Catalyst-free one-pot three-component rapid synthesis of polysubstituted pyrroles by liquid-assisted grinding
A series of polysubstituted pyrroles were rapidly synthesized in moderate to good yields via catalyst-free one-pot three-component reaction of 1,3-dicarbonyl compounds with primary amines and nitrostyrenes by using liquid-assisted grinding. This protocol provides several advantages over the conventional chemical synthesis, such as simple work-up procedure, wide substrate scope, short reaction time, and environmental friendliness. Structures of polysubstituted pyrroles were confirmed by 1 H NMR, 13 C NMR, and ESI-MS studies.
研究领域:
有机化学
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药物化学
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绿色化学
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合成方法学
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杂环化学
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DOI
高影响因子
危险品化学品经营许可证（带存储）