ACS Applied Nano Materials
·
2023
·
IF 5.9
Rui Rui Yang,Pin Wang,Fangrui Cheng,bang lan,Yuxiang Yu,Jing Wang,Shi Ye
It is essential for luminescent materials to be compatible with complex bioenvironments when used for probing biological events. Förster resonance energy transfer (FRET) is a common process in gaining enhanced luminescence signals, in which the interaction between the donor and acceptor plays a decisive role in the optical properties of heterostructured bioprobes. Yet systematic investigations on the gradient amphiphilic and electrostatic interaction effect on luminescence in a complex environment are scarce. Heteronanostructures of Tb(C12H8N2)2(NO3)3 nanocrystals and Eu3+-doped oxide nanosheets in various solutions with varied double electric layers and amphiphilic capacities are chosen for the investigation. It is found that a complex redox process takes place and an interfacial Tb–O bond is formed during preparation of the heteronanostructures. According to the decay dynamics of Tb3+ and Eu3+ emission of the heteronanostructures in various amphiphilic alcohol solvents, the interfacial Tb3+ → Eu3+ energy transfer efficiency apparently displays an extraordinary dependence on alkyl chain length after excluding the refractive index effect, while the zeta potential data suggest that the interfacial electrostatic force on the heteronanostructures should be dominant via the electric double layer in alcohol solvents with short alkyl chain. As the length of alkyl chain increases, the amphiphilic force on the heteronanostructures with amphiphilic Tb(phen)2(NO3)3 and hydrophilic Eu3+-doped nanosheets tends to be overwhelming. These competitive forces strengthen the interaction between Tb3+ and Eu3+ and result in enhancement of the interfacial Tb3+ → Eu3+ energy transfer efficiency. The research helps design potential new bioprobes concerning the interfacial interaction in amphiphilic and salty biosystems.
研究领域:
材料科学
·
生物医学工程
·
光学
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2022
·
IF 5.546
Mifa Chen,Wuhua Chen,Yefei Wang,Mingchen Ding,Zhenyu Zhang,Dongdong Liu,Dihao Mao
With the gradual exploitation and consumption of conventional petroleum resources, heavy oil is considered as one of the alternative resources for energy supply. The key to the development of heavy oil is to reduce its viscosity. Herein, an amphiphilic polymer named PTVR was synthesized, which showed satisfactory viscosity reduction and recovery of heavy oil. The PTVR was copolymerized by acrylamide (AM), sodium p-styrenesulfonate (SSS) and two functional monomers lauryl methacrylate (LMA) and methyl-2-urea-4[1H]-pyrimidinone (MAUPy). P(AMS), P(ALS) with only one functional monomer, and P(AS) without functional monomer were also synthesized in order to study the effect of functional monomer on polymer properties. The structure of PTVR was identified by 1 H NMR, FT-IR, and TGA. The wettability, interfacial activity between heavy oil and PTVR, and viscosity reduction of heavy oil by PTVR were studied and compared with other three polymers. The results show that PTVR has more excellent properties. This is benefit by the synergistic effect of functional monomers MAUPy and LMA. MAUPy is a typical quadruple hydrogen-bonded monomer. It has the ability to insert into the lamellar aggregates of asphaltenes or resins, weakening or reorganizing the original hydrogen bond interaction. The LMA with long alkyl chain increases the affinity between polymer and heavy oil, which makes the polymer easier to emulsify heavy oil. The viscosity reduction rate of PTVR for heavy oil reached 92.4%, while P(AMS), P(ALS) and P(AS) were 82.8%, 80.7% and 67.2%, respectively. Furthermore, the sand-pack flooding experiment also confirmed that PTVR increased the recovery rate of heavy oil by 14.9%, while the control group was 11.7%, 10.7% and 8.6%, respectively. The application of the amphiphilic polymer PTVR has theoretical significance for enhancing heavy oil recovery.
研究领域:
石油工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2022
·
IF 5.999
Fang Pan,Yueping Li,Yujie Ding,Songwei Lv,Rongrong You,Roja Hadianamrei,Mhd Anas Tomeh,Xiubo Zhao
Anticancer peptides (ACPs) have attracted increasing attention in cancer therapy due to their unique mechanism of action on cancer cells. The main challenge is to establish the correlation between their physicochemical properties and their selectivity and anticancer effect, leading to a clear design strategy. In this study, a series of new α-helical short peptides (coded At1-At12) with different anticancer activities were systematically designed with different amphiphilicity based on a natural α-helical antimicrobial peptide (AMP) derived from ant. Three of the designed peptides, At7, At10 and At11, showed considerable anticancer activity with low toxicity to normal skin fibroblasts. The high selectivity of the peptides is attributed to their balanced amphiphilicity and cationic nature which favours binding to the outer membrane of negatively charged cancer cells over the neutral membrane of normal mammalian cells . In addition to rapid membrane penetration, the designed peptides also damaged the mitochondria and induced mitochondrial membrane depolarization. Moreover, these peptides were found to induce apoptosis in cancer cells by up-regulating the expression of apoptotic proteins Bax and Caspase-3, down-regulating the apoptotic protein Bcl-2, and activating the Caspase enzyme-linked reaction. The results of this study reveal the potential of these peptides for clinical applications, and provide a guidance for further development of highly selective anticancer medications.
研究领域:
肿瘤学
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药学
·
分子生物学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Taihe Zhang,Lu Gao,Hong Du,Xiaoyu Huang,Wei Ge,Haisen Ta,Fu Wang
The cell plasma membrane, serving as the fundamental barrier separating cells from the extracellular environment, is a complex and dynamic structure that is crucial to cell biology. The super-resolution observation of plasma membrane morphology and dynamics in living cells, facilitated by stimulated emission depletion (STED) microscopy, holds significant importance for advancing the understanding of plasma membrane functions. Due to the photobleaching and unclear target, the development of plasma membrane nanoprobes suitable for STED imaging remains challenging. In this study, we present red fluorescent carbon dots (R-CDs) characterized by amphiphilicity and photostability. As carbon-based nanomaterials, R-CDs exhibit the targeting ability of the cell plasma membrane, resulting in a superior imaging signal-to-noise ratio. Furthermore, R-CDs enable STED imaging of plasma membranes in living cells, achieving a resolution enhancement of at least 3-fold compared to confocal imaging. Leveraging the excellent performance of R-CDs, the dynamic behavior of microstructures such as vesicles on the plasma membrane was successfully observed through time-lapse STED imaging under nanoscale. Hence, R-CDs, as fluorescent nanoprobes with good photostability and biocompatibility, demonstrate significant potential for long-term STED imaging of live-cell plasma membranes and the exploration of plasma membrane dynamics.
研究领域:
生物化学
·
纳米生物学
·
显微成像技术
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2021
·
IF 6.558
Kailiang Zhang,Yukun Ren,Tianyi Jiang,Hongyuan Jiang
Self-propelled microparticles are promising for lots of applications ranging from analytical detection to water treatment . Herein, we present an effective approach to fabricate lipophilic-hydrophilic micromotors via the photocuring of three-phase immiscible flow induced droplet templates. In the microfluidic system, two immiscible inner fluids, the lipophilic 1, 6-Hexanediol diacrylate (HDDA), and the hydrophilic poly (ethylene glycol) diacrylate (PEGDA), are simultaneously injected into a theta-shaped cylindrical capillary from two separate inlets, and they are emulsified into Janus drops when encountering the outer immiscible silicone oil. Because of the immiscible feature of droplet templates, off-chip photopolymerization strategy has been used, which can significantly decrease the blocking chance of microdevice. And also, the lipophilic-hydrophilic structure of droplets is convenient for the loading of cargos with different characteristics. More importantly, the size and configuration of droplet templates can be flexibly regulated by changing the flow rates of three different phases. Accordingly, multifunctional micromotors can be fabricated by adding different nanoparticles and materials into the HDDA or PEGDA phase first and then photocuring the droplets. Taking the bubble-propelled micromotors for example, we prepare microswimmers by loading Ag, TiO 2 and Fe 3 O 4 nanoparticles into the PEGDA phase. The swimming behaviors of micromotors in H 2 O 2 solution are systematically investigated, finding that the proportion of PEGDA phase and the concentration of H 2 O 2 both positively affect the moving speed. Furthermore, the applicability of motor particles on water treatment is successfully demonstrated by using neutral red solution as the model pollutant. And the micromotors can be recycled using magnets after the catalytic degradation process. Therefore, this micromotor generation technique and this kind of micromotor can be attractive for many applications.
研究领域:
材料科学
·
化学工程
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2016
·Vol. 133
·期 36
·
IF 1.866
Yangzhi Xie,He Huang
On the basis of 2-hydroxyl-2-methyl-1-phenylpropanone (HMPP) and poly(ethylene glycol) (PEG), we prepared amphiphilic macrophotoinitiators (HMPP–PEG–HMPP) by first reacting HMPP with isophorone diisocyanate and subsequently reacting it with PEGs with different chain lengths. Fourier transform infrared spectroscopy, high-performance liquid chromatography, and 1 H-NMR were used to confirm the structure of the amphiphilic macrophotoinitiators. Ultraviolet (UV) absorption spectra showed that the amphiphilic macrophotoinitiators had maximum absorption wavelengths that were similar to those of the low-molecular-weight photoinitiator HMPP. The photolysis rate of the amphiphilic macrophotoinitiators was slightly lower than that of HMPP, but the migration rate of the amphiphilic macrophotoinitiators from a UV-cured matrix was much lower compared to that of HMPP. Because of their amphiphilic nature, these macrophotoinitiators may play roles as both photoinitiators and emulsifiers, and they have been applied to the solution polymerization of water-soluble monomer acrylamide in water and the emulsion polymerization of methyl methacrylate. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43910.
研究领域:
材料科学
·
高分子化学
✓ 已验证
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2014
·
IF 3.107
Hailong Peng,Wenjian Li,Fangjian Ning,Lihua Yao,Mei Luo,Xuemei Zhu,Qiang Zhao,Hua Xiong
A novel amphiphilic chitosan derivative of N,N-dimethylhexadecyl carboxymethyl chitosan (DCMCs) was synthesized. The structure of DCMCs was confirmed via FT-IR and 1H NMR, and the critical micelle concentration (CMC) was investigated by fluorescence spectroscopy. The results indicated that DCMCs has hydrophilic carboxyl and hydrophobic methylene groups and the CMC value was 23.00 mg·L–1. The polymeric liposomes (DCMCs/cholesterol liposomes, DC-Ls) were developed, and its properties were evaluated. The DC-Ls exhibited multilamellar spheres with positive charge (+73.30 mV), narrow size distribution (PDI = 0.277), and good crystal properties. Salidroside was first to encapsulate into DC-Ls. Compared with traditional liposomes (phosphatidylcholine/cholesterol liposome, PC-Ls), DC-Ls showed higher encapsulation efficiency (82.46%) and slower sustained release rate. The in vitro salidroside release from DC-Ls was governed by two distinct stages (i.e., burst release and sustained release) and was dependent on the pH of the release medium. The case II transport and case I Fichian diffusion were the main release mechanisms for the entire release procedure. These results indicated that DC-Ls may be a potential carrier system for the production of functional foods that contain salidroside or other bioactive food ingredients.
研究领域:
药剂学
·
食品科学
·
生物材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Coatings
·
2022
·Vol. 12
·期 10
·1431
·
IF 3.236
Han Yan,Xin Shu,Dongliang Zhou,Yong Yang,Lu Chen,Qianping Ran
The durability of cementitious materials is significant concerning long-term performance. Nanomaterials are promising candidates for deep refinement of cement durability. Hydrophobic calcium carbonate is a widely applied and easily accessible nanomaterial. However, its hydrophobicity and poor dispersity in water prohibit its direct application in cementitious materials. In this study, hydrophobic calcium carbonate nanoparticles (HbCC) were modified using a novel amphiphilic comb-shaped dispersant that is capable of laurinol release. The modification was conducted to improve the dispersity of HbCC and their compatibility with hydration products. The dispersion-improved calcium carbonate particles (AmphCC) were characterized and tested for cement durability improvement performance. According to the results, the AmphCC particles showed a pronounced effect on improving permeation resistance of cement mortars, with water absorption and chloride penetration considerably lowered. Moreover, the introduction of AmphCC in cement did not show significant adverse effects on strength development. Compared with AmphCC, a single addition of the unmodified HbCC and the dispersant cannot achieve equivalent effects. The superior effect of AmphCC is due to the synergistic effect of good particle dispersion and controlled release of the hydrophobic molecules, which is achieved by dispersion of HbCC with binding of the dispersant.Keywords:cement;durability;nano calcium carbonate;amphiphilic dispersant
研究领域:
材料科学
·
土木工程
✓ 已验证
产品关联
DOI
高影响因子
DESIGNED MONOMERS AND POLYMERS
·
2020
·
IF 1.75
Yazhen Wang,Zhen Shi,Yu Sun,Xueying Wu,Shuang Li,Shaobo Dong,Tianyu Lan
Currently, magnetic applications have great potential for development in the field of drug carriers. In this paper, Fe3O4-PVA@SH, an amphiphilic magnetically targeting drug carrier, was prepared by using Fe3O4 and PVA with thiohydrazide-iminopropyltriethoxysilane(TIPTS). The loading capacity of Fe3O4-PVA@SH on Aspirin and the drug release kinetics of loaded drugs were studied. The obtained Fe3O4-PVA@SH exhibits excellent drug release properties in simulating the human body fluid environment (pH 7.2). Since magnetically targeting drug carriers are readily available and have excellent biocompatibility and the characteristics of drug release. This work’s development, preparing amphiphilic magnetically targeting drug carriers in drug delivery and other fields, has great significance.
研究领域:
药剂学
·
生物医学工程
·
材料科学
✓ 已验证
DOI
高影响因子
Polymer Chemistry
·
2013
·Vol. 5
·期 3
·792-798
·
IF 5.231
Yinyin Bao,Taisheng Wang,Qianbiao Li,Fanfan Du,Ruke Bai,Mario Smet,Wim Dehaen
We designed and synthesized an amphiphilic conjugated polymer P1 based on the 2,2′-biimidazole unit, and then investigated its sensing properties as an aggregation-based platform. P1 shows multicolor emission in organic solvents at different water contents, and is demonstrated to be the first multicolor fluorescent sensor for water. And it exhibits visually noticeable multicolor fluorescence response to Ag+ in aqueous dioxane and to Hg2+ ions in aqueous ethanol. In addition, the polymer–Hg2+ complex system can be used as an efficient cysteine fluorescent sensor based on the aggregation–disaggregation strategy. These results validate P1 as an efficient multifunctional platform with multicolor fluorescence response.
研究领域:
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2019
·Vol. 24
·期 20
·3747
·
IF 3.06
Weiyu Yang,Ling Guo,Fenfen Li,Xin Liu,Shaoping Nie,Mingyong Xie,Danfei Huang
Myricetin (Myr) is a phytochemical with many functional properties. However, its hydrophobicity, low bioavailability, and stability limit its application. In this study, octadecanoate oat β-glucan (OGE) was synthesized and gained recognition as a self-assembled micelle forming a polymer with a critical micelle concentration (CMC) of 59.4 μg/mL. The Myr-loaded OGE micelle was then prepared and characterized by dynamic light scattering (DLS), transmission electron microscope (TEM), X-ray diffractometer (XRD), and Fourier-transform infrared spectroscopy (FT-IR) spectra. The water solubility of Myr was greatly enhanced by forming the Myr/OGE inclusion complex. Consequently, compared to free Myr, the retention of Myr in Myr-loaded OGE micelle was effectively increased during the intestinal digestion phase, and its antioxidant activity was also improved. Overall, our findings demonstrated the potential applications of OGE polymer for the development of prospective micelle in health food, cosmetics, and pharmaceutical fields because they can aid in the delivery of hydrophobic functional compounds like Myr.Keywords:phytochemicals;myricetin;amphiphilicity;micelle;self-assembly
研究领域:
食品科学
·
药学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Danrong Cai,Rongze Sun,Yuzhe Zhou,Wentao Yan,Yong Zhou,Congjie Gao
Composting is a process of converting potentially harmful organic matter into harmless organic fertilizer through microbial fermentation. This process enables the rational use of resources and represents an embraced technology marked with sustainable development features. Hindering ammonia emissions during composting is vital, as ammonia is a valuable resource and harmful if emitted excessively. Polytetrafluoroethylene (PTFE) membranes are often used as functional covering membranes to prevent ammonia produced by composting from releasing due to its hydrophobicity . However, they are susceptible to oily aerosols in oily composting, which affects microbial decomposition in aerobic composting. Thus, the development of amphiphobic PTFE membrane is necessary and meaningful. For the amphiphobic PTFE membrane, an important issue is the amphiphobic stability of the membrane, especially in the special alkaline environment of composting. Herein, we suggest the use of the polymer to wrap around nanoparticles and PTFE membrane fibers to prepare stable amphiphobic membranes as functional covering membranes for oil-containing composting. Poly(methyl-3,3,3-trifluoropropylsiloxane) (PTFPMS) and 1H, 1H, 2H, 2H-perfluorodecyltrichlorosilane (PFTS) entangled with each other and then wrapped the nanoparticles and membrane fibers to form stable amphiphobic membranes with high roughness and low surface energy. The prepared membrane had high liquid repellency to water (～152.8°), diiodomethane (～127.5°), and n-hexadecane (～127.0°). This membrane also possessed a high anti-oil fouling. Moreover, the membrane amphiphobicity exhibited a high stability. This is attributed to the stable fixation of nanoparticles on PTFE membrane fibers with PFTS/PTFPMS. Therefore, the amphiphobicity of the membrane was not affected by ammonia. As for the ammonia filtration efficiency, the amphiphobic membrane had a filtration efficiency of 77.4 % within 10 min, an increase of 6.8 % compared to the PTFE membrane, demonstrating the potential of the membrane we developed toward hindering ammonia emission. This work provides a new way of developing high-performance membrane for the oily composting process.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）