Cutaneous melanoma, a prevalent and highly aggressive malignancy with poor prognosis, frequently leads to postoperative recurrence, presenting a significant therapeutic challenge. One of the promising cancer therapeutic methods is the induction of cuproptosis, a copper-triggered modality of mitochondrial cell death. However, its therapeutic efficacy is often limited by insufficient copper uptake and intracellular accumulation. Herein, we present a flexible and self-powered electronic patch by integrating an ultra-thin triboelectric nanogenerator (TENG) with copper-loaded nitrogen-doped carbon nanoparticles (Cu(II)-NC NPs). Extensive experimental and molecular dynamics simulation results demonstrate that the triboelectric field efficiently modulates plasma membrane permeability and fluidity, facilitating the uptake of Cu(II)-NC NPs into melanoma cells. The resulting intracellular copper accumulation increases the production of hydroxyl radicals and the depletion of glutathione, synergizing with cuproptosis to amplify copper-induced cell death. In a mouse model with incomplete melanoma resection, the patch effectively inhibits melanoma recurrence, offering a novel therapeutic paradigm to promote cancer therapy.
Wen He,Qianxiang Xiao,Haiyan Jiang,Zhenglemei Qiu,Ziyang Chang,Feng He,Qixu Chen,Xiangke Wang,Hongqing Wang
Enhanced bulk-surface charges separation and migration are essential to maximize the photocatalytic activity. In this study, ethylenediamine (EDA)-modified Zn 0.7 Cd 0.3 S nanorods (ZCS-NR-EDA) were synthesized through an integral modification approach. After 1-hour adsorption equilibrium followed by 6-minute co-irradiation with visible light and ultrasonic waves, ZCS-NR-EDA removed 99.2 % of U(VI) from the solution, significantly better than Zn 0.7 Cd 0.3 S nanoparticles (ZCS-NP) (13.6 %) and Zn 0.7 Cd 0.3 S nanorods (ZCS-NR) (25.3 %). This catalytic performance has outperformed most reported materials. Experimental and density functional theory (DFT) calculation studies confirmed that EDA modification induced polarization to establish a bulk electric field (BEF) and modified the electron distribution at the material's surface to create localized surface electric field (LSEF), while simultaneously enhancing the material's piezoelectric properties. The synergistic effect of these triple electric fields (polarization-induced BEF, LSEF, and piezoelectric field (PF)) promoted migration of bulk-surface charges, thereby enhancing catalytic performance. When applied to uranium spiked tailing water, ZCS-NR-EDA achieved up to 98.1 % U(VI) removal within 15 min of combined visible light and ultrasonic irradiation (after adsorption equilibrium). More importantly, this “tri-electric fields synergy” strategy provides a novel approach for the design of advanced photocatalytic materials.
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