Journal of Environmental Sciences
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2022
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IF 6.796
Jingming Wang,Zhiquan Yu,Yongfeng Wang,Yuanyao Chen,Lin Xiao,Yanjun Zong,Qiyuan Feng,Lianqi Peng,Huiping Zhang,Chunyan Liu
Ethylene thiourea (ETU) converted from ethylene bisdithiocarbamate (EBDC) fungicides has aroused great concern because of its prevalence and harmful effects. Although ETU-induced neurotoxicity has been reported, the potential mechanisms remain unclear. This study provided insights into its neurotoxic effects at environmentally relevant concentrations in zebrafish. Our findings showed that embryonic exposure to ETU decreased the hatch rate and delayed somite development. Furthermore, ETU treatment significantly reduced the dark velocity in the locomotion assay. The upregulated tendency of the mitogen-activated protein kinases (MAPK) pathway ( mknk1, atf4, mapkapk3 ) screened by transcriptome analysis implied motor neuron degeneration, which was validated by subsequent morphological observation, as axon length and branches were truncated in the 62.5 µg/L ETU group. However, although the rescue experiment with a p38 MAPK inhibitor (SB203580) successfully ameliorated axon degeneration, it failed to reverse the locomotion behaviors. Further exploration of transcriptome data revealed the varied expression of presynaptic scaffold protein-related genes ( pcloa, pclob, bsna ), whose downregulation might impair the neuromuscular junction (NMJ). Therefore, we reasonably suspected that ETU-induced neurobehavioral deficits might result from the combined effects of the MAPK pathway and presynaptic proteins. Considering this, we highlighted the necessity to take precautions and early interventions for susceptible ETU-exposed populations.
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高影响因子
JOM
·
2023
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IF 2.6
Zhu Yanshaozuo,Shen Xixun,Chen Qian,Xu Qunjie
A silicate and phosphate composite passive film on zinc was prepared from a composite passivation solution containing zinc dihydrogen phosphate and sodium metasilicate. The morphology, composition, valence and functional groups of the passive film with different passivation times were analyzed through field-emission scanning electron microscopy (FE-SEM), energy-dispersive spectroscopy, X-ray photoelectron spectroscopy and infrared spectroscopy to understand its evolution process. The passive film exhibits a cyclic film-forming process with a periodic ratio of silicate and phosphate, which is caused by the periodic changes in the alkalization degree of the interface between the electrode and the solution. Such periodic film-forming process promotes the passive film growth and makes the passive film uniform and dense. Electrochemical analysis, immersion tests and copper sulfate spotting tests illuminate that the composite passive film is more corrosion-resistant than the pure silicate passive film. This composite passivation film exhibits a uniform corrosion behavior with gradually expanding micropores due to the effective inhibition of inward diffusion and permeation of chloride ions by the dense film structure of cyclic growth, which avoids the pinhole corrosion and improves the protection of the passivation film.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2021
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IF 8.128
Feifei Xu,Jianghong Zhao,Jianlong Wang,Taotao Guan,Kaixi Li
High activity trifunctional non-noble electrocatalysts , targeting oxygen reduction reaction (ORR), hydrogen evolution reaction (HER), and oxygen evolution reaction (OER), are rationally designed by integrating the merits of both Co 9 S 8 nanoparticles and carbons nanosheets . Herein, Co 9 S 8 loaded with S, N co-doped carbon core–shell catalyst (Co 9 S 8 @SNC) was reasonably designed and synthesized by using the strong coordination effect between Co 2+ and C S at the molecular level. The significant synergistic effect between the S, N co-doped carbon shell and Co 9 S 8 core endows the catalyst with excellent catalytic performance for ORR, HER, and OER reactions. The carbon shell enhances the conductivity of the hybrid material , while the Co 9 S 8 core provides the main catalytic active sites. More specifically, the half-wave potential for ORR is 0.846 mV, and the overpotential at 10 mA cm −2 for OER and HER are 320 mV and 170 mV, respectively. To test its practical application, zinc-air battery assembled by Co 9 S 8 @SNC shows a high power density of 239 mW cm −2 , excellent rechargeability, and long cyclic stability. This work provides a promising and extensible method to in-situ synthesize core–shell metal sulfides loaded S, N co-doped carbon composites, which can be a promising candidate for electrocatalytic material in energy storage and conversion devices.
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Miao Tian,Jianbo Shuai,Brandon A. Bishop,Wei Zhang,Jimei Chen,Xiaohui Wang
The development of materials that can act as small-diameter artificial blood vessels (SDABV) and can withstand the dynamic mechanical pressures and strains of native blood vessels (NBV) still represents a major challenge in cardiovascular disease treatment. Here, we report a biomimetic approach inspired by the hierarchical structure and interconnectivity of NBV that enables the fabrication of cellulose-based SDABV (2–5 mm). The ABV materials have an interconnected dual-network structure with a stiff regenerative cellulose hydrogel as the matrix and a photo-polymerized poly(hydroxyethyl methacrylate) as the filler. The distribution of the poly(hydroxyethyl methacrylate) in the cellulose network displays a gradient pattern. This produces a composite gel tube material that has a hierarchical structure with a dense and smooth surface, as well as a loose porous interior, which closely resembles that of NBV. As a result, the cellulose based SDABV shows similar mechanical performance with their natural counterparts, including tensile strength (1.4 MPa), strain (93 %), Young's modulus (2.98 MPa) and toughness (1040KJ/m 3 ). Moreover, the materials show excellent suture retention and burst pressure that are sufficient to meet the requirements for ABV transplantation. In vitro biocompatibility experiments showed that the composite gel materials have excellent cell compatibility, blood compatibility, and low fibrinogen adsorption and platelet adhesion that is conducive to inhibiting thrombosis. In vivo experiments on rabbit models have shown that implanting the materials for three months does not cause blood vessel blockages or inflammatory responses. Overall, the bionic-structured and functional dual-network hydrogel grafts demonstrate tremendous potential in the application of SDABV. The knowledge gained in this study will help future design and application of novel high-performance cellulose-based SDABVs.
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JOURNAL OF FOOD SCIENCE
·
2024
·Vol. 89
·期 11
·7521-7533
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IF 3.2
Aying Wen,Fang Gao,Boru Guo,Linquan Wang,Shaofeng Yuan,Hang Yu,Yahui Guo,Yuliang Cheng,Ling Yang,Weirong Yao
Existing cleaning methods mainly focus on removing free-state pesticides. However, mancozeb can bind to the wax layer of grapes, forming bound-state residues that are difficult to remove. This study aims to develop an effective cleaning strategy to eliminate both free and bound mancozeb residues from grapes. Compared with the untreated mancozeb aqueous solution, the concentration of free mancozeb significantly decreased ( p < 0.05) after treatment with ozonated water (OW), electrolyzed water (EW), and their combination (OW+EW) for 60 min. The combined treatment synergistically promoted mancozeb degradation, thus reducing its half-life to 38% and 75% of that observed when OW and EW were used alone, respectively. To investigate the effect of the waxy layer on mancozeb removal, oleanolic acid (OLA) was selected as a representative component. The binding effect of OLA limited the degradation of mancozeb in OW and EW, extending its half-life by 1.27 and 1.20 times, respectively. Density functional theory elucidated the mechanism by which the binding of OLA affects the degradation of mancozeb. Interestingly, the decomposition of mancozeb in OW + EW was almost unaffected by the introduction of OLA, indicating that the combined treatment could effectively remove bound-state mancozeb. The combined treatment was then successfully applied to remove mancozeb from grapes. After exposure to OW + EW for 10 min, the removal efficiency of mancozeb reached up to 80.61% with minimal risks of ethylene thiourea formation. There was no obvious change in the surface color of grapes after treatment. The findings provide valuable guidance for removing mancozeb from fresh fruits rich in waxy coatings.
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高影响因子
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