LANGMUIR
·
2023
·
IF 3.9
Xiaoqing Liu,Xiangbin Sun,Peng Huang,Yufeng He,Pengfei Song,Rongmin Wang
Bacterial infection of medical devices has caused incalculable losses to maintenance costs and health care. A single coating with antibacterial function cannot guarantee the long-term use of the device, because the coating will be damaged and fall off during reuse. To solve this problem, the development of coatings with high adhesion and self-healing ability is a wise direction. In this paper, a multifunctional polyzwitterionic antibacterial hydrogel coating (PZG) composed of amphozwitterion monomer, anionic monomer, and quaternary ammonium cationic monomer was synthesized by dipping UV photoinitiated polymerization. The structure of PZGs was characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy. Ascribing to the hydrogel internal electrostatic interaction, hydrogen bond, and cation-π interaction, the obtained PZGs exhibited high ductility (>1200% strain) and appropriate strength (>189 kPa). Remarkably, PZGs could also adhere firmly on different substrates through noncovalent interaction, and their adhesion could be controlled by adjusting the amount of zwitterionic. Reversible physical interactions in polymer networks endowed hydrogels with excellent self-healing properties. In addition, PZGs exhibit good antibacterial activity and biocompatibility due to the synergistic effect of quaternary ammonium cation and amphozwitterion monomer. This work provides a multifunctional antibacterial coating for medical equipment and has broad application prospects in the biomedical field.
研究领域:
材料科学
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生物医学工程
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聚合物化学
·
生物技术
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产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2020
·
IF 6.182
Xueting Zhao,Youyou Lan,Kai Yang,Ruoxi Wang,Lijuan Cheng,Congjie Gao
This study proposes a novel strategy to fabricate antifouling UF membrane with integrated zwitterionic and TiO 2 functionality via in situ mixed-charge copolymerization and TiO 2 mineralization. The mixing of positively and negatively charged monomers at the molecular level endows membrane surface with balanced mixed-charge zwitterionic functionality, and the in situ TiO 2 mineralization endows membrane surface with well-dispersed TiO 2 nanoparticles. Thanks to the unique hydrophilicity of mixed-charges and TiO 2 , the obtained PVDF/P(MAA-TA)-TiO 2 membrane shows greatly enhanced surface hydrophilicity. The outstanding hydrophilicity of the PVDF/P(MAA-TA)-TiO 2 membrane significantly improves permeability and protein rejection compared to that of the unmodified PVDF membrane. What's more, the PVDF/P(MAA-TA)-TiO 2 membrane exhibits excellent antifouling capability against protein with flux recovery rate and fouling removal efficiency about 100%. Results of detailed fouling analysis indicate that both surface fouling and pore fouling were limited on the PVDF/P(MAA-TA)-TiO 2 membrane. The antifouling performance is mainly attributed to the synergistic hydrophilicity of mixed-charges and TiO 2 , and meanwhile the decrease in the surface electronegativity and pore size also plays a role. Results of this study provide a facile and scalable method for designing antifouling UF membrane, and highlight the promising potential of mixed-charges and TiO 2 synergy for manipulating hydrophilic and antifouling modification of UF membranes.
研究领域:
材料科学
·
环境工程
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DOI
高影响因子
MACROMOLECULES
·
2025
·
IF 5.2
Yuming Deng,Jiahui Zhou,Mengjie Si,Gaopeng Wang,Yueman Tang,Zi Rong Zhang,Jiayu Hu,Yan-jie Wang,Jintao Yang,Si Yu Zheng
Polyzwitterionic gels possess a high density of ionic groups and present great potential in ionotronics. However, zwitterionic chains are easy to be highly hydrated, leading to weak interchain interactions and a poor mechanical performance. Although metal ions like Fe3+ show great effectiveness in toughening hydrogels, they usually weaken the zwitterionic gel inversely due to the anti-polyelectrolyte effect. Herein, a special co-ion effect of Fe(ClO4)3 is found, which is adopted to toughen the zwitterionic hydrogel. In contrast to the weak effect of Fe(NO3)3, FeBr3, and FeCl3 salts on gel toughness, Fe(ClO4)3 can toughen the imidazolium-based polyzwitterion (pVBIPS) effectively. The Fe(ClO4)3-treated pVBIPS gel exhibits a high ultimate tensile stress of 1.34 MPa, a Young’s modulus of 1.2 MPa, and tensile work of 2.29 MJ/m3, surpassing many existing pure zwitterionic hydrogels. It is found that the ClO4– ions can effectively bind to the imidazolium moiety of pVBIPS and promote the formation of SO3––Fe3+ interactions; the trivalent Fe3+ ions can then bridge multiple sulfonate groups to impart the strength. This work should offer a new strategy for developing tough zwitterionic hydrogels.
研究领域:
材料科学
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化学
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产品关联
DOI
高影响因子
ACS Applied Bio Materials
·
2025
·
IF 4.7
Xueyu Wang,Zhuojun Yan,Mengmeng Yao,Xiuqiang Li,Zhongming Zhao,Cheng Cao,Zhijie Zhao,Fanglian Yao,Yuping Wei,Hong Zhang,Junjie Li
Blood-contacting devices serve as a mainstay in clinical treatment, yet thrombosis remains a major cause of device failure and poses risks to patient health. In this study, we developed a diselenide cross-linker, N,N′-bis(methacryloyl)selenocystamine (BMASC), incorporated into poly(sulfobetaine methacrylate) (PSBMA) microgels (defined as BSM) to create an enzyme-mimetic zwitterionic microgel coating (BSMC). The superhydrophilicity of PSBMA provides outstanding antifouling performance, while the diselenide bonds mimic the catalytic action of glutathione peroxidase (GPx) in generating nitric oxide (NO). The microgels are covalently anchored to substrates pretreated with polydopamine (PDA) and polyethylenimine (PEI) through an epoxy-amine ring-opening reaction. During the drying process, the interpenetrating PSBMA chains of the microgels diffuse, forming a dense and smooth hydrogel coating. The BSMC exhibits exceptional resistance to nonspecific adhesion of proteins, cells, and bacteria, with the synergistic effects of antifouling properties and NO effectively inhibiting platelet adhesion. Furthermore, rabbit blood circulation experiments demonstrate the superior antithrombotic efficacy of the BSMC. This coating holds promise as an effective solution to address the thrombus formation challenges of blood-contacting devices.
研究领域:
生物材料
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医学工程
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药物化学
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产品关联
DOI
PubMed
高影响因子
Biomimetics
·
2022
·Vol. 7
·期 2
·50
·
IF 3.743
Xutao Ma,Xiaohui Fu,Jing Sun
As awareness of environmental protection increases, environmentally friendly coatings have been receiving great interest. Zwitterionic polymers are considered promising candidates due to their biocompatibility and excellent antifouling properties. In this paper, a type of polypeptoid containing zwitterions on the side chain was synthesized via ring-opening polymerization (ROP) and post-modification. This obtained polypeptoid was subsequently grafted onto the surface of polydimethylsiloxane (PDMS) via plasma and UV-induced surface polymerization. Surface morphology and protein adsorption tests of the resulting coating were systematically carried out. The results show that the modified coating has excellent antifouling properties and thus has great potential for environmentally friendly coating applications.Keywords:zwitterionic polymers;antifouling coatings;ring-opening polymerization
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymers
·
2023
·Vol. 15
·期 5
·1270
·
IF 5
Haiyan Mao,Qun Zhang,Ling Lin,Xuemei He,Lili Wang
Polyurethanes with self-healing and reprocessing capabilities are promising in eco-friendly applications. Here, a self-healable and recyclable zwitterionic polyurethane (ZPU) was developed by introducing ionic bonds between protonated ammonium groups and sulfonic acid moieties. The structure of the synthesized ZPU was characterized by FTIR and XPS. The thermal, mechanical, self-healing and recyclable properties of ZPU were also investigated in detail. Compared with cationic polyurethane (CPU), ZPU shows similar thermal stability. The physical cross-linking network formed between zwitterion groups can dissipate strain energy as a weak dynamic bond, endowing ZPU with outstanding mechanical and elastic recovery properties, including the high tensile strength of 7.38 MPa, high elongation at a break of 980%, and fast elastic recovery ability. Additionally, ZPU exhibits a healing efficiency of over 93% at 50 °C for 1.5 h as a result of the dynamic reconstruction of reversible ionic bonds. Furthermore, ZPU can be well reprocessed by solution casting and hot-pressing with a recovery efficiency above 88%. The excellent mechanical properties, fast repairing capability, and good recyclability not only enable polyurethane with a promising application in protective coatings for textiles and paints but also make it a superior candidate as stretchable substrates for wearable electronic devices and strain sensors.Keywords:zwitterionic polyurethane;elasticity;self-healing;reprocessing
研究领域:
材料科学
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环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMOSPHERE
·
2022
·
IF 8.943
Fan Ye,Liwei Shen,Shi Liu,Huanyu Liu,Xinyuan Zhang,Zejun Zhang,Ying Yang,Xuening Feng,Yuqi Tang,Dong Xiang,Yuanzhu Mi,Xuemin Yan
This work aims to prepare two new amphiphilic and interfacial active gemini ionic liquids to treat crude oil and investigates its demulsification mechanism. Tetraethylene glycol was pretreated with thionyl chloride and used as a linker to connect succinimide or phthalimide , and then reacted with dodecyl benzene sulphonic acid to obtain the corresponding amphiphilic and interfacial active gemini ionic liquid STA or PTA, respectively. 1 H nuclear magnetic resonance spectroscopy ( 1 HNMR) and Fourier-transform infrared spectroscopy (FTIR) was used to determine the chemical structures. The demulsification tests showed the demulsification efficiency with 150 mg/L of STA or PTA at 60 °C for 30 min was 99.89% and 99.79%, respectively. Furthermore, the demulsification mechanism of STA and PTA were studied and the prominent demulsification ability of STA and PTA were attributed to the better interfacial activity and amphipathy which could destroy the asphaltenes interfacial film. These results showed that STA and PTA had excellent demulsification efficiency, which promised application in petroleum industry .
研究领域:
石油化学
·
界面化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Science
·
2025
·
IF 14.1
Tong Zhang,Tian Liang,Qichao Pan,Shouyan Zhang,Shuhua Zhang,Zhi Geng,Bo Zhu
Blood-contacting catheters are highly susceptible to thrombus formation, making heparin coating essential for reducing clinical complications. However, the limitations of heparin coatings have spurred significant efforts to develop alternative strategies. This study demonstrates a cost-efficient, mechanically viable, and universal zwitterion coating approach for long and complex catheters with near-zero fouling, super anticoagulation, and selective biocapturing. Leveraging the synergistic action of side groups, a wet-adhesive initiator-bearing polymer rapidly assembles on catheter surfaces in aqueous environments, facilitating the grafting of superhydrophilic and zwitterionic polymers onto catheter inner walls. This strategy demonstrates broad adaptability, successfully applying to ten substrates and showing exceptional versatility in modifying catheters and joints of various shapes and sizes. These coatings exhibit near-zero protein fouling across a broad pH range, and superior resistance to blood cells and bacteria. Furthermore, they maintain excellent stability under simulated bloodstream without compromising anticoagulant performance. Beyond antifouling properties, this method enables the construction of highly selective bio-interaction networks on catheter inner walls, allowing precise capture of circulating tumor cells from blood. This zwitterion coating technique, with its rapid modification, robust anticoagulant properties, and customizable bio-functionality, provides an attractive solution for, beyond catheters, a wide range of medical devices that must perform in challenging biological environments.
研究领域:
生物医学工程
·
材料科学
·
血液学
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产品关联
DOI
PubMed
高影响因子
Geoenergy Science and Engineering
·
2024
·
IF 0
Jian Wang,Jinsheng Sun,Xianbin Huang,Kaihe Lv,Xiaodong Dong,Yuan Geng,Shuixiang Xie
There is a lack of viscosity enhancers for high-temperature and high-density solid-free completion solutions in high-temperature and high-pressure oil and gas reservoirs. To address the problem of insufficient temperature resistance of biopolymers and poor performance of conventional viscosifiers in high-temperature and high-density solid-free completion fluids, an anti-temperature viscosifiers for high-density solid free completion fluids was synthesized using N,N-dimethylacrylamide(DMAA), diallyldimethylammonium chloride(DMDAAC) and the amphoteric ion [2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium Hydroxide(SBMA) as the main monomers. FPOD has salt-responsive properties. With the increase of brine concentration, the degree of stretching of FPOD molecular chain increased and formed a network structure through intermolecular forces, which provided a viscosity increasing effect on the solution. FPOD has good temperature resistance. The apparent viscosity of 1 wt% FPOD in 1.75 g/cm 3 CaBr 2 brine was 37 mPa·s, and after aging at 150 °C, the viscosity was still 32.5 mPa·s. The performance of FPOD before and after aging is better than other viscosifiers. FPOD is simple to prepare and has good viscosity enhancement effect in high density solid-free brines. Moreover, FPOD is well-compatible with other treatment agents for completion fluids, and the HTHP filtration loss of the completion fluid system with 2 wt% FPOD added at 150 °C is only 5 mL. FPOD could solve the problem of insufficient high temperature resistance and viscosity increasing performance of viscosifiers in high density brine completion fluids, and provide a new technical approach to drilling high-temperature and high-pressure oil and gas reservoirs.
研究领域:
石油工程
·
高分子化学
✓ 已验证
产品关联
DOI
PROGRESS IN ORGANIC COATINGS
·
2024
·
IF 6.5
Guanghang Bai,Ye Zhu,Huiye Cao,Ran Zhuo,Yuting Li,Ceyong Wang,Yujie Hu,Ying Sun,Xiaojie Li
Urinary catheters necessitate a surface with antifouling and lubricating properties in order to mitigate bacterial infection, calculus formation, and tissue trauma. Hydrophilic coating is a promising strategy but suffers from the complications of the manufacturing method as well as the lack of longevity. Herein, we report an antifouling and lubricating hydrophilic coating based on zwitterionic copolymer poly(2-Methacryloyloxyethyl phosphatidylcholine- co -hydroxyethyl methacrylate-co-(Benzoyl)phenyl methacrylate (poly(MPC- co -HEMA- co -BP)) through pre-gel solution spin-coating followed by UV-curing. The poly(MPC- co -HEMA- co -BP (PMHB) coatings possess hygroscopic properties that facilitate the formation of a hydrated layer, thereby leading to friction reduction. Moreover, both antibacterial and protein resistance tests substantiate the exceptional antifouling characteristics exhibited by the PMHB coating. Furthermore, after 7 days of coincubation, the antibacterial rates of PMHB coatings against Escherichia coli (E. coli) , Staphylococcus aureus (S. aureus) , and Proteus mirabilis (P. mirabilis) are 72.98 %, 75.11 %, and 88.23 %, respectively. Subsequently, PMHB coating reduced the attachment of encrustation in a 7 days artificial urine cycling experiment. This study brings new perspective on designing urinary catheter surfaces with lubricating and antifouling properties.
研究领域:
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2015
·
IF 3.088
Rui Wang,Tao Xiang,Wei-Feng Zhao,Chang-Sheng Zhao
The complex synthesis through multistep reactions and tedious purifications based on different monomers or macromolecules limits the practical applications of functional polymers. Herein, a facile approach toward a series of functional polyurethanes (PUs) is designed for versatile biological applications within fewer step reactions under mild conditions. The tertiary amino groups in the PU are converted into zwitterions or quaternary ammonium salt via simple one-step synthesis, and then used to prepare PU/polyethersulfone composite membranes. The composite membrane with tertiary amine groups exhibits significant adsorption capability to anionic dye Congo red (CR) and toxin bilirubin. The membrane bearing zwitterionic PU displays excellent blood compatibility; while which with quaternary ammonium salts has antibacterial property. Furthermore, carboxybetaine-functional composite membrane is exploited to bear Ag nanoparticles to endow with dual functions of antibacterial and antifouling properties. This work demonstrates the potential of PUs as readily available, multi-functional, and easy-to-use materials for biological applications.
研究领域:
生物材料
·
化学工程
·
医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Applied Materials Today
·
2022
·
IF 8.663
Ping Yu,Zemin He,Yuzhen Zhao,Huimin Zhang,Haiquan Zhang,Zongcheng Miao,Wenbo Shen
As an important type of liquid crystal (LC)-based smart windows for indoor illumination/privacy protection switching and energy conservation, the LC devices from polymer dispersed liquid crystals (PDLCs) have gained more attention for developing flexible intelligent optical films. However, higher voltages are generally needed to drive these devices owing to the large content of polymers and the strong anchoring effect on mesogenic molecules, which not only induces the danger of use but also increases the energy consumption of the devices. In this work, a polymerizable zwitterionic compound, which has little problem with ion accumulation compared to typical electrolytes, is explored as a new class of coating. Zwitterion-treated LC devices are also fabricated using different processing methods. Both the addition of zwitterionic layers and the processing techniques have profound effects on the electric-optical performance of the resultant devices. The driving voltage of the devices is optimized from 58 V to 15–18 V (∼2.9 V/μm to ∼0.75–0.9 V/μm) and the contrast ratio is still above 200. The haze of the optimized flexible smart film is about 89.78% and 5.38% in field-off and field-on states respectively. The electrically switchable transmittance of the flexible zwitterion-treated LC devices is also implemented on windows and the human body. Such a method offers a simple strategy for fabricating the LC devices promising for applications in wearable devices as well as in low-energy-consumption smart windows.
研究领域:
材料科学
·
光学工程
·
能源技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）