doses were estimated as 5.45 μg/kg·bw and 0.11 μmol/mol·Cr, respectively. In conclusion, this study suggested PAH4 exposure could induce hepatotoxicity and lipid metabolism disorder, evaluating the involved dose-response relationships and providing a basis for the risk assessment of PAHs.
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JOURNAL OF MOLECULAR LIQUIDS
·
2023
·
IF 6
Ji Ma,Guoxia Huang,Changxin Mo,Junsheng Li,Liujuan Yan,Qian Zhang
Benzo[b]fluorathene (BbF) is one of common polycyclic aromatic hydrocarbons with strong carcinogenic and teratogenic properties and mutagenicity in the environment. In this work, the mechanism underlying the relationship between BbF and herring sperm DNA (hs–DNA) in vitro under simulated physiological conditions was studied through multi-spectroscopic approaches (fluorescence spectroscopy, UV–Vis spectroscopy, resonance scattering spectra, and circular dichroism) coupled with agarose gel electrophoresis, fluorescence microscopy, and viscosity measurements. UV–vis and fluorescence spectra results showed that the BbF–DNA complexes formed with a binding constant of 8.95 ± 0.19 × 10 5 L/mol, and BbF bound to DNA by intercalative binding. These findings were further confirmed through circular dichroism, potassium iodide quenching experiment, salt ion effect tests, and viscosity measurement. Obtained from the resonance scattering spectral data, the saturation value of DNA with BbF was 2.4, revealing that BbF may cause DNA damage. The thermodynamic parameters revealed that the binding process was entropically driven by the spontaneous reaction between BbF and DNA. The main stabilizing forces between BbF and DNA were van der Waals force and π-π packing. Agarose gel electrophoresis and fluorescence microscopy results intuitively verified that the interaction mode of BbF and DNA was intercalation. Moreover, on the basis of intercalative binding between BbF and DNA, DNA and magnetic beads were used to selectively capture BbF, and the removal rate of BbF was 98.76%. This study provides mechanisms underlying the toxicity of BbF and novel insights into BbF clearance methods based on BbF–DNA intercalation.
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POLYMER BULLETIN
·
2019
·Vol. 77
·期 9
·4507-4522
·
IF 1.858
Liu Huijun,Zhang Jianing,Ding Ke,Chen Xiangning,Han Tao
This study aimed to establish a purifying immunoaffinity column (IAC) for four kinds of Fusarium toxins (zearalenone, deoxynivalenol, T-2, and HT-2) simultaneously using poly-glycidyl methacrylate–divinylbenzene [P(GMA–DVB)] as the column matrix. The P(GMA–DVB) microsphere was synthesized using glycidyl methacrylate (GMA) and diethylbenzene (DVB) at an optimal polymerization temperature of 80 °C, the initiator 2,2′-azodiisobutyronitrile concentration of 2.50 g/mL H 2 O, and the DVB-to-GMA ratio of 3:5 (wt.). The polymerized P(GMA–DVB) microspheres were modified with 1,6-hexanediamine, activated with glutaraldehyde, and coupled with the four toxin monoclonal antibodies. The coupling rate of the activated resin was calculated to be 95.95%. The maximum capacity of the IACs was 264 ng deoxynivalenol, 231 ng T-2, 210 ng HT-2, and 292 ng zearalenone. After eight uses, the maximum capacity had no obvious decrease. The recovery of the four Fusarium toxins on the P(GMA–DVB) IAC was 70.03–85.39% in flour, with the relative standard deviations of 4.67–15.93%. The IACs were applied to the actual flour samples.
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SYNTHESIS-STUTTGART
·
2015
·Vol. 47
·期 19
·3049-3060
·
IF 2.689
Jialin Wang,Jiaqi Liu,Hao Lan,Wenyi Chu,Zhizhong Sun
Intramolecular Friedel–Crafts acylation reactions of 2-arylphenoxyacetic acids are accomplished using trifluoroacetic anhydride or trifluoromethanesulfonic acid at 0 °C or room temperature. Depending on the reaction conditions, dibenzoxepines or arylcoumaranones are obtained in good yields and with high selectivities (83–100%). Plausible mechanistic pathways for the selective formation of the different reaction products are discussed.
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FOOD CHEMISTRY
·
2024
·
IF 8.5
Yiran Wang,Chunyu Yang,Xi Wang,Shibing Zhang,Siyi Wang,Di Wu,Kanyasiri Rakariyatham,Jiangning Hu,Qi Zhao
In our study, ammoniated hollow mesoporous silica nanoparticles (NH 2 -HMSN) with uniform diameter and stable structure were successively prepared via SiO 2 core hard template method. Fourier transformed infrared spectroscopy revealed that amino group was effectively modified. Adsorption experiments showed that adsorption capacity of NH 2 -HMSN towards free fatty acids (FFAs) was superior to aminated mesopores or silica microspheres. Following through optimization of extraction conditions, FFAs from edible oil samples were successfully gathered by NH 2 -HMSN and showed favorable linearities (0.2–90 μg g −1 ), remarkably low limit of detections (0.03–0.15 nmol g −1 ), acceptable recoveries (85.08–96.82 %) and relatively accurate precisions (1.64–4.99 %). In comparison to existing adsorbent, NH 2 -HMSN could be successfully prepared via the chemical reaction of common raw materials under normal pressure and temperature. Furthermore, NH 2 -HMSN with hollow and mesoporous structure was more effective than the current adsorbents aimed at FFAs analysis in aspect of surface area and adsorption capacity.
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Food Bioscience
·
2024
·
IF 4.8
Bo-Nan Xi,Jing-Jing Zhang,Cong Li,Xiao Xu,Qin Zeng,Yiran Zhang,Bang Chen,Yehua Shen
Antioxidants are commonly used to enhance the oxidative stability of oils, while its effects on flavor are rarely investigated. In this paper, the antioxidant capacity of two synthetic and two natural antioxidants in walnut oil (WO) were evaluated firstly. Tert -butyl hydroquinone (0.2 g/kg, TBHQ 0.2) and rosemary extract (0.5 g/kg, RE 0.5) exhibited better antioxidant activity. The volatile organic compounds (VOCs) profile changes of WO with TBHQ and RE addition were explored. It is suggested that TBHQ 0.2 and RE 0.5 can effectively delay the increase of VOCs, especially aldehydes. The concentrations of differential metabolites of WO during oxidation including 1-octen-3-ol, hexenal, and (E)-2-heptenal in RE 0.5 were lower than TBHQ 0.2 group, which were original from linolenic acid and linoleic acid. Sensory evaluation indicated TBHQ and RE can maintain the original aroma of WO during oxidation, while RE can enhance the green and fruity aroma.
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Yingjie Wang,Jinhang Zou,Congyu Zhao,Haipeng Jiang,Yuhuan Song,Le Zhang,Xin Li,Fengyou Wang,Lin Fan,Xiaoyan Liu,Maobin Wei,Lili Yang
Effective defect passivation and efficient charge transfer within polycrystalline perovskite grains and corresponding boundaries are necessary to achieve highly efficient perovskite solar cells (PSCs). Herein, focusing on the boundary location of g-C3N4 during the crystallization modulation on perovskite, molecular engineering of 4-carboxyl-3-fluorophenylboronic acid (BF) on g-C3N4 was designed to obtain a novel additive named BFCN. With the help of the strong bonding ability of BF with both g-C3N4 and perovskite and favorable intramolecular charge transfer within BFCN, not only has the crystal quality of perovskite films been improved due to the effective defects passivation, but the charge transfer has also been greatly accelerated due to the formation of additional charge transfer channels on the grain boundaries. As a result, the champion BFCN-based PSCs achieve the highest photoelectric conversion efficiency (PCE) of 23.71% with good stability.
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