INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2022
·Vol. 23
·期 19
·11202
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IF 6.208
Yuting Xiao,Ruixiao Luo,Yansong Ji,Shiwei Li,Hongmei Hu,Xiaoning Zhang
Sericin is a by-product of the silk industry. Its recycling contributes to environmental protection and the sustainable development of the cocoon silk industry. In this paper, on the basis of realizing sericin enrichment in solution, the Cu(II) adsorption capacities of sericin-derived carbon (SC), prepared at different pyrolysis temperatures, were studied. SC was characterized using scanning electron microscopy (SEM) and the zeta potential. The effects of the initial concentration of Cu(II), pH, adsorption temperature, and contact time on the adsorption process were evaluated, followed by an investigation of the mechanism of Cu(II) adsorption by SC. The results showed that SC has a porous structure that provides sites for Cu(II) adsorption. The maximum adsorption capacity of Cu(II) onto SC1050, 17.97 mg/g, was obtained at an adsorption temperature of 35 °C and a pH of 5.5. In addition, the pseudo-second-order kinetic model and Langmuir isotherm model correctly described the adsorption process of Cu(II) onto SC1050. Therefore, SC can act as a potential adsorbent for removing Cu(II) from water. This study helps promote the effective use of cocoon silk resources.Keywords:silk sericin;sericin-derived carbon;copper(II);adsorption
研究领域:
环境科学
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材料科学
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化学工程
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DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2018
·
IF 1.911
Pei Jiang,Jiabing Ran,Pan Yan,Lingyue Zheng,Xinyu Shen,Hua Tong
Bacterial cellulose/hydroxyapatite (BC/HAp) composite had favourable bioaffinity but its poor mechanical strength limited its widespread applications in bone tissue engineering (BTE). Silk fibroin, which possesses special crystalline structure, has been widely used as organic reinforcing material, and different SFs have different amino acid sequences, which exhibit different bioaffinity and mechanical properties. In this regard, bacterial cellulose-Antheraea yamamai silk fibroin/hydroxyapatite (BC-AYSF/HAp), bacterial cellulose-Bombyx mori silk fibroin/hydroxyapatite (BC-BMSF/HAp), and BC/HAp nano-composites were synthesized via a novel in situ hybridization method. Compared with BC/HAp and BC-BMSF/HAp, the BC-AYSF/HAp exhibited better interpenetration, which may benefit for the transportation of nutrients and wastes, the adhesion of cells as well. Additionally, the BC-AYSF/HAp also presented superior thermal stability than the other two composites revealed by differential thermal analysis (DTA) and thermogravimetric analysis (TGA). Compression testing indicated that the mechanical strength of BC-BMSF/HAp was greatly reinforced compared with BC/HAp and was even a little higher than that of BC-AYSF/HAp. Tensile testing showed that BC-AYSF/HAp possesses extraordinary mechanical properties with a higher elastic modulus at low strain and higher fracture strength simultaneously than the other two composites. In vitro cell culture exhibited that MC3T3-E1 cells on the BC-AYSF/HAp membrane took on higher proliferative potential than those on the BC-BMSF/HAp membrane. These results suggested that compared with BC-BMSF/HAp, the BC-AYSF/HAp composite was more appropriate as an ideal bone scaffold platform or biomedical membrane to be used in BTE.
研究领域:
生物材料学
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医学工程
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DOI
PubMed
高影响因子
Colloid and Interface Science Communications
·
2020
·
IF 2.831
Yan Fang Cheng,Yi Hong Mei,Gnanasekar Sathishkumar,Zhi Song Lu,Chang Ming Li,Feng Wang,Qing You Xia,Li Qun Xu
Silk sericin (SS), a by-product in the field of sericulture, is degummed from raw silk and mostly discarded in silk processing wastewater, causing water pollution. However, it could be interesting to explore the possible utilization of hydrophilic SS as a value-added product in the antifouling application. In this work, natural tannic acid (TA) and SS were conjugated via hydrogen bonding interactions, and the resulting TA/SS conjugates were deposited on the titanium (Ti) surfaces through surface adhesive trihydroxyphenyl groups in TA. The current coating strategy avoids the usage of toxic reagents and reactants and represents an eco-friendly way to fabricate antifouling coatings. The successful co-deposition of TA and SS on the Ti surfaces were confirmed by the static contact angle, X-ray photoelectron spectroscopy (XPS), and surface zeta potential measurements. The TA/SS co-deposited Ti (Ti-TA/SS) surfaces show good protein repellent as well as platelet and bacterial anti-adhesive properties. In addition, the Ti-TA/SS surfaces exhibit low cytotoxicity towards L929 mouse fibroblast cells.
研究领域:
生物材料
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医学工程
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DOI
高影响因子
MOLECULES
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2018
·Vol. 23
·期 7
·1821
·
IF 3.098
Yejing Wang,Rui Cai,Gang Tao,Peng Wang,Hua Zuo,Ping Zhao,Ahmad Umar,Huawei He
Silk sericin is a protein from a silkworm’s cocoon. It has good biocompatibility, hydrophilicity, bioactivity, and biodegradability. However, sericin could not be used in biomedical materials directly because of its frangible characteristic. To develop multifunctional sericin-based materials for biomedical purposes, we prepared a sericin/agar (SS/agar) composite film through the blending of sericin and agar and repetitive freeze-thawing. Then, we synthesized silver nanoparticles (AgNPs) in situ on the surface of the composite film to endow it with antibacterial activity. Water contact angle, swelling and losing ratio, and mechanical properties analysis indicated that the composite film had excellent mechanical property, hydrophilicity, hygroscopicity, and stability. Scanning electron microscopy and X-ray photoelectron spectroscopy analysis confirmed the successful modification of AgNPs on the composite film. X-ray powder diffraction showed the face-centered cubic structures of the AgNPs. This AgNPs modified composite film exhibited an excellent antibacterial capability againstEscherichia coliandStaphylococcus aureus. Our study develops a novel AgNPs/sericin/agar composite film with enhanced mechanical performance and an antimicrobial property for potential biomedical applications.Keywords:silk sericin;agar;silver nanoparticles;antimicrobial activity
研究领域:
生物材料学
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医学材料
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2022
·Vol. 23
·期 3
·1668
·
IF 6.208
Yansong Ji,Xiaoning Zhang,Zhenyu Chen,Yuting Xiao,Shiwei Li,Jie Gu,Hongmei Hu,Guotao Cheng
The recycling and reuse of biomass waste for the preparation of carbon-based adsorbents is a sustainable development strategy that has a positive environmental impact. It is well known that a large amount of silk sericin (SS) is dissolved in the wastewater from the silk industry. Utilizing the SS instead of discharging it into the environment without further treatment would reduce environmental and ecological problems. However, effective enrichment of the SS from the aqueous solution is a challenge. Here, with the help of carboxymethyl chitosan (CMCS), which can form a gel structure under low voltage, an SS/CMCS hydrogel with SS as the major component was prepared via electrodeposition at a 3 V direct-current (DC) voltage for five minutes. Following a carbonization process, an SS-based adsorbent with good performance for the removal of methylene blue (MB) from an aqueous solution was prepared. Our results reveal that the SS/CMCS hydrogel maintains a porous architecture before and after carbonization. Such structure provides abundant adsorption sites facilitating the adsorption of MB molecules, with a maximum adsorptive capacity of 231.79 mg/g. In addition, it suggests that the adsorption is an exothermic process, has a good fit with theLangmuirmodel, and follows the intra-particle diffusion model. The presented work provides an economical and feasible path for the treatment of wastewater from dyeing and printing.Keywords:silk sericin;hydrogel;carbonization;adsorption;methylene blue
研究领域:
环境科学
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材料科学
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废水处理
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DOI
PubMed
高影响因子
Science of Advanced Materials
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2018
·Vol. 10
·期 6
·761-768
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IF 1.318
Yang Meirong,Wang Yejing,Cai Rui,Tao Gang,Chang Huaipu,Ding Chaoxiang,Zuo Hua,Shen Hong,Zhao Ping,He Huawei
Silk sericin is an inexpensive and readily available natural protein with good reactive activity, biocompatibility and biodegradability for biomaterial application. To develop sericin-based materials for potential antibacterial application, a novel and non-toxic sericin/glycerol (SS/Gly)
film was prepared by blending sericin with glycerol. Mechanical properties, water contact angle, moisture absorption rate and water retention ratio of the prepared SS/Gly films were measured. The results indicated that a SS/Gly composite film containing 40% (wt) glycerol exhibited excellent
flexibility, moderate tensile strength and good hydrophilicity. Then, silver nanoparticles (AgNPs) were synthesized in situ on the surface of SS/Gly film to endow the film with antimicrobial activity. Scanning electron microscopy revealed that sericin and glycerol had good compatibility,
and that AgNPs synthesis was dependent on ultraviolet irradiation time. X-ray photoelectron spectroscopy demonstrated the presence of AgNPs on the surface of SS/Gly film. Inhibition zone and bacterial growth assays suggested that the prepared AgNPs/SS/Gly film had excellent antimicrobial activities
against both Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive). Inductively coupled plasma atomic absorption spectroscopy showed that the synthesized AgNPs could be easily released from the composite film. The developed AgNPs/SS/Gly film has therefore
shown great potential in antibacterial applications, such as wound dressing and skin tissue engineering.
研究领域:
生物材料学
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微生物学
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材料科学
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DOI
高影响因子
POLYMER
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2025
·
IF 4.5
Xin Luo,Yue Ma,Yanlei Hu,Huazhong Ma,Juan Yu,Liang Liu,Meijuan Chen,Yimin Fan
This study focused on the fabrication of a composite material composed of silk fibroin (SF) and sericin (SS). The "one-pot" method was proposed, directly introducing the two components into a formic acid-calcium chloride system to create gel-like material that possesses an abundance of porous structures and remarkable mechanical properties and toughness. By using a solvent exchange and evaporation technique, composite films were produced with outstanding tensile toughness even under wet conditions. Moreover, the influence of the formic acid-calcium chloride dissolution system on sericin and the composite material was investigated. Overall, this study provided a novel and effective approach to produce composite materials with desirable properties by using silk fibroin and sericin. It also highlighted the crucial role of both the formic acid-calcium chloride dissolution system and ethanol-water gradient treatment in the fabrication process. This research has implications for the development of new materials with potential applications in the fields of medicine, biotechnology, and tissue engineering.
研究领域:
生物材料学
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医学工程
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材料科学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
·
IF 8.025
Chunru Wang,Junyao Li,Xiangsheng Han,Shuai Liu,Xintao Gao,Chuanlong Guo,Xiaochen Wu
Silk sericin (SS) has become a noticeable drug nanocarrier due to its excellent biocompatibility and bioactivity. To further extend the application of SS, a facile one-step process was constructed to fabricate SS-stabilized-drug composites. Various insoluble drugs can be encapsulated into SS with high loading amount, and showed good dispersity in aqueous solution. For example, proanthocyanidins (PAC), a natural polyphenol with initial antioxidant and anti-inflammatory effects, can be loaded on SS to form SS/PAC composites. The SS/PAC can disperse uniformly in aqueous solution with an average particle diameter of ~136 nm, and showed high drug loading amount of 1767 mg/g. The SS/PAC exhibited high antioxidant efficiency and excellent biocompatibility (non-irritant, non-hemolysis, and non-cytotoxicity), could remarkably alleviate the symptoms of dextran sulfate sodium-induced ulcerative colitis by decreasing the disease activity index scores, inhibiting the shortening of colon length, regulating oxidative stress , suppressing inflammation, and reversing the histopathological injuries. This work provides a simple method to fabricate SS-stabilized-drug composites, promises high potential in therapeutic and pharmaceutical applications .
研究领域:
药理学
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生物材料学
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消化病学
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产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR BIOSCIENCE
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2023
·
IF 4.6
Chunru Wang,Yingjie Xiang,Wenjie Ma,Chuanlong Guo,Xiaochen Wu
Ulcerative colitis is a chronic inflammatory bowel disease with a high recurrence rate. Natural phytochemical compounds are increasingly being considered as preventative and supportive treatments for this condition. However, the poor water solubility and stability of many of these compounds limit their effectiveness in vivo. To address this issue, fisetin (FT), a natural phytochemical with poor solubility, was stabilized using silk sericin (SS) to create a composite (SS/FT). The therapeutic potential of the SS/FT on ulcerative colitis was extensively investigated, and the results showed that it effectively alleviated the body weight loss and colon length shortening induced by dextran sulfate sodium. Notably, SS/FT downregulated the immune response, decreased colonic histopathological lesions, and reduced the cGAS/STING signal activation. This suggests that SS/FT may offer a promising therapy for treating ulcerative colitis. This article is protected by copyright. All rights reserved
研究领域:
药理学
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炎症性肠病
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天然产物化学
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DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
·
2020
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IF 4.152
Yuqing Wang,Danyu Yao,Linhao Li,Zhiyong Qian,Wei He,Rui Ding,Haifeng Liu,Yubo Fan
Biomaterial implantation is followed by an inflammatory cascade dominated by the macrophages, which polarized to the proinflammation M1 phenotype or prohealing M2 phenotype. Generally, silk sericin (SS) is considered to be of high immunogenicity associated with native silk fibers. The blends of silk fibroin (SF) and SS in different mass ratios might elicit different host immune responses and induce macrophage phenotype switch. The objective of this study was to assess the effects of electrospun SF–SS fibrous films with different mass ratios (10:0, 9:1, 8:2, and 7:3) on the macrophage phenotypes and explore the optimal ratio of SF and SS for angiogenesis. Our results indicated that the macrophages were activated by the addition of SS. When the mass ratio of SF and SS reached 7:3, the film displayed the highest degree of vascularization. The macrophages were induced to secrete more M1 and M2 cytokines accompanying with high M2/M1 ratio. Taken together, this study provided a perspective to promote neovascularization by modulating appropriate host response and macrophage phenotypes in tissue engineering field.
研究领域:
生物材料
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免疫学
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组织工程
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
FIBERS AND POLYMERS
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2022
·Vol. 23
·期 3
·658-665
·
IF 2.347
Lv Zongyu,Tan Ting,Hussain Munir,Zhou Wenlong,Ma Mingbo
Naturally colored silk (NCS) fades easily during wet processing and home washing due to the loss of pigment, which is accompanied by dissolution of the sericin layer. This study proposed a green and effective strategy for fixing the sericin of NCS to improve the color fastness of NCS textiles under wet conditions. The sericin of NCS was crosslinked with a bifunctional epoxy resin, poly(ethylene glycol) diglycidyl ether (PEGDE), in the presence of calcium chloride as a catalyst. The influences of the concentrations of PEGDE and the catalyst, pH, temperature, and reaction time on the crosslinking effect were investigated. The results showed that crosslinking NCS under optimum conditions could result in a 5.11 % weight gain. After crosslinking, the pigment in the sericin layer exhibited a considerable fixation fastness under wet conditions due to the low solubility of the crosslinked sericin. The K/S value of crosslinked NCS decreased by only 15.9 % after washing 15 times, which is much lower than that of uncrosslinked NCS (43.8 %). Crosslinking of NCS also improved its antioxidant capacity retention against repeated home washing. This study proposed an effective sericin-crosslinking strategy that could be used not only for fixing the color of NCS but also for sericin-grafted textiles and sericin-based biomaterials.
研究领域:
纺织科学
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材料科学
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绿色化学
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DOI
高影响因子
LANGMUIR
·
2024
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IF 3.7
Xinpeng Chen,Jiazhuang Chen,Jin Cheng,Runshan Chu,Lili Xing,Yurong Sun,Jiabao Wu,Guoqiang Chen,Tieling Xing
In this work, silk was selected as the substrate, and formic acid was utilized to create a rough texture on the silk. The conductive fabrics made from AgNWs and silk were created by applying multiple layers of silver nanowire dispersion onto the textured silk fabrics (SFs). The silk was immersed in a dispersion containing polydopamine (PDA), sericin (SE), tannic acid (TA), and silver nanowire under specific temperature conditions. After being cured at 120 °C, the three silver nanowire/silk fabrics (AgNWs/SFs), PDA/AgNWs/SF, SE/AgNWs/SF, and TA/AgNWs/SF, exhibited square resistances of 7.37, 540, and 200 Ω/sq, respectively. The method used to prepare the AgNW conductive SF is straightforward, resulting in fabrics that possess excellent thermal stability and resistance to washing. These fabrics also exhibit a range of useful properties, including conductivity, electrothermal capabilities, electrochemical functionality, human body sensing, hydrophobicity, and antimicrobial properties. These characteristics make them highly promising for various applications, such as human body motion detection, electronic textiles, electrothermal textiles, and antimicrobial applications.
研究领域:
材料科学
·
纺织工程
·
纳米技术
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）