Antioxidants
·
2025
·Vol. 14
·期 10
·1206
·
IF 6.6
Haoyu Liu,Zhen Yang,Qian Chen,Hongjuan Zhang,Yu Liu,Di Wu,Dan Shao,Shengyi Wang,Baocheng Hao
Chronic inflammatory bowel disease, ulcerative colitis (UC), currently lacks specific drugs for clinical treatment, and screening effective therapeutic agents from natural plants represents a critical research strategy. This study aimed to investigate the therapeutic potential of the flavonoid extract of Polygonum viviparum L. (TFPV) against UC. Liquid chromatography-mass spectrometry (LC-MS) was used to identify the chemical components of TFPV, while cell and animal models were employed to evaluate its anti-inflammatory effects on lipopolysaccharide (LPS)-induced inflammation. The mechanism of anti-inflammatory action was further investigated using a mouse model of UC induced by dextran sulfate sodium (DSS). The results revealed the identification of 32 bioactive components in TFPV, with major compounds such as kaempferol, luteolin, galangin, and quercetin. TFPV effectively mitigated inflammatory damage induced by LPS in IPEC-J2 cells and C57BL/6 mice. In the UC modeled by DSS, TFPV attenuated intestinal inflammation by reducing pro-inflammatory cytokines IL-1β, IL-6, and TNF-α; increasing the anti-inflammatory cytokine IL-10; up-regulating tight junction protein expression such as Claudin-1, Occludin, and ZO-1; and inhibiting the expression of PI3K, AKT, NF-κB, and IL-17 proteins. Analysis of mice fecal samples through 16S rRNA gene sequencing demonstrated that TFPV adjusted the equilibrium of gut microbiota by boosting the abundance of Dubosiella and diminishing that of Enterococcus , Romboutsia , and Enterobacter . Untargeted metabolomics analysis further revealed that TFPV reduced inosine and ADP levels while increasing dGMP levels by the regulation of purine metabolism, ultimately resulting in decreased uric acid levels and thereby alleviating intestinal inflammation. Additionally, TFPV safeguarded the intestinal mucosal barrier by enhancing the expression of tight junctions. In conclusion, TFPV alleviates UC by blocking the PI3K/AKT/NF-κB and IL-17 signaling pathways, lessening intestinal inflammation and injury, safeguarding intestinal barrier integrity, balancing gut microbiota, and lowering uric acid levels, suggesting its promise as a therapeutic agent for UC.
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Materials Today Bio
·
2026
·
IF 11
Shiqing Ma,Mengzhen Cui,Kexin Chang,Guohua Yang,Le Li,Bo Kou,Bo Xu,Yaoyang Li,Fuli Liu,Mengying Jin,Yo Shibata,Jun Zhou,Rui Li
Implant integration is severely impacted by diabetes mellitus impaired bone formation and chronic inflammation. Pronounced fluctuations in blood glucose levels further hinder therapeutic regulation, rendering static drug-release strategies inadequate. To address this issue, we developed a trabecular tantalum implant with a porous structure mimicking cancellous bone mechanics, coated with phenylboronic acid–modified mesoporous silica nanoparticles loaded with aspirin. This design enables dynamic, glucose-responsive, dual-mode drug delivery; under normoglycemia, aspirin is released slowly to promote osteogenesis, whereas under hyperglycemia, its release is accelerated to suppress inflammation. In vitro, the coating enhanced the osteogenic differentiation of stem cells and promoted M2 macrophage polarization. In a diabetic rat defect model, this system improved osseointegration and reduced inflammatory responses. These findings indicate that we developed a metabolically adaptive implant surface that integrates trabecular tantalum with glucose-responsive nanocarriers. By coupling drug release kinetics with the metabolic status, this strategy addresses the dual obstacles of impaired osteogenesis and inflammation in diabetes and advances the development of smart biomaterials for clinical translation.
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SYNTHETIC METALS
·
2026
·
IF 4.6
Shuang Luo,Feiyang Shen,Junyao Li,Wenrong Cai,Yong Kong
A molecularly imprinted electrochemical sensor is facilely designed for the detection of eugenol (EU). Copper nanoparticles (CuNPs) are first electrodeposited on the surface of a glassy carbon electrode (GCE) and act as the built-in probe. By using EU as the template molecules, o -phenylenediamine (o-PD) monomers are electropolymerized on the surface of the CuNPs/GCE. After the removal of the EU template molecules with the ethanol/water mixture, the molecularly imprinted electrochemical sensor is obtained. According to the cathodic peak currents ( I pc ) of copper oxide generated from the oxidation of the CuNPs probe on the differential pulse voltammograms (DPVs), sensitive detection of EU can be achieved. The EU sensor shows a wide linear concentration range from 0.05 to 100 μM with a low limit of detection (LOD) of 0.022 μM under the optimized conditions. Additionally, the EU sensor exhibits excellent specificity, repeatability, reproducibility and stability. Finally, the developed EU sensor is used for the detection of EU in real samples, and reliable results are obtained.
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TOXICOLOGY LETTERS
·
2026
·
IF 2.9
Liwei Yang,Zhili Ge,Xuehan Ding,Jingjing Shi,Jiaxin Zhang,Tianyou Wang,Huibin Jiang,Xinyu Zhang,Liting Zhou
Tributyl phosphate (TBP) can lead to abnormal hepatic lipid metabolism. Inflammation triggered by the cGAS-STING may be involved in it. Within this research, we investigated the involved mechanisms of TBP-induced lipid metabolic disorders. Rats and BRL-3A cells are used as models to determine the liver toxicity of TBP. Aspirin was used to alleviate the inflammation induced by TBP. RU.521 and H151 were employed to inhibit the activation of cGAS-STING. HE staining was applied to observe liver injury. The mitochondrial structure was observed with transmission electron microscopy. The quantification of lipid levels was achieved through colorimetry. The concentrations of inflammatory factors were assessed by ELISA. The expression levels of genes involved in lipid metabolism and cGAS-STING signaling pathway were detected by Q-PCR and western blot. TBP induced hepatocyte swelling and disorganized cord structures of rat livers. Following exposure to TBP, there is an elevation in the concentrations of triglycerides (TG) and total cholesterol (T-CHO), and the mRNA and protein expression levels of FASN, SREBP2, and PPARγ also showed a significant increase( P < 0.05). TBP exposure enhanced interleukin-6 (IL-6) production and this effect is reversed by aspirin treatment( P < 0.05). In BRL-3A cells, inhibiting cGAS-STING signaling pathway decreased the IL-6 concentrations and reversed the lipid accumulation caused by TBP( P < 0.05). Taken together, our results suggest TBP induced histopathological damage in rat livers, including hepatocyte swelling and disorganized cord structures. It also caused alterations in mitochondrial structure. Moreover, TBP can mediate inflammatory responses via the cGAS-STING, which in turn leads to hepatic lipid accumulation.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9
Yu Zhang,Cuiyu Huang,Qiao Hu,Jingjing Hui,Xiwen He,Langxing Chen,Yukui Zhang
Fluoroquinolones residues pose direct threats to the ecological system and human health, hence it is important to effectively remove them from aqueous environment. In this work, a composite of bimetallic ZnCo-metal organic framework (MOF) functionalized electrospun polyacrylonitrile (PAN) nanofibers (ZnCoMOF@PAN) was prepared using room-temperature in situ growth approach for efficient adsorption of ciprofloxacin (CIP). The ZnCoMOF@PAN revealed well-defined crystallinity and exceptional BET surface area (1267.87 m 2 /g). The systematic adsorption studies (kinetics, isotherms, and thermodynamics) showed that the CIP adsorption process was spontaneous and the adsorption isotherms obeyed the Freundlich model, and the pseudo-second-order kinetics model could be well fitted to the adsorption behavior. Remarkably, the maximum adsorption capacity of ZnCoMOF@PAN to CIP can reach 872.32 mg/g, which is significantly higher than that of other reported adsorbents. In addition, the adsorption of CIP onto ZnCoMOF@PAN was dominated by a synergistic effect of multiple interactions: electrostatic attraction, hydrogen bonding, complexation, π-π stacking, and hydrophobic effects. Furthermore, the composite exhibited excellent adsorption selectivity, maintaining over 90% removal efficiency for CIP in various real water matrices. After 5 consecutive adsorption-desorption cycles, it still retained more than 90% of its original removal efficiency, demonstrating great potential for practical application in wastewater treatment.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.1
Chenyan Lu,Dajie Zou,Ning Zhang,Huye Li,Yanyan Jia,Huan Wang
In this study, the hexane extract of Asters tataricus was used as the carbon source, and ethylenediamine and 4-bromophenylene diamine were selected as dopants to prepare nitrogen and bromine co-doped carbon dots (N,Br-CDs) by the hydrothermal synthesis method. The obtained fluorescent probe has a uniform particle size distribution, good water solubility and high stability, with a fluorescence quantum yield of 48.43%. Under 420 nm excitation conditions, N,Br-CDs exhibited the strongest fluorescence emission at 513 nm, indicating that the sensing system was in the “ON” state. Subsequently, TA was introduced as a quencher to induce static quenching of the N,Br-CDs system, significantly weakening the fluorescence intensity and switching the sensing system from “ON” to “OFF”. Finally, after EM was introduced into the N,Br-CDs/TA system, EM preferentially formed a complex with TA and weakened its quenching effect on the quantum dots, thereby achieving fluorescence recovery and returning the sensing system from the “OFF” state to the “ON” state. Based on the above mechanism, an “ON-OFF-ON” fluorescence sensing system with N,Br-CDs as the luminescent substrate was constructed for the sensitive detection of TA and EM. The results showed that the system exhibited good linear response to TA, with the linear ranges being 1.50–22.94 μM and 34.88–348.42 μM, respectively, and the limits of detection being 0.2168 μM and 2.1797 μM, respectively (LOD, S/N = 3). The linear range for EM was 1.93–377.08 μM, with a detection limit of 0.6693 μM. Furthermore, the sensor system was capable of quantitatively determining TA and EM in human serum, Huangshui River water, and milk matrices, demonstrating its potential for broad application in environmental monitoring and bioanalysis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2026
·
IF 5.2
Yuzhe Wang,Lu sheng,Lin Bu,Huijuan Li,Jianxin Wu,Qing Huang
Phospholipid vesicle-based permeation assay (PVPA) is widely applied as in vitro skin alternative model by mimicking stratum corneum to evaluate the transdermal application of drugs and chemicals. However, it is composed of lipid components only, which suffer from limitations of achieving accurate permeability prediction. To remedy this shortcoming, inactive immortalized human keratinocytes (HaCaT) were integrated as component to construct epidermal-mimicking model: EpiPVPA. The EpiPVPA could tolerate the pH 3–10 as well as up to 30% ethanol and was stable for 2 weeks at 4 ℃. And the permeation evaluation by Franz diffusion test of 14 drugs demonstrated that EpiPVPA model is comparable to porcine skin with strong correlation. After quantitative structure–property relationship (QSPR) analysis of physicochemical descriptors of 14 drugs, HLB, TPSA, and log P were selected as main factors applied to build multiple linear regression (MLR) equation, and the corresponding linear correlation R 2 was elevated to 0.9010. EpiPVPA model is feasible to be applied to permeation evaluation of drugs and cosmetics.
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ARCHIV DER PHARMAZIE
·
2026
·Vol. 359
·期 1
·e70181
·
IF 3.6
Yuanlin Luo,Xiaozhuan Jia,Hai Ren,Yue Zhu,Can Ren,Jiao Zhao,Heng Xu,Yi Wang,Lu Zhao,Zhenzhong Yang
Anticoagulation is the cornerstone for preventing thrombosis in coronary heart disease patients with atrial fibrillation or a mechanical heart valve. Guanxinjing formula (GXJF) demonstrates anticoagulant effects, while its anticoagulant substances and mechanisms remain unclear. In this study, the chemical composition of GXJF was identified, establishing a chemical basis for the discovery of anticoagulant substances. Then, a phenotype-anchored hierarchical strategy (the formula, the medicinal materials, and the representative compounds) was developed to reveal active substances, especially synergy. Meanwhile, phenotype-based topological network analysis was employed to delineate the pivotal targets. Dynamic blood flow imaging analysis in zebrafish was used to evaluate the effect of active substances in vivo. This approach enables rapid identification of active substances by hierarchically eliminating interference from inactive components, uncovers potential synergistic effects, and accelerates target identification by focusing on phenotype-relevant protein networks. Pentagalloylglucose, (+)-catechin, senkyunolide A, and lithospermic acid were considered as the anticoagulant substances of GXJF. Notably, synergy between hydroxysafflor yellow A and anhydrosafflor yellow B were discovered. Topological network analysis and enzyme activity assays suggested that they exert anticoagulant effects by inhibiting coagulation factors Xa and Ⅱa. These findings provide support for the clinical application of GXJF and establish a foundation for its quality control.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Baoli Wang,Yuhang Zhang,Yijun Zhang,Yan Deng,Feng Yang
Uniform Co 3 O 4 nanoparticles with abundant active sites loaded on the N-doped graphite carbon was prepared. • Co 3 O 4 /NC based electrochemical sensor was fabricated to detect chloramphenicol in environmental samples. • The proposed sensor presents wider linear ranges and lower detection limit. Chloramphenicol (CAP), a typical broad-spectrum antibiotic, poses considerable threats to human health due to its residues transferring through the food chain. Thus, the development of fast and highly sensitive detection technologies for CAP is of great practical importance. Herein, a Co 3 O 4 @NC nanocomposite was prepared via a controllable thermal decomposition-oxidation approach. This composite was further employed as an electrode modification material to construct a novel electrochemical platform, which was designed for the quantitative detection of CAP. Characterizations revealed that Co 3 O 4 nanoparticles were wrapped in the carbon sheet in the prepared Co 3 O 4 @NC nanocomposite with a specific surface area of 285.5 m 2 /g, along with affluent oxygen vacancy active sites. Electrochemical performance measurements indicated that Co₃O₄@NC exhibits excellent electrocatalytic reduction activity toward CAP. Under optimized experimental conditions, differential pulse voltammetry (DPV) was employed to detect CAP, and the sensor emerged a linear detection range of 0.1–500 μmol/L with a low detection limit of 12.4 nmol/L, outperforming most electrochemical sensors for CAP reported in previous papers. Additionally, it owned good selectivity, as the relative standard deviation (RSD) of the CAP detection signal was less than 5% even as the other familiar interfering species were concomitant. It also demonstrated remarkable stability, repeatability, and anti-interference ability. When applied to the actual determination of CAP residues in environmental samples, the sensor yielded recovery rates of 97.02%–104.23% for marine sediment samples and 99.77%–104.06% for seawater samples, with all RSD values below 5.1%. This study realizes the structural and performance regulation of Co₃O₄ materials through a simple and feasible strategy, providing a new sensing platform for the rapid detection of trace CAP and offering novel insights into the application of metal oxides in electrochemical sensing fields. Download: Download high-res image (126KB) Download: Download full-size image
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JOURNAL OF FOOD SCIENCE
·
2026
·Vol. 91
·期 8
·e71394
·
IF 4.1
Yizhuo Zhang,Jun Huang,Rongqing Zhou,Suyi Zhang,Yong Li,Rui Huang,Rui Liu,Chongde Wu
Litchi processing generates large quantities of seed by-products that are rich in starch and polyphenols but remain underutilized. In this study, the bioactivity and prebiotic potential of litchi seed vinegar (EHA-B-S1), a sustainable product derived from litchi seed by-products, were systematically evaluated. EHA-B-S1 displayed measurable in vitro antioxidant activity: total antioxidant capacity (4 mmol Trolox equivalents per mL), DPPH radical-scavenging of 50 µmol Vc equivalents per mL, and ABTS radical-scavenging activity of 1.0 mmol Vc equivalents per mL. EHA-B-S1 displayed moderate inhibitory capacity against α-amylase, α-glucosidase, and pancrelipase, and its performance was close to that of acarbose and orlistat. During probiotic-mediated fermentation, EHA-B-S1 rapidly acidified the fermentation environment, treatment resulted in higher measured biomass of Lactobacillus acidophilus , Lactobacillus rhamnosus , Lactiplantibacillus plantarum , and partially sustained Bifidobacterium longum compared with the control. The increase in metabolic activity showed higher short-chain fatty acid production, especially acetic acid, and expanded flavonoid diversity from 36 to 47 detected compounds; total flavonoid content increased to approximately 176% of the initial level. Network pharmacology analysis further predicted that these flavonoids may be associated with multiple metabolic and inflammatory pathways, providing hypotheses for future mechanistic studies. Collectively, the experimentally observed in vitro activities and fermentation-associated metabolite changes support further investigation of litchi seed vinegar as an upcycled bioactive fermented-food candidate, whereas its molecular targets, physiological effects, and health relevance require targeted cellular and in vivo validation.
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JOURNAL OF MOLECULAR STRUCTURE
·
2026
·
IF 4.9
Qiumei Zhang,Lixin Liu,Yunan Zhang,Yufeng Jiao,Lili Wu,Ji Zhao,Yuning Wang,Huiyi Yang,Xinyu Tian,Xingqi Zhang
For the first time, the effect of the solvent system on the type and morphology of crystals during crystal preparation has been elucidated. • Investigated the principle of solvent proton-donating ability on the formation of salicylic acid from ASP hydrolysis and ENR-SA drug salts. • By regulating the solvent system, not only was the directed preparation of drug cocrystals/salts achieved, but the physicochemical properties of the drugs were also improved. During the synthesis of the ENR-ASP drug-drug cocrystal, we unexpectedly obtained not only single crystals of the ENR-ASP cocrystal but also single crystals of the ENR-salicylic acid (SA, a hydrolysate of ASP) pharmaceutical salt. These synthesis conditions were screened, and the resulting structures were characterized by SXRD, PXRD, and HOMO-LUMO calculations. The results showed that when an ethyl acetate-acetonitrile mixture was used as the solvent, ENR and ASP formed a cocrystal via hydrogen bonding. In contrast, when a methanol-acetonitrile mixture was used, ASP underwent hydrolysis to SA, and ENR and SA formed a salt via CAHB. Accordingly, MeOH, which has a strong proton-donating capacity, promoted the hydrolysis of ASP to SA and facilitated proton transfer between ENR and SA, leading to the formation of the ENR-SA pharmaceutical salt. In contrast, EtOAc, with a weak proton-donating capacity, neither induced hydrolysis of ASP nor enabled proton transfer between ENR and ASP, resulting in the formation of the ENR-ASP cocrystal. As expected, both crystalline forms exhibited higher solubility and permeability than the parent drugs. The cocrystal’s enhanced solubility may result from reduced lattice energy due to hydrogen bonding, whereas the salt’s improvement likely arises from CAHB via proton transfer. The observed changes in permeability may be due to altered local polarity caused by variations in polar sites within the crystal structures, which may also create favorable conditions for antibacterial activity. Furthermore, both forms showed superior anti-inflammatory activity to ASP, and their in vitro antibacterial activity exceeded that of ENR. Download: Download high-res image (241KB) Download: Download full-size image
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Food Science & Nutrition
·
2026
·Vol. 14
·期 8
·e72200
·
IF 5
Fanke Zeng,Yuxiang Zhu,Xiaoyan Li,Ruyi Li,Lei Pan,Yaping Dai,Shaodan Peng,Lei Fang,Jihua Li,Wei Zhou
Litchi seeds are by-products produced from the fruit consumption, which contain rich phenolic compounds and have been traditionally used in inflammatory pain relief. This study sought to reveal phenolic profiles in the litchi seeds from different cultivars and explore their contributions to anti-inflammatory, analgesic potentials. Purified polyphenols were derived from five cultivars of litchi seeds, including Baitangying (BTY), Baila (BL), Feizixiao (FZX), Heiye (HY), and Huaizhi (HZ). Fifteen flavonoids, two phenolic acids, one coumarin, and two tannins were characterized using UPLC-Q/TOF-MS, while procyanidin A 1 , procyanidin A 2 , and phlorizin were identified as major phenolic compounds in HPLC. HY contained relatively higher phenolic contents. The polyphenols from different cultivars effectively inhibited LPS-induced generation of ROS, NO, IL-6, TNF- α , and PGE 2 in RAW 264.7 macrophages, which was tightly associated with the contents of procyanidin A 1 , procyanidin A 2 , and phlorizin. Procyanidin A 1 played a relatively significant role, which could strongly bind to iNOS, COX-2 and their mixture with procyanidin A 2 and phlorizin exhibited better effect in the NO inhibition. Furthermore, the litchi seed polyphenols were demonstrated to inhibit xylene-induced ear edema and acetic acid-induced abdominal writhing in mice. Thus, the litchi seed polyphenols possessed potentials to be utilized as anti-inflammatory and analgesic agents.
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