JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2018
·
IF 2.441
Xuran Wang,Ming Gao,Jiajia Gao,Xuedong Wang,Meiping Ma,Huili Wang
Herein, we established an ionic liquid (IL)-based liquid-solid transformation microextraction (IL-LTME) combined with HPLC-UV detection for the simultaneous determination of triclosan (TCS) and its methylated product, methyltriclosan (MTCS), in human fluids. The IL-LTME method was based on an in situ metathesis between hydrophilic IL and ion-exchange salt to form a solid hydrophobic IL. According to the above principle, a hydrophilic IL, [C 12 MIM]Br, was selected as the extractant, and NH 4 PF 6 as ion-exchange salt. The prominent advantages of the newly developed method are: (1) the in-situ reaction between the extractant [C 12 MIM]Br and ion-exchange salt NH 4 PF 6 changed the IL from hydrophilic to hydrophobic that avoiding the stick of ionic liquid on the tube wall; (2) bubbling with NH 3 greatly increased the contact area between IL-extractant and analytes resulting in improved extraction recovery; and (3) solidification of the [C 12 MIM] PF 6 provided a good separation and avoided the use of specialized equipment. A series of main parameters were optimized by single-factor screening and central composite design as follows: 0.9 mL of NaOH, 2.0 min of second ultrasonically time, 10 min of centrifugation time, 21 mg of extractant [C 12 MIM]PF 6 , 2.4 min of ultrasonic time, 65 mg of NH 4 PF 6 and 13.8 min of cooling time. Under the optimized conditions, the limits of detection for TCS and MTCS were 0.126–0.161 μg L −1 in plasma samples, and 0.211–0.254 μg L −1 in urine samples, respectively. The extraction recoveries for TCS and MTCS were in the range of 94.1–103.8%. The intra-day and inter-day precisions were 1.00–4.74% and 1.02–5.21%, respectively. In general, the IL-LTME method is environment-friendly, time-saving, economical, high efficient and robust with low detection limits and high recoveries. Thus, the newly developed method has excellent prospects for sample pretreatment and analysis of trace TCS and MTCS in blood and urine samples.
研究领域:
分析化学
·
环境科学
·
医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ULTRASONICS SONOCHEMISTRY
·
2018
·
IF 6.012
Xuedong Wang,Mei Wang,Xuran Wang,Liyang Du,Fangyu Chu,Weinan Ding,Haidong Gu,Huili Wang
A microextraction method was developed based on utilization of a novel ionic liquid (IL) [C 4 MIM][NCA] as disperser and conventional ILs as extractor (IL-IL-DLLME). This method was integrated with an in-situ metathesis reaction to achieve high extraction efficiency by eliminating the loss of analytes in the discarded disperser after microextraction. Ultrasonic energy was compared to traditional mechanical shaking to accelerate the in-situ metathesis reaction. A 3-min ultrasonic treatment provided similar extraction efficiency as a 120-min mechanical shaking. Due to their strong acidity and lower solubility than traditional hydrophilic ILs, utilization of [C 4 MIM][NCA] in the IL-IL-DLLME procedure increased extraction recoveries (ERs) for triclosan (TCS) and methyltriclosan (MTCS) by 10–12% and also avoided an extra pH adjustment step. A series of operational parameters were optimized using single-factor screening and central composite design as follows: 65 µL extraction solvent, 150 µL [C 4 MIM][BF 4 ] and [C 4 MIM][NCA] (132/18, v/v, μL) as dispersive solvent, 0.16 g NH 4 PF 6 and 3.3 min ultrasonic time. Under optimized conditions with a fortification of 100 µg kg −1 , ERs were 92.6–93.4% for TCS and 92.7–94.2% for MTCS in bovine milk and chicken egg samples. LODs for TCS and MTCS were 0.16–0.24 µg kg −1 and the enrichment factors were 21.8–23.1. Inter- and intra-day precisions had relative standard deviations of 3.3–5.4% for the optimized method. Overall, this newly developed IL-IL-DLLME method was effective for detecting trace levels of TCS and MTCS in real-world, animal-based foods. Prominent advantages of the new method include high precision and accuracy, high extraction efficiency, simple analytical operations, and no use of organic solvents making the procedure environmentally benign.
研究领域:
分析化学
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2021
·
IF 6.291
Yanyan Li,Guozhong Dong,Jianye Li,Jianxing Xiang,Jingrui Yuan,Huili Wang,Xuedong Wang
Herein, we synthesized a kind of magnetic covalent organic framework nanohybrids (NiFe 2 O 4 @COF), and integrated it with polydimethyl siloxane and silicone rubber curing agent for solid phase microextraction (SPME) fiber coating. The fiber coating demonstrated a porous and uniform surface with the BET specific surface of 169.7 m 2 g -1 . As for seven environmental analytes, the NiFe 2 O 4 @COF-based SPME fiber coating gave the higher extraction recoveries for triclosan (TCS) and methyltriclosn (MTCS) than those of fenpropathrin, bifenthrin, permethrin, fenvalerate and deltamethrin. Several operational parameters were rigorously optimized, such as extraction temperature, extraction time, thermal desorption time, solution pH and salt effect. Combined with the GC-ECD detection, the newly developed microextraction method supplied the wide linear range of 0.1–1000 µg L -1 with the correlation coefficients of > 0.9995. The limits of detection (LODs) and limits of quantitation (LOQs) reached as low as 1–7 ng L -1 and 3.3–23 ng L -1 , respectively. The intra-day and inter-day precisions in six replicates ( n = 6 ) were < 3.55% and < 5.06%, respectively, and the fiber-to-fiber reproducibility ( n = 3) was < 7.64%. To evaluate its feasibility in real samples, the fortified recoveries for TCS and MTCS, at low (0.2 µg L -1 ), middle (2.0 µg L -1 ) and high (20.0 µg L -1 ) levels, varied between 81.9% and 119.1% in tap, river and barreled waters as well as male, female and children urine samples. Especially, it is worth mentioning that the NiFe 2 O 4 @COF-based SPME coating fiber can be recycled for at least 150 times with nearly unchanged extraction efficiency. Moreover, the extraction recoveries by the as-fabricated fiber coating were much higher than those by three commercial fibers (PDMS, PDMS/DVB and PDMS/DVB/CAR). Overall, the NiFe 2 O 4 @COF-based SPME is a convenient, sensitive, efficient and “green” pretreatment method, thereby possessing important application prospects in trace monitoring of TCS-like pollutants in complex liquid matrices.
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Water
·
2022
·Vol. 14
·期 4
·576
·
IF 3.53
Jing Wang,Haoran Man,Li Sun,Shuying Zang
Industrial grade carbon black was pretreated and used for adsorption of triclosan (TCS) in water, and its adsorption performance was investigated by static adsorption experiments and fixed bed adsorption experiments. The effects of pH and temperature on the adsorption capacity were investigated and the adsorption performance of carbon black and activated carbon on TCS was compared. As the pH or temperature decreased, the adsorption of TCS by carbon black increased. Carbon black had a maximum adsorption capacity of 18.62 mg/g on TCS, which was somewhat lower than the activated carbon. Furthermore, the breakthrough time increased with increasing bed height, decreasing flow rate and decreasing initial TCS concentration in the fixed bed adsorption studies. The breakthrough time was 14.33 days at a bed depth of 4.2 mm, a flow rate of 2 mL/min, and an initial TCS concentration of 0.5 mg/L TCS. The model from The Bed Depth Service Time (BDST) was well-fitting.Keywords:carbon black;triclosan;adsorption;BDST model
研究领域:
环境科学
·
化学工程
✓ 已验证
DOI
高影响因子
Sustainability
·
2022
·Vol. 14
·期 19
·12872
·
IF 3.889
Zihan Lang,Lidong Xue
Triclosan (TCS) has been widely employed as active ingredient in household products and has received attention for its hepatotoxicity, endocrine disruption and disturbance on immune function. Polylactic acid (PLA) has been highlighted as an alternative biodegradable microplastic, and the knowledge about the adsorption affinity towards TCS is limited. In this study, the ability to act as carrier of TCS by PLA and non-biodegradable microplastics, including polystyrene (PS), polyvinyl chloride (PVC) and polyethylene (PE) with different particle sizes were explored. The influence factors (e.g., dosage, pH and salinity), adsorption kinetics and isotherms were also investigated. Batch experiment results indicated that the TCS adsorption onto PLA and non-biodegradable microplastics exhibited a pronounced pH-dependent pattern (pH of 4, 7 and 10), and the adsorption capacity decreased gradually as pH increased. Furthermore, the adsorption capacity of TCS on PS, PVC and PE decreased as salinity increased from 0 to 3.5%, while no significant inhibition for the sorption capacity of PLA was observed. The adsorption kinetic data of TCS was best fitted with the pseudo-second order model. The Freundlich model with R2(0.999) was suitable to describe the adsorption isotherms of TCS on PLA, while the isotherms data of TCS on PS, PVC and PE was fitted by linear and Freundlich model. The higher adsorption capacity of PLA (38.6 mg g−1) compares to those of PS, PVC and PE (31.3, 11.4 and 9.64 mg g−1, respectively), illustrated by the fact that the physicochemical properties of microplastics have a noticeable impact on adsorption process, and the biodegradable PLA is a stronger vector than the non-biodegradable microplastics.Keywords:triclosan;polylactic acid;vector;pH-dependent
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Jianzhong Ma,Chongxin An,Lei Zhang
In this work, we synthesized an acid-responsive zinc metal–organic framework (ZIF-8) at room temperature by a solvent method, which can not only be used as an antibacterial by releasing zinc ions but also as a carrier for antibacterial material encapsulation. Subsequently, the broad-spectrum antibacterial triclosan (TCS) was encapsulated in ZIF-8 by the impregnation method, and a long-term antibacterial and antimildew material with slow-release effect TCS@ZIF-8 was synthesized successfully. The encapsulation rate and drug loading rate of TCS@ZIF-8 prepared by adjusting the mass ratio of ZIF-8 and TCS were 71.9 and 25.1%, respectively. Further, TCS@ZIF-8 was introduced into polyacrylate (PA) emulsion, and PA/TCS@ZIF-8 nanocomposite emulsion was prepared successfully by the physical blending method. When the pH of the coating surface became slightly acidic due to the metabolic byproducts of microbial growth, ZIF-8 in PA/TCS@ZIF-8 disintegrated to release Zn2+ and TCS, which can effectively kill bacteria and mold. When the dosage of TCS was 4.0 wt %, the antibacterial rate of the PA/TCS@ZIF-8 nanocomposite film against Escherichia coli and S. aureus was 100 and 97.3%, respectively. Finally, PA/TCS@ZIF-8 nanocomposite emulsion-coated leather was prepared by the spraying method. Compared with the control group that did not use ZIF-8-encapsulated TCS, PA/TCS@ZIF-8 nanocomposite emulsion-coated leather not only showed better antibacterial and antimildew effects but also showed long-term antibacterial and antimildew performance even after being treated under hot and humid environments of 90% humidity and 40 °C for 30 days. Overall, this study not only provides theoretical guidance into the preparation of long-term antibacterial and antimildew coatings for leather but also has great application prospects in paper, clothing, furniture, and other fields, which has great significance in protecting consumers from the invasion of bacteria and mildew.
研究领域:
材料科学
·
皮革化学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL TECHNOLOGY
·
2018
·
IF 1.666
Shizong Wang,Jianlong Wang
Triclosan is an extensively applied antimicrobial agent which has been frequently detected in the environment. In this paper, the degradation of triclosan and its main intermediates was investigated during the combined irradiation and biological treatment. The results showed that triclosan degradation increased with increase of absorbed dose, the removal efficiency of triclosan was 62%, 77%, 87%, 91% and 94%, respectively at 1, 2, 3, 4 and 5 kGy. The final removal efficiency of triclosan after the combined irradiation and biological process was 81%, 86%, 90%, 92% and 95%, respectively. During the irradiation process, two main intermediates, that is, 4,4′-2′-phenoxyphenol (Intermediate 1) and 4-chloro-2′-phenoxyphenol (Intermediate 2) were detected, in which Intermediate 1 dominated during the irradiation process. In the following biological treatment process, Intermediates 1 and 2 could be further degraded. In single biological treatment process, the final removal efficiency of triclosan was 54%, and Intermediates 1 and 2 were detected. Intermediate 1 could be biodegraded while Intermediate 2 could not. The concentration of Intermediate 2 increased during biological treatment process. In conclusion, irradiation as pre-treatment process can enhance the degradation of triclosan and improve the biodegradability of Intermediate 2. Combined irradiation and biological process can be promising for treating antibiotic-containing wastewater.
研究领域:
环境科学
·
微生物学
✓ 已验证
DOI
高影响因子
ENVIRONMENTAL POLLUTION
·
2017
·
IF 5.099
Tengda Ding,Kunde Lin,Lianjun Bao,Mengting Yang,Juying Li,Bo Yang,Jay Gan
Triclosan is one of the most frequently detected emerging contaminants in aquatic environment. In this study, we investigated the biouptake, toxicity and biotransformation of triclosan in freshwater algae Cymbella sp. The influence of humic acid , as a representative of dissolved organic matter , was also explored. Results from this study showed that triclosan was toxic to Cymbella sp. with 72 h EC 50 of 324.9 μg L −1 . Humic acid significantly reduced the toxicity and accumulation of triclosan in Cymbella sp. SEM analysis showed that Cymbella sp. were enormously damaged under 1 mg L −1 triclosan exposure and repaired after the addition of 20 mg L −1 humic acid. Triclosan can be significantly taken up by Cymbella sp. The toxicity of triclosan is related to bioaccumulated triclosan as the algal cell numbers decreased when intracellular triclosan increased. A total of 11 metabolites were identified in diatom cells and degradation pathways are proposed. Hydroxylation, methylation , dechlorination , amino acids conjunction and glucuronidation contributed to the transformative reactions of triclosan in Cymbella sp., producing biologically active products (e.g., methyl triclosan) and conjugation products (e.g., glucuronide or oxaloacetic acid conjugated triclosan), which may be included in the detoxification mechanism of triclosan.
研究领域:
环境科学
·
毒理学
·
水生生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
·
2020
·
IF 6.793
Cen Yin,Xianhai Yang,Tianyi Zhao,Peter Watson,Feifei Yang,Huihui Liu
The effects of microplastics on aquatic organisms are drawing growing attention, but little has been focused on their effects on the toxicity of other chemicals. In this study, we examined the acute and chronic toxicity of micro-polystyrene (5.8 μm dia.), and its effects on the toxicity of three antimicrobial agents (triclosan, triclocarban and methyl-triclosan) to Daphnia magna . Results indicated that polystyrene had a low acute toxicity with an EC 50 of 36.5 mg/L. The presence of polystyrene (1 mg/L) did not produce significant effect on the acute toxicity of three chemicals, because the 95% confidence intervals of their EC 50 values had a large overlap of 11.3%–48.3%. For the 21 day chronic toxicity, polystyrene alone had significant toxicity with concentrations of at least 2 mg/L, which prolonged the time of the first brood, limited the number of broods, and reduced the total number of neonates. Compared with the chemicals alone, the addition of polystyrene enhanced their reproduction toxicity. Based on the various reproduction indicators, an intrinsic rate of natural increase ( r m ) was calculated to assess the rate of population growth. Results suggested that the r m values of three chemicals decreased in the presence of PS, and further decreased with increasing PS concentrations. Among the three chemicals, methyl-triclosan was the most affected. These results suggested that the presence of microplastics would exacerbate the detrimental influence of pollutants on Daphnia magna .
研究领域:
环境科学
·
毒理学
·
水生生态学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2014
·Vol. 4
·期 109
·63620-63626
·
IF 3.708
Yuchen Liu,Xiangdong Zhu,Feng Qian,Shicheng Zhang,Jianmin Chen
Recently, considerable attention has been given to the hydrothermal liquefaction (HTL) of waste rice straw for the production of bio-oil and hydrochar. However, hydrochar material could not be directly applied in the environmental field, due to its limited porosity and surface area. In order to improve the porosity and adsorption capacity of rice straw-derived hydrochar, it was activated and magnetized to a magnetic activated carbon. The activation condition for hydrochar was firstly considered, due to the negative effect of the magnetic medium. Results suggested that the as-prepared magnetic activated carbon possessed a large surface area (around 674 m2 g−1), and exhibited both a high adsorption capacity and a fast adsorption rate for triclosan (TCS) removal. In addition, magnetic activated carbon can be easily recovered from aqueous solutions by an external magnetic field. Overall, the waste rice straw-derived hydrochar can be transformed to a highly efficient magnetic adsorbent for TCS removal.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
RADIATION PHYSICS AND CHEMISTRY
·
2020
·
IF 2.226
Zhonglei Zhang,Dongming Hu,Hai Chen,Chuanhong Chen,Youxue Zhang,Shijun He,Jianlong Wang
In this study, gamma radiation was used for triclosan (TCS) degradation with addition of persulfate (PS) to enhance the mineralization of TCS. The influence of absorbed doses, PS concentration, and initial pH value on TCS degradation and mineralization was examined. The results showed that the degradation and mineralization of TCS were remarkably enhanced in the presence of PS. With addition of 1.5 mM PS, 8 mg/L TCS could be completely degraded at 300 Gy, which was much lower than that of the control group without PS (600 Gy). Furthermore, with addition of PS, higher mineralziaiton of TCS could be observed. The intermediates produced during the decomposition of TCS were identified and the possible degradation pathway was proposed. In addition, the biodegradability of TCS solution, as well as the intermediate products, was evaluated by a Wabo micro-respiration tester for 12 h. It demonstrated that the biodegradability of TCS solution increased after gamma radiation, which could be further enhanced by persulfate, suggesting that the combination of gamma radaition with persulfate could be a promising alternative process for the degradation of antibiotics in the wastewater.
研究领域:
环境科学
·
放射化学
✓ 已验证
DOI
高影响因子
ENVIRONMENTAL POLLUTION
·
2025
·
IF 7.3
Ping Ding,Jiayi Zhang,Xin Li,Pengcheng Ma,Guocheng Hu,Lijuan Zhang,Yunjiang Yu
The use of triclosan (TCS)-containing disinfectants has become increasingly prevalent in response to the COVID-19 pandemic, leading to a heightened presence of TCS in aquatic ecosystems. Thyroid hormones (THs), which are essential for numerous developmental and metabolic processes, are structurally similar to TCS, rendering it prone to exert endocrine-disrupting effects. In this study, we demonstrate that TCS can induce thyroid hormone disruption in zebrafish, with transgenerational consequences. Zebrafish embryos were exposed to environmentally relevant concentrations of TCS (0, 1, 3, and 10 μg/L) for 30, 60, and 180 days. TCS accumulated in zebrafish over an extended period, causing significant, dose-dependent alterations in TH levels. Furthermore, TCS significantly thereby interfered with the expression of thyroid axis-related genes in the P0-F1 generations. Molecular docking further confirmed that TCS induces transgenerational thyroid effects through potentially strong interactions with thyroglobulin (TG), interfering with the normal physiological function of THs. These findings suggest that TCS at environmentally relevant concentrations can exert ecologically harmful effects by disrupting THs. A rigorous ecological assessment of TCS is recommended before promoting or substituting antimicrobial agents in future disinfection products.
研究领域:
环境科学
·
毒理学
·
内分泌学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）