RSC Advances
·
2019
·Vol. 9
·期 41
·23579-23588
·
IF 3.049
Pingfeng Fu,Yanhong Ma,Huifen Yang,Gen Li,Xiaofeng Lin
The diethyl dithiocarbamate (DDC) collector, a precursor of toxic N-nitrosamines, is detected in flotation wastewaters usually at the ppm level. In this study, the O3 and O3/Vacuum-UV (O3/VUV) processes were compared to investigate the efficient removal of DDC with a low risk of N-nitrosamine formation. The results showed that 99.55% of DDC was removed at 20 min by O3/VUV, and the degradation rate constant was 3.99 times higher than that using O3-alone. The C, S and N mineralization extents of DDC using O3/VUV reached 36.36%, 62.69% and 79.76% at 90 min, respectively. O3/VUV achieved a much higher mineralization extent of DDC than O3-alone. After 90 min of degradation, O3/VUV achieved lower residual concentrations of CS2 and H2S, and released lower amounts of gaseous sulfur byproducts compared to O3-alone. The solid phase extraction and gas chromatography-mass spectrometry (SPE/GC–MS) analysis indicated that the main byproducts in O3/VUV degradation of DDC were amide compounds without the detection of N-nitrosamines. The avoidance of N-nitrosamine formation might be attributed to exposure of UV irradiation and enhanced formation of ˙OH radicals in the O3/VUV system. The degradation pathways of DDC were proposed. This work indicated that O3/VUV was an efficient alternative treatment technique for the removal of DDC flotation collector with low risk of N-nitrosamine formation.
研究领域:
环境科学
·
化学工程
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DOI
PubMed
高影响因子
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
·
2014
·Vol. 99
·期 7
·3211-3220
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IF 3.811
Wang Xiangqian,Wu Chao,Liu Nan,Li Sujing,Li Wei,Chen Jianmeng,Chen Dongzhi
A Pseudomonas sp. strain WL2 that is able to efficiently metabolize ethyl mercaptan (EM) into diethyl disulfide (DEDS) through enzymatic oxidation was isolated from the activated sludge of a pharmaceutical wastewater plant. One hundred percent removal of 113.5 mg L −1 EM and 110.3 mg L −1 DEDS were obtained within 14 and 32 h, respectively. A putative EM degradation pathway that involved the catabolism via DEDS was proposed, which indicated DEDS were further mineralized into carbon dioxide (CO 2 ), bacterial cells, and sulfate (SO 4
2− ) through the transformation of element sulfur and ethyl aldehyde. Degradation kinetics for EM and DEDS with different initial concentrations by strain WL2 were evaluated using Haldane-Andrews model with maximum specific degradation rates of 3.13 and 1.33 g g −1 h −1 , respectively, and maximum degradation rate constants of 0.522 and 0.175 h −1 using pseudo-first-order kinetic model were obtained. Results obtained that aerobic degradation of EM by strain WL2 was more efficient than those from previous studies. Substrate range studies of strain WL2 demonstrated its ability to degrade several mercaptans, disulfides, aldehydes, and methanol. All the results obtained highlight the potential of strain WL2 for the use in the biodegradation of volatile organic sulfur compounds (VOSCs).
研究领域:
微生物学
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环境科学
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DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2020
·
IF 6.551
Lixun Zhang,Fangxin He,Wei Mao,Yuntao Guan
It is still a great challenge to find an eco-friendly, easy-to-synthesize, and cheap adsorbent to rapidly remove Cr(VI) to ppb level in the Cr(VI)-polluted water. Herein, a new layered double hydroxide nanocage intercalated with diethyldithiocarbamate (DDTC-LDH) was fabricated via a facile calcination-rehydration method. The DDTC-LDH rapidly decreased Cr(VI) concentration from 5 to <0.05 mg/L within 35 min, and only a few seconds were required to completely remove it at an initial concentration of 0.5–1 mg/L, primarily attributed to the effective adsorption-reduction of Cr(VI) to Cr(III) by sulfur atoms in C S and C S groups. Attractively, the generated Cr(III) was also quickly removed to below 0.1 mg/L via an opportune Lewis hard-hard interaction with C–SO x groups produced through C S oxidation. Additionally, Cr(VI) could be removed by DDTC-LDH at a wide pH application range (3.17–10.78) and with weak effects by coexisting anions (Cl − , NO 3 − , CO 3 2− , SO 4 2− , and PO 4 3− ). We systematically analyzed and proposed the mechanisms for Cr(VI) removal by the DDTC-LDH, orderly containing electrostatic attraction, Cr(VI) complexation by sulfur atoms in C S and C S groups, reduction of the Cr(VI) to Cr(III) by the C S and C S groups, and Cr(III) complexation by sulfur atoms in C–SOx groups. Our results provide new insights into the Cr(VI) removal using organosulfur compounds , that is to say, the organosulfur group Lewis hardness increased (from C–S to C–SOx) as the Cr species Lewis hardness increased (from Cr(VI) to Cr(III)), so as to opportunely ensure fast and efficient capture of both Cr(VI) and Cr(III) via Lewis acid-base interactions.
研究领域:
环境科学
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材料科学
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DOI
PubMed
高影响因子
MOLECULAR PHARMACEUTICS
·
2020
·
IF 4.321
Ying Peng,Peng Liu,Yingcai Meng,Shuo Hu,Jinsong Ding,Wenhu Zhou
Disulfiram (DSF), an old alcohol-aversion drug, has been repurposed for cancer therapy, and mechanistic studies reveal that it needs to be metabolized to diethyldithiocarbamate (DTC) and subsequently coordinates with copper(II) to form the DTC–copper complex (CuET) for anticancer activation. Here, we utilized this mechanism to construct a CuET self-delivery nanosystem based on the metal coordination polymer for highly robust and selective cancer therapy. In our design, the nanoparticles were facilely prepared under mild conditions by virtue of the strong coordination between Cu2+ and DTC, yielding 100% CuET loading capacity and allowing for further hyaluronic acid (HA) modification (CuET@HA NPs). The CuET@HA NPs could selectively deliver into cancer cells and release the active component of CuET in response to both endo/lysosome acidic pH and intracellular abundant GSH, which induces strong cytotoxicity toward cancer cells over normal cells taking advantage of the p97 pathway interference mechanism. Upon intravenous injection, the self-assembled system could passively accumulate into a tumor and elicit potent tumor growth inhibition at a dose of 1 mg/kg without any noticeable side effects. Given the cost-effective and easily scaled-up preparation, our designed nanosystem provides a promising strategy to pave the way for clinical translation of DSF-based cancer chemotherapy.
研究领域:
纳米技术
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药学
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癌症研究
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材料科学
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生物医学工程
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DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2020
·
IF 9.038
Mengke Li,Liang Hu,Hui Zhong,Zhiguo He,Wei Sun,Daolin Xiong
The recycling of solid wastes is obligable as it can reduce the environmental pollution and prevent the diffusion of secondary pollution. In this study, a novel cheap adsorbent was prepared by modifying electrolytic manganese residue (EMR) with EDTA. The maximum adsorption capacity of adsorbents for diethyl dithiocarbamate (DDTC) was 133.46 mg/g under initial pH of 7.32 at room temperature. Adsorption kinetics study revealed the DDTC adsorption on EDTA-EMR is mainly controlled by chemisorption and isotherm studies implied the adsorption is a monolayer process. Mechanism exploration found that the DDTC molecules could enter into the holes of EDTA-EMR, and the transition metal-based sorption sites were crucial for the target molecule immobilization and chelation. High pH value (> 10) was found to have inhibited the adsorption capacity of adsorbent, which should be due to the fact that the decreasing of functional groups on adsorbents surface and the competition between DDTC and OH – . The ionic strength has negligible effect on the adsorption and the as-synthesized adsorbents showed excellent performance after five cycles. The overall results reveal that EDTA-EMR is a promising adsorbent ascribed by its low cost, good recyclability and excellent adsorption capacity.
研究领域:
环境科学
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化学工程
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DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Sizhu Tian,Xuwen Li,Jia Jiang,Li Tang,Hanqi Zhang,Yong Yu,Ziwei Zhang
Water soluble copper sulfide (CuS) nanoparticles were synthesized using l -cysteine as the ligand. Multiple biotins were conjugated to the antibody of rabbit IgG, and the streptavidin was attached to the CuS nanoparticles. The Cu 2+ ions enclosed in the nanoparticles were used as the electron spin resonance (ESR) probes and detected with ESR spectrometer. The immunoassay reaction was resulted in the formation of the coating antibody attached to the microplate well, the detecting antibody labeled with the biotins, and the streptavidin attached to the CuS nanoparticles. After the immunoassay reaction was performed, large amount of Cu 2+ /Cu + ions inside the nanoparticles were released with the help of diethyldithiocarbamate (DDC) and the Cu 2+ -DDC complex formed. The Cu 2+ -DDC complex was extracted into n -butanol, which was used as the analytical sample. Both ESR and UV–vis signals were collected for the analytical sample. The double logarithm standard curve was well simulated with a linear regression equation. The limits of detection of the rabbit IgG were 1.76 pg/mL and 2.36 pg/mL by ESR and UV–vis method, respectively. The detection range using ESR as the detector was from 8.8 pg/mL to 500 ng/mL, covering almost 5 magnitude orders of the rabbit IgG concentrations. The rabbit serum was analyzed and the rabbit IgG concentration was found to be 7.76 mg/mL. The reproducibility of the present method was good enough with the intra-assay error within 3.4 % and the inter-assay error within 11.2 %. The spiked serum samples were analyzed and the experimental results indicated that the recoveries were from 108.2 to 113.7%.
研究领域:
生物化学
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分析化学
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纳米技术
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DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 57
·51823-51829
·
IF 3.289
Juan Chen,Yu-e Shi,Min Zhang,Jinhua Zhan
The nonvolatile inorganic explosives deposition on various surfaces requires rapid in situ detection by homeland security. Surface enhanced Raman spectroscopy (SERS), a prompt and sensitive detection method, has been widely applied in chemical and biological samples analysis. The most popular noble metal nanoparticle colloids, prepared by chemical reduction with citrate or hydroxylamine, are generally negatively charged. This study demonstrates that the negatively charged silver nanoparticles were transformed into the positively charged ones by sodium diethyldithiocarbamate (DDTC), a potent copper chelating agent. The zeta potential of DDTC modified silver colloid is about 32.1 mV, suggesting its positively charged nature. The XPS and SERS spectra indicate the positively charged silver nanoparticles resulted from the bidentate configuration leading to the redistribution of the free electron pair in N atom and formation of the CN+ bonding of DDTC. The positively charged silver nanoparticles can be used in the detection of inorganic explosives anions with a subnanogram detection limit through electrostatic interactions. The common organic explosive picric acid (PA) could also be detected through a similar interaction force.
研究领域:
分析化学
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材料科学
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环境安全
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DOI
高影响因子
MINERALS ENGINEERING
·
2025
·
IF 5
Song Zou,Liyong Xu,Xinyang Yu,Hong Zhong
Effective collectors are crucial for efficient galena (PbS) flotation beneficiation. This study introduces a novel synergistic mixed collector system, comprising sodium diethyl dithiocarbamate (DTC) and O,O’-bis(2-butoxyethyl) ammonium dithiophosphate (BEAT), for enhancing galena recovery and selectivity against sphalerite. Microflotation tests demonstrated that a premixed DTC/BEAT system (1:1 M ratio, at the total dosage of 2 × 10 −5 mol/L) at pH ∼ 7.0 achieved a remarkable galena recovery of 94.23 %, significantly outperforming single collectors. This synergistic effect was further validated through bench-scale flotation of lead–zinc sulfide ores. Wettability results indicated that the mixed DTC/BEAT scheme induced superior hydrophobicity on galena surfaces compared to either single collector. Zeta potential, FTIR and XPS spectra verified the co-adsorption of both DTC and BEAT collectors onto the galena surface. The findings provide an effective strategy for improving galena flotation efficiency in mineral processing.
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高影响因子
RSC Advances
·
2016
·Vol. 6
·期 34
·28229-28235
·
IF 3.289
Huile Jin,Liyun Chen,Aili Liu,Lei Guan,Dewu Yin,Pengsheng Lin,Shun Wang,Weizhong Jiang
Both microwave and conventional oil bath heating approaches are investigated for the fabrication of CdS nanocrystals through the thermolysis of a single source precursor cadmium diethyldithiocarbamate (CED), which allows us to gain further insight into the thermodynamic aspect of the synthesis. The analysis illustrates that nearly monodispersed sea-urchin-shaped CdS nanocrystals are obtained with the microwave method, whereas nanospheres covered by chunky protuberances are achieved with an oil bath approach. Such experiments suggest that microwave heating facilitates the growth of CdS along the [002] direction. In addition, we explored the catalytic activity of CdS in the photodegradation of rhodamine B, in which the CdS prepared through a microwave approach greatly outperformed that prepared through oil bath heating and the commercial CdS nanoparticles. Such enhancement arises from the higher specific surface area and crystallinity of the sea-urchin-shaped nanocrystals.
研究领域:
材料科学
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纳米技术
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化学工程
·
光化学
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产品关联
DOI
高影响因子
MINERALS ENGINEERING
·
2022
·
IF 5.479
Huizhen Xiao,Guifang Wang,Guangchuan Liang,Jinliang Zhu,Jun Qiu,Chenhui Ding,Sridhar Komarneni
The mining and processing of lead-zinc ores produce many lead-zinc ore tailings, which can cause harm by releasing toxic metal ions to the environment. Therefore, the leaching characteristics, acid generation capacity, and fractions of released heavy metals from two Pb-Zn tailings, one from Guangxi designated as F and another from Inner Mongolia designated as YD, have been investigated in this work. Here, sodium diethyl dithiocarbamate functionalized montmorillonite (DDTC-Mt) was synthesized to remediate both F and YD tailings. It was found that YD tailings have a stronger acid generation potential than F tailings, and both of them could be further oxidized and release acid. Moreover, YD showed a certain buffering capacity to acid rain due to its higher calcite content, while the leaching amounts of heavy metals from F was larger than YD resulting from the former’s higher weathering degree. DDTC-Mt resulted in a superior stabilization performance to Zn, Mn and Pb from both tailings with optimal stabilization ratios, which are all above 94%. The remediating effect of DDTC-Mt on F was better than that of YD, which could be ascribed to the fact that F contained lower amount of carbonate minerals because of a higher degree of weathering in the latter. The leaching amounts and stabilization ratios of the four elements increased with increasing time and dose of DDTC-Mt, however, temperature and pH showed little or no effect. Mineralogical analysis showed minerals in F and YD before and after leaching were mainly quartz, while the contents of sphalerite and pyrite in F-DDTC-Mt and YD-DDTC-Mt decreased although they were more than those in F and YD without DDTC-Mt after leaching for 72 h. DDTC-Mt could inhibit the release of heavy metals to a certain extent by covering the surface of tailings via complexation and precipitation. Furthermore, DDTC-Mt coating can prevent the oxidation of tailings.
研究领域:
环境科学
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矿物加工
·
土壤化学
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DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2023
·
IF 10.8
Chen Xiao,Jiayuan Li,Xing Wang,Shiyou Li,Chen Xu,Zhijie Zhang,Ao Hua,Ze-yang Ding,Bi-xiang Zhang,Xiangliang Yang,Zifu Li
Cancer stem cells (CSCs) have been recognized as the culprit for tumor progression, treatment resistance, metastasis, and recurrence while redox homeostasis represents the Achilles' Heel of CSCs. However, few drugs or formulations that are capable of elevating oxidative stress have achieved clinical success for eliminating CSCs. Here, we report hydroxyethyl starch stabilized copper-diethyldithiocarbamate nanoparticles ( [email protected] NPs), which conspicuously suppress CSCs not only in vitro but also in numerous tumor models in vivo . Furthermore, [email protected] NPs effectively inhibit CSCs in fresh tumor tissues surgically excised from hepatocellular carcinoma patients. Mechanistically, we uncover that hydroxyethyl starch stabilized copper-diethyldithiocarbamate nanocrystals via copper‑oxygen coordination interactions, thereby promoting copper-diethyldithiocarbamate colloidal stability, cellular uptake, intracellular reactive oxygen species production, and CSCs apoptosis . As all components are widely used in clinics, [email protected] NPs represent promising treatments for CSCs-rich solid malignancies and hold great clinical translational potentials. This study has critical implications for design of CSCs targeting nanomedicines .
研究领域:
纳米技术
·
肿瘤学
·
药学
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产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2024
·
IF 8.2
Jiacheng Sun,Bo Yan,Hongxing Chen,Shuchen Tu,Junhao Zhang,Tao Chen,Qinzi Huang,Yuting Zhang,Lingtian Xie
Currently, risk assessment and pollution management in mines primarily focus on toxic metals, with the flotation agents being overlooked. However, the combined effects of metals and flotation agents in mines remain largely unknown. Therefore, this study aimed to evaluate the combined effects of Cd and two organic flotation agents (ethyl xanthate (EX) and diethyldithiocarbamate (DDTC)), and the associated mechanisms. The results showed that Cd + EX and Cd + DDTC exhibited synergistic toxicity. The EC 50 values for luminescent bacteria were 1.6 mg/L and 1.0 mg/L at toxicity unit ratios of 0.3 and 1, respectively. The synergistic effects were closely related with the formation of Cd(EX) 2 and Cd(DDTC) 2 micro/nano particles, with nano-particles exhibiting higher toxicity. We observed severe cell membrane damage and cell shrinkage of the luminescent bacteria, which were probably caused by secondary harm to cells through the released CS 2 during their decomposition inside cells. In addition, these particles induced toxicity by altering cellular levels of biochemical markers and the transcriptional levels of transport proteins and lipoproteins, leading to cell membrane impairment and DNA damage. This study has demonstrated that particulates formed by Cd and flotation agents contribute to the majority of the toxicity of the binary mixture. This study helps to better understand the complex ecological risk of inorganic metals and organic flotation agents in realistic mining environments.
研究领域:
环境科学
·
毒理学
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矿物加工
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生态毒理学
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）