The incorporation of functional nanoparticles within block copolymer micelles can form hybrid materials with desired optical, electronic, and magnetic properties. A versatile approach was developed to prepare ultralong nanofibers through the cooperative assembly of block copolymers and nanoparticles in emulsions. Enthalpic and entropic factors collectively contributed to the synergistic assembly of block copolymers and nanoparticles for the formation of uniform hybrids. The nanoparticles were precisely aligned in the central cores of the nanofibers which can reach to tens of micrometers. The uniform and ultralong nanofibers may serve as building blocks for constructing integrated architectures or devices for fundamental study and practical applications in nanoscience and nanotechnology.
Wenchao Geng,Linsheng Xue,Yuling Li,Jiangying Ji,Xinxin Yuan,Lihua Ding,Ruiying Yang
Herein, a novel silver ion-loaded gold microemulsion assemblies (Au/Ag + MAs) mediated multifunctional signal amplification strategy was proposed to construct a sensitive immobilization-free photoelectrochemical (PEC)/colorimetric biosensor for carcinoembryonic antigen (CEA) detection. Through the sandwiched reaction among CEA, the CEA aptamer (DNA1) loaded on the Au nanoparticles (NPs) functionalized iron oxide (Fe 3 O 4 ) nanospheres and another CEA aptamer (DNA2) immobilized on Au/Ag + MAs , a complex is formed and acquired by magnetic separation. Then, Au/Ag + MAs of the complex are disassembled into Au NPs and Ag + ions driven by an acetone response, and the obtained demulsification solution is transferred to the cadmium sulfide/cadmium telluride (CdS/CdTe) photoactive composites modified electrode . Based on the multiple inhibition functions (blocking effect of oleylamine; energy transfer effect of Au NPs; and electron snatching effect of Ag + ), the photocurrent of the electrode decreases obviously, resulting in the ultrasensitive detection of CEA (a detection limit of 16 fg mL −1 ). Interestingly, the ion-exchange reactions between CdS/CdTe composites and Ag + ions generate silver sulfide/silver telluride (Ag 2 S/Ag 2 Te) composites, and a color change of composites can be distinguished directly, leading to a quick visual detection of CEA. Compared with the traditional single-modal assay for CEA, such dual-modal PEC/colorimetric assay is a more accurate and reliable due to different mechanisms and independent signal conversion. This work will offer a new perspective for the applications of various self-assemblies in PEC bioanalysis .
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