SCIENCE OF THE TOTAL ENVIRONMENT
·
2021
·
IF 7.963
Zhilin Qiu,Guiying Li,Taicheng An
The wide presence of volatile organic amines in atmosphere has been clarified to relate to adverse effects on human respiratory health. However, toxic effects of them on human respiratory tract and their metabiotic mechanism of in vivo transformation have not been elucidated yet. Herein, cell viability and production of reactive oxygen species (ROSs) were first investigated during acute exposure of trimethylamine (TMA) to bronchial epithelial cells (16HBE), along with identification of toxic metabolites and metabolic mechanisms of TMA from headspace atmosphere and cell culture. Results showed that cell activity decreased and ROS production increased with raising exposure TMA concentration. Toxic effects may be induced not only by TMA itself, but also more likely by its cellular metabolites. Increased dimethylamine identified in headspace atmosphere and cell solution was the main metabolite of TMA, and methylamine was also confirmed to be a further metabolite. In addition, TMA can also be oxygenated to generate N , N -dimethylformamide and N , N ′-Bis(2-hydroxyethyl)-1,2-ethanediaminium by N-formylation or hydroxylation, which was considered to be the participation of cytochrome P450 (CYP) enzymes. Overall, we can conclude that respiratory tract cells may produce more toxic metabolites during exposure of toxic organic amines, which together further induce cellular oxidative stress and necrosis. Hence, the environment and health impact of metabolites as well as original parent atmospheric organic amines should be paid more attention in further researches and disease risk assessments.
研究领域:
毒理学
·
环境健康
·
细胞生物学
✓ 已验证
DOI
高影响因子
ACS ES&T Engineering
·
2025
·
IF 6.7
Ao Zhong,Kehan Li,Zeyu Duan,Haiqiang Wang,Zhongbiao Wu
Trimethylamine (TMA) is a common malodorous compound that poses serious environmental and health risks. Four different structures of cerium oxide (CeO2), namely, cubes, hollow spheres, octahedrons, and spindles, were successfully synthesized via a hydrothermal method and then used for TMA degradation in a vacuum ultraviolet photocatalytic oxidation system. All the synthesized catalysts exhibited enhanced activity compared with commercial CeO2. The hollow-sphere CeO2 demonstrated high catalytic performance, achieving 75.9% mineralization of TMA within 90 min and substantially reduced ozone generation (stable 0 ppm in outlet). Additionally, the total outlet concentration of secondary nitrogenous pollutants (NOx and NH3) remained below 2.5 ppm. In situ infrared spectroscopy was employed to elucidate the degradation pathway of TMA under vacuum ultraviolet irradiation, comparing sphere CeO2 with commercial CeO2. The superior TMA degradation performance of the hollow-sphere CeO2 was attributed to its higher Ce3+ ratio as well as increased oxygen, increased charge separation efficiency, and radical generation. This study provides new insights into the optimization of CeO2-based photocatalysts to efficiently degrade TMA and offers promising solutions for odor control and environmental protection.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Yalin Zhang,Xueli Yang,Xianwen Yan,Zhen Sun,Zheng Hu,Wenlu Liu,Yehong Cheng,Guofeng Pan
Preparation of a gas sensor capable of rapidly and accurately detecting trimethylamine is crucial for environmental monitoring, food safety and human health. In this study, Au-In-ZnO with an irregular nanoparticle structure was prepared using simple metal–organic-framework synthesis method and in-situ reduction process. The Au-In-ZnO sensor exhibited a high response of 260.2 to 100 ppm trimethylamine at 250 °C, which is 32 times higher than that of pristine ZnO (350 °C), with the optimal operating temperature lowered by 100 °C. Meanwhile, the sensor had a short response time (2 s), enabling it to quickly react to leaked trimethylamine during practical applications. Additionally, the sensor also possessed low detection limit (0.3 ppm, R air /R gas =2.0), high selectivity, excellent moisture resistance, good repeatability, and long-term stability. The mechanism of gas-sensitive properties enhancement was analyzed in combination with the conduction mechanism of hypervalent ions and the electronic and chemical sensitization of noble metals. This study provides a potential gas-sensitive material for the efficient measurement and rapid evaluation of trimethylamine.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2017
·
IF 2.986
Zhuoqi Li,Peng Song,Zhongxi Yang,Qi Wang
In situ diffusion growth of CoMoO 4 nanoparticles on the surface of MoO 3 nanobelts was achieved through a facile method. The microstructures, morphologies, and chemical composition of the nanocomposites were investigated based on X-ray diffraction, field-emission electron scanning microscopy, transmission electron microscopy , energy dispersive spectroscopy, and X-ray photoelectron spectra. The characterization results confirmed CoMoO 4 nanoparticles uniformly distributed on the surface of the MoO 3 nanobelts. The trimethylamine sensing properties of pristine MoO 3 and CoMoO 4 /MoO 3 nanocomposites were investigated using a static system. The experimental results revealed that heterojunction structure of CoMoO 4 /MoO 3 nanocomposites displayed low working temperature and enhanced sensing performance. The response of CoMoO 4 /MoO 3 nanocomposites to 100 ppm trimethylamine was ∼104.8 at 220 °C, which was four times higher than that of pure MoO 3 at 280 °C. The reason for the enhanced sensing properties of CoMoO 4 /MoO 3 nanocomposites is attributed mainly to the formation of the p–n junction between the p-type CoMoO 4 nanoparticles and the n-type MoO 3 nanobelts.
研究领域:
材料科学
·
传感技术
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 4
·1-12
·
IF 2.8
Wang He,Li Sirui,Zhu Hang,Yu Shaoyuan,Yang Tianye,Zhao Hongwei
For the rapid and accurate detection of trimethylamine (TMA) hazardous gases, a metal organic framework (MOF) derived bayberry-like In 2 O 3 architectures gas sensor was successfully prepared by a rapid and facile hydrothermal synthesis (30 min) and subsequent precise annealing process. The gas sensitivity test results show that the MOF-derived bayberry-like In 2 O 3 sensor has a low operating temperature of 120 °C, a response value of 23.2 to 20 ppm trimethylamine, a fast response speed of 1.4 s, and good selectivity and stability. In addition, the gas-sensing mechanism of the sample is discussed. It is considered that the unique MOF-derived bayberry-like architectures and the abundance of oxygen vacancies are the main reasons for its excellent gas-sensing performance. A possible growth mechanism is proposed by observing the morphological evolution of the samples at different stages. With excellent gas sensitivity, the MOF-derived bayberry-like In 2 O 3 architectures sensor will be an outstanding candidate for TMA gas detection application, seafood freshness detection, and renal disease detection.
研究领域:
材料科学
·
环境科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Food Science & Technology
·
2023
·
IF 2.3
Xinjie Xiong,Caixia Ding,Haiming Shi,Hong Zhang,Yanlan Bi,Xuebing Xu
Fragrant rapeseed oil is produced through roasting and hot-pressing. However, the formation of trimethylamine (TMA) during its production can negatively impact the aroma of the oil. This study aimed to find the potential precursors and pathways of TMA formation in fragrant rapeseed oils. A simplified model containing water, oil, and various possible precursors (choline, sinapine, betaine, choline glycerophosphate, phosphatidylcholine, and trimethylamine oxide) was used to quantify the changes in the precursors and intermediates involved in the formation of TMA. The results showed that all of the precursors contributed to the formation of TMA with choline exhibiting the highest conversion rate (24.88%). Choline was found to serve as both a precursor and an intermediate. Sinapine, which was present in rapeseed at a high level (8920.85 mg/kg), was also identified as an important precursor for TMA formation. Furthermore, a higher heating temperature, a longer heating time, and a higher amount of water content were found to potentially lead to increased TMA formation.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2022
·
IF 3.322
Chunxia Shi,Maohua Pei,Yao Wang,Qian Chen,Pan Cao,Luyi Zhang,Jin Guo,Wei Deng,Luwen Wang,Xun Li,Zuojiong Gong
Evidence shows that trimethylamine (TMA)/trimethylamine-N-oxide (TMAO) is closely related to non-alcoholic fatty liver disease (NAFLD). The conversion of TMA to TMAO is mainly catalyzed by flavin-containing monooxygenases 3 (FMO3) and FMO1. In this study, we explored the role of TMA in the process of NAFLD. The human NAFLD liver puncture data set GSE89632 and rat TMAO gene chip GSE135856 was downloaded for gene differential expression analysis. Besides, oleic acid (OA) combined with palmitate were used to establish high-fat cell model. TMA, TMAO and FMO1-siRNA were used to stimulate L02 cells. Contents of free fatty acid (FFA), triglyceride (TG), TMAO, FMO1 and unfolded protein response (UPR) related proteins GRP78, XBP1 , Derlin-1 were detected. Our results showed that FMO1 and PEG10 were important in the progression of NAFLD. Immunohistochemistry showed that FMO1 in NAFLD liver was increased. In addition, the contents of FFA, TG, FMO1 expression, and TMAO were significantly increased after OA + palmitate and TMA stimulation. However, after silencing FMO1 with siRNA, the expressions of these molecules were decreased. Besides, the protein levels of GRP78, XBP1, Derlin-1 were increased after TMAO treatment (all P < 0.05). In Conclusion, high fat and TMA could induce the expression of FMO1 and its metabolite TMAO. When FMO1 is silenced, the effects of high fat and TMA on TMAO are blocked. And the role of TMAO in NAFLD may be through the activation of UPR.
研究领域:
肝病学
·
分子生物学
·
代谢组学
·
胃肠病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Bioscience
·
2024
·
IF 4.8
Shiqin Qing,Zhaoqing Yang,Wuyin Weng,Ping Li,Zhongyang Ren,Linfan Shi
Trimethylamine (TMA), which is known to severely affect consumer acceptance and application, is the main compound of sea cucumber intestinal peptides. Herein, different V-type crystalline starches (V 6a/h , V 7a/h , V 8a/h ) were prepared using high amylose maize starch for the adsorption of TMA. After analyzing the structure of V-type starches, the V 8 -type starch had a smaller and more evenly dispersed particles with additional surface pores and cracks, and reduced relative crystallinity compared with V 6 - and V 7 -type starch. The relative crystallinity of V 6a -, V 6h -, V 7a -, V 7h -, V 8a -, and V 8h -type starches was 59.1%, 51.8%, 42.7%, 41.3%, 40.4%, and 40.1%, respectively. Adsorption models for V-type starches and TMA helped to analyze the adsorption kinetics characteristics and investigate the effect of different V-type starches on adsorption. Moreover, its adsorption kinetics process agreed with pseudo-second-order kinetic model ( R 2 > 0.96). Note that different V-type starches demonstrate good adsorption effects on TMA, and the removal rate is as follows: V 8h > V 8a > V 7h > V 7a > V 6h > V 6a . Herein, we used environmental protection and food-grade V-type starches to effectively adsorb TMA and ensure a theoretical foundation for enhancing the flavor and quality of functional seafoods.
研究领域:
食品科学
·
生物化学
✓ 已验证
DOI
高影响因子
Analytical Methods
·
2014
·Vol. 6
·期 9
·2965-2972
·
IF 1.938
Qi Wang,Yun-Fei Xie,Wei-Jun Zhao,Peng Li,He Qian,Xiao-Zhi Wang
A fast and quantitative method for the detection of biogenic amines based on the microchip-based high-field asymmetric waveform ion mobility spectrometry (FAIMS) technique was established for evaluating the degree of spoilage of pork stored at room temperature. Trimethylamine (TMA) was selected as a good indicator for its volatility and high proton affinity. Analysis of standard TMA showed the same characteristic peak with the pork sample. The limit of detection of the system for TMA dissolved in deionized water, with 100 μL of 8 mol L−1 NaOH, was 3 ng and the measurement was accomplished within 15 s. The relative standard deviation (RSD) was 6.20%. The delivery of the sample gas was based on the dynamic headspace method. The effect of the storage time on the formation of biogenic amines was examined, and not surprisingly, the content of TMA increases over time. The total volatile basic nitrogen (TVB-N) was measured simultaneously based on the classical semi-micro Kjeldahl method. A good correlation coefficient between these two methods was obtained, the correlation coefficient was 0.952. Therefore the microchip-based FAIMS technique provides a quantitative classification of the spoilage or freshness of pork, especially when a rapid detection is needed.
研究领域:
食品科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
Advanced Intelligent Systems
·
2022
·Vol. 4
·期 12
·2200169
·
IF 7.298
Wenjie Ren,Changhui Zhao,Gaoqiang Niu,Yi Zhuang,Fei Wang
Artificial senses like electronic nose, which ameliorates the problem of poor selectivity from single gas sensor, have elicited keen research interest to monitor hazardous gases. Herein, the doping effects of gallium on In 2 O 3 nanotubes (NTs) are investigated and a four-component sensor array for the detection of trimethylamine (TMA) is reported. All-gallium-doped/alloyed In 2 O 3 (Ga-In 2 O 3 ) sensors show improved sensitivity and selectivity to TMA at an operating temperature of 240 °C, with 5 mol% Ga-doped/alloyed one displaying the highest response in the range of 0.5–100 ppm and the lowest detection limit of 13.83 ppb. Based on the gas-sensing properties, a four-component sensor array is fabricated, which shows unique response patterns in variable-gas backgrounds. Herein, back propagation neural network (BPNN), radial basis function neural network (RBFNN), and principal component analysis-based linear regression (PCA-LR) are trained with the gas-sensing data to discriminate different gases with high accuracy, as well as to predict the concentrations of target gases in different gases and gas mixtures. Furthermore, accuracies of 92.85% and 99.14% can be achieved for the classification of six gases (three single gases and three binary gas mixtures) and for the prediction of TMA concentrations in the presence of different concentrations of TMA and acetone, respectively.
研究领域:
材料科学
·
电子工程
·
化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2021
·
IF 8.742
Yang Liu,Guiliang Li,Qiu Han,Haibo Lin,Qiang Li,Gang Deng,Fu Liu
Dialysis membranes capable of preventing coagulation and inflammation and achieving high toxin clearances are highly desired for clinical hemodialysis. Here, we constructed an electro-neutral and hydrophilic surface on Polysulfone (PSf) membrane, which both improved the hemocompatibility and toxin clearance. The membrane surface was modified with trimethylamine N-oxide (TMAO) through Michael addition reaction and subsequent crosslinking with glycidyl ether oxypropyl trimethoxysilane (KH560). Saltwater fish inspired zwitterionic monomer TMAO without spacers between positive and negative headgroups is thought to generate a hydrated and net-charged layer that prevents non-specific plasma proteins and platelets adsorption and activation. Coagulation time, serine protease Factor XIIa, bradykinin (BK), kallikrein (KLK) and anaphylatoxins (C3, C5 and SC5b-9) were examined to explore blood compatibility. All results showed that the highly hydrated and electro-neutral surface could efficiently alleviate the activation of the coagulation cascade, kallikrein-kinin system (KKS) and complement system simultaneously. Furthermore, the modified PSf membrane is favorable to toxins clearance (e.g., urea, creatine, lysozyme and vitamin B12) during simulated dialysis process. It is manifested that the TMAO based surface modification is feasible for improving the hemocompatibility and toxin clearance of dialysis membranes.
研究领域:
生物医学工程
·
材料科学
·
血液学
✓ 已验证
产品关联
DOI
高影响因子
Foods
·
2022
·Vol. 11
·期 15
·2372
·
IF 5.561
Yahui Li,Yanxiao Li,Jiyong Shi,Zhihua Li,Xin Wang,Xuetao Hu,Yunyun Gong,Xiaobo Zou
A novel, operational, reliable, flexible gas sensor based on silk fibroin fibers (SFFs) as a substrate was proposed for detecting the freshness of pork. Silk is one of the earliest animal fibers utilized by humans, and SFFs exposed many biological micromolecules on the surface. Thus, the gas sensor was fabricated through polyaniline (PANI) and silver nanowires (AgNWs) and deposited on SFFs by in-suit polymerization. With trimethylamine (TMA) as a model gas, the sensing properties of the PANI/AgNWs/silk composites were examined at room temperature, and the linear correlativity was very prominent between these sensing measures and the TMA measures in the range of 3.33 μg/L–1200 μg/L. When the pork sample is detected by the sensor, it can be classified into fresh or stale pork with the total volatile basic nitrogen (TVB-N) as an index. The result indicated that the gas sensor was effective and showed great potential for applications to detect the freshness of pork.Keywords:polyaniline;silver nanowires;silk;trimethylamine;gas sensor;pork freshness
研究领域:
食品科学
·
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）