JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
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2021
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IF 6.064
Yafei Li,Xiaocheng Lan,Boyang Liu,Tiefeng Wang
A stable and highly efficient supported Cu-Ni catalysts for the conversion of ethyl levulinate (EL) to γ-valerolactone (GVL) was developed. The catalysts were characterized by XRD, TEM, TPD, TPR, and XPS. The support effect of metal oxides (Al 2 O 3 , SiO 2 , ZrO 2 , and TiO 2 ) revealed that Cu-Ni supported on Al 2 O 3 showed the highest activity for EL hydrogenation to ethyl 4-hydroxypentanoate (EHP) and the subsequent intramolecular esterification of EHP to GVL. EHP intramolecular esterification to GVL in the ethanol solution was a reversible reaction with an equilibrium constant of 24 at 453 K. A simplified reaction kinetic network was established. The solvent had a significant influence on the reaction equilibrium and the catalyst stability. Cu-Ni/Al 2 O 3 in n-hexane solvent gave a higher GVL yield than that in ethanol solvent, and showed better recyclability than that in toluene solvent. With optimizing the conditions, Cu-Ni/Al 2 O 3 gave 99.9% conversion and 98% selectivity to GVL with a space–time yield of 1.13 g GVL g cat -1 h −1 in n-hexane solvent with good recyclability.
研究领域:
化学工程
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催化材料科学
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FOOD CHEMISTRY
·
2023
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IF 8.8
Yu Mu,Jun Huang,Rongqing Zhou,Suyi Zhang,Hui Qin,Hanlan Tang,Qianglin Pan,Huifang Tang
Bioaugmenting Daqu is an effective strategy to improve the quality of Baijiu, but its effect on overall flavor profiles and aroma-active compounds is unknown. Here, 168 volatiles were determined from fresh strong-flavor Baijiu (SFB) and bioaugmented Daqu increased their diversity and altered the flavor characteristics. Among 49 odorants identified by aroma extraction dilution analysis, 29 aroma-active compounds had odor activity values ≥1, of which 18, 8, and 3 components exhibited the highest content in the SFB fermented by fortified-, space- and conventional- Daqu , respectively. The contribution of increasing ethyl hexanoate and decreasing ethyl lactate of fresh SFB by bioaugmented Daqu was confirmed, and their content changed from 4650 and 1890 mg/L (conventional-SFB) to 6680 and 1760 mg/L (fortified-SFB) and 6130 and 1710 mg/L (space-SFB). Meanwhile, the discriminators among different samples were determined by multivariate statistical analysis. These findings are beneficial for the optimization and improvement of Baijiu aroma.
研究领域:
食品科学
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化学
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代谢组学
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感官科学
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Science Advances
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2025
·Vol. 11
·期 43
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IF 12.5
Lin Su,Dongdong Jin,Neng Xia,Bo Hao,Yihang Jiang,Qinglong Wang,Haojin Yang,Xin Wang,Kai Fung Chan,Xing Ma,Jacqueline Pui Wah Chung,Philip Wai Yan Chiu,Li Zhang
Endoluminal stent implantation is a common intervention strategy for treating obstructive lesions, but conventional delivery systems struggle to reach deep, tortuous ducts. To overcome this limitation, we present a magnetically controlled microrobot that integrates two functional modules: a magnetic actuation (MA) module for agile navigation and an ultrasound-responsive self-expanding stent module (ST module) for lesion-specific dilation. The system uses a dynamically tunable assembly mechanism governed by rotational direction enabling integrated locomotion (clockwise) and on-demand module separation (counterclockwise) at stenotic sites. The platform is compatible with intraoperative ultrasound, allowing real-time navigation and thermally triggered expansion in physiological environments. By synergizing programmable magnetic actuation, ultrasound-mediated expansion, and clinical workflow compatibility, the robot can navigate tortuous phantom ducts, achieving controlled stent deployment within 3 seconds and complete expansion within 30 seconds, permitting minimally invasive treatment of biliary strictures. This work advances microrobotic stent delivery by overcoming key barriers to clinical translation in endoluminal interventions.
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Nature Communications
·
2026
·
IF 18.1
Su Xiaoyu,Wang Lei,Wang Zhaozhong,Yang Le,Li Mingjie,Zhu Dazhao,Li Zhijun,Yuan Weizheng,Chang Honglong,Wang Binglu
Shape-morphing mechanisms help organisms adapt to their environment and have inspired applications in advanced systems. Designing microrobots that are both miniaturized and capable of fast shape changes is challenging, as performance can be weakened at small scales. Ultrasound offers advantages such as fast response, repeatability, and programmability, making it suitable for enabling shape-morphing microrobots. Here, we introduce an acoustic micromachine composed of two microbubbles connected by a microhinge. Acoustic-field excitation generates interaction forces between the bubbles, enabling complete micromachine deformation within milliseconds. We also present design principles for programmable acoustic deformation, enabling both forward and inverse design, precise control, and information storage. By tuning the excitation amplitude, the micromachine can switch between multiple modes. As proof of concept, microlotus and microbird structures are demonstrated with controllable and stable performance.
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Analytical Methods
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2026
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IF 2.6
Jun-Xia Li,Min Gong,Chao Ma,Yao-Yao Li,Ling-Xiao Liu,Bin Wang,Jin-Jing Ren,Sheng-Ming Lei,Yun-Guo Liu
Rosa rugosa Thunb. can be skillfully blended with high-quality, mellow Baijiu to produce Rose Lujiu (RL), which emits a delightful aroma. In this study, e-nose, e-tongue, GC-MS, and GC-IMS were employed to analyze the aromatic compounds. Relative odor activity value (ROAV) analysis and orthogonal partial least squares discriminant analysis (OPLS-DA) were employed to comprehensively assess volatile compounds and predict key aroma compounds. A total of 111 volatile compounds were identified using GC-MS analysis. Additionally, GC-IMS analysis identified a total of 70 aroma compounds, among which 13 key contributors to the aroma were determined based on odor activity thresholds. These results indicate that ethyl acetate, ethyl butanoate, propyl hexanoate, and 3-methyl-1-butanol emerged as pivotal odorants enabling discrimination among different RL samples. These findings would provide valuable data for the application of commercial samples in the flavor modulation of RL.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Yukun Yang,Jian Liu,Rong Guo,Baoqing Bai,Tao Bo,Jinhua Zhang,Ligang Yu,Huilin Liu,Ying Zhang,Shuo Wang
A three-channel sensor array based on Au@Pt NPs was constructed. • Au@Pt NPs with dual-function characteristics was designed. • Discrimination of light aroma-type Baijiu (LAB) was achieved. • Different years, production processes, price gradients, and adulterated were analyzed. • This method highlighted simple to operate, rapid in detection. The development of light aroma-type Baijiu (LAB) industry proposes a growing need for developing rapid and accurate discrimination method for the quality control of LAB. This study innovatively constructed a dual-mode three-channel sensor array based on the gold/platinum nanoparticles (Au@Pt NPs) with surface engineering. In this case, two colorimetric sensor channels based on ascorbic acid/para-aminophenol-chloroauric acid-nanozyme (AA/ pAP-HAuCl₄-Au@Pt NPs) and one fluorescent sensor channel based on nanozyme‑hydrogen peroxide- o -phenylenediamine (Au@Pt NPs-H₂O₂-OPD) were established. Experimental results demonstrate the colorimetric and fluorescence mode can accurately quantify four organic acids and three aldehydes in Baijiu, respectively. Samples including 17 different years and 9 different production processes of basic liquors of LAB, 48 different price gradients of commercial LAB, and adulterated LAB were analyzed. Discrimination with an accuracy exceeding 96% by Linear Discriminant Analysis, Hierarchical Cluster Analysis, and leave-one-out cross-validation was achieved. The dual-mode three-channel sensor array is characterized by simplicity, rapidity and accuracy, providing a new idea for the quality discrimination and market regulation of Baijiu.
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ANALYTICA CHIMICA ACTA
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2026
·
IF 6.1
Haiyan Cao,Bin Yang,Wenfei Dong,Wenbing Shi
Background The accurate detection of 2,3,5,6-tetramethylpyrazine (TMP) in complex matrices is significant for food quality control and biomedical analysis. Despite this need, a dedicated optical sensing platform for TMP has not been reported to date. Results Here, we present a novel ratiometric fluorescent probe based on a Tb–EDTA complex, which introduces a sensing strategy founded on coordination-induced modulation of the ligand-to-metal charge transfer (LMCT) process. Specific coordination of TMP's pyrazine nitrogen atoms to the Tb 3+ center results in a characteristic ratiometric response: quenching of the emission at 548 nm and concomitant enhancement at 650 nm. The probe exhibits excellent analytical performance with a linear range of 0.1―40 μM, a detection limit of 0.038 μM, and high selectivity over structurally similar interferents. Its practical applicability is demonstrated by reliable quantification of TMP in real samples, including sauce-flavor Baijiu, sake, and human urine, with recoveries of 94.54–104.82% and relative standard deviations below 10.57%. Significance This work establishes a pioneering optical sensing approach for TMP detection, providing a valuable analytical tool for flavor assessment in alcoholic beverages and pharmacological monitoring in biological systems.
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Foods
·
2026
·Vol. 15
·期 17
·3002
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IF 6
Min Li,Yulin Wang,Huajuan Yin,Xu Jing,Yunlong Li
Triazole fungicides (TFs) are widely used in cereal production due to their potent fungicidal activity and broad-spectrum efficacy. Nonetheless, residues of TFs in food products may pose risks to food safety and human health. Therefore, the development of efficient and environmentally friendly sample preparation methods is paramount for the reliable determination of TFs. Herein, a novel green solvent-based dispersive liquid–liquid microextraction method coupled with high-performance liquid chromatography (DLLME-HPLC) was developed for the determination of TFs in cereal samples. The prepared magnetic deep eutectic solvents (MDESs), composed of nonanoic acid and ferric hydroxide, served as green, magnetically responsive extraction solvents, enabling rapid magnetic separation without centrifugation. Four bio-based solvents (BBSs) were investigated as green dispersive solvents to facilitate the dispersion of MDESs and replace conventional toxic organic dispersants, thereby further enhancing the environmental sustainability of the extraction procedure. Owing to the combined effects of hydrophobic interactions, hydrogen-bonding networks, and magnetic responsiveness, the proposed method achieved efficient extraction and rapid phase separation while minimizing solvent consumption and operational complexity. The greenness of the method was evaluated using multiple green analytical chemistry metrics, confirming its low environmental impact, reduced waste generation, and improved operational safety compared with conventional DLLME procedures. Under optimized conditions, the method was successfully applied to determine TFs in rice, wheat, corn, buckwheat, and oat samples, achieving recoveries ranging from 75.0% to 101.9% and relative standard deviations of 1.6–4.8%. The developed DLLME method provides a rapid, sensitive, and environmentally friendly strategy for cereal pesticide residue analysis and expands the application of MDESs and BBSs in green sample preparation.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Xiaotong Lyu,Meiyi Zhou,Qian Wang,Lihuan Lang,Kemin Linghu,Chunhui Wei,Liangcai Lin,Paul A. Kilmartin,Cuiying Zhang
A systematic study was undertaken of the flavor disparities of Jiangxiang-flavor Baijiu produced across southern and northern China. Five non-volatile organic acids, seven amino acids, and twenty-one volatile compounds (OAV > 1) were identified, with 14 key aroma-active compounds determined through aroma omission and triangle tests. Quantitative targeted flavoromics and partition coefficient method were undertaken through descriptive sensory analysis. Sensory evaluation shows the intensities of floral, fruity, acidic, and grain aromas of the fourteen key aroma-active compounds were enhanced in the presence of non-volatiles. Partition coefficient analysis demonstrates that non-volatiles enhance the aroma release of most key aroma-active compounds, which aligns with sensory evaluation results showing significantly intensified fruity and floral notes following non-volatile supplementation. Co-adding organic acids and amino acids had a lower promoting effect on some volatiles than adding organic acids alone. The findings guide Baijiu production by optimizing fermentation to control non-volatile accumulation and modulate volatile release.
研究领域:
食品科学
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发酵工程
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化学
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ELECTROPHORESIS
·
2025
·
IF 2.5
Shuxuan Jin,Qian Wu,Shiqi Chang,Shaojiang Zeng,Jiqiu Yin,Huipeng Ma
Tumor–macrophage interactions play a key role in various physiological and pathological processes, such as angiogenesis, immune suppression, and extracellular matrix remodeling. In this study, a biomimetic microfluidic chip was developed to simulate the immune microenvironment of glioma through the co-culture of glioma cells and macrophages in a three-dimensional (3D) matrix. Glioma cells were embedded in collagen I solution after forming spheroids in the microwell array chip and subsequently co-cultured with macrophages in different channels. This chip enabled the real-time monitoring of morphological changes in macrophages, the invasion of glioma cell spheroids, and molecular interactions between different cell types. Two distinct cell types could be extracted and isolated in situ for subsequent molecular biological detection, such as Western blotting or qPCR. The results demonstrated that glioma cell spheroids significantly enhanced invasiveness in the presence of macrophages. Moreover, the phenotype of macrophages altered from M0 to M2 (tumor-supportive) under the influence of tumor cells. The molecular mechanism mediating this reciprocal process was extensively explored. It is believed that this 3D microfluidic tumor model could serve as a useful tool for studying the biological properties of the glioma microenvironment. In addition, a more comprehensive understanding of the mechanisms involved in glioma metastasis could be obtained, especially of how tumor inflammatory cells, including tumor-associated macrophages (TAM), affect invasion process.
研究领域:
生物工程
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癌症生物学
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免疫学
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微流控技术
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细胞生物学
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高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Yanjia Liu,Tingting Bai,Daohong Wu,Maojun Yao
Metal ions can promote the aging of Baijiu and improve its sensory quality. However, the aging mechanism mediated by metal ions remains unclear. The content of esters, alcohols, and pH decreased while the acids content, viscosity, and conductivity increased after adding metal ions. 20 kinds of aroma components were identified in Baijiu including esters, acids, alcohols, and aldehydes by Gas chromatography-mass spectrometry (GC–MS). Spectroscopy and electrochemical analysis demonstrated that Fe 3+ has a higher affinity than Cu 2+ for the flavor compounds, and both Fe 3+ and Cu 2+ exhibit stronger affinity with acids than corresponding esters. Scanning Electron Microscope (SEM) demonstratesd that Baijiu can form lamellar, spherical, flower-like, and crystal-like morphology during aging. The colloidal particles exhibit different elemental composition according to Energy Dispersive Spectrometer (EDS). These results indicated Baijiu aging is regulated by transition metal ions, thereby providing a theoretical foundation for Baijiu aging by selecting appropriate aging medium and storage conditions.
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ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Zhiang Zhang,Bing Han,Ruokun He,Shuaiqi Ren,Jiahao Fan,Wenzheng Han,Xumin Hou,Hesheng Wang,Zhuo-Chen Ma
Drawing inspiration from the doubly reentrant microstructures on springtail skins, surfaces exhibiting repellency to liquids with very low surface tension, are well developed. However, utilizing doubly reentrant microstructures for controllable wettability switching, especially for liquids with low surface tensions, still remains a challenge. Herein, a strategy is presented involving two-photon lithography-assisted molding to fabricate doubly reentrant soft microstructures (DRSMs) with real-time magnetic responsiveness. Owing to the high spatial resolution enabled by two-photon absorption and the dissolvable molding template, the 3D reentrant features are well preserved in the DRSMs based on the magnetic elastomer. Accordingly, the fabricated magnetic DRSMs exhibit switchable repellency for nearly all commonly used solvents within 1 s. Furthermore, the additional doubly reentrant micro-fence design surrounding the doubly reentrant micropillars allows the DRSMs to switch wettability even when fully immersed in liquids. These DRSMs demonstrate sufficient abilities for on-demand analyte enrichment and drug release. This work may not only serve as a design strategy to enhance the responsiveness of DRSMs but also significantly simplify the wetting switching system, which is highly attractive across various fields in biomedical and microelectronic applications.
研究领域:
材料科学
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柔性机器人
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微加工
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仿生学
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表面工程
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应用物理学
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高影响因子
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