APPLIED CATALYSIS A-GENERAL
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2020
·
IF 5.006
Haodong Duan,Xiaolei Xu,Kangwei Leng,Ge Guo,Qing Yu,Xinjin Li,Yuxi Han,Jun Gao,Zhongwei Wang
The characteristics of the reaction for the preparation of dichlorophenylphosphine (DCPP) via benzene and PCl 3 in the presence of AlCl 3 were studied. Some unique characteristics were observed when a catalytic amount of AlCl 3 was used. Namely, more than one mole of DCPP was obtained per mole AlCl 3 , the reaction solution was layered, and DCPP could be directly separated. Our mechanistic study showed that benzene reacted with PCl 3 to form DCPP-AlCl 3 , and DCPP-AlCl 3 dissociated into DCPP and AlCl 3 , continuing to catalyze this reaction. This resulted in the high catalytic efficiency of AlCl 3 . The layering of the reaction solution was caused by the immiscibility of DCPP-AlCl 3 with the raw materials, greatly facilitating the dissociation process of DCPP-AlCl 3 . The formation of diphenylphosphorus chloride (DPC) was due to a continuous Friedel-Crafts reaction between DCPP and benzene. DPC cooperated with AlCl 3 to form the stable coordination compound DPC-AlCl 3 that did not dissociate and was responsible for the deactivation of AlCl 3 .
研究领域:
有机化学
·
催化化学
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产品关联
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2020
·
IF 6.551
Haiyang Zhang,Mian Wei,Xiangyu Lu,Qinghong Sun,Chuqiao Wang,Jiuyan Zhang,Honggang Fan
Aluminum (Al) is an inorganic pollutant that induces nerve cells apoptosis and necroptosis, thereby causing depression and neurodegenerative diseases. IL-1β/JNK signaling pathway can regulate apoptosis and necroptosis. However, it remains unclear whether IL-1β/JNK signaling pathway is involving in the regulation of Al-induced hippocampal neural cells apoptosis and necroptosis. To investigate the mechanism of Al on neural cells apoptosis and necroptosis, rats were orally exposed to different doses of AlCl 3 for 90 days. The open-field test results showed that AlCl 3 caused depressive behavior in rats. Histopathological evidence showed that AlCl 3 induced hippocampal neural cells apoptosis and necrosis. Moreover, Bax/Bcl-2 mRNA expression ratio, caspase-3 activity and mRNA expression and TUNEL positive rates were upregulated, meanwhile, TNF-α mRNA and protein expression levels, TNFR1, RIP1, RIP3 and MLKL proteins levels were increased, while caspase-8 protein level was decreased in the hippocampus of Al-exposed groups. These results proved that AlCl 3 induced hippocampal neural cells apoptosis and necroptosis. Combined with histopathology and correlation analysis, we deduced that hippocampal neural cells were more likely to undergo necroptosis at high doses (450 mg/kg) of AlCl 3 , while <150 mg/kg AlCl 3 tended to induce apoptosis. Finally, AlCl 3 increased the proteins level of IL-1β, IL-1RI, IL-1RAcP, JNK and p-JNK, indicating that AlCl 3 activated IL-1β/JNK signaling pathway. However, the application of IL-1 receptor antagonist (IL-1Ra) inhibited the phosphorylation of JNK and the related genes expression of apoptosis and necroptosis caused by AlCl 3 . Thus, we concluded that AlCl 3 induced hippocampal neural cells death and depression-like behavior in rats by activating IL-1β/JNK signaling pathway.
研究领域:
神经科学
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药理学
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毒理学
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
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2015
·
IF 2.084
Zheng Cao,Yang Fu,Xudong Sun,Qiuyue Zhang,Feibo Xu,Yanfei Li
Exposure to aluminum (Al) suppresses bone formation. Osteoblastic differentiation plays a key role in the process of bone formation. However, the effect of Al on osteoblastic differentiation is still controversial, and the mechanism remains unclear. To investigate the effect of Al on osteoblastic differentiation and whether Wnt signaling pathway was involved in it, the primary rat osteoblasts were exposed to 1/40 IC50, 1/20 IC50 and 1/10 IC50 of aluminum trichloride (AlCl 3 ) for 24 h, respectively. The activity analysis of alkaline phosphate, qRT-PCR analysis of type I collagen, alkaline phosphate, Wnt3a and Dkk-1, Western blot analysis of p-GSK3β, GSK3β and β-catenin protein and Immunofluorescence staining for β-catenin suggested that AlCl 3 inhibited osteoblastic differentiation and Wnt/β-catenin pathway. Moreover, we found exogenous Wnt3a application reversed the inhibitory effect of AlCl 3 on osteoblastic differentiation, accompanied by activating the Wnt/β-catenin pathway. Taken together, these findings suggest that AlCl 3 inhibites osteoblastic differentiation through inactivation of Wnt/β-catenin pathway in osteoblasts.
研究领域:
药理学
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细胞生物学
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分子生物学
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DOI
PubMed
高影响因子
GREEN CHEMISTRY
·
2023
·Vol. 25
·期 12
·4781-4792
·
IF 9.8
Chunxiao Gong,Zhaoyang Ju,Kuichuan Sheng,Ximing Zhang
Improper disposal of large quantities of crustacean shell waste from the food industry has caused serious environmental problems and waste of resources. Shell biorefinery is an emerging concept that upcycles the major components of crustacean shell waste, such as chitin, into value-added chemicals and materials. Producing biomass-derived 5-hydroxymethylfurfural (HMF) has been a hot topic over the past decades, while efficient conversion of shell-derived chitin into HMF is not available due to its water-insoluble and chemically-stable features. Herein, we develop a sustainable and efficient HMF production route from chitin. Chitin was treated with formic acid under mild conditions to synthesize formylated chitin (FC), which was subsequently converted to HMF in dimethyl sulfoxide (DMSO)–H2O media. Results showed that FC achieved a 53.2% HMF yield at 160 °C for 10 min catalyzed by AlCl3 in the co-solvent system (DMSO : H2O = 4 : 1, v/v), which is 11 times higher than the yield obtained from chitin under the same condition. The grafted formyl groups on FC significantly enhanced its noncovalent interactions with DMSO molecules, enhancing the accessibility and reactivity for HMF production. The reaction mechanisms were proposed and simulated with density functional theory calculations, and the intramolecular hydrogen migration is the rate-determining step in the reaction pathways. This study highlights a green and simple approach for chitin valorization.
研究领域:
化学工程
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环境科学
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材料科学
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DOI
高影响因子
CHEMOSPHERE
·
2018
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IF 4.427
Haiyang Zhang,Peiyan Wang,Hongyan Yu,Kaiyuan Yu,Zheng Cao,Feibo Xu,Xu Yang,Miao Song,Yanfei Li
Aluminum (Al) is a recognized environmental pollutant that causes neuroinflammatory lesions, leading to neurodegenerative diseases. Interleukin-1 (IL-1) signaling pathway is responsible for regulating inflammatory lesions. However, it remains unclear whether IL-1 signaling pathway is involved in neuroinflammatory lesions induced by Al exposure. In the present study, one hundred and twenty Wistar rats were orally exposed to 0, 50, 150 and 450 mg/kg BW/d aluminum trichloride (AlCl 3 ) for 90 days, respectively. We found that AlCl 3 exposure increased hippocampal Al concentration, reduced hippocampus coefficient, impaired cognitive ability, deteriorated microstructure of hippocampal CA1 and CA3 regions, increased reactive oxygen species (ROS) level, activated astrocytes and microglia, increased pro-inflammatory cytokines contents and mRNA expressions, and decreased anti-inflammatory cytokines contents and mRNA expressions in the hippocampus. These results indicated that AlCl 3 induced the hippocampal inflammatory lesion (HIL). Moreover, AlCl 3 exposure increased the mRNA and protein expression of IL-1 signaling pathway core components in the hippocampus, demonstrating that AlCl 3 activated IL-1 signaling pathway. Furthermore, the correlation between interleukin-1β (IL-1β) content and HIL and activation of the IL-1 signaling pathway was analyzed. Results showed that IL-1β content was positively correlated with pro-inflammatory cytokines contents and mRNA expressions and activation of IL-1 signaling pathway, and was negatively correlated with hippocampus coefficient, anti-inflammatory cytokines contents and mRNA expressions, and the number of hippocampal neurons. The above results demonstrate that AlCl 3 -induced HIL is associated with IL-1 signaling pathway, in which IL-1β is a link.
研究领域:
神经科学
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药理学
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毒理学
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免疫学
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产品关联
DOI
PubMed
高影响因子
BIOLOGICAL TRACE ELEMENT RESEARCH
·
2015
·Vol. 171
·期 1
·116-123
·
IF 1.748
Zhang Qiuyue,Cao Zheng,Sun Xudong,Zuang Cuicui,Huang Wanyue,Li Yanfei
Aluminum (Al) is the most abundant metal in the earth’s crust. Al accumulates in erythrocyte and causes toxicity on erythrocyte membrane. The dysfunction of erythrocyte membrane is a potential risk to hypertension. The high Al content in plasma was associated with hypertension. To investigate the effect of AlCl 3 on blood pressure and the function of erythrocyte membrane, the rats were intragastrically exposed to 0, 64(1/20 LD 50 ), 128(1/10 LD 50 ), and 256(1/5 LD 50 ) mg/kg body weight AlCl 3 in double distilled water for 120 days, respectively. Then, we determined the systolic and mean arterial blood pressures of rats, the osmotic fragility, the percentage of membrane proteins, the activities of Na + /K + -ATPase, Mg 2+ -ATPase, Ca 2+ -ATPase, catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-pX), and malondialdehyde (MDA) content of the erythrocyte membrane in this experiment. The results showed that AlCl 3 elevated the systolic and mean arterial blood pressure of rats, increased the osmotic fragility, decreased the percentage of membrane protein, inhibited the activities of Na + /K + -ATPase, Mg 2+ -ATPase, Ca 2+ -ATPase, CAT, SOD and GSH-pX, and increased the MDA content of erythrocyte membrane. These results indicate that AlCl 3 may induce hypertension by disturbing the function of erythrocyte membrane.
研究领域:
药理学
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毒理学
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心血管研究
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DOI
PubMed
高影响因子
JOURNAL OF BIOTECHNOLOGY
·
2025
·
IF 3.9
Kang Zhao,Sha-Sha Zhao,Quan-Wei Liu,Zhen Liu
To address the challenge of lignin removal while preserving cellulose in lignocellulosic biomass valorization, this study developed a novel ternary deep eutectic solvent (DES) system composed of triethylbenzyl ammonium chloride (T, as hydrogen bond acceptor), copper chloride (Lewis acid catalyst), and ethylene glycol (EG, hydrogen bond donor) for microwave-assisted pretreatment of corn straw. The DES was designed to leverage synergistic effects between Lewis acid catalysis and hydrogen bond disruption for selective lignin extraction. Optimization via Box-Behnken experimental design revealed that optimal delignification (96.52%) and hemicellulose removal (94.60%) with 94.79% cellulose retention were achieved under microwave conditions of 130°C, 40 min, liquid-solid ratio 13.1, and CuCl₂/T molar ratio 0.198. Comparative characterization of raw and pretreated biomass using SEM, FT-IR, and XRD demonstrated that T-CuCl₂-EG disrupted the lignocellulose matrix by breaking ether/ester bonds in lignin-carbohydrate complexes, selectively solubilizing lignin/hemicellulose while preserving cellulose crystallinity. This work provides a sustainable and efficient strategy for biomass fractionation, with potential applications in biorefineries.
研究领域:
生物资源技术
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绿色化学
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生物质转化
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可持续能源
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Zhang Ziyuan,Chen Hongzhi,Ran Ke,Lai Jingsong,Xie Jinli,He Zhiyu
this study aimed to optimize the reaction conditions, specifically pH and temperature, for the phosphate functionalization of silver nanoparticles (AgNPs). An orthogonal array experimental design was employed to systematically investigate the influence of these parameters on the modification process. Each batch of phosphate-modified AgNPs was subsequently assessed for its performance in detecting UO 2 2+ ions. The results indicated that modification with disodium hydrogen phosphate at pH 9 and 60 °C provided the most effective functionalization, yielding optimal UO 2 2+ sensing capability. Following modification, the average particle size of AgNPs increased from 5 to 10 nm to 10–12 nm, accompanied by increased uniformity and colloidal stability. Using these functionalized AgNPs, a rapid colorimetric method for UO 2 2+ detection in nuclear industry applications was developed. Selectivity tests against various metal ions confirmed the nanosensor's high specificity for UO 2 2+ . Upon introduction of UO 2 2+ , aggregates with the structure “UO 2 2+ –phosphate–AgNPs” formed in the colloidal system, inducing a detectable shift in the localized surface plasmon resonance (LSPR) absorption peak and producing a clear colorimetric response. The sensor exhibited a linear detection range from 5 × 10 −7 M to 3.0 × 10 −6 M, with a limit of detection (LOD) of 5 × 10 −7 M and a correlation coefficient (R 2 ) of 0.97. Application of the sensor to simulated nuclear wastewater demonstrated distinct and reliable colorimetric changes. Overall, this work presents a cost-effective and efficient approach for the selective detection of UO 2 2+ , offering potential utility for monitoring uranium in nuclear industry settings
研究领域:
纳米技术
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环境监测
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核化学
·
传感器与生物传感器
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产品关联
DOI
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
·
2025
·
IF 5.4
Meng Kong,Zixuan Xu,Haifei Lu,Yumeng Chen,Yini Zhang,Xia Jiang,Ping Wang
Ethnopharmacological relevance ShengHui decoction (SHD), a traditional Chinese herbal formula, has long been used clinically to mitigate Alzheimer’s disease (AD), demonstrating significant efficacy in alleviating cognitive impairment. However, its molecular mechanisms remain insufficiently understood. Aim of the study To clarify the effects of SHD on oxidative stress–related markers and inflammatory cytokines in an aluminum chloride (AlCl 3 )-induced zebrafish model of AD and as well as uncover its underlying mechanisms in alleviating oxidative stress and neuroinflammation.. Materials and methods Ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) was employed to identify the bioactive constituents of SHD. Behavioral tests and histopathological analyses were then conducted to evaluate the effects of SHD (0.74, 1.48, and 2.96 mg/mL) on apoptosis and amyloid-beta (Aβ) deposition in an AlCl 3 -induced AD zebrafish model. Biochemical assays and enzyme-linked immunosorbent assay were used to quantify superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-Px), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), IL-1 beta (IL-1β), and IL-18.. Western blot analysis was performed to determine the protein expression of nuclear factor erythroid 2–related factor 2 (Nrf2), heme oxygenase-1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO1), nuclear factor-kappa B p65 (NF-κB p65), phosphorylated NF-κB p65 (p–NF-κB p65), and NOD-like receptor family pyrin domain containing 3 (NLRP3). Results UPLC–MS/MS profiling identified phenolic acids, saponins, lignans/coumarins, flavonoids, and aliphatic alcohols as the main constituents of SHD. SHD significantly ameliorated cognitive deficits and histopathological abnormalities in AlCl 3 -induced zebrafish. Moreover, SHD attenuated oxidative stress by upregulating Nrf2, HO-1, and NQO1 expression, while downregulating AlCl 3 -induced levels of NF-κB p65, p–NF-κB p65, NLRP3 and pro-inflammatory factors. Conclusions SHD effectively improved cognitive performance and reduced AD-like pathological lesions in AlCl 3 -induced zebrafish. Importantly, SHD exhibits both antioxidant and anti-inflammatory activities by activating the Nrf2/HO-1 axis and inhibiting NF-κB signaling, thereby alleviating oxidative stress and neuroinflammatory responses in AD. These findings provide experimental evidence supporting SHD as a potential therapeutic agent for AD, and substantiate the traditional Chinese medicine principle of tonifying the kidney and replenishing essence in the treatment of AD.
研究领域:
药理学
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神经科学
·
民族药理学
·
分子生物学
·
中医中药
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产品关联
DOI
PubMed
高影响因子
Environmental Technology & Innovation
·
2025
·
IF 7.1
Lei Zheng,Rongzhen Ma,Hong Liu,Changsheng Jiang,Cheng Song
A microfluidic-fluorometric platform integrated with carbon dots was developed for the real-time and sensitive detection of Chromium(VI) (Cr 6 + ). Chitosan and o-Phenylenediamine were used as precursors to synthesize nitrogen-doped carbon dots (OPD-CDs) via a solvothermal method. The OPD-CDs exhibited a monodisperse spherical nanostructure with an average diameter of 3.86 ± 0.09 nm, a quantum yield of 36.77 %, and a surface enriched with amino and carboxyl functional groups. Cr 6+ induced selective fluorescence quenching through a charge transfer mechanism, where electron donation from surface amines suppressed radiative recombination, accompanied by emission red-shift and increased Stokes shift. Furthermore, quenched OPD-CDs was able to restore fluorescence by adding H 2 O 2 . OPD-CDs demonstrated a detection limit of 0.73 μM and a linear range of 0.2–210 μM under the conventional spectrofluorometry. When incorporated into a microfluidic chip, the OPD-CDs integrated platform achieved a rapid response within 1 min, a detection limit of 1.04 μM, and high selectivity against 26 potential interfering ions. Spike-recovery tests in tap and river water samples yielded recoveries of 98.6–104.7 % (RSD ≤ 2.2 %), confirming its practicality for on-site water quality monitoring. This study innovatively merges optoelectronics features of carbon dots with the microfluidic miniaturization, enabling portable and real-time monitoring of Cr 6+ , which highlights critical needs for rapid detection of heavy metals in accidental pollution events and water quality surveillance.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Shuangshuang Hou,Hui Gao,Peixuan Xie,Shiwei Jin,Fengtian Wu,Bien Tan
Microporous hyper-cross-linked polymers appending variant electron-withdrawing functional groups have enormous potential for selective CO 2 adsorption and separation, whereas these functionalities by lowering the charge density of monomers will decrease their reaction activity, which in turn is unfriendly for the direct and highly efficient preparation of polymers with high CO 2 uptake capacity. Herein a new amide “insertion” strategy for knitting polymers with ideal electron-withdrawing functionalities was advanced, and in this manner, a series of carboxyl enriched novel polymers were synthesized via the one-pot Friedel-Crafts alkylation reaction by using fluorene derivatives as emerging building blocks. The created polymer 3 possessing BET surface area 1947 m 2 g −1 have a CO 2 uptake of up to 20.03 wt% at 273.15 K/1.00 bar. Besides, the carboxyl and amide groups in structure could bestow the polymers an enhanced CO 2 /N 2 selectivity of 33.17 at 273.15 K. In addition, the hierarchical porosity and CO 2 adsorption capability of manufactured polymers can be intriguingly tailored, and prolonging the carboxylated side chains of building blocks by inserting different quantities of amide group will be propitious for bettering the porosity and CO 2 capturing capacity of manufactured polymers. Supported by charge density distribution simulation and electrostatic potential calculation, the peculiar changes in polymer structures and CO 2 adsorption features were also explained.
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DOI
高影响因子
Food Chemistry-X
·
2025
·
IF 8.2
Qian-Da Xu,Zhi-Long Yu,Qiang He,Wei-Cai Zeng
Regulation of different metal ions on the properties, structure, self-assembly and encapsulating capabilities of soybean globulin (SG)-tannic acid (TA) conjugates were investigated. Through coordination interactions, metal ions promoted the supramolecular self-assembly of SG, resulting in the efficient encapsulation of β-carotene in its hydrophobic domains. Fe 3+ and Cu 2+ enhanced particle integrity by forming stable metal–polyphenol networks, while Al 3+ and Zn 2+ achieved the highest β-carotene encapsulation efficiency due to their appropriate capability to interact with SG/TA and lower destructive effect on β-carotene. In the presence of TA, Fe 3+ /Cu 2+ imparted strong pH stability to the carriers, Al 3+ /Mg 2+ /Zn 2+ preserved β-carotene under light/heat/oxygen conditions, and Al 3+ /Zn 2+ promoted superior antioxidant activity and β-carotene bioaccessibility during digestion. These findings demonstrate that metal ions with distinct coordination characteristics significantly influence the functionality of SG–TA conjugates, offering insights for the rational design of metal-induced protein–polyphenol delivery systems.
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）