Tumor Eradication by Boron Neutron Capture Therapy with 10B-enriched Hexagonal Boron Nitride Nanoparticles Grafted with Poly(glycerol)
Boron neutron capture therapy (BNCT) has emerged as a treatment modality with high precision and efficacy of intractable tumors. At the core of effective tumor BNCT are 10 B carriers with facile preparation as well as advantageous pharmacokinetic and therapeutic profiles. We herein report the design and preparation of sub-10 nm 10 B-enriched hexagonal boron nitride nanoparticles grafted with poly(glycerol) (h- 10 BN-PG), and their application to cancer treatment by BNCT. By virtue of their small particle size and outstanding stealth property, h- 10 BN-PG nanoparticles accumulate efficiently in murine CT26 colon tumors with a high intratumor 10 B concentration of 8.8%ID/g or 102.1 μg/g at 12 h post-injection. Moreover, h- 10 BN-PG nanoparticles penetrate into the inside of the tumor parenchyma and then are taken up by the tumor cells. BNCT comprising a single bolus injection of h- 10 BN-PG nanoparticles and subsequent one-time neutron irradiation results in significant shrinkage of subcutaneous CT26 tumors. h- 10 BN-PG-mediated BNCT not only causes direct DNA damage to the tumor cells, but also triggers pronounced inflammatory immune response in the tumor tissues, which contributes to long-lasting tumor suppression after the neutron irradiation. Thus, the h- 10 BN-PG nanoparticles are promising BNCT agents to eradicate tumor through highly efficient 10 B accumulation. This article is protected by copyright. All rights reserved
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