MOLECULES
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2022
·Vol. 27
·期 14
·4466
·
IF 4.927
Xue Li,Jun Wu,Fan Fang,Hongping Li,Lei Wang,Hui Wan,Guofeng Guan
Based on the acid–base neutralization, the (1-methylimidazolium)(tetrazol-1-yl)borane was successfully synthesized by taking advantage of the acidity of the tetrazole and the basicity of the 1-methylimidazole borane complex. Through HRMS, NMR, and FT−IR, the structure of synthetic compounds was characterized in detail. Concerning about the (1-methylimidazolium)(tetrazol-1-yl)borane, it had an ignition−delay time of about 25 ms and a density specific impulse over 351 s·g/cm3, making it a suitable candidate for green hypergolic fuels. Moreover, it also demonstrated that introducing tetrazole into the borane could be an appropriate strategy to adjust the performance of the energy of those borane compounds.Keywords:borane;azole;hypergolic fuel;acid–base neutralization
研究领域:
化学
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材料科学
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能源研究
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DOI
PubMed
高影响因子
BIORESOURCE TECHNOLOGY
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2024
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IF 9.7
Binyuan Gao,Xi Liu,Yudie Wu,Haina Cheng,Hongbo Zhou,Yuguang Wang,Zhu Chen
The cost of detoxification and neutralization poses certain challenges to the development of an economically viable lactic acid biorefinery with lignocellulosic biomass as feedstock. Herein, red mud, an alkaline waste, was explored as both a detoxifying agent and a neutralizer. Red mud treatment of lignocellulosic hydrolysate effectively removed the inhibitors generated in dilute acid pretreatment, improving the lactic acid productivity from 1.0 g/L·h −1 to 1.9 g/L·h −1 in later fermentation. In addition, red mud could replace CaCO 3 as a neutralizer in lactic acid fermentation, which in turn enabled simultaneous bioleaching of valuable metals (Sc, Y, Nd, and Al) from red mud. The neutralization of alkali in red mud by acids retained in lignocellulosic hydrolysate and lactic acid produced from fermentation led to effective dealkalization, rendering a maximum alkali removal efficiency of 92.2 %. Overall, this study offered a win–win strategy for the valorization of both lignocellulosic biomass and red mud.
研究领域:
生物工程
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环境科学
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化学工程
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DOI
PubMed
高影响因子
ACS ES&T Engineering
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2022
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IF 0
Dazhong Yang,Zheting Chu,Xuezhen Feng,Qiuyue Ge,Ranhao Wang,Juan Zhang,Shangying Li,Renji Zheng,Wenfei Wei,Shuping Yi,Hong Chen
Both alkaline heavy metal (HM) contaminated red mud (RM) recycling and Cr(VI) polluted soil remediation are severe hazardous environmental problems. Herein, we developed a novel integrated approach to neutralize and stabilize the hazardous RM via the introduction of Ca2+ and Cl– dual ions. When 3% CaCl2·2H2O is added, the pH of RM is reduced from 11.0 to 8.9, and the Pb, Cr, Zn, Cu, and As leaching concentrations from RM are suppressed lower than the environmental standards of China and the World Health Organization (Pb, Cr, Zn, Cu < 0.50 mg/L; As < 10 μg/L). Detailed mechanism studies reveal that the pH neutralization is attributed to the novel OH– flocculation effect ascribing to Ca2+ charge neutralization and Cl– promoted proton neutralization. Furthermore, as the pH decreases, the HM adsorption capacity of RM is enhanced, achieving stable HM immobilization. The treated RM can be further employed to remediate Cr(VI) contaminated soil (Cr concentration 570 ppm; treated RM weight percentage in soil 5.0%), which can suppress 56.0% Cr mobility in soil and 68.4% bioaccumulated Cr in the harvested vegetables. Overall, this work demonstrates an ecofriendly “waste-to-soil remediation” strategy to solve both the solid waste and soil pollution problems.
研究领域:
环境科学
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土壤学
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DOI
EBioMedicine
·
2022
·
IF 11.205
Mengyi Zhang,Yimeng An,Xi Wu,Meina Cai,Xinyu Zhang,Chaoying Yang,Jincheng Tong,Zhimin Cui,Xueli Li,Weijin Huang,Chenyan Zhao,Youchun Wang
Summary Background Influenza A (H3N2) virus (A/H3N2) has complex antigenic evolution, resulting in frequent vaccine strain updates. We aimed to evaluate the protective effect of the vaccine strains on the circulating strains from past ten years and provide a basis for finding a broader and more efficient A/H3N2 vaccine strain. Methods Eighty-four representative circulating A/H3N2 strains were selected from 65,791 deposited sequences in 2011–2020 and pseudotyped viruses were constructed with the VSV vector. We immunized guinea pigs with DNA vaccine containing the A/H3N2 components of the vaccine strains from 2011 to 2021 and tested neutralizing antibody against the pseudotyped viruses. We used a hierarchical clustering method to classify the eighty-four representative strains into different antigenic clusters. We also immunized animals with monovalent vaccine stock of the vaccine strains for the 2020–2021 and 2021–2022 seasons and tested neutralizing antibody against the pseudotyped viruses. Findings The vaccine strains PE/09, VI/11 and TE/12 induced higher levels of neutralizing antibody against representative strains circulating in recommended year and the year immediately prior whereas vaccine strains HK/14, HK/19 and CA/20 induced poor neutralization against all representative strains. The representative strains were divided into five antigenic clusters (AgV), which were not identical to gene clades. The AgV5 strains were most difficult to be protected among the five clusters. Compared with single-dose immunization, three doses of monovalent vaccine stock (HK/19 or CA/20) could induce stronger and broader neutralizing antibodies against strains in each of the antigenic clusters. Interpretation The protective effect of vaccine strains indicated that the accurate selection of A/H3N2 vaccine strains must remain a top priority. By increasing the frequency of immunization, stronger and broader neutralizing antibodies against strains in all antigenic clusters were induced, which provides direction for a new immunization strategy. Funding This work was supported by a grant from National Key R&D Program of China (No. 2021YFC2301700 ).
研究领域:
病毒学
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免疫学
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流行病学
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DOI
PubMed
高影响因子
Environmental Science & Technology Letters
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2023
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IF 10.9
Lin Du,Li Xu,Kun Li,Christian George,Maofa Ge
Anthropogenic air pollutants can be involved in biogenic secondary organic aerosol (SOA) formation. However, such interactions are currently one of the least understood aspects of atmospheric chemistry. Herein, SOA formation via chemical interactions between anthropogenic SO2, NH3, and O3 and biogenic β-caryophyllene was investigated. It is shown that although SO2 considerably enhanced SOA formation, this enhancing effect was weakened by NH3 when SO2 and NH3 coexisted. NH3-induced neutralization of particle acidity generated by SO2 oxidation may be the primary driving factor of this weakening effect. Molecular-level characterization using high-resolution quadrupole time-of-flight mass spectrometry revealed additional connections between NH3-induced changes in SOA composition and aerosol acidity. Specifically, the lower relative abundances of several main products generated in the presence of SO2 and NH3 than those formed in the presence of only SO2 were consistent with their suppressed formation by lower seed acidity. The suppression of oligomer formation by NH3 provided more evidence for the weakening of acid-catalyzed processes caused by acidity neutralization. Accordingly, the current study demonstrates that NH3 as a less effectively regulated alkaline gas resulting from an unbalanced reduction of different pollutants must be considered with caution when evaluating effects of SO2 on SOA formation via anthropogenic–biogenic interactions.
研究领域:
大气化学
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环境科学
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DOI
高影响因子
Polymers
·
2020
·Vol. 12
·期 1
·72
·
IF 3.426
Qiang Sun,Huaili Zheng,Xuebin Hu,Jun Li,Rui Zhao,Chun Zhao,Wei Ding
In this study, a novel system was set up by preparing a magnetic flocculant combining with ultraviolet/H2O2to realize the rapid enrichment and degradation of diclofenac sodium (DCFS). For the magnetic flocculant, template anion polyacrylamide (TAPAM) with anion micro-block structure was prepared. Thereafter, polydopamine was used to modify TAPAM, Fe3O4nanoparticles was grafted to the modified TAPAM by chelation, named template anion polyacrylamide-polydopamine-Fe3O4(TAPAM-PDA-Fe3O4). Furthermore, the TAPAM-PDA-Fe3O4preparation protocol was optimized by the response surface method (RSM). In the DCFS enrichment section, the rapid separation of flocs from water was realized by an external magnetic field and it indicated that the π–π stacking effect was dominant in neutral/alkaline condition, whereas charge neutralization was favored in acidic conditions. Meanwhile, a DCFS enrichment kinetic curve was much fitted by the pseudo-second-order kinetic model and DCFS enrichment isothermal curve was close to the Freundlich isothermal model, indicating the dependence of DCFS quantity enriched by TAPAM-PDA-Fe3O4and a multilayer heterogeneous enrichment process. The degradation experiment confirmed that DCFS was effectively degraded by ultraviolet/H2O2/TAPAM-PDA-Fe3O4and the maximum value of DCFS degradation efficiency reached 98.1%. Furthermore, the regeneration experiment showed that the enrichment and degradation efficiency of DCFS could maintain a relatively high level in the initial three recycles.Keywords:diclofenac sodium;π–π stacking;charge neutralization;enrichment;degradation
研究领域:
环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
Signal Transduction and Targeted Therapy
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2022
·Vol. 7
·期 1
·1-10
·
IF 38.104
Wu Jiajing,Nie Jianhui,Zhang Li,Song Hao,An Yimeng,Liang Ziteng,Yang Jing,Ding Ruxia,Liu Shuo,Li Qianqian,Li Tao,Cui Zhimin,Zhang Mengyi,He Peng,Wang Youchun,Qu Xiaowang,Hu Zhongyu,Wang Qihui,Huang Weijin
Emerging SARS-CoV-2 variants are the most serious problem for COVID-19 prophylaxis and treatment. To determine whether the SARS-CoV-2 vaccine strain should be updated following variant emergence like seasonal flu vaccine, the changed degree on antigenicity of SARS-CoV-2 variants and H3N2 flu vaccine strains was compared. The neutralization activities of Alpha, Beta and Gamma variants’ spike protein-immunized sera were analysed against the eight current epidemic variants and 20 possible variants combining the top 10 prevalent RBD mutations based on the Delta variant, which were constructed using pseudotyped viruses. Meanwhile, the neutralization activities of convalescent sera and current inactivated and recombinant protein vaccine-elicited sera were also examined against all possible Delta variants. Eight HA protein-expressing DNAs elicited-animal sera were also tested against eight pseudotyped viruses of H3N2 flu vaccine strains from 2011–2019. Our results indicate that the antigenicity changes of possible Delta variants were mostly within four folds, whereas the antigenicity changes among different H3N2 vaccine strains were approximately 10–100-fold. Structural analysis of the antigenic characterization of the SARS-CoV-2 and H3N2 mutations supports the neutralization results. This study indicates that the antigenicity changes of the current SARS-CoV-2 may not be sufficient to require replacement of the current vaccine strain.
研究领域:
病毒学
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免疫学
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流行病学
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DOI
PubMed
高影响因子
LANGMUIR
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2025
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IF 3.9
Jingwen Luo,Mingshuo Cui,Xiaodong Lian,Bin Yuan,Chenhao Song,Yingchao Ma,Yapei Wang
The multicomponent structure and the large area of oil–water interfaces make multiple emulsions promising for use in cosmetic manufacturing, food industries, and agricultural production. However, the high energy input and extensive use of emulsifiers in the process of multiple emulsion preparation severely limit their application. In this work, we propose a simple but highly efficient emulsification strategy to realize one-step multiple emulsions. To this end, the interfacial acid–base neutralization reaction by oleic acid and ammonia is employed as the driving force to construct a spontaneous emulsifying system, thus realizing emulsion formation in a low-energy manner. Moreover, the products generated by the interfacial neutralization reaction can act as emulsifiers to stabilize both the O/W and W/O interfaces and construct multiple emulsions with an O/W/O structure. Compared to conventional methods of multiple emulsion formation, the one-step multiple emulsion method driven by an interfacial neutralization reaction can significantly reduce the energy consumption and the emulsifier dosage during the emulsifying process, thus avoiding the probable environmental problems caused by the residual emulsifiers. This study not only provides a new idea for the preparation of multiple emulsions but also effectively promotes the development of low-surfactant emulsification methods.
研究领域:
化学工程
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材料科学
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食品科学
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产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
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2024
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IF 10
Meng-Meng Chen,Han-Wen Tian,Yuan-Qiu Cheng,Yu-Xin Yue,Yu-Chen Pan,Dong-Sheng Guo
Snakebite is a medical emergency that often leads to high mortality and morbidity in tropical and subtropical regions. The diversity in venom composition between various types of snakes necessitates the use of different specific antivenom treatments, which presents clinical and financial challenges in the management of snakebites. Therefore, developing a broad-spectrum antidote to neutralize complex and diverse snake venoms has assumed critical importance. Herein, a broad-spectrum antidote is developed through molecular recognition and coassembly to neutralize four kinds of snake venom toxins, those are three-finger toxin (3FTx), snake venom metalloproteinase (SVMP), phospholipase A 2 (PLA 2 ), and snake venom serine protease (SVSP), which have high abundance and toxicity. The coassembly of sulfonate-modified amphiphilic calixarene (SCA) and amphiphilic cyclodextrin (CD) is employed to neutralize the toxicity of 3FTx, 1,2-dodecanedithiol (DDT) and thioetheramide phosphorylcholine (TEAPC) are introduced through coassembly to neutralize toxicity of SVMP and PLA 2 , respectively, and the nafamostat (NT), which can be loaded through the host-guest complexation, is employed to neutralize toxicity of SVSP. The broad-spectrum antidote, NT@SCA/CD/DDT/TEAPC, effectively neutralizes key toxins from the most medically important cobra and vipers, significantly improving survival rates of poisoned mice. This study conceptually validated the feasibility of broad-spectrum detoxification and also offers a conveniently integrated supramolecular strategy.
研究领域:
医学
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生物化学
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药理学
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产品关联
DOI
PubMed
高影响因子
Chemical Engineering and Processing-Process Intensification
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2024
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IF 3.8
Liran Hu,Shan Li,Tao Luo,Dehua Xu,Xiushan Yang,Xinlong Wang
The escalating production of titania via the sulfuric acid method has led to increase in the titania waste acid (TWA) production. 6 to 8 tons of waste acid, containing 20 to 25 wt% sulfuric acid, are generated for 1 ton of titania. In China, nearly 30 million tons of TWA were produced in 2021. Currently, various utilization methods are employed for TWA treatment, with limestone neutralization and concentration methods being the most used. These methods have drawbacks such as substantial waste production and high operational costs. This work proposes a new process for directly neutralizing TWA with iron oxides (hematite and magnetite) produced by chemical reduction of ferrous sulfate. The study investigated the rates and limitations of the reactions between TWA and iron oxides under various temperature and liquid-solid ratios. Furthermore, the morphology, chemical composition and reactivity of remaining solid left in the reaction mixture were analyzed, the kinetic and thermodynamic properties of the reactions between iron oxides and TWA were calculated. This work provides a systematical and comprehensive study of the reactions between hematite or magnetite and TWA from the perspectives of thermodynamics and kinetics, providing fundamental data and crucial parameters for the intensification of the TWA treatment processes.
研究领域:
化学工程
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环境科学
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产品关联
DOI
高影响因子
NATURE
·
2024
·Vol. 626
·期 7997
·86-91
·
IF 50.5
Fang Wensheng,Guo Wei,Lu Ruihu,Yan Ya,Liu Xiaokang,Wu Dan,Li Fu Min,Zhou Yansong,He Chaohui,Xia Chenfeng,Niu Huiting,Wang Sicong,Liu Youwen,Mao Yu,Zhang Chengyi,You Bo,Pang Yuanjie,Duan Lele,Yang Xuan,Song Fei,Zhai Tianyou,Wang Guoxiong,Guo Xingpeng,Tan Bien,Yao Tao,Wang Ziyun,Xia Bao Yu
Electrolysis that reduces carbon dioxide (CO 2 ) to useful chemicals can, in principle, contribute to a more sustainable and carbon-neutral future 1 , 2 , 3 , 4 , 5 , 6 . However, it remains challenging to develop this into a robust process because efficient conversion typically requires alkaline conditions in which CO 2 precipitates as carbonate, and this limits carbon utilization and the stability of the system 7 , 8 , 9 , 10 , 11 , 12 . Strategies such as physical washing, pulsed operation and the use of dipolar membranes can partially alleviate these problems but do not fully resolve them 11 , 13 , 14 , 15 . CO 2 electrolysis in acid electrolyte, where carbonate does not form, has therefore been explored as an ultimately more workable solution 16 , 17 , 18 . Herein we develop a proton-exchange membrane system that reduces CO 2 to formic acid at a catalyst that is derived from waste lead–acid batteries and in which a lattice carbon activation mechanism contributes. When coupling CO 2 reduction with hydrogen oxidation, formic acid is produced with over 93% Faradaic efficiency. The system is compatible with start-up/shut-down processes, achieves nearly 91% single-pass conversion efficiency for CO 2 at a current density of 600 mA cm −2 and cell voltage of 2.2 V and is shown to operate continuously for more than 5,200 h. We expect that this exceptional performance, enabled by the use of a robust and efficient catalyst, stable three-phase interface and durable membrane, will help advance the development of carbon-neutral technologies.
研究领域:
化学工程
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能源科学
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环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Molecular Biomedicine
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2025
·Vol. 6
·期 1
·1-14
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IF 10.1
Ao Danyi,Peng Dandan,He Cai,Ye Chunjun,Hong Weiqi,Huang Xiya,Lu Yishan,Shi Jie,Zhang Yu,Liu Jian,Wei Xiawei,Wei Yuquan
Despite the declared end of the COVID-19 pandemic, SARS-CoV-2 continues to evolve, with emerging JN.1-derived subvariants (e.g., KP.2, KP.3) compromising the efficacy of current XBB.1.5-based vaccines. To address this, we developed an mRNA vaccine encoding the full-length spike protein of JN.1, incorporating GSAS and 2P mutations and encapsulated in lipid nanoparticles (LNPs). The JN.1-mRNA vaccine elicited robust humoral and cellular immune responses in mice, including high JN.1-specific IgG titers, cross-neutralizing antibodies, and increased T follicular helper (Tfh) cells, germinal center (GC) B cells, and T cell cytokines. Importantly, immunity persisted for up to six months and induced RBD-specific long-lived plasma cells. We also compared the immune responses induced by homologous and heterologous vaccination regimens, and our results demonstrated that the heterologous regimen—combining JN.1-mRNA with a recombinant protein vaccine (RBD JN.1 -HR)—induced stronger responses. These findings highlight the JN.1-mRNA vaccine constitutes an effective prophylactic approach against JN.1-related variants, as it induces potent neutralizing antibody responses across all tested lineages. This enhanced immunogenicity is expected to significantly reduce hospitalization rates and mitigate post-COVID complications associated with JN.1 and KP.3 infections. This study emphasizes the need for timely vaccine updates and the adaptability of mRNA vaccines in addressing emerging pathogens, providing a framework for combating future infectious diseases. Collectively, these results offer critical insights for vaccine design and public health strategies in response to emerging SARS-CoV-2 variants.
研究领域:
病毒学
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免疫学
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疫苗学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）