MATERIALS & DESIGN
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2026
·
IF 8.2
Ziwei Li,Qiuying Wu,Rui Ni,Jingjing Wang,Meiyang Yang,Wenyuan Zhang,Jiaming Li,Dan Peng,Lin Song,Yao Liu
Qu@NPs/ADSCs@CS-gel integrates anti-inflammatory, antibacterial, immunomodulatory properties for infected wound healing. • Hydrogel with genipin-crosslinked chitosan/silk sericin, encapsulated ADSCs, and surface-attached ROS-responsive Qu@NPs. • Qu@NPs release quercetin in response to ROS, effectively scavenging ROS and reducing inflammation while preserving SOD activity. • Hydrogel inhibits M1 polarization & inflammatory cytokines, promotes M2 transition & creates regenerative microenvironment. • Enhances antibacterial, proliferation, re-epithelialization, angiogenesis, collagen deposition, accelerates wound repair. Chronic infected wounds face healing challenges due to the interplay of persistent infection, excessive inflammation, and impaired angiogenesis. Conventional dressings often address only one pathological aspect, resulting in limited therapeutic effects. To overcome these barriers, we developed a multifunctional hydrogel Qu@NPs/ADSCs@CS-gel that integrates anti-inflammatory, antibacterial, and immunomodulatory activities. The system was fabricated from genipin-crosslinked chitosan and silk sericin into a biocompatible hydrogel (CS-gel) that exhibits antibacterial activity and permits cellular matrix permeability. Adipose-derived stem cells (ADSCs) were encapsulated within this hydrogel, while reactive oxygen species (ROS)-responsive quercetin-loaded nanoparticles (Qu@NPs), based on poly(propylene sulfide)-poly(ethylene glycol) (PPS-PEG), were attached to its surface. Upon wound contact, Qu@NPs are released from Qu@NPs/ADSCs@CS-gel, and PPS-PEG breaks down in response to ROS to release quercetin, effectively eliminating ROS and alleviating the inflammatory response, thereby establishing a regenerative microenvironment for ADSC-mediated repair. Qu@NPs/ADSCs@CS-gel exhibited potent antibacterial activity, reduced ROS accumulation in macrophages while preserving superoxide dismutase (SOD) activity. Furthermore, it inhibited M1 macrophage polarization and pro-inflammatory cytokine secretion, while promoting transition to the M2 phenotype. These effects collectively improved cell proliferation, re-epithelialization, angiogenesis, and collagen deposition, accelerating the three phases of wound repair. Our findings support Qu@NPs/ADSCs@CS-gel as an advanced dressing for infected wounds.
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2026
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IF 8.8
Wei Liu,Lin Wang,Kunyi Wang,Xinzhi Liang,Ting Liu,Jingxuan Tan,Xiaoyong Qiu,Jingcheng Hao
Double-layer fibers control gaseous microenvironment, suppressing respiration. • Double-layer fibers possesses high selectivity of CO 2 and O 2 . • The dual mechanism—gas regulation and bioactive—prolongs the quality of fruits. Respiration is the primary driver of postharvest deterioration in highly perishable fruits, as both plant tissues and associated microorganisms rapidly consume available nutrients and accelerate quality loss. Modulating the surrounding gaseous environment is therefore critical for mitigating respiration-the most important factor of driving spoilage. In this study, double-layer fiber films with selective gas permeability were developed to regulate O 2 and CO 2 levels within localized microenvironments. Their asymmetric structure established a mildly hypoxic and CO 2 -enriched atmosphere, achieving a gas selectivity of 11.39 ± 0.88 and effectively lowering respiratory intensity. The fibers also provided antibacterial and antioxidative functions, contributing to reduced microbial contamination and oxidative degradation. When applied to litchi, the films extended the effective commercial shelf life to approximately 9 days and significantly delayed overall spoilage throughout a 15-day evaluation period under controlled storage conditions. Beyond their demonstrated efficacy, these fibers show considerable potential for advancing food preservation strategies, offering meaningful opportunities for more sustainable packaging solutions. Their dual-action mechanism—integrating gas regulation with biological active—positions them as a versatile material platform for addressing spoilage challenges in highly perishable fruits. Download: Download high-res image (89KB) Download: Download full-size image
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ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Muhammad Saqib,Wen-Xin Chen,Yun Lei,Ai-Lin Liu
Chemiluminescence (CL) assays are often constrained by the limited availability of coreactants that combine strong signal amplification with biocompatibility. Herein, we report for the first time that sericin, a natural protein derived from silk, serves as a highly efficient coreactant in the lucigenin CL system under alkaline conditions. Impressively, this new lucigenin–sericin CL system generates an unprecedented ∼43-fold higher emission intensity compared to the traditional lucigenin–hydrogen peroxide system. Moreover, the mechanistic studies reveal that sericin, with its electron-rich functional groups, significantly promotes the generation of superoxide radicals (O2•–). This, in turn, accelerates the lucigenin oxidation pathway, leading to significant enhancement in CL signal. Leveraging this enhanced system, we developed a dual-function CL platform for the ultrasensitive detection of sericin (limit of detection, LOD = 0.12 μM) and superoxide dismutase (SOD, LOD = 0.28 ng/mL), exhibiting an extended linear range spanning from 0.25 to 50 μM and 0.5 to 60 ng/mL, respectively, the latter based on CL quenching phenomena. This method offers compelling superiority in terms of simplicity, rapid analysis, enhanced sensitivity, higher selectivity, and cost-effectiveness. Moreover, this method successfully achieved the detection of sericin in cosmetics and the SOD in human serum samples. Importantly, this work represents the first chemiluminescent method for sericin detection. In addition, the system exhibited high sustainability and practical utility, as confirmed by AGREE (greenness) and BAGI (blueness) assessment tools. Furthermore, it introduces a new class of protein-based coreactants for CL systems, expanding the frontier of (bio)analytical detection.
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PubMed
高影响因子
MACROMOLECULES
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2025
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IF 5.2
Ming-Liang Wu,Jin-Feng Li,Xiao-Li Ku,Yi-Dong Li,Jian-Bing Zeng
Conductive elastomers integrating robust mechanical properties and room-temperature self-healing capability present great potential for advanced technologies, yet their fabrication remains challenging due to the inherent trade-off between strength and reparability, coupled with inadequate interfacial adhesion. We propose an innovative “one-stone-three-birds” strategy to address these challenges by developing supramolecular elastomer composites (SECs) through the incorporation of polydopamine (PDA) into a carboxylated cellulose nanofiber (CCNF)-reinforced oxidized natural rubber (ONR) system. The composite features a segregated architecture, where the ONR matrix is compartmentalized by the CCNF network with PDA localized within the CCNF phase. This strategic integration yields three major benefits: First, PDA enhances interfacial interactions between the ONR and CCNF, boosting mechanical robustness (15.33 MPa tensile strength, 834% elongation) while enabling remarkable ambient self-healing efficiency (87.5% recovery). Second, PDA’s excellent photothermal conversion facilitates light-activated, precise, and rapid self-healing and provides the SECs with promising thermoelectric properties. Third, PDA’s inherent adhesiveness allows for easy dip-coating of conductive materials onto the SECs surface to endow conductivity, resulting in flexible strain sensors with excellent sensitivity, reliability, and durability. Our innovative approach establishes a new paradigm in self-healing material design through molecular-level interfacial engineering and hierarchical structure control, simultaneously addressing critical challenges in mechanical robustness, dynamic reparability, and functional adaptability.
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高影响因子
Materials
·
2026
·Vol. 19
·期 13
·2695
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IF 3.7
Yang Yuan,Jiawei Zhang,Fangzheng Yu,Chen Wang,Jiale He,Zheng Zhao
Bacterial infections and excessive reactive oxygen species (ROS) severely impede wound healing. However, traditional hydrogels often lack the integrated antibacterial and antioxidant properties required for effective treatment. To overcome these limitations, a natural thioctic acid (TA)-based multifunctional composite hydrogel (PTA-Arg/SAS) was developed. Arginine (Arg) served as a green inducer for the aqueous ring-opening polymerization of TA. Concurrently, salicylic acid-grafted sericin (SAS) was introduced to inhibit poly(thioctic acid) (PTA) depolymerization via the formation of stable sulfur-aryl (S-Ar) bonds. The hydrogel exhibits self-healing capability, injectability, and robust tissue adhesion to porcine skin (1877 Pa dry; 1663 Pa wet). Furthermore, SAS endowed the system with potent antibacterial (99.1% againstE. coli, 97% againstS. aureus) and antioxidant activities (98.2% ABTS and 72.7% DPPH radical scavenging rates). In vitro evaluations confirmed the viability of L929 cells (>98% over 3 days) and a negligible hemolysis ratio (<5%). Consequently, this study provides a strategy for fabricating next-generation bioactive dressings for complex wound management.
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高影响因子
CHEMOSPHERE
·
2023
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IF 8.8
Tongtong Xu,Ang Li,Xudong Zheng,Biao Ji,Jinfeng Mei,Man Zhou,Zhongyu Li
Gadolinium is widely applied in medical and high-tech materials because of special magnetic properties. Recovery of gadolinium from waste rare earth products has both economic and environmental value. In this experiment, honeycomb porous composite aerogels were constructed using sericin and sodium alginate mixed with functionally modified carboxymethylated cellulose nanocrystals for the adsorption and separation of gadolinium ions. There were large numbers of carboxyl groups as well as hydroxyl groups on the surface of sodium alginate and filamentous protein, which provided more sites for the adsorption of gadolinium ions. Besides, a stable honeycomb structure appeared on the surface of composite aerogels when the mixture of filamentous protein and sodium alginate was 1:1, which increased the specific surface area of materials to 140.65 m 2 g −1 . Additionally, the imprinted composite aerogels Ic-CNC/SSA were prepared by virtue of the imprinting technology , enhancing the adsorption selectivity of composite aerogels for gadolinium. The adsorption experiments revealed that the maximum adsorption capacity of Ic-CNC/SSA reached 93.41 mg g −1 at pH 7.0, indicating good selective adsorption of gadolinium ions. In summary, such composite aerogels provide great potential and reference value for the selective adsorption of gadolinium ions in industry.
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2023
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IF 3
Ting Wu,Haiying Liu,Hongcai Wang,Yanan Bu,Jiayi Liu,Xiuqiong Chen,Huiqiong Yan,Qiang Lin
Sodium alginate (SA) possesses good biocompatibility and can form hydrogel materials under certain conditions, which has been widely used in tissue engineering. However, the absence of cellular recognition sites and low mechanical strength for single-component alginate (ALG) hydrogels limit their practical applications. Therefore, enhancing the shortcomings of ALG hydrogels and augmenting their characteristics hold immense importance for their medical uses. In this study, comprehensively considering the excellent properties of cellulose nanocrystals (CNCs) and sericin (SS), the alginate/sericin/cellulose nanocrystalline (ALG/SS/CNCS) composite hydrogels were constructed by interpenetrating network (IPN) technique using hydroxyapatite/D-glucono-δ-lactone (HAP/GDL) as the endogenous ionic cross-linking agent of SA, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride/N-hydroxysuccinimide (EDC/NHS) as the chemical covalent cross-linking agent of SS and CNCS as the reinforcing agent. The effects of SS and CNCs additions on the comprehensive properties of ALG/SS/CNCs composite hydrogels, such as their morphologies, structure, mechanical properties, swelling, degradability, and cytocompatibility were investigated. The findings indicated that the ALG/SS/CNCS IPN composite hydrogels which were created through the physical blending of SA and SS, displayed a consistent three-dimensional form and a porous configuration. The weak mechanical strength of pure ALG hydrogels can be effectively improved and the swelling stability and mechanical properties of the composite hydrogels can be enhanced through the construction of IPN network and the incorporation of CNCs, thanks to the presence of intermolecular hydrogen bonding. The biodegradability of ALG/SS/CNCS composite hydrogels increased as the SS content increased, indicating that SS facilitated their biomineralization due to its inherent susceptibility to degradation. The results of the cell compatibility test conducted in a laboratory setting showed that SS and CNCS had the ability to enhance the attachment, proliferation, and differentiation of MC3T3-E1 cells on the ALG/SS/CNCS composite hydrogels. Hence, incorporating SS and CNCS into the alginate matrix to create IPN composite hydrogels could significantly enhance the physicochemical and biological characteristics of ALG hydrogels, thus rendering them appropriate for tissue engineering purposes.
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
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IF 2.8
Kaifeng Gu,Yingdong Chen,Qi He,Yong Zhou
Nanofiltration plays an increasingly important role in liquid separation scenarios. Membrane preparation processes are important factors affecting the separation effect of nanofiltration. Protein molecules are often added to the preparation process of nanofiltration membranes to improve their precise separation performance. Sericin is a protein material with excellent water solubility, and it doesn't pose any additional harm to the environment. In this study, a sericin-assisted interfacial polymerization process for nanofiltration membrane was proposed to improve the membrane forming process. The sericin in aqueous solution improved the surface properties and pore structure of the separation layer. After careful verification, we believed that the nanofiltration membrane prepared using 1% piperazine, 0.1% 1,3,5-Benzenetricarbonyl trichloride, and 0.02% sericin had the best performance. It showed a rejection rate of Na 2 SO 4 99%, MgSO 4 98%, MgCl 2 95%, NaCl 27%, LiCl 20%. At 2 bar operating pressure, the permeate flux could be increased from 15 to 25 L m −2 h −1 . The Mg 2+ /Li + separation factor could reach 20, and the SO 4 2− /Cl − separation factor could reach 60. The nanofiltration membrane had excellent salt separation performance. It had a great application prospect in seawater desalination pretreatment, lithium extraction from salt lakes, and water softening.
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高影响因子
International Journal of Nanomedicine
·
2025
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IF 6.5
Lulu Zhang,Haiyang Liu,Jin Ren,Junyi Shao,Yanrong Cao,Shuangshuang Wang,Changchun Peng,Shengwen Shao,Haixia Ge,Jingmou Yu
Background Stimuli-responsive polymer-drug nanoparticles have emerged as a versatile and effective platform for delivering drugs in the treatment of malignant tumors. The integration of chemo-phototherapy has gained increasing prominence due to its remarkable synergistic antitumor effects.Methods Hydrophilic sericin (Ser) was linked to antitumor drug doxorubicin (DOX) via a disulfide bond. The obtained Ser-ss-DOX conjugate was characterized by Fourier-transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1H NMR) and dynamic light scattering (DLS). The near-infrared (NIR) fluorescent dye IR780 was encapsulated into Ser-ss-DOX by a dialysis method. The physical state of IR780 within Ser-ss-DOX/IR780 nanoparticles was analyzed by differential scanning calorimetry (DSC). The photothermal properties and drug release behavior of IR780-loaded nanoparticles were systematically investigated. Cellular uptake and reactive oxygen species (ROS) generation capacity and in vitro cytotoxicity of IR780-containing nanoparticles were studied in 4T1 breast cancer cells. In addition, 3D multicellular tumor spheroid model was conducted to investigate the antitumor activity of the nanoparticles.Results The Ser-ss-DOX conjugate was successfully synthesized. Ser-ss-DOX and Ser-ss-DOX/IR780 nanoparticles were spherical in shape, and their particle sizes measured by DLS were 326 and 190 nm, respectively. IR780 was in an amorphous state within the Ser-ss-DOX/IR780 nanoparticles. The loading contents of DOX and IR780 were 8.26% and 2.78%, respectively. Ser-ss-DOX/IR780 exhibited ideal photothermal properties in vitro and reduction-sensitive drug release in a high glutathione (GSH) environment. Ser-ss-DOX/IR780 displayed higher cellular uptake in 4T1 cells than Ser-ss-DOX and free DOX. Under 808 nm laser irradiation, Ser-ss-DOX/IR780 showed a strong capacity to generate ROS. Importantly, Ser-ss-DOX/IR780 with laser irradiation effectively inhibited the growth of 4T1 cells and 3D multicellular tumor spheroids.Conclusion This work demonstrated that Ser-ss-DOX/IR780 integrated dual functionalities of chemotherapy and phototherapy, thereby enabling substantial potential for application in tumor treatment.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
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IF 4.9
Tianyue Zhao,Ran Wang,Shengnan Wei,Lexin Zhang,Zhiwei Liu,Mingli Wang,Tifeng Jiao
In this work, the self-assembled films of sericin protein (SP), silk fibroin (SF), and dye molecules were prepared by the Langmuir-Blodgett (LB) technique. Surface-enhanced Raman scattering (SERS) experiments demonstrated that the SP/saffron T (ST)-80 and SF/ST-60 composite LB films exhibited good Raman enhancement characteristics with enhancement factors (EFs) of 5.74×10 4 and 7.05×10 4 , respectively. The relative standard deviations (RSDs) of Raman intensity were 7.19% and 18.40%, respectively, confirming the uniformity of the composite LB films. Furthermore, photoelectric conversion efficiencies indicate that the electrodes fabricated from SP/ST and SF/ST film electrodes have high carrier rates and good photocurrent generation properties. This study provides novel insights into the fabrication of multifunctional SP/dye and SF/dye composite LB films, demonstrating their potential applications in SERS and photovoltaic conversion.
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高影响因子
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