Molbank
·
2015
·Vol. 2015
·期 4
·M871
·
IF 0
Shuitao Yu,Xiaohu Feng,Weiyou Zhou,Zhengjun Xia,Mingguang Zhang,Yang Chen,Zaixin Chen
A new tetrahalogenated benzoic acid 4-chloro-2,3,5-trifluorobenzoic acid was synthesized from methyl 2,3,4,5-tetrafluorobenzoate via three steps. The structure of the newly synthesized compound was established by FTIR, NMR, MS and elemental analysis.Keywords:4-chloro-2,3,5-trifluorobenzoic acid;synthesis;amination;Sandmeyer reaction
研究领域:
有机化学
·
药物化学
✓ 已验证
DOI
JOURNAL OF MEMBRANE SCIENCE
·
2020
·
IF 7.183
Xia Fu,Liping Zhu,Songmiao Liang,Yan Jin,Shuguang Yang
While polyvinylidene fluoride (PVDF) is widely used as a commercial UF membrane material, PVDF membrane often encounters fouling problems which significantly reduce the separation performance and service life of membrane. In this work, a special fluoro-contained polymer, sulfonated poly(α,β,β-trifluorostyrene) (SPTFS), is used to improve the hydrophilicity of PVDF membrane, thus to enhance the water flux and antifouling property of the membrane. PVDF membranes with different doping amount of SPTFS are prepared through conventional non-solvent induced phase separation method. Effects of doping SPTFS on the surface morphology , porosity, water contact angle and zeta potential of the prepared membranes are investigated. Compared with the pristine PVDF membrane, the SPTFS-doped membranes show improved hydrophilic property with enlarged finger-like pore structure , decreased water contact angle and higher negative surface charge density, as well as the increased filtration water flux. The enhanced anti-fouling property of the membrane is demonstrated by the cyclic filtration test and the in-situ monitoring of the adsorption and desorption of pollutants using a quartz crystal microbalance.
研究领域:
材料科学
·
环境工程
✓ 已验证
DOI
高影响因子
Materials Today Energy
·
2022
·
IF 9.257
ZhiLong Han,Han Zhang,Qiang Wu,ShuPing Li,Wei Zhong,RenJie He,ShiJie Cheng,Jia Xie
Silicon-sulfur (Si-S) full cells show significant potential in energy storage due to their high theoretical energy density compared to commercial lithium-ion batteries. Nevertheless, a majority of electrolytes reported for Si-S full cells still cannot meet the requirements of stable long-duration cycling. Herein, we report a high-areal-capacity Si-S full cell consisted with prelithiated SiO, thick Li 2 S-Se 0.05 S 0.95 @pPAN electrode and a trifluorobenzene (F 3 B) modified and diluted high-concentration electrolytes. This novel electrolyte can effectively mitigate the volume expansion of the prelithiated SiO anode and enhance the utilization of active S in the cathode, showing excellent compatibility with electrodes. The assembled Si-S full cell using modified electrolyte displays remarkable cyclability over 100 cycles at 0.1C, exhibiting higher capacity retention (54.0% vs . 17.5%) than the pristine electrolyte without F 3 B. More importantly, a full cell with a thick sulfur cathode (16 mg/cm 2 ) exhibits a superior initial areal capacity of 8.34 mAh/cm 2 and high-capacity retention of 52% after 80 cycles, even at a lean electrolyte condition (2 μL/mg). This work provides guidance for the achievement of high-performance Si-S full cells under lean electrolytes.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
DOI
高影响因子
PEST MANAGEMENT SCIENCE
·
2022
·Vol. 78
·期 7
·2851-2859
·
IF 4.462
Shuirong Zhang,Fuchuan Gu,Ying Du,Xuyang Li,Changwei Gong,Jian Pu,Xuemei Liu,Xuegui Wang
BACKGROUND Laodelphax striatellus (Fallén) (Hemiptera: Delphacidae) is one of the most important insect pests of rice, and it has been able to develop strong resistance to many insecticides. Triflumezopyrim, a new type of mesoionic insecticide developed by Corteva Agriscience, showed high biological activity in controlling piercing-sucking insect pests such as planthopper and leafhopper. RESULTS In this study, we continuously selected a susceptible laboratory stain (Unsel) of L. striatellus for 16 generations by exposing it to triflumezopyrim in the laboratory. A 45.1-fold triflumezopyrim-resistant strain (Tri-sel) was established, in which cross-resistance to nitenpyram and acetamiprid was not detected. The realized heritability ( h 2 ) of the Tri-sel strain was estimated at 0.13. The mortalities of the testing F 1 (the offspring of a cross between Unsel and Tri-sel strains) suggested that the resistance of L. striatellus to triflumezopyrim was autosomal and incompletely dominant, as well as a polygenic inheritance. In addition, the results of synergist experiment showed that P450s potentially contributed to the triflumezopyrim resistance. The activities of detoxification enzymes in the Unsel and Tri-sel strains indicated that the activity of P450s in the Tri-sel strain was significantly increased, consistent with the results of synergist experiments. Furthermore, 12 P450 genes demonstrated significant up-regulation. CONCLUSIONS L. striatellus has a certain risk of resistance to triflumezopyrim after continuous selection. Triflumezopyrim resistance did not result in cross-resistance to neonicotinoid insecticides. The up-regulation of multiple P450 genes may mediate triflumezopyrim resistance in L. striatellus . © 2022 Society of Chemical Industry.
研究领域:
昆虫学
·
害虫管理
·
分子生物学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Energy Chemistry
·
2023
·
IF 13.1
Mingsheng Qin,Ziqi Zeng,Qiang Wu,Xiaowei Liu,Qijun Liu,Shijie Cheng,Jia Xie
Ethylene carbonate (EC) is susceptible to the aggressive chemistry of nickel-rich cathodes, making it undesirable for high-voltage lithium-ion batteries (LIBs). The arbitrary elimination of EC leads to better oxidative tolerance but always incurs interfacial degradation and electrolyte decomposition. Herein, an EC-free electrolyte is deliberately developed based on gradient solvation by pairing solvation-protection agent (1,3,5-trifluorobenzene, F 3 B) with propylene carbonate (PC)/methyl ethyl carbonate (EMC) formulation. F 3 B keeps out of inner coordination shell but decomposes preferentially to construct robust interphase, inhibiting solvent decomposition and electrode corrosion. Thereby, the optimized electrolyte (1.1 M) with wide liquid range (−70–77 °C) conveys decent interfacial compatibility and high-voltage stability (4.6 V for LiNi 0.6 Mn 0.2 Co 0.2 O 2 , NCM622), qualifying reliable operation of practical NCM/graphite pouch cell (81.1% capacity retention over 600 cycles at 0.5 C). The solvation preservation and interface protection from F 3 B blaze a new avenue for developing high-voltage electrolytes in next-generation LIBs.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
Surfaces and Interfaces
·
2023
·
IF 6.2
Ye Jiang,Lijun Du,Wenyuan Lang,Shuyu Liu,Bing Xue,Shuguang Yang
Novel thin-film-composite (TFC) nanofiltration (NF) membranes with polysulfone (PSF)/sulfonated polytrifluorostyrene (SPTFS) substrate and polyethyleneimine (PEI)/SPTFS selective layer were fabricated via the combination of phase inversion and stepwise interfacial complexation. As the increase in SPTFS additive during phase inversion, PSF/SPTFS substrates exhibited macrovoids cross-sectional structures, smaller water contact angle, lower surface zeta potential, and excellent water flux. The PEI/SPTFS selective layer was constructed through stepwise interfacial complexation. Attenuated total reflection flourier transformed infrared spectroscopy (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS) results verified the successful complexation of polyelectrolytes on PSF/SPTFS substrate. The water flux and selectivity experiments revealed that the TFC membrane with a single PEI/SPTFS bilayer (TFC-1) presented a desired pure water flux of 28.0 (L m −2 h −1 bar −1 ) and excellent dye rejections of MB, CR, AR66 above 98 %. Moreover, TFC-1 membrane demonstrated a ∼11-fold lower adsorption of bovine serum albumin (BSA, 5.8 µg cm −2 ) compared to the pristine PSF membrane, indicating a great static anti-pollution performance. This study provides a facile strategy to prepare fluoropolymer-modified NF membranes with high water flux, excellent dye rejection and low non-specific adsorption.
研究领域:
材料科学
·
环境工程
·
膜技术
✓ 已验证
产品关联
DOI
高影响因子
CURRENT MOLECULAR MEDICINE
·
2023
·
IF 2.5
Kuang Xinmou,Su Minru,Li Hao,Sheng Xiaolan,Cai Huan,Xie Shuilin,Liu Zhonghua
Background: 3-Amino-4-(2,4,5-trifluorophenyl) butyric acid has potential
pharmacological effects in promoting insulin secretion. Menthol promotes drug
transdermal absorption and hypoglycemic effects.
Objective: The objective of the study was to combine the 3-amino-4-(2,4,5-
trifluorophenyl) butyric acid and menthol to develop a new candidate drug molecule
that can be used as a hypoglycemic drug in type II diabetes.
Methods: In this study, the molecular structure of 3-amino-4-(2,4,5-trifluorophenyl)
butyric acid in sitagliptin was modified by replacing pyrazine imidazole with menthol.
The structure of the target compound was characterized by nuclear magnetic
resonance (NMR). The anti-diabetic activity of BHF in N000180 BKS.Cg-Dock7m+/
+Leprdb/Nju mice with spontaneous diabetes was preliminarily studied.
Results: A potential multi-target drug molecule, 3-amino-4-(2,4,5-trifluorophenyl)
butyrate (BHF), was synthesized by combining 3-amino-4-(2,4,5-trifluorophenyl) butyric
acid and menthol. BHF is suitable for hyperglycemic mice and has a significant
hypoglycemic effect; the low dose of 10 mg/kg-1 started to be effective, and the high
dose of 40 mg/kg-1 was more effective than the positive drug metformin.
Conclusion: In this study, BHF has been synthesized and presented significant
antidiabetic activities.
研究领域:
药理学
·
药物化学
·
代谢病学
✓ 已验证
DOI
高影响因子
Science Advances
·
2025
·Vol. 11
·期 38
·
IF 12.5
Xuefei Jia,Kaicheng Zhang,Xiaofeng Gao,Xufeng Liao,Yujie Yang,Weisheng Li,Xiaojing Lv,Xinyu Zhao,Jiali Liu,Yitong Ji,Zhongliang Yan,Qingguo Du,Fuzhi Huang,Zhiwei Ren,Yaxin Zhai,Wenchao Huang,Yang Bai,Canglang Yao,Qianqian Lin,Yi-Bing Cheng,Jinhui Tong
Wide-bandgap (WBG; >1.65 electron volts) perovskites based on iodine-bromine (I-Br) mixed halides are critical components of perovskite-based tandem solar cells (TSCs). However, the uncontrolled crystallization dynamics of Br-rich species lead to reduced grain sizes and high defect densities in WBG perovskite films. Herein, a multifunctional additive 3,4,5-trifluorobenzamide (TFBZ) was introduced to enhance the crystallinity and passivate defects of the methylammonium (MA)–free WBG perovskite films. The TFBZ demonstrates superior passivation capability compared to benzamide, effectively mitigating both iodine vacancies and undercoordinated Pb 2+ defects via fluorine-enhanced interactions. In addition, the fluorine substituents in TFBZ could form N–H···F hydrogen bonds with formamidinium iodide to retard the crystallization rate of the perovskite. This proposed method is effective in defect passivation and crystal growth modulation for both 1.67– and 1.79–electron volt MA-free WBG perovskites, enabling the fabrication of MA-free all-perovskite TSCs with an encouraging power conversion efficiency of 29.01% (certified at 28.52%).
研究领域:
材料科学
·
光伏技术
·
半导体物理
·
纳米材料
·
能源化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Zhenqiang Fan,Zongqiong Lin,Zepeng Wang,Jianfeng Wang,Minhao Xie,Jianfeng Zhao,Kai Zhang,Wei Huang
In this work, we fabricated a dual-wavelength electrochemiluminescence ratiometric biosensor based on electrochemiluminescent resonance energy transfer (ECL-RET). In this biosensor, Au nanoparticle-loaded graphitic phase carbon nitride (Au-g-C3N4) as a donor and Au-modified dimethylthiodiaminoterephthalate (TAT) analogue (Au@TAT) as an acceptor were investigated for the first time. Besides, tetrahedron DNA probe was immobilized onto Au-g-C3N4 to improve the binding efficiency of the transcription factor and ECL ratiometric changes on the basis of the ratio of ECL intensities at 595 and 460 nm, which were obtained through the formation of a sandwich structure of DNA probe–antigen–antibody. Our biosensor achieved the assay of NF-κB p50 with a detection limit of 5.8 pM as well as high stability and specificity.
研究领域:
分析化学
·
生物传感器
·
电化学
·
纳米技术
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）