Analytical Methods
·
2024
·
IF 2.7
Zhaoze Lu,Jian Yu,Kaihua Wang,Wei Cheng,Likai Hou
Micro-droplets have significant applications in microbiologies, pharmaceuticals, cosmetics, and synthetic materials. Here, we present for the first time a near-infrared (NIR) light-triggered double-emulsion drop (DED) bursting method for generating a large number of micro-droplets in several micron. Under the irradiation of NIR light, the inner water phase of the DED containing a trace amount of Prussian blue (PB) rapidly heats up and evaporates rapidly to generate microbubbles due to the photothermal property of PB. By controlling the light intensity, the DED can inflate itself by coalescing these constant microbubbles to burst immediately and tear the middle oil phase to form a large number of micro-droplets. The performance of micro-droplets generated by NIR light-triggered DED bursting is investigated at different oil shell thickness (HO), oil phase viscosity (ηO) and oil type. HO and ηO are both key factors affecting the generation of micro-droplets. DED with lower HO and ηO can generate lower polydispersity and large quantity of micro-droplets by NIR-triggered DEDs bursting. The proportion of micro-droplets below 10 μm can reach up to 95%. Furthermore, camellia oil, as middle oil phase of DEDs, also can be used to generate lower polydispersity and large quantity of micro-droplets in several micron. The presented bursting method has a great potential to generate micro-droplets for micro/nano and biotechnology applications.
研究领域:
微生物学
·
药学
·
合成材料科学
·
生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2023
·
IF 4.2
Yao-Yao Su,Da-Wei Pan,Chuan-Fu Deng,Shi-Hao Yang,Yousef Faraj,Rui Xie,Xiao-Jie Ju,Zhuang Liu,Wei Wang,Liang-Yin Chu
A rotation-based microfluidic system with simple device setup and flow manipulation is developed for facile production of controllable emulsion droplets and liquid jets as well as functional microparticles and microfibers. The system consists of a vertically fixed injection tube and a rotating container. This system allows controllable production of single emulsion droplets and single-phase jets with adjustable uniform sizes, and predictable scale-up performance via numbering-up capillary to achieve an enhanced production rate. By flexibly changing the capillary geometry, this system can controllably produce single emulsion droplets with dual-phasic and triphasic morphologies, double emulsion droplets with core–shell and multicore–shell morphologies, and dual-phasic Janus jets. Moreover, this system can controllably fabricate versatile microparticles and microfibers from their droplet and jet templates via fast solidification without microchannel blocking in the open container. This work provides a powerful platform for promoting the wide-scale impact of microfluidics in material science, chemical, and biological fields.
研究领域:
材料科学
·
化学
·
生物学
✓ 已验证
产品关联
DOI
高影响因子
PHYSICS OF FLUIDS
·
2023
·Vol. 35
·期 12
·
IF 4.6
Pang Yan,Li Lin,Ru Jiahe,Zhou Qiang,Wang Xiang,Liu Zhaomiao
The application performance of droplets, including the size and core-shell volumetric ratio of a double emulsion droplet, is investigated under various geometric sizes and flow rates in a flow-focusing capillary device. This study uses three-dimensional (3D) printing to create a novel substrate to assemble capillaries and make the inner dimension of the device tunable. Droplet generation is separated into two regions (uniform or non-uniform) based on the interface coupling shapes, where different generation modes are classified based on the rupture form of the multilayer interfaces. A map of the generation modes is established based on geometric size and flow conditions. In the dripping mode, interface coupling and its effect on generation are analyzed by the interface necking process for the two generation sub-modes (with/without a ball). The local capillary number of the double emulsion droplet is established for these sub-modes to analyze variations in the inner droplet volume, which helps propose the volume predictive model of inner and outer droplets.
研究领域:
微流控技术
·
材料科学
·
生物工程
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2020
·
IF 7.489
Guangbin Ji,Fei Yang,Yanzhao Yang,Jingjing Wei,Zhijie Yang
Hypothesis The ability to control the assembly of micro/nanosized particles at liquid-liquid interface with external inputs promises new opportunities in nanofabrication and biomedicines. This work aims to demonstrate a way to control of dynamic assembly of nanoparticles at liquid-liquid interface by light and magnetic field, which consequently enables the formation of dynamic emulsion droplets. Experiments Magnetic Fe 3 O 4 nanoparticles functionalized with azobenzene moieties (Fe 3 O 4 @AZO) were synthesized and were dispersed in toluene/(N, N -dimethylformamide, DMF) binary solvent. After irradiation with UV or visible light , the assembly behavior of these Fe 3 O 4 nanoparticles were evaluated by electron microscopy and fluorescent microscopy. Findings Under UV light , Fe 3 O 4 @AZO nanoparticles were self-assembled due to the increase of dipolar interaction from the photoisomerization of azobenzene and polar molecules , DMF, were harvested from a binary solvent of DMF/toluene. While under visible light, a relief of dipolar interactions between Fe 3 O 4 @AZO nanoparticles can induce the secondary assembly of these Fe 3 O 4 @AZO nanoparticles at DMF-toluene interface, resulting in DMF droplets covered by a layer of nanoparticle superlattices . More importantly, coupled with a magnetic field, these emulsion droplets can be shaped into one dimensional ones during the interfacial assembly process, thereby giving rise to dynamic emulsions controlled by light and magnetic field.
研究领域:
材料科学
·
纳米技术
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2018
·Vol. 14
·期 39
·1802107
·
IF 9.598
Youchuang Chao,Sze Yi Mak,Shakurur Rahman,Shipei Zhu,Ho Cheung Shum
Droplets containing ternary mixtures can spontaneously phase-separate into high-order structures upon a change in composition, which provides an alternative strategy to form multiphase droplets. However, existing strategies always involve nonaqueous solvents that limit the potential applications of the resulting multiple droplets, such as encapsulation of biomolecules. Here, a robust approach to achieve high-order emulsion drops with an all-aqueous nature from two aqueous phases by osmosis-induced phase separation on a microfluidic platform is presented. This technique is enabled by the existence of an interface of the two aqueous phases and phase separation caused by an osmolality difference between the two phases. The complexity of emulsion drops induced by phase separation could be controlled by varying the initial concentration of solutes and is systematically illustrated in a state diagram. In particular, this technique is utilized to successfully achieve high-order all-aqueous droplets in a different aqueous two-phase system. The proposed method is simple since it only requires two initial aqueous solutions for generating multilayered, organic-solvent-free all-aqueous emulsion drops, and thus these multiphase emulsion drops can be further tailored to serve as highly biocompatible material templates.
研究领域:
生物技术
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2016
·Vol. 34
·期 4
·475-482
·
IF 1.811
Wang Wei-cai,Shi Kai,Pan Yan-xiong,Peng Chao,Zhao Zi-liang,Liu Wei,Liu Yong-gang,Ji Xiang-ling
In this work, monodisperse giant polymersomes are fabricated by dewetting of water-in-oil-in-water double emulsion droplets which are assembled by amphiphilic block copolymer molecules in a microfluidic device. The dewetting process can be tuned by solvation between solvent and amphiphilic block copolymer to get polymersomes with controllable morphology. Good solvent (chloroform and toluene) hinders dewetting process of double emulsion droplets and gets acornlike polymersomes or patched polymersomes. On the other hand, poor solvent (hexane) accelerates the dewetting process and achieves complete separation of inner water phase from oil phase to form complete bilayer polymersomes. In addition, twin polymersomes with bilayer membrane structure are formed by this facile method. The formation mechanism for different polymersomes is discussed in detail.
研究领域:
材料科学
·
生物工程
✓ 已验证
产品关联
DOI
高影响因子
Materials Chemistry Frontiers
·
2021
·Vol. 5
·期 19
·7306-7314
·
IF 6.482
Xuejie Liu,Xuan Yue,Nan Yan,Wei Jiang
Three-dimensional (3D) superlattice materials self-assembled from functional inorganic nanoparticles (NPs) have attracted extensive attention due to the unique properties of the building blocks and additional intriguing collective properties derived from the interaction between adjacent NPs. However, the spontaneous assembly of inorganic NPs into 3D free-standing plasmonic superlattices still remains an enormous challenge. Herein, we report a facile and universal strategy to assemble gold nanoparticles (AuNPs) tethered with polystyrene (PS) and poly(2-vinylpyridine) (P2VP) homopolymers into 3D free-standing sheet-like superlattices by systematically tuning the oil/water interfacial tension and the interfacial instability of emulsion droplets. The prepared sheet-like superlattices are multilayer and the AuNP building blocks stack as tetrahedra, in which each AuNP building block is partially sitting on the three other nearby nanoparticles. Moreover, the interparticle distance between adjacent NPs can be effectively regulated by varying the molecular weight of the tethered PS ligands on the surface of AuNPs. This template-free approach provides a novel and effective route to manipulate nanoparticles into free-standing ordered 3D superlattices with a wide range of potential applications.
研究领域:
材料科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2022
·
IF 5.999
Liyun Huang,Kui Wu,Shuhan Cai,Haosen Yu,Defei Liu,Wenbing Yuan,Xin Chen,Hongbing Ji
The monodisperse double emulsions obtained by microfluidic method can serve as ideal templates for preparing core-shell alginate microcapsules, which have attracted much attention in biological applications, such as drug delivery systems and cell encapsulation , tissue engineering. However, the formation behavior and dynamic analysis of double emulsion with an alginate shell is still unclear due to the complex rheological behavior of alginate solutions. Herein, we employ a dual-coaxial microfluidic device to generate the high-quality double emulsion droplets with alginate shell, focusing on the effects of the fluid properties of alginate solution in the middle phase (viscosity, μ m ) and the fluid flow rate on the droplet formation mechanism. As the viscosity of the middle fluid (μ m ) increased, the size of compound droplets (D 2 ) increased and the size of inner droplets (D 1 ) decreased, and the break-up regimes occurred a dripping-to-jetting transition when μ m = 160 mPa s. The number of encapsulated inner droplets can be predicted and precisely controlled by regulating the generation frequency of inner (f 1 ) and outer droplets (f 2 ). The breakup dynamics of the alginate thread are also analyzed by using the volume-of-fluid/continuum-surface-force (VOF/CSF) method. The results show that the pressure and velocity in the neck of pinch-off is lower in the jetting than that in the dripping regime. This study will provide useful guidance for the rational design and controllable preparation of core-shell alginate microcapsules.
研究领域:
生物技术
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER
·
2020
·
IF 4.231
Tingting Cui,Xiang Li,Zizhun Wang,Lixin Wu,Haolong Li
3D confined assembly in emulsion droplets is an effective way to prepare block copolymer particles with tunable nanostructures . In this process, the multi-component interaction at the droplet interface plays a crucial role, which is mainly dominated by surfactants . Here, we report the utilization of a polymer surfactant, ammonium-terminated polystyrene chains (N–PS n ), to control the 3D confined assembly of poly(styrene- block -2-vinylpyridine) (PS- b -P2VP). N–PS n shows a different interfacial tuning ability from small molecular surfactants, which can not only stabilize the emulsion droplets but also increase the volume fraction of PS components through fusing its PS chains with PS- b -P2VP. Consequently, unusual nanostructured PS- b -P2VP particles were obtained based on a binary surfactant system of N–PS n and poly(vinyl alcohol), e.g. , the rarely reported toroid-stacked ellipsoidal particles. The morphological formation mechanism was systemically studied by regulating the molecular weight of N–PS n. These results provide a new surfactant platform to tune the confined assembly of block copolymers.
研究领域:
材料科学
·
化学工程
·
高分子化学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Sijia Li,Yanxia Qiao,Hong Li,Yajie Zhang,Jingyan Zhang,Haiqiang Deng,Huiping Sun,Yan Li
We report the collisions of attoliter water-in-hydrophobic ionic liquid (IL) emulsion droplets as studied via an emulsion droplet reactor (EDR) on a carbon ultramicroelectrode (C-UME). The water-in-IL emulsion was prepared by the ultrasonic processing of a hydrophobic ionic liquid (1-decyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide, [C 10 mim][NTf 2 ]) and a potassium hydroxide solution containing guanine as the redox species. The ionic liquid is a three-in-one agent of dispersant, emulsifier, and supporting electrolyte. Under an appropriate potential, we observed the discrete collision behaviors of single emulsion droplets at the C-UME by chronoamperometry and obtained the current–time ( i − t ) curves of collisions. From the results of water-in-IL emulsion droplets collision, we discussed the collision frequency, size distribution, i − t decay behavior of emulsion droplets, and explored possible mechanisms. Furthermore, the effects of the aqueous phase supporting electrolyte and the viscosity of the ionic liquid on the collision behaviors of the emulsion droplets were investigated. Based on the results of single droplet collision, a water-in-IL emulsion collisional system was successfully established employing a hydrophobic ionic liquid without the addition of a hydrophobic supporting electrolyte.
研究领域:
化学
·
电化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF PHYSICAL CHEMISTRY B
·
2017
·
IF 3.177
Yan Zhang,Yun He,Nan Yan,Yutian Zhu,Yuexin Hu
Recently, it has been reported that the incorporation of functional inorganic nanoparticles (NPs) into the three-dimensional (3D) confined self-assembly of block copolymers (BCPs) creates the unique nanostructured hybrid composites, which can not only introduce new functions to BCPs but also induce some interesting morphological transitions of BCPs. In the current study, we systematically investigate the cooperative self-assembly of a series of size-controlled and surface chemistry-tunable gold nanoparticles (AuNPs) and polystyrene-b-poly(2-vinylpyridine) (PS-b-P2VP) diblock copolymer within the emulsion droplets. The influences of the size, content, and surface chemistry of the AuNPs on the coassembled nanostructures as well as the spatial distribution of AuNPs in the hybrid particles are examined. It is found that the size and content of the AuNPs are related to the entropic interaction, while the surface chemistry of AuNPs is related to the enthalpic interaction, which can be utilized to tailor the self-assembled morphologies of block copolymer confined in the emulsion droplets. As the content of PS-coated AuNPs increases, the morphology of the resulting AuNPs/PS-b-P2VP hybrid particles changes from the pupa-like particles to the bud-like particles and then to the onion-like particles. However, a unique morphological transition from the pupa-like particles to the mushroom-like particles is observed as the content of P4VP-coated AuNPs increases. More interestingly, it is observed that the large AuNPs are expelled to the surface of the BCP particles to reduce the loss in the conformational entropy of the block segment, which can arrange into the strings of necklaces on the surfaces of the hybrid particles.
研究领域:
材料科学
·
纳米技术
·
高分子化学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING & TECHNOLOGY
·
2019
·Vol. 42
·期 6
·1330-1340
·
IF 2.418
Xiaojun Wang,Jiayi Zhu,Ting Shao,Xuan Luo,Lin Zhang
An innovative coaxial capillary device with a size-comparable outlet channel was designed to meet the challenges for controllable production of highly monodisperse millimeter-sized double-emulsion droplets by one-step dripping. The technique of two angled junctions, coaxial capillaries, and compound channel geometry was introduced to convert the millifluidics to microfluidic hydrodynamic features. The relevant nondimensional numbers for a typically regular dripping in this kind of millifluidic flows were similar to those in common microfluidic devices. Effects of the rival forces due to the fluid factors on droplet formation were clarified to explain the dynamic behaviors of double-emulsion formation and to establish the mechanism of droplet breakup. The results helped to understand the coaxial flow pattern for obtaining a more precise droplet size control and to develop high-throughput setups for chemistry, physics, and biology.
研究领域:
化学工程
·
生物技术
·
物理学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）