Journal of Forensic and Legal Medicine
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2015
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IF 0.76
Mingjie Deng,Meiling Zhang,Xueli Huang,Jianshe Ma,Lufeng Hu,Guanyang Lin,Xianqin Wang
Hydrogen sulfide poisoning is a common occupational hazard, whose mortality and incidence rates are first and second, respectively, among occupational poisoning incidents in China. The main target organs of its toxicity are in the central nervous system and respiratory system. However, there are currently no specific direct tests that can be used to diagnose poisoned patients. In this study, we developed a serum metabonomic method using orthogonal partial least squares-discriminate analysis (OPLS-DA), based on gas chromatography–mass spectrometry (GC/MS) to evaluate the effect of chronic poisoning by hydrogen sulfide in rats. The OPLS-DA data demonstrated that the model group (n = 60) differed significantly from the control group (n = 30), suggesting that the metabolic profiles of the two groups are markedly different. Alterations in the levels of some metabolites such as citrate, galactose , lactate, mannose , inositol , urea, phosphate, alanine and valine were detected by OPLS-DA analysis. We observed changes in metabolic pathways including lipid metabolism , energy metabolism and amino metabolism in the model group. Our results indicate that GC/MS-based metabonomic methods may provide novel detection means for chronic hydrogen sulfide poisoning.
研究领域:
毒理学
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分析化学
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医学
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DOI
PubMed
高影响因子
Reaction Chemistry & Engineering
·
2024
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IF 3.4
You Fang,Peng Zhang,Mengya Guo,Shuke Guo,Fujiang Wang,Mingxing Tang
In the recycling of waste lubricating oil, the rapid deactivation of catalysts during the hydrotreating process limits their industrial application. In this paper, a three-reactor process is proposed for the refining of waste lubricating oil, which is compared with the conventional two-reactor process. Experimental results reveal that the three-reactor technique demonstrates enhanced performance in hydrodesulfurization (HDS), hydrodechlorination (HDCl), hydrodenitrogenation (HDN), hydro-decolorization, and demetallization, effectively doubling the service life of the catalysts. Characterization of the deactivated catalysts identifies carbon deposition, silicon (Si) poisoning, and boron (B) poisoning as the primary factors contributing to catalyst deactivation. The presence of a protective agent (the second catalyst) within the three-reactor process effectively removes Si and B, thereby mitigating the Si and B poisoning of the primary hydrogenation catalyst, and extending the catalyst's lifespan. This approach offers a viable solution to the challenge of frequent catalyst deactivation encountered during the high-value utilization of waste lubricating oils, thereby providing an effective pathway for overcoming this issue in the chemical industry.
研究领域:
化学工程
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催化科学
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环境科学
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产品关联
DOI
高影响因子
BIOLOGICAL TRACE ELEMENT RESEARCH
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2023
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IF 3.9
Wu Shihao,Zhao Peng,Wang Aihua,Dong Linpei,Wu Xiaojun,Wang Jifen,Zhang Yunfeng
Monochromatic excitation X-ray fluorescence (ME-XRF) spectrometry is a novel technique for trace element analysis, characterized by its simplicity, rapidity, and low cost. The objective of this study was to evaluate the applicability of ME-XRF technique for the measurement of thallium in biological samples. Acute and subacute thallium poisoning experiments were conducted to simulate various scenarios, with blood, urine, and 10 distinct organs collected. Detection was initially performed using ME-XRF technique, followed by validation with inductively coupled plasma mass spectrometry (ICP-MS). Excellent agreement between ME-XRF and ICP-MS values was demonstrated by means of paired sample t-tests and intraclass correlation coefficients. Subsequently, the practical implementation of the proposed technique was demonstrated through an actual case study. In conclusion, this study validates ME-XRF as a suitable alternative to ICP-MS for the measurement of trace heavy metals in biological samples. These efforts promote the development of simpler and faster techniques for heavy metal detection, thereby presenting novel avenues for the prevention and diagnosis of heavy metal poisoning.
研究领域:
分析化学
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毒理学
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医学检验
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DOI
PubMed
高影响因子
Catalysts
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2021
·Vol. 11
·期 3
·324
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IF 4.146
Jinkun Guan,Lusha Zhou,Weiquan Li,Die Hu,Jie Wen,Bichun Huang
SO2poisoning is a great challenge for the practical application of Mn-based catalysts in low-temperature selective catalytic reduction (SCR) reactions of NOxwith NH3. A series of Gadolinium (Gd)-modified MnOx/ZSM-5 catalysts were synthesized via a citric acid–ethanol dispersion method and evaluated by low-temperature NH3-SCR. Among them, the GdMn/Z-0.3 catalyst with the molar ratio of Gd/Mn of 0.3 presented the highest catalytic activity, in which a 100% NO conversion could be obtained in the temperature range of 120–240 °C. Furthermore, GdMn/Z-0.3 exhibited good SO2resistance compared with Mn/Z in the presence of 100 ppm SO2. The results of Brunauer–Emmett–Teller (BET), X-ray photoelectron spectroscopy (XPS), temperature-programmed reduction of H2(H2-TPR) and temperature-programmed desorption of NH3(NH3-TPD) illustrated that such catalytic performance was mainly caused by large surface area, abundant Mn4+and surface chemisorbed oxygen species, strong reducibility and the suitable acidity of the catalyst. The in situ diffuse reflectance infrared Fourier transform spectra (DRIFTS) results revealed that the addition of Gd greatly inhibited the reaction between the SO2and MnOxactive sites to form bulk manganese sulfate, thus contributing to high SO2resistance. Moreover, in situ DRIFTS experiments also shed light on the mechanism of low-temperature SCR reactions over Mn/Z and GdMn/Z-0.3, which both followed the Langmuir–Hinshelwood (L–H) and Eley–Rideal (E–R) mechanism.Keywords:SO2poisoning;low temperature;NH3-SCR;in situ DRIFTS
研究领域:
催化化学
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环境科学
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产品关联
DOI
高影响因子
FUEL
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2024
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IF 6.7
Qitong Xue,Jiaying Xing,Jianjun Chen,Jinxing Mi,Jianqiang Shi,Yao Wang,Junhua Li,Zhiming Liu
V 2 O 5 /TiO 2 has been wide used in the selective catalytic reduction of NO x by NH 3 (NH 3 -SCR). However, the poisoning mechanism of thallium (Tl) on the catalytic performance of commercial V 2 O 5 /TiO 2 catalyst has remained unclear. Herein, we have systematically investigated the poisoning effect of Tl based on the different characterizations and DFT calculations. It was found that the strong interaction between V and Tl exists, resulting in the transformation of V from monomeric VO x to polymeric and crystalline VO x , the formation of V-O-Tl species, a decrease in the active V 5+ sites, and the inhibition of the adsorption and activation of NH 3 on both Brønsted and Lewis acid sites. Mechanistic studies further confirmed that inactive nitrate intermediate species gradually accumulated over V 2 O 5 /TiO 2 catalyst surface due to the presence of Tl. A combination of factors ultimately led to the deactivation of the V 2 O 5 /TiO 2 catalyst. This study unveils the poisoning mechanism of Tl on V-based catalysts and shed light on the design of Tl-tolerant NH 3 -SCR catalysts.
研究领域:
环境科学
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催化化学
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DOI
高影响因子
Materials
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2021
·Vol. 14
·期 20
·5958
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IF 3.623
Xusheng Ren,Zhiliang Ou,Bang Wu
The activated coke is a promising support for catalysts, and it is important to study the performance of the activated coke catalyst on the removal of NOx. In the current research, a series of the activated coke-supported Mn–Cu catalysts are prepared by the incipient wetness impregnation method. The effects of the molar ration of Mn/Cu, the content of Mn–Cu, the calcination temperature, and reaction space velocity on NO conversion are investigated, and it was found that the 8 wt.% Mn0.7Cu0.3/AC had the best catalytic activity when the calcination temperature was 200 °C. The existence of SO2caused the catalyst to deactivate, but the activity of the poisoning catalyst could be recovered by different regeneration methods. To uncover the underlying mechanism, BET, XPS, XRD, SEM and FTIR characterizations were performed. These results suggested that the specific surface area and total pore volume of the poisoning catalyst are recovered and the sulfite and sulfate on the surface of the poisoning catalysts are removed after water washing regeneration. More importantly, the water washing regeneration returns the value of Mn3+/Mn4+, Cu2+/Cu+, and Oα/Oβ, related to the activity, basically back to the level of the fresh catalyst. Thus, the effect of water washing regeneration is better than thermal regeneration. These results could provide some helpful information for the design and development of the SCR catalysts.Keywords:activated coke;low-temperature NH3-SCR;sulfur poisoning;regeneration
研究领域:
催化化学
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环境科学
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DOI
PubMed
高影响因子
JOURNAL OF FOOD QUALITY
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2021
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IF 2.45
Wei Wei,Shue Wang,Xue-Jun Zhang,Jiu-Xun Zhang,Zheng-Wang Chen,Jia-Ying Huang,Ye-Wang Zhang
Objective. To investigate the effects of mung bean peptide and its’ complexes on promoting lead excretion and neuroprotection of zebrafish. Methods. The lead poisoning models of zebrafish were established by lead acetate solution; the models were treated with high and low concentrations (58.3 and 175 μg/mL) of mung bean peptides, with high, medium, and low concentrations (27.8, 83.3, and 250 μg/mL) of mung bean peptide complexes, separately. The effects of the mung bean peptide complexes on the lead content, axonal fluorescence intensity, and peripheral motor nerve length changes were identified in the zebrafish model, and the effects of mung bean peptide and its’ complexes on zebrafish's lead excretion, axonal protection rate, and peripheral movement promotion rate of nerve regeneration were calculated. Results. The effects of high concentration of mung bean peptide (175 μg/mL) in promoting lead excretion was 29% (), and the effect of high concentration of mung bean peptide complexes (250 μg/mL) in promoting lead excretion was 30% (). The other concentrations of mung bean peptide and its’ complex groups did not show a noticeable lead excretion effect. The protective effects of mung bean peptide at concentrations of 58.3 and 175 μg/mL against zebrafish axonal injury were 98% and 101% (), and the peripheral nerve regeneration promotion effects were 29% () and 42% (), respectively. The protective effects of mung bean peptide complexes at concentrations of 27.8, 83.3, and 250 μg/mL against zebrafish axonal injury were 85%, 78%, and 93% (); peripheral nerve regeneration promotion rates were 46%, 50%, and 50% (). Conclusion. The mung bean peptide and its’ complexes can effectively promote the discharge of lead in the zebrafish lead poisoning and have protective and regeneration effects on zebrafish nerves.
研究领域:
毒理学
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神经生物学
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营养学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2022
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IF 7.139
Wenxin Liu,Jiabin Zou,Shuni Li,Jinkun Li,Feihu Li,Zili Zhan,Yeguang Zhang
Hydrogen sensors are easily deactivated by hexamethyldisiloxane (HMDSO) poisoning. Moreover, the existing anti-poisoning strategies can also damage the overall sensing performance of these hydrogen sensors. Therefore, a new bilayer design with a Pd/In 2 O 3 sensitive layer and an In 2 O 3 /Al 2 O 3 catalytic filter layer is proposed to avoid the deactivation of hydrogen sensors. The In 2 O 3 /Al 2 O 3 layer helps in hindering HMDSO and its decomposition products from reaching the Pd/In 2 O 3 layer. The H 2 response of the sensors is enhanced due to the small size of In 2 O 3 and the electronic sensitization of Pd. As a result, the bilayer sensors exhibit high response (Ra/Rg = 53) and ultra-fast response time (1 s) towards 3000 ppm H 2 at 365 °C. The resistance and the H 2 response of the bilayer sensors are almost unchanged after 40 min of 10 ppm HDMSO poisoning. In this paper, the mechanism of resistance against silicone poisoning and the H 2 response of the bilayer sensors are discussed from the separation of sensing and catalytic filtration reactions to the behavior of adsorbed oxygen.
研究领域:
材料科学
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传感器技术
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产品关联
DOI
高影响因子
Journal of Environmental Sciences
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2021
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IF 5.565
Weilai Wang,Fan Zhang,Yunfei Zhang,Lei Xu,Yuansheng Pei,Junfeng Niu
Hydrodechlorination is a promising technology for the remediation of water body contaminated with trichloroethylene (TCE). In this work, the liquid-phase hydrogenation of TCE by Raney Ni (R-Ni) and Pd/C under an open system have been studied, in which nascent H 2 (Nas-H 2 ) generated in situ from the cathode acted as a hydrogen source. Experimental results showed that TCE was completely eliminate from the solution through the synergistic effects of hydrodechlorination and air flotation due to the formation of continuous micro/nano-sized Nas-H 2 bubbles from the cathode. Furthermore, the effects of inorganic anions and organic solvents on R-Ni and Pd/C hydrogenation activity were investigated, respectively. The results showed that NO 3 − and acetonitrile can form a competitive reaction with TCE; Sulfur with lone-pair electrons will cause irreversible poisoning to these two catalysts, and have a stronger inhibitory effect on Pd/C. This work helps to realize the separation of volatile halogenated compounds from water environment and provides certain data support for the choice of catalyst in the actual liquid-phase hydrogenation system.
研究领域:
环境科学
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催化化学
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产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS A-GENERAL
·
2025
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IF 4.8
Xinyu Liu,Chengxiong Wang,Feng Feng,Yinglong Wu,Shiying Chang,Guangxin Liu,Dong Tian,Weinan Yang,Xianming Cheng,Dongxia Yang,Kongzhai Li,Yunkun Zhao
Catalyst deactivation caused by SO 2 poisoning generally hinders commercial viability of CO oxidation catalysts in the field of industrial flue gas purification. XPS results, CO-DRIFTS spectra and DFT calculations suggested that Pt was highly-dispersed and remained the oxidative states on SnO 2 support, resulting in that the rate-determining step of CO oxidation is to clean up the adsorbed CO and PtS 2 species is readily formed in a SO 2 -contained hydrothermal environment. It predominantly maintained metallic Pt 0 in the Pt/WO 3 catalyst, thereby led to cleaning up the activated oxygen atoms as the rate-determining step. It is very difficult to remove the sulfur species in SO 2 -poisoned catalysts within 600 °C and the mechanisms of CO oxidation are not affected by SO 2 poisoning for Pt/SnO 2 and Pt/WO 3 catalysts. These findings provide some significant insights to understand the mechanisms of CO oxidation and SO 2 -tolerance.
研究领域:
催化化学
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环境科学
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理论计算化学
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产品关联
DOI
高影响因子
Analytical Methods
·
2018
·Vol. 10
·期 22
·2604-2613
·
IF 2.073
Xianxin Qiu,Longjie Zhong,Ying Gan,Kaiqi Su,Shihui Hu,Ping Wang
Okadaic acid is a kind of fat-soluble diarrhetic shellfish poison existing extensively in shellfish. The rapid on site detection of shellfish contaminated by the toxin is a serious problem. Herein, a new method combining a kit with the Bionic e-Eye was developed for the rapid detection of okadaic acid on site. After optimization the kit reached a very low limit of detection, 0.19 μg L−1, and the linear detection range was 0.2–10 μg L−1. The cross reaction rate with dinophysistoxins 1 was 23.6%. The kit had a small cross reaction with other kinds of toxin like saxitoxin, gynotoxin 2 & 3 and pectenotoxins 2-b. The recovery range was about 75.78–102.56%, and the CVs were lower than 20%. A correlation analysis was conducted between the Bionic e-Eye and a microplate reader in PBS and shellfish backgrounds. The detection results of the real shellfish samples by the Bionic e-Eye exhibited great consistency with high performance liquid chromatography. The total time taken to perform the detection was less than 90 minutes. Above all, the method integrated kit with the Bionic e-Eye was very suitable for the rapid detection of okadaic acid on site.
研究领域:
食品科学
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分析化学
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毒理学
✓ 已验证
DOI
高影响因子
Journal of Forensic and Legal Medicine
·
2024
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IF 1.2
Zhonghao Yu,Yuhao Yuan,Qing Shi,Hang Gao,Erjuan Zhao,Jinghong Ma,Yiwu Zhou
Brodifacoum, a long-acting anticoagulant rodenticide, exerts inhibitory effects on blood coagulation factor synthesis, leading to abnormal clotting function and potential fatality. Poisoning of accidental exposure to brodifacoum is not rare, but death from brodifacoum poisoning can be largely avoided with timely and long-term effective treatments, consequently, forensic data on fatalities due to brodifacoum poisoning may be limited. This paper presents a case of brodifacoum-induced homicide, detailing the medial records and pathological changes observed in multiple organs. Furthermore, t liquid chromatography–tandem mass spectrometry (LC-MS/MS) was employed to measure the concentrations of brodifacoum in blood, hydropericardium, and urine 40 days post-poisoning (1 day post-mortem), yielding values of 0.097 μg/mL, 0.089 μg/mL, and 0.007 μg/mL respectively. The aim of this article is to contribute towards forensic identification of fatalities resulting from brodifacoum poisoning while also serving as a reference for clinical diagnosis in similar cases.
研究领域:
法医学
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毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）