INORGANICA CHIMICA ACTA
·
2021
·
IF 2.545
Xingliang Li,Juncai Lu,Wanjun Mu,Baihua Chen,Daibing Luo,Bijun Liu,Yanqiu Yang,Hongyuan Wei,Shuming Peng
Nitrilotri–3–propanoic Acid (NTPA) and Tris(2–carboxyethyl) phosphine (TCEP) possess similar skeleton. This pair of isostructural ligands is a perfect set to assess the differences of uranyl (UO 2 2+ ) complexes with N–tricarboxylate versus P–tricarboxylate. The protonation reactions of NTPA and TCEP were investigated by potentiometry and calorimetry. Complexation of uranyl with the both ligands was studied by potentiometry and structural analysis. The results indicate that central trialkylamine in NTPA has a higher affinity for the proton than trialkylphosphine in TCEP. Crystal structures and NMR analyses indicate that central amine of NTPA and central phosphine of TCEP are not involved in the bonding. NTPA/UO 2 2+ complex is more stable than TCEP/UO 2 2+ complex. This difference cannot be explained by electronic effect of central N and P atoms because of nonbonding interactions. The higher stability of UO 2 2+ /NTPA versus UO 2 2+ /TCEP may be due to the fact that the central N atom of NTPA has a lower steric hindrance than the central P atom of TCEP. Another possible reason is that UO 2 2+ /TCEP complexes have different coordination modes from UO 2 2+ /NTPA complexes.
研究领域:
化学
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配位化学
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核化学
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DOI
高影响因子
Communications Biology
·
2025
·Vol. 8
·期 1
·1-10
·
IF 5.1
Lin Huaying,Lv Yongxin,Zhang Yu
Medium-chain alkanes have strong ecological impacts on marine ecosystems due to their persistence, toxicity, and ability to travel long distances. Microbial degradation is the dominant and ultimate removal process for n-alkanes in the deep ocean, where high hydrostatic pressure (HHP) regulates microbial activity. To gain insight into the impact of hydrostatic pressure (HP) on n-alkane degradation, we applied the deep-ocean experimental simulation to culture Alcanivorax xenomutans A28, a novel piezotolerant bacterium strain from trench sediment, with n-C 16 as the sole carbon source under different HPs (0.1, 40, and 80 MPa). Activity analysis demonstrated that HHP stimulated the n-C 16 complete mineralization ratio. Transcriptomic and metabolomic analyses showed that HHP induced the intracellular oxidative stress and accelerated the tricarboxylic acid (TCA) cycle. These results indicate a shift of n-alkanes biodegradation pattern regulated by HP, elucidating the fate and ecological risk of n-alkanes in the deep ocean.
研究领域:
微生物学
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海洋生态学
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环境科学
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产品关联
DOI
PubMed
高影响因子
CRYSTAL GROWTH & DESIGN
·
2021
·
IF 4.076
Biao-Biao Hao,Xin-Xin Wang,Chen-Xi Zhang,Qinglun Wang
On the basis of the carboxylic structure of trimesic acid (TMA) and 5-borono-1,3-benzenedicarboxylic acid (B-BDC), here two hydrogen-bonded organic frameworks (HOFs), HOF 1 (MA-TMA) and HOF 2 (MA-B-BDC), were prepared by reacting melamine (MA) with trimesic acid and 5-borono-1,3-benzenedicarboxylic acid, respectively. The as-prepared HOF 1 and HOF 2 with 3D supramolecular structure exhibit excellent performance in proton transport. AC impedance test shows that the proton conductivities of HOF 1 and HOF 2 reach 3.11 × 10–4 S·cm–1 (343 K, 98% RH) and 4.32 × 10–4 S·cm–1 (323 K, 98% RH), respectively. To increase the proton conductivity, Im@HOF 1 and Im@HOF 2 were obtained by introducing imidazole (Im), which acts as a jumping site for proton transfer. The proton conductivities of Im@HOF 1 and Im@HOF 2 reached 4.12 × 10–4 S·cm–1 (333 K, 98% RH) and 1.20 × 10–3 S·cm–1 (353 K, 98% RH), respectively. This is the first time that guest molecules were introduced into HOFs. The stability and proton conductivity of the HOFs are improved due to the interaction of imidazole with carboxyl groups and water molecules.
研究领域:
材料科学
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化学
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DOI
高影响因子
Journal of Biobased Materials and Bioenergy
·
2019
·Vol. 13
·期 1
·53-61
·
IF 0
Li Ke,Nie Xiaoan,Jiang Jianchun
Novel C-(22)-triesters of tricarboxylic acid (TMabc) were synthesized via transesterification and Diels-Alder (DA) reaction. The structure of these triesters is similar to the dioctyl phthalate (DOP), which has been used as a polyvinyl chloride (PVC) plasticizer. By comparative study,
the results showed that, the five synthesized compounds had higher heat stability than DOP and four of them had plasticizing effects on PVC films, which can also reduce the usage amount of DOP effectively; X-ray diffraction showed that these four kinds of plasticizer effectively change the
crystallization of PVC; mechanical testing and fracture forms indicate that the TM111 and TM122 offered the best plasticization in the PVC films better than or similar to DOP. TM111 offered excellent plasticizing performance, in complete accordance with the test results of dynamic thermal
mechanical analysis (DMA). In addition, a plasticizer model for TMabc according to the structure of TMabc was depicted, and as well as a theoretical basis for further development and use of TMabc was provided.
研究领域:
材料科学
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高分子化学
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产品关联
DOI
INTERNATIONAL IMMUNOPHARMACOLOGY
·
2025
·
IF 4.7
Tianying Bian,Hu li,Haohao Liu,Mudi Guo,Yiding Zhang,Pinli Hu,Meihua Chen
Objectives To explore the effects and biological mechanism of apabetalone on periodontal inflammation by regulating glycolysis and metabolites. Methods A ligature-induced periodontitis model was established in mice and apabetalone was administered on the ligation silk for two weeks. Inflammation levels and alveolar bone absorption were explored using micro-computed tomography and histopathological analysis. To observe the role of apabetalone in macrophage polarization and the macrophage-mediated immune microenvironment, a Luminex assay, quantitative real-time polymerase chain reaction, a conditioned medium experiment, a Seahorse extracellular flux assay and quantitative metabolomics were used for molecular biological analysis. Results Apabetalone-treated mice exhibited ameliorated alveolar bone loss and inflammatory infiltration in the periodontium. Furthermore, apabetalone significantly inhibited the production of proinflammatory cytokines and suppressed the levels of M1-specific biomarkers both in vivo and in vitro . Apabetalone also promoted the osteogenic potential of mouse periodontal ligament cells in a macrophage-mediated microenvironment. Apabetalone restrained LPS-induced glucose uptake and lactic acid production. Apabetalone inhibited glycolysis by suppressing the transcription and protein expression of hexokinase 2, glucose transporter 1 and phosphofructokinase-2/fructose-2,6- bisphosphatase 3 (PFKFB3) in a dose-dependent manner. Quantitative analysis of certain carbohydrates involved in energy metabolism revealed that apabetalone reserved the disruption of the tricarboxylic acid (TCA) cycle and inhibited glycolysis and the pentose phosphate pathway. In addition, apabetalone increased the oxygen consumption rate. Conclusion Collectively, these findings indicate that apabetalone improves the periodontal immune microenvironment by regulating metabolites in macrophages. Apabetalone exerts anti-inflammatory and osteo-protective effects by replenishing the broken TCA cycle and suppressing glycolysis. Apabetalone is a potential candidate for the treatment of periodontitis.
研究领域:
口腔医学
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免疫学
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代谢组学
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DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2022
·Vol. 51
·期 46
·17620-17628
·
IF 4.569
Juan Zhang,Jun Zhao,Bo Jin,Rufang Peng
The Zn–BTC, Co–BTC and Zn–Co–BTC series metal–organic frameworks were successfully prepared by a gas–solid two-phase flow (GSF) method with zinc nitrate, cobalt nitrate, and 1,3,5-benzenetricarboxylic acid (H3BTC) as raw materials. Single-crystal structures were obtained by the solvothermal method, and the structure and thermal stability of the target materials were characterized by FT-IR, XRD, SEM, energy-dispersive X-ray spectroscopy and DTA. The three obtained target substances were applied to catalyze the thermal decomposition of ammonium perchlorate (AP), and the performance was longitudinally compared. Testing and calculation results showed that when 10 wt% of the sample was added, monometallic Zn–BTC and Co–BTC lowered the AP pyrolysis temperature by 64.1 °C and 92.3 °C, respectively, and their activation energies decreased from 215.96 kJ mol−1 to 136.27 kJ mol−1 and 125.29 kJ mol−1, respectively. Bimetallic Zn–Co–BTC lowered the AP pyrolysis peak by 103.1 °C and the activation energy to 115.56 kJ mol−1, indicating that the series of samples exhibited good catalytic performance, and the catalytic effect of the bimetallic sample was significantly better than those of the monometallic samples.
研究领域:
材料科学
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催化化学
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产品关联
DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2022
·Vol. 24
·期 38
·6751-6761
·
IF 3.756
Qiang Zhao,Qi-yang Li,Jing Li
In this study, a tricarboxypyridine ligand 3-((5-carboxypyridin-3-yl)oxy)phthalic acid (H3cppa) that combines three distinct types of functional groups (COOH, O-ether and N-pyridyl) was used to construct metal complexes by a hydrothermal reaction, and eight new complexes were constructed, namely, [Zn(μ3-Hcppa)·2H2O]n (1), [Cd(μ4-Hcppa)·H2O]n (2) [Cd(μ2-H2cppa)2·2H2O]n (3), [Mn(μ2-Hcppa)·(phen)·H2O] (4), [Co3(μ3-cppa)2·19H2O]n (5), [Co(μ2-H2cppa)2·2H2O]n (6), [Co(μ3-Hcppa)·(phen)·2H2O]n (7), and [Fe(μ2-H2cppa)2·2H2O]n (8). The complexes were all characterized at room temperature by single crystal X-ray diffraction, infrared analysis and elemental analysis in the solid state; structure analyses reveal that complexes 1 and 2 have 2D network structures, complexes 3, 5, 6, 7, and 8 have a 1D chain structure and complex 4 has a 0D structure. In addition, luminescence behavior of complexes 1–3 was investigated and magnetic properties of complexes 4–8 were studied. The fluorescence test results show that the fluorescence intensities of complexes 1, 2 and 3 are lower than that of the ligand; the magnetic results indicate antiferromagnetic interactions in complexes 4, 5, 6, and 7 and weak ferromagnetic interactions in complex 8.
研究领域:
化学
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材料科学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Zhen Guo,Renlu Han,Yun Gao,Jie Fu,Zekai Zhuang,Yafei Hou,Jiancheng Yu,Keqi Tang
Abnormal metabolic symbiosis is one of the most typical features of tumors that distinguishes them from normal tissues. Disrupting tumor metabolic symbiosis has been recognized a promising tumor therapeutic approach. However, a single pathway intervention strategy greatly impedes its treatment efficiency. Herein, α-cyano-4-hydroxycinnamic acid (CHCA) and elesclomol (ES) co-loaded Cu 7 S 4 nanoplatform (named as CCE) is developed to synchronously intervene tricarboxylic acid (TCA) cycle and lactic acid metabolism through self-enhanced cuproptosis and acidosis for tumor metabolic symbiosis destruction. CCE could be triggered by up-regulated glutathione (GSH) in cancer cells to release ES, CHCA, Cu ions, and S 2− ions. On the one hand, ES significantly improves the influx efficiency of Cu ions to mitochondria where cuproptosis is initiated and TCA cycle is attacked. Meanwhile, the H 2 S produced by the binding of S 2− to H + in acidic tumor cells could induce mitochondrial damage and inhibit Cu ions efflux by depriving energy supply. Moreover, the GSH consumption reduces its chelation with Cu ions. Collectively, the increased intracellular Cu ions level significantly boosts cuproptosis mediated proteotoxicity of TCA cycle, thus aggravating TCA cycle injury. On the other hand, CHCA down-regulates the expression of monocarboxylate transporters 4 (MCT4) and inhibits lactic acid transport between tumor cells, causing the tumor cytoplasm acidification. Interestingly, H 2 S accelerates lactate production by promoting the glucose uptake to further potent the lactate metabolic disorder. In vitro and in vivo experiments confirm anti-tumor efficacy and biosafety of CCE. This study further enriches tumor therapeutic strategy.
研究领域:
肿瘤生物学
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代谢调控
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生物化学
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产品关联
DOI
高影响因子
CHEMOSPHERE
·
2020
·
IF 5.778
Xiaoqing Li,Mingxia Zhang,Yong Li,Xiangyang Yu,Jinfang Nie
Root exudates are released by plant roots and are important carrier substances for material exchange and information transmission among plants and the rhizosphere. In the present study, the effect of dinotefuran on root exudates of Chinese cabbage ( Brassica rapa var. chinensis ) was investigated. The physiological activities revealed that dinotefuran uptake caused oxidative stress in vegetable tissues even at low dinotefuran exposure levels. The metabolic profile of plant root exudates acquired by LC-QTOF/MS was clearly changed by dinotefuran, where the numbers of both up- and down-regulated MS peaks increased with increasing dinotefuran concentration. Under dinotefuran stress, some osmotic adjustment substances (proline and betaine) and defence-related metabolites (spermidine, phenylalanine and some phenolic acids) were significantly upregulated, which may help plants adapt to adverse environmental conditions. Specifically, the contents of some phenylalanine-derived secondary metabolites increased with increasing dinotefuran concentration, which may increase the external detoxification ability of plants. Moreover, respiration metabolism was significantly affected, where some intermediates in the TCA cycle (succinic acid and malic acid) were upregulated with low-level dinotefuran exposure; however, anaerobic respiration products (lactic acid and 3-phenyllactic acid) were accumulated at high exposure levels. In addition, the release of glucosinolates was significantly inhibited in both dinotefuran treatment groups.
研究领域:
植物学
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环境科学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
Journal of the Taiwan Institute of Chemical Engineers
·
2025
·
IF 6.3
Yaoyao Huang,Ran Li,Junxuan Chen,Jinmei Deng,Zhenyi Leng,Fenglan Lu,Yuanfei Mei,Wei Fan,Liang Ao,Yongqiang Li,Huaili Zheng
Background Efficient lead extraction and recovery from wastewater are crucial for advancing sustainable metal recycling and reducing environmental pollution. Method Herein, a chitosan-TMA composite (CSTA) was synthesized via one-step cross-linking of chitosan with trimesic acid, exhibiting superior Pb(II) adsorption selectivity and capacity in aqueous solutions. Significant Findings The experimental results showed that the maximum adsorption capacity of CSTA for Pb(II) reached 98.59 mg/g at the optimal pH value of 6.0, which was much higher than that of unmodified chitosan (17.62 mg/g). Further investigation of the adsorption process revealed that the Pb(II) adsorption behavior on CSTA followed the pseudo-second-order kinetic model, suggesting a predominantly chemisorption-controlled process, and conformed to the Langmuir adsorption isotherm model with a theoretical maximum capacity of 104.17 mg/g at room temperature. Competitive adsorption experiments in a multi-cation solution (containing Zn 2+ , Cu 2+ , Ni 2+ , Co 2+ , Sr 2+ , Cd 2+ , and Ag + , pH 6.0) demonstrated CSTA's exceptional selectivity for lead, achieving a high adsorption capacity of 96.33 mg/g, significantly surpassing that of other metal ions. Combined experimental and characterization analyses revealed that Pb(II) removal primarily occurs via coordination with oxygen atoms from carboxylic acid groups in TMA. This work provides both an effective adsorbent for lead-contaminated wastewater treatment and mechanistic insights for designing biomass-based water purification materials.
研究领域:
环境科学
·
材料科学
·
化学工程
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水污染控制
·
生物质材料
✓ 已验证
产品关联
DOI
高影响因子
Talanta Open
·
2023
·
IF 0
Yuting Kang,Baoshan Zhang,Huiru Li,Guoliang Huang,Huiqing Lv,Kezhi Jiang
The tricarboxylic acid cycle is an important metabolic route in almost all living bodies, yet current analytical methods for the detection of the relevant tricarboxylic acids (TCAs) in biological samples are still unsatisfactory due to their complex matrix and physicochemical properties. In this work, a sample method based on solid phase extraction (SPE) in conjunction with liquid chromatography-mass spectrometry (LC-MS) analysis has been developed for the simultaneous determination of 7 TCAs, including α-ketoglutaric acid, malic acid, malonic acid, aconitic acid, citric acid, succinic acid and fumaric acid, in mice faeces. By treatment with macroporous styrene chelate resin and solid phase extraction, the matrix in mice feces was selectively and efficiently removed. Under optimized parameters, the limit of quantitation for the TCAs was in the range of 1-50 ng/mL, and the content of the TCAs in mice feces was determined with a recovery range of 76.2 % to 128.4 %. Interestingly, the content of malic acid, malonic acid, succinic acid and fumaric acid in the normal mice's feces was found to be 2-10 times higher than that of obese mice, indicating a new potential method for the diagnosis of obesity.
研究领域:
代谢组学
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分析化学
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医学
✓ 已验证
DOI
ACS Synthetic Biology
·
2025
·
IF 3.9
Zheng Lei,Jinyong Wu,Caiwen Lao,Jin Wang,Yanyi Xu,He Li,Lixia Yuan,Xiangsong Chen,Jianming Yao
Ectoine is an important natural macromolecule protector that helps extremophiles maintain cellular stability and function under high-salinity conditions. Recently, the development of microbial strains for high-level ectoine production has become an attractive research direction. In this study, we constructed an efficient plasmid-free ectoine-producing strain. We modified the 5′-untranslated region of the ectABC gene cluster from Halomonas elongate to fine-tune the expression of genes ectA, ectB, and ectC. Furthermore, we optimized the carbon flow across the MEP pathway, the TCA cycle, and the aspartic acid metabolic pathway. Subsequently, we blocked the production of byproducts from the aspartic acid metabolic pathway and dynamically regulated the TCA cycle to coordinate the balance between strain growth and production. The final strain was tested in a 5-L fermenter, which reached 118.5 g/L at 114 h of fermentation. The metabolic engineering strategies employed in this study can be used for the biosynthesis of other aspartate derivatives.
研究领域:
微生物学
·
生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）