Environmental Science and Ecotechnology
·
2023
·
IF 12.6
Si-Qi Zhang,Ping Li,Shu-Wen He,Shao-Ying Xing,Zhi-Han Cao,Xue-Li Zhao,Cuici Sun,Zhi-Hua Li
Microplastics (MPs), an emerging group of pollutants, not only have direct toxic effects on aquatic organisms but also cause combined toxicity by absorbing other pollutants. Triphenyltin (TPT), one of the most widely used organotin compounds, has adverse effects on aquatic organisms. However, little is known about the combined toxicity of MPs and TPT to aquatic organisms. To investigate the individual and combined toxicity of MPs and TPT, we selected the common carp ( Cyprinus carpio ) for a 42-day exposure experiment. Based on the environmental concentrations in a heavily polluted area, the experimental concentrations of MPs and TPT were set at 0.5 mg L −1 and 1 μg L −1 , respectively. The effects of MPs combined with TPT on the carp gut–brain axis were evaluated by detecting gut physiology and biochemical parameters, gut microbial 16S rRNA, and brain transcriptome sequencing. Our results suggest that a single TPT caused lipid metabolism disorder and a single MP induced immunosuppression in carp. When MPs were combined with TPT, the involvement of TPT amplified the immunotoxic effect induced by MPs. In this study, we also explored the gut–brain axis relationship of carp immunosuppression, providing new insights for assessing the combined toxicity of MPs and TPT. At the same time, our study provides a theoretical basis for evaluating the coexistence risk of MPs and TPT in the aquatic environment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2022
·
IF 10.753
Qiaoqiao Wang,Jingjing Miao,Anran Zhao,Manni Wu,Luqing Pan
Retinoid X receptor (RXR) and peroxisome proliferators-activated receptors (PPAR) have been shown as important targets of endocrine disrupting effects caused by organotin compounds (OTCs). In vitro methods for non-model species are instrumental in revealing not only mechanism of toxicity but also basic biology. In the present study, we constructed the GAL4 factor-based recombinant yeast systems of RXRα/RXRα (RR), RXRα/PPARα (RPα) and RXRα/PPARγ (RPγ) of the scallop Chlamys farreri to investigate their transcriptional activity under the induction of OTCs (tributyltin chloride, triphenyltin chloride, tripropyltin chloride and bis(tributyltin)oxide), their spiked sediments and five other non‑tin compounds (Wy14643, rosiglitazone, benzyl butyl phthalate, dicyclohexyl phthalate and bis(2-ethylhexyl) phthalate). The results showed that the natural ligand of RXR, 9-cis-retinoic acid (9cRA), induces transcriptional activity in all three systems, while four OTCs induced the transcriptional activity of the RR and RPα systems. None of the five potential non‑tin endocrine disruptors induced effects on the RPα and RPγ systems. The spiked sediment experiment demonstrated the feasibility of the recombinant yeast systems constructed in this study for environmental sample detection. These results suggest that OTCs pose a threat to affect function of RXRα and PPARα of bivalve mollusks. The newly developed GAL4 factor-based yeast two-hybrid system can be used as a valuable tool for identification and quantification of compounds active in disturbing RXR and PPAR of bivalves.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2022
·Vol. 30
·期 10
·26387-26396
·
IF 5.19
Cao Zhihan,Li Ping,Ru Jinchuang,Cao Xuqian,Wang Xu,Liu Bin,Li Zhi-Hua
Triphenyltin (TPT) is a herbicide and antifouling agent that has been widely used. After TPT flows into water bodies, it will cause toxic effects on marine life. We evaluated the effect of environmental concentration level (0, 10, 100, and 200 ng/L) on the cell density, antioxidant capability, and photosynthesis-related genes in the marine Chlorella sp. The results showed that 10 and 100 ng/L TPT can promote the growth of marine Chlorella sp., 200 ng/L TPT can inhibit the growth of marine Chlorella sp., and the TPT toxicity was accumulative. The chlorophyll composition changed. The content of chlorophyll a in 100 ng/L and 200 ng/L groups was significantly higher than that in the control group ( p < 0.05) in 13 days. The content of chlorophyll b in the 100 ng/L and 200 ng/L groups in 1 day and 13 days was significantly different from that in the control group ( p < 0.05). The content of total chlorophyll in the 100 ng/L and 200 ng/L groups in 13 days was higher than that in the control group ( p < 0.05). The 200 ng/L group began to suffer oxidative damage on the 12th day, and the pigment protein complex responded to oxidative damage through self-feedback regulation. On the 18th day, chld , cao , psy , rbcS , and rbcL genes were downregulated, and psbA gene was upregulated in the 10 ng/L and 100 ng/L groups, which may be a feedback regulation of self-oxidative damage. This paper analyzed toxicity of environmental levels of TPT to marine Chlorella sp., which provided new data support for the comprehensive evaluation of its marine ecological toxicity.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2023
·
IF 6.8
Xiuxiu Chen,Donghui Zhu,Fan Zhang,Ouyang Li,Fan Yang,Zhijun Bao
Triphenyltin is an environmental contaminant widely used in antifouling paints and can cause toxicity in various organs in living organisms. However, its effects on intestinal function and the microbiome of the gut remain unknown. The objective of this study was to explore the intestinal toxicity of triphenyltin in mice by orally administering 0, 1.875, 3.75, and 7.5 mg/Kg to adult male mice for 8 weeks. Results showed that triphenyltin caused ileum tissue damage, induced oxidative stress, upregulated inflammation-related gene expression and increased serum tumor-necrosis factor α (TNF-α) levels in mice. Triphenyltin impaired ileum barrier function by downregulating Muc2 , ZO-1 , Occludin and their protein levels at 3.75 and 7.5 mg/Kg. TPT exposure led to partial inflammation and decreased mucin mRNA expression in the colon. Triphenyltin altered intestinal micro-ecological balance and fecal metabolome in mice. In conclusion, triphenyltin alters the mouse gut microbiota and fecal metabolome.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYST
·
2020
·Vol. 145
·期 6
·2286-2296
·
IF 3.978
Huiyu He,Miaomiao Tian,Lihuan Hu,Li Yang
The determination of trace-amount organotins in plastic food packaging materials is of great significance in food safety. However, due to the complexity of organotins and sample treatment processes, it is still a challenging task. Here, we report a method for the sensitive and simultaneous determination of organotins in plastic food packaging materials and edible oils, by utilizing sheathless capillary electrophoresis-electrospray ionization-mass spectrometry. The method of sample pretreatment with ultrasonic extraction and solid phase extraction is used to eliminate interference. The results showed low limits of detection (LODs) of 2 pg mL−1–50 pg mL−1 and excellent inter/intra-day repeatability. Good average recoveries in the range of 80.27% to 108.52% were obtained at three spiked concentrations, with a relative standard deviation less than 8.71%. The successful simultaneous determination of the target analytes will pave the way for further assessment of contamination and migration behaviour of organotins from packaging materials to food, which is of great significance for evaluating and controlling food safety.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Wei Zhang,XiaoLi Cheng,Xianfa Zhang,Yingming Xu,Shan Gao,Hui Zhao,Lihua Huo
Distinctive mesoporous SnO 2 microtubes were synthesized via a facile and environmentally friendly solvothermal method. The gas sensor based on such SnO 2 microtubes exhibited not only the lower detection limit to detect formaldehyde and remarkable selectivity comparison with other various gases when operating within 92 °C, but also good linear relationship under concentration ranges of ppm level (1–100 ppm) and ppb level (10–100 ppb). The sensing properties of such SnO 2 microtubes have been greatly improved compared to previously reported hollow structures. This might be attributed to their large specific surface area and porous structure, which can promote the diffusion of gas molecules and their adsorption on the surface of the sensing material.
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 6
·3117-3124
·
IF 3.108
Zhen Liu,Le Wang,Weiwei Bian,Min Zhang,Jinhua Zhan
Preclinical research reveals the risk of organotin compounds (OTCs) as potent endocrine disruptors, immunotoxicants and environmental obesogens for mammals. OTCs are commercial antifungal agents which are found extensively in clothing, female hygiene products and childcare articles. OTCs have been listed as restricted chemicals by REACH Regulation (Annex XVII). Here, a hyphenated method combining surface enhanced Raman spectroscopy (SERS) with solid phase microextraction (SPME) is proposed for rapid screening of OTCs. A porous Ag layer was synthesized in situ and served as the SERS-active SPME coating for adsorption. The SERS spectra of trimethyltin chloride, tributyltin chloride and triphenyltin chloride were investigated, the bands at 554 cm−1, 1410 cm−1 and 999 cm−1, respectively, being selected as the characteristic peaks for quantitative determination. The extraction conditions were optimized. The good stability and uniformity of porous Ag fibers insure a high enhancement factor of 9.1 × 105 and low LOD of 0.2 ppb for triphenyltin chloride. The proposed method was successfully applied to identify a mixture of OTCs in a textile matrix with satisfactory results.
✓ 已验证
产品关联
DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2024
·
IF 6.2
Xiuxiu Chen,Donghui Zhu,Renshan Ge,Zhijun Bao
Triphenyltin (TPT) is a widely used biocide known for its high toxicity to various organisms, including humans, and its potential contribution to environmental pollution. The aging process leads to progressive deterioration of physiological functions in the elderly, making them more susceptible to the toxic effects of environmental pollutants. This study aimed to investigate the mitigating effect of fecal transplantation in young mice on the toxicological impairment caused by TPT exposure. For the study, 18-month-old mice were divided into four groups with six replicates each. The control group was fed a basal diet, the TPT group was exposed to 3.75 mg/Kg TPT, the feces group received fecal transplantation from 8-week-old young mice, and the combined group was exposed to 3.75 mg/Kg TPT after receiving fecal transplantation. Compared with the elderly control group, TPT induced significant upregulation of mRNA expression of pro-inflammatory factors ( IL-1β, IL-6, TNF-α ), while the anti-inflammatory factor gene IL-10 was significantly suppressed. The mRNA expression of intestinal barrier proteins ( Claudin, Occludin, Muc2 ) was also significantly downregulated. However, fecal transplantation in young mice alleviated TPT-induced changes in inflammatory factors, ameliorated oxidative stress, and increased the activities of antioxidant enzymes (including SOD, CAT, GSH-Px). Further analysis using 16 s RNA showed that exposure to TPT led to changes in the composition of the intestinal flora. Untargeted metabolomics observations of feces from older mice revealed that exposure to TPT resulted in altered fecal metabolites. Fecal transplantation in young mice altered the microbiota of TPT-exposed older mice, especially by enhancing the levels of core probiotics. Similar beneficial effects were observed through untargeted metabolomics. Overall, this study highlights the potential benefits of young fecal transplantation in protecting the elderly from the toxicity of TPT, offering a promising approach to improve healthy aging.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Songlin Wang,Chi Chen,Peng Yang,Yu Guo,Bingxing Wang,Hongying Niu,Qiying Zhang,Jianji Wang
Dimethyl carbonate (DMC) is an important synthetic intermediate with widespread applications in the chemical industry. In recent years, the one-step conversion of CO2 into DMC has gained significant attention, but the development of an efficient catalytic system remains a considerable challenge to realize this process. Herein, a series of organotin-oxometalate coordination polymers were developed for DMC synthesis from CO2 and methanol without any solvent/dehydrating agent, and it was found that the metal complexes displayed excellent catalytic performances, especially (nBu3Sn)2MoO4 with the n-butyl group (Bu) was very active, and a high DMC yield (15.7 mmol gcat–1) and high TON value (3.90) were achieved under mild conditions, which was remarkably higher than the recently reported catalytic systems. Moreover, the polymer was highly stable and easy to be recycled with no significant activity loss. Experimental and in situ FT-IR studies revealed that the synergetic catalysis of [Bu3Sn]+ and [MoO4]2– to active CO2 and methanol was the key reason for improved catalytic activity. This study offers a promising strategy for the efficient synthesis of organic carbonates catalyzed by metal complexes to realize better CO2 utilization.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Jiamiao Wang,Jurong Lv,Zheyu Shen,Yan Liu,Xia Gao,Qiang Chen,Pei Liang
Organotin compounds (OTCs) are a hazardous substance that threatens the environment and human health. This study aims to detect organotin effectively. The first step was to compute the Raman spectra of organotin substances using density functional theory (DFT). This was followed by the collection of experimental data for the corresponding spectra. Finally, the gold and silver nanoparticles were prepared as substrates for surface-enhanced Raman scattering (SERS) detection. The SERS spectra were used to extract Raman characteristics that exclusively belong to the same type of metabolites. Additionally, a correspondence was established between these Raman characteristics and their respective vibration modes. The database contains the original SERS spectra and mapping data of the mentioned OTCs, along with the detailed characteristics of their Raman peaks, particularly their unique ones. The results indicate that silver nanoparticles are an effective substrate for SERS detection, providing a sensitive technique for trace detection of organotin compounds.
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Environmental Science
·
2024
·
IF 3.3
Huang Yuanyuan,Yang Qingwei,Song Ling,Ran Hongjie,Jiang Hui,Sun Da
In this study, we investigated the oxidative mechanisms of nano zero-valent iron (nZVI) enhanced potassium ferrate (K2FeO4), focusing on tributyltin (TBT) and triphenyltin (TPhT) as target pollutants. The addition of nZVI enhanced the degradation of both organic tin compounds by K2FeO4, exhibiting pseudo-first-order kinetics influenced by pH, carbonate, and fulvic acid. nZVI, as a reducing agent, facilitated the generation of stronger oxidizing species Fe (V) and Fe (IV) from K2FeO4 through electron transfer. The presence of hydroxyl radicals (OH) was confirmed by tert-butyl alcohol (TBA) verification. Intermediate products of TBT degradation by nZVI-enhanced K2FeO4 were identified using GC-MS, confirming de-alkylation leading to stepwise oxidation to inorganic tin ions. Due to excessively long Sn-C bonds in diphenyltin, rendering them unstable, Density Functional Theory (DFT) calculations were employed. Results indicated that Fe (IV) and Fe (V) predominantly attacked the Sn-C bonds of TPhT, while OH primarily targeted the benzene ring. HOMO energy levels suggested that Fe (V) was more prone to oxidizing TPhT than Fe (IV). Gibbs free energy calculations demonstrated that, in the presence of Fe (IV) and Fe (V), the energy barrier for breaking bonds and oxidizing into inorganic tin ions decreased, favoring the process over the self-decomposition of TPhT. Additionally, the lower energy barrier for OH indicated an easier degradation of TPhT. This study reveals that nZVI-enhanced K2FeO4 effectively removes TBT and TPhT, contributing to the understanding of the ferrate-mediated degradation mechanism of organic tin compounds. The findings offer insights and theoretical guidance for remediating organic tin pollution in aquatic environments.
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Yangyang Li,Ji Li,Ting Li,Xiaoli Cheng,Yingming Xu,Shan Gao,Lihua Huo
Chlorine (Cl 2 ), a toxic and hazardous gas with a pungent odor, has already posed threat to air quality and human health. Therefore, developing chlorine sensors with high response and low power consumption is crucial. In this work, raspberry-like SnO 2 decorated uniformly with SnS nanoparticles was synthesized via a facile solvothermal method followed by an in-situ sulfurization process, which can be used for highly selective and sensitive detection of Cl 2 at 50 °C. The SnS/SnO 2 sensor exhibits ultrahigh response (R g /R a = 1136) toward 10 ppm Cl 2 at optimal working temperature of 50 °C, achieving low detection limit down to 0.05 pp m (S = 1.52), which is 2.5 times higher than that of pure SnO 2 sensor. Its superior sensing performance can be attributed to the formation of the p-n heterostructure, which accelerates electron transfer within the material. More importantly, the as-prepared SnS/SnO 2 sensor still exhibits effective and stable detection performance toward residual chlorine in daily life, significantly extending its practical applicability and providing valuable reference for developing high-performance near room-temperature gas sensors.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）